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A B C D E F Figure 4. Analogs with possible biological activity A: 28 X=NH Z= CH 2 RRR B: 28 X=NH Z=O RRR C: 28 X=NH Z=O SSS D: 28 X=NH Z=CO SSS E: 29 X=O Z=CH 2 RSS F: 29 X=NH Z=CH 2 RRR Meeting of Minds 2006 82
As seen from the distance data above, it is possible that there is a collation between the backbone of the structure and the distance between the rings. The structures that had similar ring distances to paclitaxel were either analog 28 or 29 therefore, seems to be a preference for the 6-8- 6 backbone to achieve a similar ring distance. By comparison of 28-NH-CH 2 -RRR and 29-NH-CH 2 -RRR from above it could be concluded that the additional methyl group on 29 makes no difference in determining the distance between the methyl groups. 28-NH-CH 2 -RRR has a distance of 10.87Å and 29-NH-CH 2 -RRR has a distance of 10.77Å. Therefore, the additional methyl group is not necessary for the molecule to have a similar ring distance. References: [1] Eisenhauer, E.A.; Vermorken, J. B. Drugs 1998, 55, 9. [2] Kobayashi, M.; Takaori-Kondo, A.; Shindo, K.; Mizutani, C.; Ishikawa, T.; Uchiyama, T. Intern. Med. 2002, 41, 1209. [3] Georg, G.I.; Chen, T. C.; Oijma, I. ACS Symposium Series No. 583; Vyas, D.M., Ed.; American Chemical Society: Washington DC, 1995. [4] Hamel, E. Med. Res. Rev. 1996, 16, 207. [5] Snyder, J. P.; Nettles, J.H.; Cornett, B.; Downing, K.H.; Nogales, E. Proc. Natl. Acad. Sci. USA 2001, 98, 5312. [6] Geng, X.; Geney, R.; Pera, P.; Bernacki, R.J.; Oijma, I. Biorg. Med. Chem. Lett. 2004, 14, 3491. [7] Holton, R.A.; Somora, C.; Kin, H.B.; Liang, F.; Biedger, R.J.; Boatman, P.D.; Shino, M.; Smith, C.C.; Kim, S.C.; Nadizadeh, H.; Suzuki, Y.; Tao, C.L.; Vu, P.; Tang, S.H.; Zhang, P.S.; Murthi, K.K.; Gentile, L.N.; Liu, J.H. J. Am. Chem. Soc. 1994, 116, 1597. [8] Edwards, N. www.bris.ac.uk/Depts/Chemistry/MOTM/taxol/taxol.htm, June 20, 2006. [9] Abdessamad, A.; Saha, N.; Schmidt, F.; Monneret, C.; Florent, J.C., Bioorganic & Medicinal Chemistry. 2006, 5012-5019. [10] Zand, A.; Wagner, G.; Song, J.; Tischler, J, Letters in Drug Design & Discovery. 2005, 2, 355-363. Meeting of Minds 2006 83
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Meeting of Minds XIV Journal of Und
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ABOUT THE MEETING OF MINDS: JOURNAL
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TABLE OF CONTENTS Preface Contribut
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DIFFERENCES IN TEACHING: INNER-CITY
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1995. The teacher believed they are
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In studies of age related declines
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slightly smaller than the incongrue
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Since the requirements of surviving
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Table 2 Observed behaviors of Imara
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Figure 2 Relative frequencies of de
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References Alexander, R. D. “The
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She goes for it. She proves to the
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Hypotheses The current study examin
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Previous fMRI research suggests tha
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[LDL’s] carry cholesterol from th
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for amounts in excess of 0.5 grams.
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Dewey, David L. “Hydrogenated Oil
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These are the tranquillized Fifties
Page 37 and 38: The reader is thrust out of the mem
Page 39 and 40: WHEN THE SAINTS GO MARCHING OUT: CO
Page 41 and 42: What follows is a description of tw
Page 43 and 44: The ceiling of the church is adorne
Page 45 and 46: Against the back wall of the church
Page 47 and 48: Bibliography Bowen, John R. Religio
Page 49 and 50: (Gough, 1957). Because individuals
Page 51 and 52: References Bochner, A., di Salvo V.
Page 53 and 54: It is difficult for many critics, a
Page 55 and 56: It seems clear that Bishop is not a
Page 57 and 58: “SHE WAS ONLY A SLIP OF A THING B
Page 59 and 60: women are strong enough to care for
Page 61 and 62: had the luxury of doing business
Page 63 and 64: Chinese students regularly had as m
Page 65 and 66: The age of the participants ranged
Page 67 and 68: Table 3 illustrates the results of
Page 69 and 70: If I was to further this study, I w
Page 71 and 72: idomain conductivities (σ iL , σ
Page 73 and 74: Meeting of Minds 2006 67
Page 75 and 76: THEORETICAL INVESTIGATIONS ON ADSOR
Page 77 and 78: 1T 3T 5T Figure 1: The cluster mode
Page 79 and 80: The N-O bond lengths also show a si
Page 81 and 82: The relative energies of the NO ads
Page 83 and 84: INVESTIGATION OF SUBSTITUTED CYCLOO
Page 85 and 86: were 9 possibilities from the X and
Page 87: 28 O O RSS NA 8.6 28 O O SSS NA 8.6
Page 91 and 92: continually touches her and plays w
Page 93 and 94: In the last scene, Act 5.4, the tra
Page 95 and 96: Tristan was the one who had her bef
Page 97 and 98: Bibliography Béroul. The Romance o
Page 99 and 100: given day one could observe a cheat
Page 101 and 102: Many countries have taken Latin Ame
Page 103 and 104: References and Works Cited Andaló,
Page 105 and 106: differentiates human beings from an
Page 107 and 108: has to beg the wind to help her. Th
Page 109 and 110: APOCALYPSE, WHEN? Joanne Chiu Facul
Page 111 and 112: Lowell’s energetic diction connec
Page 113 and 114: The apocalypse has come and as with
Page 115 and 116: RELIGION AS A MANIPULATIVE TOOL IN
Page 117 and 118: With a sense of his mastery of stra
Page 119 and 120: References Arenal, Electa and Stace
Page 121 and 122: constructed a visual lexicon aggres
Page 123 and 124: them as the hoods plot their next t
Page 125 and 126: The motivation behind Guston’s re
Page 127 and 128: LANGUAGE ACQUISITION: A PARADOX OF
Page 129 and 130: GUNTHER VON HAGEN’S GESTALT PLAST
Page 131 and 132: are borrowed directly from the visu
Page 133 and 134: In general, science museums do not
Page 135 and 136: The report suggests that war-crimes
Page 137 and 138: DATA MINING IN BIOINFORMATICS: USIN
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Zealand, which was ranked 77 th in
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THE JENSEN LANDSCAPE AT HENRY AND C
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number of Boxelder trees increased
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Figure 3. The distribution of Sugar
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THE EFFECT OF RETINOIDS ON REGENERA
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deparaffinized in xylene. After the
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A B C Figure 2 Photographs of tadpo
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IU/mL retinoids is the best concent
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