A B C D E F Figure 4. Analogs with possible biological activity A: 28 X=NH Z= CH 2 RRR B: 28 X=NH Z=O RRR C: 28 X=NH Z=O SSS D: 28 X=NH Z=CO SSS E: 29 X=O Z=CH 2 RSS F: 29 X=NH Z=CH 2 RRR Meeting <strong>of</strong> Minds <strong>2006</strong> 82
As seen from the distance data above, it is possible that there is a collation between the backbone <strong>of</strong> the structure and the distance between the rings. The structures that had similar ring distances to paclitaxel were either analog 28 or 29 there<strong>for</strong>e, seems to be a preference <strong>for</strong> the 6-8- 6 backbone to achieve a similar ring distance. By comparison <strong>of</strong> 28-NH-CH 2 -RRR and 29-NH-CH 2 -RRR from above it could be concluded that the additional methyl group on 29 makes no difference in determining the distance between the methyl groups. 28-NH-CH 2 -RRR has a distance <strong>of</strong> 10.87Å and 29-NH-CH 2 -RRR has a distance <strong>of</strong> 10.77Å. There<strong>for</strong>e, the additional methyl group is not necessary <strong>for</strong> the molecule to have a similar ring distance. References: [1] Eisenhauer, E.A.; Vermorken, J. B. Drugs 1998, 55, 9. [2] Kobayashi, M.; Takaori-Kondo, A.; Shindo, K.; Mizutani, C.; Ishikawa, T.; Uchiyama, T. Intern. Med. 2002, 41, 1209. [3] Georg, G.I.; Chen, T. C.; Oijma, I. ACS Symposium Series No. 583; Vyas, D.M., Ed.; American Chemical Society: Washington DC, 1995. [4] Hamel, E. Med. Res. Rev. 1996, 16, 207. [5] Snyder, J. P.; Nettles, J.H.; Cornett, B.; Downing, K.H.; Nogales, E. Proc. Natl. Acad. Sci. USA 2001, 98, 5312. [6] Geng, X.; Geney, R.; Pera, P.; Bernacki, R.J.; Oijma, I. Biorg. Med. Chem. Lett. 2004, 14, 3491. [7] Holton, R.A.; Somora, C.; Kin, H.B.; Liang, F.; Biedger, R.J.; Boatman, P.D.; Shino, M.; Smith, C.C.; Kim, S.C.; Nadizadeh, H.; Suzuki, Y.; Tao, C.L.; Vu, P.; Tang, S.H.; Zhang, P.S.; Murthi, K.K.; Gentile, L.N.; Liu, J.H. J. Am. Chem. Soc. 1994, 116, 1597. [8] Edwards, N. www.bris.ac.uk/Depts/Chemistry/MOTM/taxol/taxol.htm, June 20, <strong>2006</strong>. [9] Abdessamad, A.; Saha, N.; Schmidt, F.; Monneret, C.; Florent, J.C., Bioorganic & Medicinal Chemistry. <strong>2006</strong>, 5012-5019. [10] Zand, A.; Wagner, G.; Song, J.; Tischler, J, Letters in Drug Design & Discovery. 2005, 2, 355-363. Meeting <strong>of</strong> Minds <strong>2006</strong> 83
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Meeting of Minds XIV Journal of Und
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ABOUT THE MEETING OF MINDS: JOURNAL
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TABLE OF CONTENTS Preface Contribut
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DIFFERENCES IN TEACHING: INNER-CITY
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1995. The teacher believed they are
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In studies of age related declines
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slightly smaller than the incongrue
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Since the requirements of surviving
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Table 2 Observed behaviors of Imara
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Figure 2 Relative frequencies of de
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References Alexander, R. D. “The
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She goes for it. She proves to the
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Hypotheses The current study examin
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Previous fMRI research suggests tha
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[LDL’s] carry cholesterol from th
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for amounts in excess of 0.5 grams.
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Dewey, David L. “Hydrogenated Oil
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These are the tranquillized Fifties
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- Page 75 and 76: THEORETICAL INVESTIGATIONS ON ADSOR
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Zealand, which was ranked 77 th in
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THE JENSEN LANDSCAPE AT HENRY AND C
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number of Boxelder trees increased
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Figure 3. The distribution of Sugar
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THE EFFECT OF RETINOIDS ON REGENERA
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deparaffinized in xylene. After the
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A B C Figure 2 Photographs of tadpo
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IU/mL retinoids is the best concent