MOM 2006 journal for pdf.pmd - University of Michigan-Flint
MOM 2006 journal for pdf.pmd - University of Michigan-Flint
MOM 2006 journal for pdf.pmd - University of Michigan-Flint
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Figure 4 below. These results <strong>of</strong> the theoretical study will then be used to determine which <strong>of</strong> the<br />
analogs will be studied further. Those analogs that are similar to paclitaxel will be synthesized<br />
and the actual biological activity will then be discovered.<br />
Table 1: Selected Phenyl Ring Distance Calculation Results<br />
Analog X Z Stereochemistry 1-3 Distance (Å) 2-3 Distance(Å)<br />
26 O CH 2<br />
RSS NA 8.4<br />
26 O CH 2<br />
SRR 6.7 8.8<br />
26 O CH 2<br />
SSS NA 8.4<br />
26 O CO SSS 5.6 NA<br />
26 O O RSS NA 8.5<br />
26 O O SSS NA 8.4<br />
26 NH CH 2<br />
SSS NA 8.3<br />
26 NH CO RSS NA 8.8<br />
26 NH CO SRR 6.1 NA<br />
26 NH CO SSS NA 8.8<br />
27 O CH 2<br />
RSS 8.4 NA<br />
27 O CO RSS NA 8.4<br />
27 O CO SRR 7.7 NA<br />
27 O CO SSS NA 8.3<br />
27 O O RSS 8.5 NA<br />
27 O O SSS 7.4 8.6<br />
27 CH 2<br />
CH 2<br />
RRR NA 8.6<br />
27 CH 2<br />
O RRR NA 8.5<br />
27 CH 2<br />
O SRR 8.5 NA<br />
27 NH CH 2<br />
RSS NA 8.4<br />
27 NH CH 2<br />
SRR 5.7 NA<br />
27 NH CH 2<br />
SSS NA 8.4<br />
27 NH CO SSS NA 8.7<br />
27 NH CO RRR 7.6 NA<br />
27 NH CO RSS 9.1 NA<br />
27 NH O RSS(1/3) 7.9 8.4<br />
27 NH O SSS NA 8.4<br />
28 O CH 2<br />
SRR 6.3 NA<br />
28 O CO RSS NA 8.9<br />
28 O CO SSS NA 8.9<br />
Meeting <strong>of</strong> Minds <strong>2006</strong> 80