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Xenotransplantation - Nuffield Council on Bioethics

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Terms of reference<br />

Working Party <strong>on</strong> Xenografts<br />

Terms of Reference<br />

1 To review recent and prospective advances in xenografts and the current and<br />

prospective applicati<strong>on</strong>s of such procedures. For these purposes xenografts are<br />

defined as the transplantati<strong>on</strong> of animal cells, tissues or organs into human beings.<br />

2 To identify and c<strong>on</strong>sider the ethical issues arising from current and prospective uses<br />

of xenografts, including in particular:<br />

a<br />

b<br />

c<br />

d<br />

e<br />

the ethical aspects of the case for xenografts in the light of alternative<br />

procedures or practices, taking into account current and potential benefits<br />

and current and potential difficulties;<br />

the use of animals as sources of cells, tissues or organs;<br />

the special care and maintenance of the animals intended for that use;<br />

the ethical implicati<strong>on</strong>s of transferring human genes into animals to allow<br />

the subsequent transplantati<strong>on</strong> of animal cells, tissues or organs into human<br />

beings,<br />

any other ethical issues arising from experimentati<strong>on</strong> with transgenic<br />

animals to enable their use as sources of xenografts - taking account, in<br />

particular, of the possibilities of the transmissi<strong>on</strong> of disease across species<br />

boundaries.<br />

vii

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