The ethics of research involving animals - Nuffield Council on ...
The ethics of research involving animals - Nuffield Council on ...
The ethics of research involving animals - Nuffield Council on ...
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T h e e t h i c s o f r e s e a r c h i n v o l v i n g a n i m a l s<br />
3 October 2003, Biology Department, University <str<strong>on</strong>g>of</str<strong>on</strong>g> York<br />
Members <str<strong>on</strong>g>of</str<strong>on</strong>g> the Working Party who attended the meeting included Nick Ross, Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor John<br />
Spencer, Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor J<strong>on</strong>athan Wolff, Dr Sandy Thomas and Harald Schmidt.<br />
Staff at the Biology Department <str<strong>on</strong>g>of</str<strong>on</strong>g> the University <str<strong>on</strong>g>of</str<strong>on</strong>g> York:<br />
Programme<br />
Dr Patricia Couls<strong>on</strong><br />
Dr Betsy Pownall<br />
Dr Harv Isaacs<br />
Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor Henry Leese<br />
Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor Alan Wils<strong>on</strong><br />
Mike Snelling<br />
Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor Alistair Fitter<br />
Dr Piran White<br />
Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor Ge<str<strong>on</strong>g>of</str<strong>on</strong>g>f Hall<br />
APPENDIX 4: METHOD OF WORKING<br />
■ Introducti<strong>on</strong> to basic and applied <str<strong>on</strong>g>research</str<strong>on</strong>g> <str<strong>on</strong>g>involving</str<strong>on</strong>g> amphibians and rodents;<br />
■ tour <str<strong>on</strong>g>of</str<strong>on</strong>g> the animal facilities and discussi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> scientific, regulatory and ethical issues with staff<br />
and students relating to developmental studies <strong>on</strong> fertilised eggs <str<strong>on</strong>g>of</str<strong>on</strong>g> frogs; studies for improved<br />
fertility treatment using mice, and cattle and pig embryos; the development <str<strong>on</strong>g>of</str<strong>on</strong>g> a<br />
schistosomiasis vaccine <str<strong>on</strong>g>involving</str<strong>on</strong>g> snails, worms and mice.<br />
3 October 2003, the c<strong>on</strong>tract <str<strong>on</strong>g>research</str<strong>on</strong>g> organisati<strong>on</strong> Covance (a c<strong>on</strong>tract <str<strong>on</strong>g>research</str<strong>on</strong>g> organisati<strong>on</strong>),<br />
Harrogate<br />
Members <str<strong>on</strong>g>of</str<strong>on</strong>g> the Working Party who attended the meeting included Nick Ross, Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor John<br />
Spencer, Pr<str<strong>on</strong>g>of</str<strong>on</strong>g>essor J<strong>on</strong>athan Wolff, Dr Sandy Thomas and Harald Schmidt<br />
Staff at Covance:<br />
Dr Chris Springall<br />
Vice President, Toxicology<br />
Colleagues with expertise in toxicology <str<strong>on</strong>g>research</str<strong>on</strong>g> and ethical review<br />
Programme:<br />
■ Introducti<strong>on</strong> to scientific and regulatory aspects relating to the toxicity testing <str<strong>on</strong>g>of</str<strong>on</strong>g> new<br />
medicines and agrochemicals;<br />
■ tour <str<strong>on</strong>g>of</str<strong>on</strong>g> the animal facilities and discussi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> scientific and animal welfare related issues with<br />
staff c<strong>on</strong>cerning <str<strong>on</strong>g>research</str<strong>on</strong>g> <strong>on</strong> pregnant rabbits to assess the toxicity <str<strong>on</strong>g>of</str<strong>on</strong>g> a pesticide <strong>on</strong> fetuses; the<br />
testing <str<strong>on</strong>g>of</str<strong>on</strong>g> anti-diabetes compounds in mice; <str<strong>on</strong>g>research</str<strong>on</strong>g> <str<strong>on</strong>g>involving</str<strong>on</strong>g> captive-bred macaque m<strong>on</strong>keys;<br />
and systemic toxicity studies in beagles;<br />
■ discussi<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> methodological and regulatory issues relating to toxicity testing including the<br />
functi<strong>on</strong> and adequacy <str<strong>on</strong>g>of</str<strong>on</strong>g> the severity banding <str<strong>on</strong>g>of</str<strong>on</strong>g> the Home Office and the scientific scope and<br />
limitati<strong>on</strong>s <str<strong>on</strong>g>of</str<strong>on</strong>g> alternatives to tests such as the Draize test.<br />
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