Institute of Bone Science OSSTEM IMPLANT - 3GO
Institute of Bone Science OSSTEM IMPLANT - 3GO
Institute of Bone Science OSSTEM IMPLANT - 3GO
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<strong>Bone</strong> Grafting Material Test Data<br />
▶ Products<br />
Product Category Mfg. Mfg. Process Spec.<br />
CANOSS Allograft Hansbiomed Chemically processed <strong>of</strong> Human bone(protein deactivation),<br />
grinded after freeze drying.<br />
Bio-oss Xenograft Geistlich Chemically processed <strong>of</strong> Bovine bone, grinded after heat<br />
processed <strong>of</strong> 300℃<br />
Flake type<br />
Chip type, 0.25~1.0mm<br />
Cerabone Xenograft aap biomaterials Grinded after heat processed <strong>of</strong> 1100℃ Chip type, 0.5~1.0mm<br />
Osteon Synthetic Dentium High Molecule Polymer Template used Chip type, 0.5~1.0mm<br />
HA Synthetic <strong>OSSTEM</strong> High Molecule Polymer Template used Chip type, 0.25~1.0mm<br />
▶ Test Method<br />
-. Model : Rabbit skull defect model (defect diameter 5mm)<br />
-. Period : 3, 6 wks<br />
-. N number : 3 (3 per each wk / total no. 6)<br />
-. Implement Method : Certain amt. <strong>of</strong> Graft material mixed with blood, and implement to<br />
defect area.<br />
-. Evaluation Method: after death, Scan via Micro CT to measure new bone growth<br />
percentage(%). Compare with other products.<br />
<strong>Institute</strong> <strong>of</strong> <strong>Bone</strong> <strong>Science</strong><br />
<strong>OSSTEM</strong> <strong>IMPLANT</strong>
Test Result – Week 3 mCT Data<br />
CANOSS Bio-oss Cerabone Osteon HA<br />
Grafting Mat.<br />
New <strong>Bone</strong><br />
<strong>Institute</strong> <strong>of</strong> <strong>Bone</strong> <strong>Science</strong><br />
<strong>OSSTEM</strong> <strong>IMPLANT</strong>
Test Result – Week 6 mCT Data<br />
CANOSS Bio-oss Cerabone Osteon HA<br />
<strong>Institute</strong> <strong>of</strong> <strong>Bone</strong> <strong>Science</strong><br />
<strong>OSSTEM</strong> <strong>IMPLANT</strong>
Test Result<br />
CANOSS<br />
Bio-oss<br />
Cerabone<br />
Osteon<br />
HA<br />
Week 3<br />
Week 6<br />
Average<br />
Individual #1 Individual #2 Individual #3 Individual #1 Individual #2 Individual #3<br />
Average<br />
<strong>Bone</strong> % 38.8 25.7 32.3 37.5 50.6 44.1<br />
STDEV 5.7 5.9 3.9 5.9<br />
<strong>Bone</strong> % 27.4 29.6 45.2 34.1 56.1 63.0 37.1 52.1<br />
STDEV 4.8 7.3 9.4 4.7 8.7 3.6<br />
<strong>Bone</strong> % 45.5 33.2 41.2 40.0 62.4 73.6 45.9 60.6<br />
STDEV 3.0 3.6 8.9 3.2 8.8 5.4<br />
<strong>Bone</strong> % 48.7 28.8 38.0 38.5 49.5 60.3 57.2 55.7<br />
STDEV 6.4 6.8 7.3 6.0 9.0 6.8<br />
<strong>Bone</strong> % 33.9 25.6 60.0 39.8 69.5 62.4 67.0 66.3<br />
STDEV 4.9 3.2 11.5 7.5 9.5 9.6<br />
<strong>Institute</strong> <strong>of</strong> <strong>Bone</strong> <strong>Science</strong><br />
<strong>OSSTEM</strong> <strong>IMPLANT</strong>
Summary<br />
-. After 3 Wks: Cerabone > HA > Osteon > Bio-oss > CANOSS in order showed bone % results.<br />
-. After 6 Wks: HA > Cerabone > Osteon > Bio-oss > CANOSS in order showed bone % results.<br />
-. Comparing Bio-oss and Cerabone, there were no significant differences during Wk 3.<br />
But, during Wk 6, Cerabone showed higher bone % (p-value ≤ 0.05).<br />
-. When testing CANOSS(allograft), mixing it with blood has not been smooth process which resulted<br />
unequal bone graft material distribution in defect areas. Also, since it is flake type, it could not perform<br />
scaffolding function to regenerate new bone<br />
<strong>Institute</strong> <strong>of</strong> <strong>Bone</strong> <strong>Science</strong><br />
<strong>OSSTEM</strong> <strong>IMPLANT</strong>
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