Pediatric Gastroenterology - UT Southwestern

Andrew Feranchak, M.D.
Associate Professor,
Director, Pediatric Gastroenterology,
Willis C. Maddrey, M.D. Professor of Liver
Disease
Faculty
Pediatric Gastroenterology
2011 Academic Review
As the major program in North Texas caring for children with gastrointestinal (GI)
disorders, the Division of Gastroenterology at UT Southwestern provides patientcentered
care to an ever expanding population. Our mission is to improve the lives
of children with gastrointestinal and liver diseases through quality care, innovative
clinical programs, education and training of healthcare providers, and state-of-the-art
basic, translational, and clinical research.
This nationally recognized division includes distinguished individuals focusing on
diverse areas of Gastroenterology, including molecular biology of cholestatic liver
disease, neurogastroenterology, chronic viral hepatitis, inflammatory bowel disease,
therapeutic endoscopy, intestinal rehabilitation, and liver transplantation.
We continue to provide a full-service outreach consultative practice at Children’s at
Legacy and have opened an outreach GI consultation clinic at Southlake. Both of these
outreach practices are thriving and have substantially increased our new patient visits.
Specialized multidisciplinary clinics include:
• Chronic abdominal pain (GI, anesthesiology/pain management, psychology)
• Aero-digestive disorders (GI, ENT, pulmonary, psychology)
• Cystic fibrosis (GI, pulmonary, nutrition, psychology)
• Inflammatory bowel disease (GI, nutrition, psychology)
• Intestinal failure (GI, surgery, nutrition and psychology)
The Division underwent a change in leadership at the end of 2011 as Dr. John Andersen,
who led the division for 21 years, accepted a new position as Vice Chair of Clinical
Operations for the Department of Pediatrics. Dr. Drew Feranchak was appointed
the new Director for the Division of Gastroenterology and was named the Willis C.
Maddrey, M.D. Professor of Liver Disease. Additionally, Dr. Brad Barth was appointed
the new Clinical Director for the Division.
Amal Aqul, M.D.
Assistant Professor
Edaire Cheng, M.D.
Instructor
Other changes include the addition of two new
faculty members to our division last year. We are
John Andersen, M.D.
Professor, Vice Chair of
Clinical Operations
Bradley Barth, M.D.
Associate Professor,
Clinical Director
pleased to recognize recruitment of Dr. Amal Aqul, a clinical hepatologist specializing
in the care of children with liver disorders, and Dr. Edaire Cheng a physician-scientist
studying the pathogenesis of eosinophilic esophagitis, who both completed their
pediatric gastroenterology fellowships at UT Southwestern in 2011. This brings the
total number of full-time faculty to 17. The other division faculty are:
Nandini Channabasappa, M.D.
Assistant Professor
Amal Dutta, M.D., Ph.D.
Assistant Professor
Aakash Goyal, M.D.
Assistant Professor
Koorosh Kooros, M.D.
Assistant Professor
Qin Li, M.D., Ph.D.
Instructor
Ashish Patel, M.D.
Assistant Professor
Charina Ramirez, M.D.
Assistant Professor
Norberto Rodriguez-Baez, M.D.
Associate Professor
Michael Russo, M.D.
Associate Professor
Rinarani Sanghavi, M.D.
Assistant Professor
Meghana Sathe, M.D.
Assistant Professor
M. Gaith S. Semrin, M.D.
Assistant Professor
Additionally, 11 Advanced Practice Providers, including eight Nurse Practitioners and three Physician Assistants, work
within the GI Division to provide additional resources to the care of our patients both in the inpatient and outpatient
settings.
1

Research Activities
Funded gastroenterology research spans a wide range of important areas in both basic science and clinical investigation.
Hepatology, both basic and clinical, comprises the most active area of investigation.
The Liver Research Laboratory, headed by Dr. Andrew Feranchak, is investigating basic mechanism of bile formation and
hepatobiliary transport, the regulatory role of purinergic signaling in biliary secretion, and mechanisms of fatty liver disease.
Dr. Feranchak, a NIH-funded investigator, is recognized internationally for his innovative approaches to elucidating the
basic mechanisms regulating bile formation and signaling within the liver. Dr. Feranchak’s research is pivotal, since it is
very likely that therapeutic interventions for cholestatic liver disease await a basic understanding of the basic mechanisms
of bile flow.
The Liver Research Laboratory also includes Dr. Amal Dutta,
supported by grants from the American Liver Foundation and
Children’s Medical Center Foundation, who is investigating novel
targets for the treatment of cholestatic liver disease. Dr. Qin Li is the
newest member of the Liver Research Laboratory and is working to
identify the pathways involved in bile formation. The Laboratory
is supported by Charles Kresge, lab manager, and provides training
opportunities for post-doctoral fellows, residents, and students.
Dr. Norberto Rodriguez-Baez is the principle investigator at our
site for a national, multicenter, NIH-supported study examining
the causes for fulminant hepatic failure in children. Dr. Rodriguez-
Baez’s second group of studies involves treatment of chronic
hepatitis B and C.
The second general area of active clinical research involves inflammation in the GI tract.
• Dr. Ashish Patel is leader of the nutritional management algorithm development for the Trailblazer Collaborative for
pediatric Inflammatory Bowel Disease.
• Dr. Edaire Cheng is exploring basic mechanisms responsible for the pathogenesis of eosinophilic esophagitis, while Dr.
John Andersen is investigating new treatments for the disorder.
• Dr. Rina Sanghavi is exploring new therapies for constipation and motility disorders.
Clinical Activities
The nationally recognized clinical programs of the Division of Gastroenterology are housed at Children’s Medical Center
Dallas with satellite activity at Children’s at Legacy and Southlake. In the patient-centered environment, 15 gastroenterology
physicians, 8 gastroenterology nurse practitioners, 3 physician assistants, and a child psychologist embedded in the
gastroenterology program, provide multidisciplinary, comprehensive state-of-the-art care for children with virtually any
gastrointestinal or liver problem.
In addition to gastroenterologists, outpatients are seen in parallel by four nurse practitioners with the support of six nursecoordinators
and five medical assistants. The entire program is supported by a psychologist, two full-time dieticians, childlife,
social work, a pharmacist and an enterostomal therapist/educator.
Gastroenterology Clinical Laboratory. The gastroenterology laboratory staff of five nurses and two medical assistants is capable
of supporting not only routine endoscopic procedures, but also therapeutic endoscopy (ERCP, balloon enteroscopy and capsule
endoscopy) and a full range of motility procedures (anorectal, esophageal, antroduodenal, small bowel and colonic).
The division also provides several specialized clinical programs, including:
• Neurogastroenterology Program, under the direction of Dr. Rina Sanghavi, provides evaluation and management
of children with a wide range of disorders including abdominal pain, vomiting, constipation and complex motility
disorders.
New outpatient visits 3,845
Follow-­‐up outpatient visits 8,192
Gastroenterology procedures (Dallas) 2,501
(includes 1,440 endoscopies; 647 colonoscopies; 37 ERCP; 118 ileoscopies/sig)
• Hepatology & Liver Transplantation Program which is producing internationally recognized research and clinical
studies in acute liver failure, viral hepatitis, and chronic liver diseases. The liver transplant program ranks among the
busiest in the United States with results second to none.
606
• Intestinal Rehabilitation Program, under the direction of Dr. Nandini Channa, is one of the largest in the country and
1570
the only program of this type in the Southwest.
• Southwestern Center for Pediatric Inflammatory Bowel Disease (IBD), directed by Dr. Ashish Patel, provides
specialized care for children with inflammatory bowel disease, conducts research into new treatments, and participates
in national consortiums, such as the Trail Blazer Collaborative and the ImproveCareNow program, 2865 establishing
quality
2,242
improvement indicators and benchmarks in order to rapidly advance patient care and optimize outcomes.
• Therapeutic Endoscopy Program, directed by Dr. Brad Barth, is one of fewer than 10 programs in the United States
performing specialized, cutting-edge endoscopic procedures, including endoscopic retrograde cholangiopanereatography
*(24-­‐bed unit dedicated to gastroenterology and liver, including transplantation)
Gastroenterology procedures (Dallas)
Endoscopies 1,440
Colonoscopies 647
ERCP 37
Ileoscopies/sig 118
647
37 118
1,440
Endoscopies
(ERCP) in children of all ages.
New outpa1ent visits
Colonoscopies
• Referrals are accepted for all of these programs and a Gastroenterology physician is on call Follow daily up to outpa1ent take calls visits from
ERCP
physicians.
Procedures
Ileoscopies/sig
Statistics for a busy unit at Children’s:
2,501
8,192
1,296
659
3,845
Legacy
Follow up outpa1ent visits
New outpa1ent visits * 24-bed unit dedicated to gastroenterology and liver,
1570
Follow up outpa1ent visits including transplantation
2865 Procedures
Procedures 606
5041
Southlake
New outpa1ent visits 640
Education and Training
Follow up outpa1ent visits 662
2
The division continues to provide new and innovative training strategies 1302 for students, residents, fellows, and junior faculty,
as well as educational programs to the local community and nationally.
The Fellowship program, directed by Drs. Norberto Rodriguez and Meghana Sathe, provides comprehensive training for
six gastroenterology fellows (two annually) in specialized clinical care, diagnostic and therapeutic endoscopy, and basic and
clinical research. Focused areas of research by our current fellows include: 640
• hepatobiliary transport physiology
662
• pathogenesis of eosinophilic esophagitis
• mechanisms of pruritus associated with chronic liver disease
• metabolic liver disease
• immunobiology of IBD
Presentations/Teaching Activities
Inpa1ent admissions*
Inpa1ent consulta1ons
New outpa1ent visits
Follow-­‐up outpa1ent
visits
Gastroenterology
procedures (Dallas)
Follow up outpa1ent visits
John M. Andersen, M.D.
• “Celiac Disease,” Pediatric Grand Rounds, UT Health Science Center at Tyler, November 2011
Amal Aqul, M.D.
• “Infusion Reaction to Infliximab,” Pediatric Morbidity and Mortality Conference,” UT Southwestern, February 2011
• “Prevention of Neurodegeneration in Niemann-Pick Type C1 Mice,” Second Pediatric Senior Fellow Conference, UT
Southwestern, May 2011
3
606
2865
Legacy
1570
New outpa1ent visits
New outpa1ent visits
662
Southlake
New outpa1ent visits
640
Follow up outpa1ent visits

Bradley Barth, M.D.
• “Hands-On Endoscopy Training: Single Balloon Enteroscopy,”
NASPGHAN Annual Meeting, Orlando, FL, October 2011
• “Getting the Most Out of Your Fellowship,” Teaching and Tomorrow
Luncheon, NASPGHAN Annual Meeting, Orlando FL, October 2011
Nandini Channabassapa, M.D.
• “Overview of Gastroenterology,” UT Arlington School of Nursing, January 2011
Edaire Cheng, M.D.
• “Eotaxin-3 Expression After Stimulation with IL-13 and IL-4 in Esophageal
Squamous Cell Lines from Patients with Eosinophilic Esophagitis and
GERD,” Digestive Disease Week, Chicago, IL, May 2011
• “Differences in Th2 cytokine-induced Eotaxin-3 Expression in Esophageal
Squamous Cell Lines from Patients with Eosinophilic Esophagitis and
GERD,” NASPGHAN Annual Meeting, Orlando, FL, October 2011
Amal Dutta, M.B.B.S, Ph.D.
• “Regulation of TMEM16A by a Novel Mechanism Involving PKC in Biliary
Epithelium,” Experimental Biology Meeting, Washington, DC, April 2011
• “PKC Regulates TMEM16A-Dependent Transport in Biliary Epithelium,”
AASLD Annual Meeting, San Francisco, CA, November 2011
Drew Feranchak, M.D.
Dr. Edaire Cheng
Poster presentation at the 2 nd Annual
Pediatric Senior Fellow Research Day
• “Regulation of Bile Formation by Extracellular Nucleotides,” Invited Lecturer, Digestive Health Center Seminar Series,
Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, March 2011
• Organizer and Co-chair, “Recent Advances in Neonatal Cholestatic Disorders,” PAS and Asian Society for Pediatric
Research Joint Meeting, Denver, CO, May 2011
• “Regulation of Liver Bile Formation by the Vesicular Nucleotide Transporter SLC17A9,” PAS and Asian Society for
Pediatric Research Joint Meeting, Denver, CO, May 2011
• “Progress in Determining Causes of Neonatal Cholestatic Disorders,” PAS and Asian Society for Pediatric Research
Joint Meeting, Denver, CO, May 2011
• “Regulation of Bile Formation by Mechanosensitive Pathways,” Invited Lecturer, Mount Sinai Medical Center, New
York, NY, July 2011
• “Gastrointestinal Manifestations of Cystic Fibrosis,” Topic Symposium, NASPGHAN Annual Meeting, Orlando, FL,
October 2011
• Co-moderator, “Biliary Epithelium: Secretion and Development,” AASLD Annual Meeting, San Francisco, CA, November 2011
Koorosh Kooros, M.D.
• “Reading Capsule Endoscopy Videos: An Introduction for GI Fellows Part 1: Identifying Normal vs. Abnormal
Variants,” Webinar Facilitator, June 2011
• “Reading Capsule Endoscopy Videos: An Introduction for GI Fellows Part 2: Case Studies with the Expert,” Webinar
Facilitator, June 2011
Ashish Patel, M.D.
• “Pediatric Inflammatory Bowel Disease: A Biological Journey,” UT Southwestern, April 2011
• “Pediatric Inflammatory Bowel Disease,” UT Health Science Center at San Antonio, June 2011
• “Treatment Approaches in IBD: Options,” UT Southwestern/Crohn’s & Colitis Foundation of America, UT
Southwestern, December 2011
Nortberto Rodriguez-Baez, M.D.
• “Gastroesophageal Reflux in Children,” Physical Medicine and Rehabilitation Didactic Conference, UT Southwestern,
March 2011
• “Acute Liver Failure in Children,” IV Congreso Colombiano y del Caribe, Enfermedades Digestivas en Niños, Santa
Marta, Colombia, April 2011
• “Hepatitis B in Children,” IV Congreso Colombiano y del Caribe, Enfermedades Digestivas en Niños, Santa Marta,
Colombia, April 2011
• “I’m Tired! – Sleep Deprivation in Residents and Fellows,” Fellowship Core Conference, Pediatric Gastroenterology
Division, UT Southwestern, June 2011
• “Variceal Bleeding in Children,” IV Jornadas Internacionales de Emergencias Pediátricas en Gastroenterología,
Hepatología y Nutrición, Quito, Ecuador, July 2011
• “Jaundice in Children,” IV Jornadas Internacionales de Emergencias Pediátricas en Gastroenterología, Hepatología y
Nutrición, Quito, Ecuador, July 2011
• “Gastrointestinal Diseases in International Adoptees,” NASPGHAN Annual Meeting, Orlando, FL, October 2011
• “Gastroenterology Jeopardy,” NASPGHAN Annual Meeting, Orlando, FL, October 2011
• “Acute Liver Failure in Children,” Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition
(LASPGHAN) Meeting, Punta Cana, Dominican Republic, November 2011
Michael Russo, M.D.
• “Clinical Perspectives in Gastroesophageal Reflux,” National Association of Neonatal Therapists Annual Conference,
May 2011
Rina Sanghavi, M.D.
• “Recent Advances in SMA and other Neuromuscular Disease,” Texas Scottish Rite Hospital for Children, Dallas,
February 2011
Meghana Sathe, M.D.
• “Pancreatic Enzymes and Nutrition,” Children’s Dallas CFIT Day, April 2011
• “Baby Care,” BAPS Swaminarayan Sanstha Healthfair, Dallas, April 2011
• “AGS and Nutrition; AGS and Endocrine Issues,” Alagille’s Alliance Conference, Chicago, IL, June 2011
Awards and Honors
John M. Andersen, M.D.
• Best Pediatric Specialists in Dallas, D Magazine
• Texas Super Doctors, Texas Monthly
• Top US Doctors, U.S. News
• Best Doctors in America
• IBC’s Top 100 Health Professionals
Amal Aqul, M.D.
• One of Best Five Abstracts, 2 nd Pediatric Senior Fellow Conference, UT
Southwestern
• Featured Article, Journal of Neuroscience, June Issue
Bradley Barth, M.D.
• Best Doctors in America
• Best Pediatric Specialists in Dallas, D Magazine
Edaire Cheng, M.D.
• Distinguished Achievement Award, North American Conference of
Gastroenterology Fellows
Amal Dutta, M.B.B.S, Ph.D.
• Honorable Mention, APS Award, GI and Liver Section
Drew Feranchak, M.D.
• Awared the Willis C. Maddrey, M.D. Professorship in Liver Disease
Ashish Patel, M.D.
• Best Pediatric Specialists in Dallas, D Magazine
Michael Russo, M.D.
• Best Pediatric Specialists in Dallas, D Magazine
Publications
Dr. Amal Aqual
Oral presentation at the 2 nd Annual
Pediatric Senior Fellow Research Day
1. Aqul A, Liu B, Ramirez CM, Pieper AA, Estill S, Burns DK, Liu B, Repa JJ, Turley SD and Dietschy JM. Unesterified
cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving
cholesterol export from this compartment. The Journal of Neuroscience, June 22, 2011 31(25): 9404-9413.
2. Barth BA. Capsule Endoscopy and Small Bowel Enteroscopy. In: Pediatric Gastrointestinal and Liver Disease, Fourth
Edition. Wyllie R, Hyams J, Kay M (ed). Saunders Elsevier, 2011:679-685.
3. Barth BA. Enteroscopy in children. Curr Opin Pediatr. 2011;23(5):530-4.
4. Chandra M, Zhou H, Li Q, Muallem S, Hofmann SL, Soyombo AA. A role for the Ca2+ channel TRPML1 in gastric
acid secretion, based on analysis of knockout mice. Gastroenterology. 2011 Mar;140(3):857-67.
5. Cheng E, Winter HS, Spechler SJ. “Relationship of Eosinophilic Esophagitis To Gastroesophageal Reflux”. Eosinophilic
Esophagitis. Eds. Liacouras C, Markowitz J. New York: Springer, 2011.
6. Crandall W, Kappelman MD, Colletti RB, Leibowitz I, Grunow JE, Ali S, Baron HI, Berman JH, Boyle B, Cohen S,
Del Rosario F, Denson LA, Duffy L, Integlia MJ, Kim SC, Milov D, Patel AS, Schoen BT, Walkiewicz D, Margolis
P. ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network. Inflamm
Bowel Dis. 2010 Jul 2. [Epub ahead of print], IBD 2011 Jan; 17 (1): 450-7.
7. Desilets DJ, Banerjee S, Barth BA, Kaul V, Kethu SR, Pedrosa MC, Pfau PR,Tokar JL, Varadarajulu S, Wang A,
Wong Kee Song LM, Rodriguez SA; ASGE TechnologyCommittee. Endoscopic simulators. Gastrointest Endosc.
2011;73(5):861-7.
4 5

8. Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC,
Feranchak AP. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by
extracellular nucleotides, in biliary epithelium. J Biol Chem 2011; 286:766-776.
9. Hong JH, Li Q, Kim MS, Shin DM, Feske S, Birnbaumer L, Cheng KT, Ambudkar IS, Muallem S. Polarized but
differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic. 2011
Feb;12(2):232-45. doi: 10.1111/j.1600-0854.2010.01138.x. Epub 2010 Nov 24.
10. Huo X, Juergens S, Zhang X, Rezaei D, Yu C, Strauch ED, Wang J-Y, Cheng E, Meyer F, Wang DH, Zhang Q, Spechler
SJ, Souza RF. Deoxycholic Acid Causes DNA Double Strand Breaks while Inducing Apoptotic Resistance through NFkB
Activation in Benign Barrett’s Epithelial Cells. American Journal of Physiology, 301:G278-G286, 2011.
11. Kappelman MD, Crandall WV, Colletti RB, Goudie A, Leibowitz IH, Duffy L, Milov DE, Kim SC, Schoen BT, Patel AS,
Grunow J, Larry E, Fairbrother G, Margolis P. Short pediatric Crohn’s disease activity index for quality improvement
and observational research. Inflamm Bowel Dis. 2011 Jan; 17 (1):112-7
12. Long MD, Crandall WV, Leibowitz IH, Duffy L, del Rosario F, Kim SC, Integlia MJ, Berman J, Grunow J, Colletti RB,
Schoen BT, Patel AS, Baron H, Israel E, Russell G, Ali S, Herfarth HH, Martin C, Kappelman MD. Prevalence and
epidemiology of overweight and obesity in children with inflammatory bowel disease. Inflamm Bowel Dis. 2011 Oct;
17 (10):2162-8
13. Mittal VS, Sathe M, Troendle D, Cox M. An 18-month-old boy with severe dermatitis, edema, muscle wasting. Pediatr
Ann. 2011 Aug;40(8)393-6.
14. Pedrosa MC, Barth BA, Desilets DJ, Kaul V, Kethu SR, Pfau PR, Tokar JL,Varadarajulu S, Wang A, Wong Kee Song LM,
Rodriguez SA; ASGE TechnologyCommittee. Enhanced ultrasound imaging. Gastrointest Endosc. 2011;73(5):857-60.
15. Pfau PR, Banerjee S, Barth BA, Desilets DJ, Kaul V, Kethu SR, Pedrosa MC,Pleskow DK, Tokar J, Varadarajulu S, Wang
A, Song LM, Rodriguez SA. Sphincter of Oddi manometry. Gastrointest Endosc. 2011;74(6):1175-80.
16. Ramirez CM, Liu B, Aqul A, Taylor AM, Repa JJ, Turley SD and Dietschy JM. Quantitative role of LAL, NPC2, and
NPC1 in lysosomal cholesterol processing defined by genetic and pharmacologic manipulations. Journal of Lipid
Research Volume 52, 2011
17. Rojas I, Rodriguez-Baez N. Wilson Disease. The NASPGHAN Fellows Concise Review of Pediatric Gastroenterology,
Hepatology and Nutrition. Editors: Judith Sondheimer, MD and Christine Waasdorp Hurtado, MD – October 2011.
18. Rojas I, Rodriguez-Baez N. Elevated Aminotransferases. The NASPGHAN Fellows Concise Review of Pediatric
Gastroenterology, Hepatology and Nutrition. Editors: Judith Sondheimer, MD and Christine Waasdorp Hurtado, MD
– October 2011.
19. Sathe MN, Woo K, Kresge C, Bugde A, Luby-Phelps K, Lewis MA, Feranchak AP. Regulation of purinergic signaling
in biliary epithelial cells by exocytosis of SLC17A9-dependent ATP-enriched vesicles. J Biol Chem 2011; 286:25363-76.
20. Stoll ML, Punaro M, Patel AS. Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile
idiopathic arthritis. J Rheumatol. 2011 Oct; 38(10): 2274-5.
21. Tokar JL, Banerjee S, Barth BA, Desilets DJ, Kaul V, Kethi SR, Pedrosa MC, Pfau PR, Pleskow DK, Varadarajulu S,
Wang A, Song LM, Rodriguez SA. Drug-eluting/biodegradable stents. Gastrointest Endosc. 2011;74(5):954-8.
22. Varadarajulu S, Banerjee S, Barth BA, Desilets DJ, Kaul V, Kethu SR, Pedrosa MC, Pfau PR, Tokar JL, Wang A, Wong
Kee Song LM, Rodriguez SA. GI endoscopes. Gastrointest Endosc. 2011;74(1):1-6.
23. Varadarajulu S, Banerjee S, Barth B, Desilets D, Kaul V, Kethu S, Pedrosa M, Pfau P, Tokar J, Wang A, Song LM,
Rodriguez S. Enteral stents. Gastrointest Endosc. 2011;74(3):455-64.
24. Walji-Virani S, Russo MA. An infant with yellow umbilical drainage. Gastroenterology, 2011 Jun;140(7):e5-6.
25. Yamaguchi S, Jha A, Li Q, Soyombo AA, Dickinson GD, Churamani D, Brailoiu E, Patel S, Muallem S. Transient
receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion
channels. J Biol Chem. 2011 Jul 1;286(26):22934-42.
26. Yang D, Li Q, So I, Huang CL, Ando H, Mizutani A, Seki G, Mikoshiba K, Thomas PJ, Muallem S. IRBIT governs
epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65.
doi: 10.1172/JCI43475.
27. Zhang HY, Zhang X, Yu C, Huo X, Cheng E, Wang DH, Zhang Q, Spechler SJ, Souza RF. Cancer-Related Inflammation
and Barrett’s Carcinogenesis: Interleukin-6 and STAT3 Mediate Apoptotic Resistance in Transformed Barrett’s Cells.
American Journal of Physiology, 300:G454-G460, 2011.
Notable Abstracts, Presentations, and News Articles
Presentation & Abstract. October 2011.
3. Russo MA, and Yoon L. GERD and Proton Pump Inhibitors. Pediatric Society of Greater Dallas. 1st Quarter 2011.
Grants
NIH and Other Government Grants & Contracts
Edaire Cheng, M.D.
Antecedents & Sequelae of Childhood Onset Diseases
Child Health Research Career Development Award Program
NIH, 1K12 HD-068369-01
09/01/11 – 08/31/13
Andrew P. Feranchak, M.D.
Mechanosensitive ATP Release and Signaling in Cholangiocyte
NIH, 5 R01 DK078587-05
03/01/08 – 02/28/13
NIH and Other Government Subcontracts
Ashish Patel, M.D.
Genome-Wide Association (GWA) Identified Predictors of Response to Anti-TNFa Therapy in Pediatric Inflammatory
Bowel Disease
NIH/Cedars Sinai Medical Center, 5 R21 DK084554-02
08/01/10 – 07/31/12
Gene Discoveries in Subjects with Crohn’s Disease of African Descent
NIH R01-DK087694-01A1
12/01/2010 – 11/30/13
Norberto Rodriguez-Baez, M.D.
Multi-Center Group to Study Acute Liver Failure in Children
NIH/University of Pittsburgh, 2 U01 DK072146-06
09/01/10 – 08/31/15
Non-governmental Organization Grants and Contracts
Edaire Cheng, M.D.
Differences in Eotaxin-3 Expression in Esophageal Cells from Patients with Eosinophilic Esophagitis and
Gastroesophageal Reflux Disease
American Gastroenterological Association, Fellowship to Faculty Transition Award
07/01/11 – 06/30/13
Amal Dutta, Ph.D.
Regulation of Biliary Secretion and Bile Formation by the Ca2+-activated Channel TMEM16A
American Liver Foundation, 2010 Liver Scholar-02
07/01/10 – 06/30/13
Andrew P. Feranchak, M.D.
Development and Characterization of a Polarized Cystic Fibrosis Bile Duct Epithelial Model
Cystic Fibrosis Foundation, FERANC11/0-01
04/01/11 - 03/31/13
1. Squires R, Dhawan A, Alonso E, Narkewicz, M, Rodriguez-Baez N, Kelly D, Bucuvalas J, Karpen S, Shneider B, Rand
E, Lobritto S, Rosenthal P, Murray K, Kerkar N, Ng V, Subbarao G, Rudnick D, Lopez M J, Schwarz K, Romero R,
Elisofon S, Robuck P, Lawlor S, Belle S for the Pediatric Acute Liver Failure Study Group. A prospective clinical trial
shows that intravenous N-acetylcysteine (NAC) does not improve survival in pediatric patients with non-acetaminophen
acute liver failure. Presented at the Digestive Disease Week and the AASLD Plenary Session, Chicago, IL – May 2011.
2. Walji-Virani S, Russo MA. Persistent vomiting: An unusual anatomic variant. NASPGHAN Annual Meeting Poster
6 7

Ashish Patel, M.D.
Risk Stratification & Identification of Immunogenetic and Microbial Markers of Complicated Disease Course in
Pediatric Crohn’s Disease
Crohn’s and Colitis Foundation/Emory University, s499572
07/01/10 – 06/30/11
Building Modular Pediatric Chronic Disease Registries (Improve Care Now)
Improve Care Now
07/01/11 – 06/30/12
Sponsored Clinical Trials
John M. Andersen, M.D.
Open-Lbl Sfty Study of Reslizumab (CTx55700) for Trtmt of Pediatric Sbjs with Eosinophilic Esophagitis Who
Completed Study Res-5-0002
Cephalon Inc., Res-5-0004
10/14/09 – Present
Pharmacodynamics of Intravenous Mepolizumab in Pediatrics Subjects
GlaxoSmithKline, MEE103219
11/27/06 – Present
Reslizumab (CTX55700) in the Treatment of Eosinophilic Esophagitis
Ception Therapeutics, Award ID: RES50002
08/01/02 – Present
Study of Reslizumab in Pediatric Subjects with Eosinophilic Esophagitis
Premier Research
10/06/09 – Present
Ashish Patel, M.D.
Ph 2 Study of Certolizumab Pegol in Children & Adolescents w/Active Crohn’s Disease (NURTURE Study)
UCB Biosciences, Inc., C87035
03/31/10 – Present
Multi-Center Observational Registry of Pediatric Pts w/Inflammatory Bowel Disease
Centocor Research and Development, Inc., C0168Z02
08/14/08 – Present
Norberto Rodriguez-Baez, M.D.
Evaluation of the Pharmacokinetics, Safety, Tolerability, and Efficacy of Entecavir (ETV) in Pediatric
Subjects with Chronic Hepatitis B Virus (HBV) Infection who are HBeAg-Positive
Bristol-Myers Squibb Company, AI463028
04/01/07 – Present
Assessment of the Safety, Efficacy, Tolerability and Phamacokinetics of PEG-Intron Plus REBETOL in Pediatric
Patients with Chronic Hepatitis C
Schering-Plough Research Institute, P02538
11/01/05 – Present
Rinarani M. Sanghavi, M.D.
Pharmacokinetics of Lubiprostone in Pediatric Patients with Constipation
Sucampo Pharmaceuticals, SPI0211SC0641
02/01/08 – Present
Development of an Instrument to Measure Quality of Life in Children with Chronic Constipation and Soiling
Medical College of Wisconsin, 08-014LUB.01
11/01/09 – Present
8