efsa-opinion-chromium-food-drinking-water
efsa-opinion-chromium-food-drinking-water efsa-opinion-chromium-food-drinking-water
Chromium in food and drinking water For calculating the chronic dietary exposure to Cr(III), food consumption and body weight data at the individual level were accessed in the Comprehensive Database. Occurrence data and consumption data were linked at the lowest FoodEx possible. In addition, the different food commodities were grouped within each food category to better explain their contribution to the total dietary exposure to Cr(III). For each country, exposure estimates were calculated per dietary survey and age class (see Section 5.1.1). Chronic exposure estimates were calculated for 26 different dietary surveys carried out in 17 different European countries. Not all countries provided consumption information for all age groups and in some cases the same country provided more than one consumption survey. 6.1.1. Mean and high dietary exposure to trivalent chromium The mean and the high (95 th percentile) chronic dietary exposures to Cr(III) were calculated separately for each dietary survey using consumption data recorded at the individual level and for both LB and UB mean concentrations. Minimum, median and maximum exposure estimates across dietary surveys and age groups are reported in Table 8. Detailed mean and 95 th percentile dietary exposure estimates calculated for each of the 26 dietary surveys are presented in Appendix G. In accordance with the specifications of the EFSA Guidance on the use of the Comprehensive database (EFSA, 2011b), 95 th percentile estimates for dietary surveys/age classes with less than 60 observations are not considered since they may not be statistically robust. Mean chronic dietary exposure values, across the different dietary surveys and age classes, ranged from 0.6 μg/kg b.w. per day (minimum LB) to 5.9 μg/kg b.w. per day (maximum UB). The 95 th percentile dietary exposure ranged from 1.1 μg/kg b.w. per day (minimum LB) to 9.4 μg/kg b.w. per day (maximum UB). EFSA Journal 2014;12(3):3595 48
Chromium in food and drinking water Table 8: Summary statistics of the chronic exposure assessment (g/kg b.w per day) for Cr(III) across European dietary surveys. Estimates were rounded up to one decimal place. Mean dietary exposure (g/kg b.w per day) Lower bound (LB) Upper bound (UB) Min Median Max Min Median Max Infants 1.5 - (a) 2.2 1.9 - (a) 3.6 Toddlers 2.3 2.4 4.6 3.1 3.7 5.9 Other children 1.6 2.4 3.5 2.1 3.3 4.9 Adolescents 0.9 1.2 2.1 1.2 1.6 2.5 Adults 0.8 0.9 1.2 1.0 1.2 1.6 Elderly 0.6 0.8 1.0 1.0 1.1 1.4 Very Elderly 0.7 0.8 1.2 1.0 1.1 1.5 95 th percentile dietary exposure (b) (g/kg b.w per day) Lower bound (LB) Upper bound (UB) Min Median Max Min Median Max Infants 4.8 - (c) - (c) 9.4 - (c) - (c) Toddlers 3.4 4.5 5.9 4.5 6.7 9.0 Other children 2.9 4.2 7.3 3.7 5.6 7.9 Adolescents 1.7 2.4 4.1 2.3 2.9 4.8 Adults 1.2 1.5 2.0 1.7 2.0 2.6 Elderly 1.1 1.3 1.5 1.6 1.7 2.0 Very Elderly 1.2 1.6 1.8 1.7 2.0 2.3 b.w. : body weight. (a): Not calculated since estimates were only available from two dietary surveys; (b): The 95 th percentile estimates obtained on dietary surveys/age classes with less than 60 observations may not be statistically robust (EFSA, 2011b). Those estimates were not included in this table. (c): Not calculated since estimates were only available from one dietary survey. 6.1.2. Contributions of different food groups to chronic exposure to trivalent chromium by age class The dietary exposure to Cr(III) and the contribution of different foods is presented divided by age class and individual dietary survey. It is important to mention that some dietary surveys (DIPP and FINDIET 2007) reported the consumption data at the disaggregated level (e.g. reporting the amount of flour instead of the amount of bread), which could have influence on the contribution of specific food categories to the dietary exposure to Cr(III). Before calculating the dietary exposure, the available foods were grouped to explain their contribution to the total exposure to Cr(III). Although some food commodities such as tea, coffee and cocoa are described in more than one food category (described within ‘Vegetables and vegetable products’ but also within ‘Non-alcoholic beverages’), they were all grouped as ‘Non-alcoholic beverages’ when describing the contribution to the dietary exposure to Cr(III). Appendix E shows the different groups that were created. 6.1.2.1. Infants and toddlers The results for infants should be cautiously interpreted as only two dietary surveys are available. Mean dietary exposure to Cr(III) for infants ranged between 1.5 µg/kg b.w. per day and 3.6 µg/kg b.w. per day (minimum LB and maximum UB). The 95 th percentile dietary exposure for the single qualifying study was 4.8 μg/kg b.w. per day (LB) and 9.4 μg/kg b.w. per day (UB). In the infant population the exposure to Cr(III) came basically from two different food categories. ‘Foods for infants and small children’ made the highest contribution (34-53 % of the total) followed by ‘Milk and dairy products’ (13-18 % of the total) (Figure 10). As in previous scientific opinions, a mean consumption of human milk of 800 mL per day and a maximum of 1200 mL per day (EFSA CONTAM Panel, 2011) was considered representative for a breast-fed infant of three months and 6.1 kg b.w. For the occurrence value, an average Cr(III) EFSA Journal 2014;12(3):3595 49
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Chromium in <strong>food</strong> and <strong>drinking</strong> <strong>water</strong><br />
Table 8: Summary statistics of the chronic exposure assessment (g/kg b.w per day) for Cr(III)<br />
across European dietary surveys. Estimates were rounded up to one decimal place.<br />
Mean dietary exposure (g/kg b.w per day)<br />
Lower bound (LB)<br />
Upper bound (UB)<br />
Min Median Max Min Median Max<br />
Infants 1.5 - (a) 2.2 1.9 - (a) 3.6<br />
Toddlers 2.3 2.4 4.6 3.1 3.7 5.9<br />
Other children 1.6 2.4 3.5 2.1 3.3 4.9<br />
Adolescents 0.9 1.2 2.1 1.2 1.6 2.5<br />
Adults 0.8 0.9 1.2 1.0 1.2 1.6<br />
Elderly 0.6 0.8 1.0 1.0 1.1 1.4<br />
Very Elderly 0.7 0.8 1.2 1.0 1.1 1.5<br />
95 th percentile dietary exposure (b) (g/kg b.w per day)<br />
Lower bound (LB)<br />
Upper bound (UB)<br />
Min Median Max Min Median Max<br />
Infants 4.8 - (c) - (c) 9.4 - (c) - (c)<br />
Toddlers 3.4 4.5 5.9 4.5 6.7 9.0<br />
Other children 2.9 4.2 7.3 3.7 5.6 7.9<br />
Adolescents 1.7 2.4 4.1 2.3 2.9 4.8<br />
Adults 1.2 1.5 2.0 1.7 2.0 2.6<br />
Elderly 1.1 1.3 1.5 1.6 1.7 2.0<br />
Very Elderly 1.2 1.6 1.8 1.7 2.0 2.3<br />
b.w. : body weight.<br />
(a): Not calculated since estimates were only available from two dietary surveys;<br />
(b): The 95 th percentile estimates obtained on dietary surveys/age classes with less than 60 observations may not be<br />
statistically robust (EFSA, 2011b). Those estimates were not included in this table.<br />
(c): Not calculated since estimates were only available from one dietary survey.<br />
6.1.2. Contributions of different <strong>food</strong> groups to chronic exposure to trivalent <strong>chromium</strong> by<br />
age class<br />
The dietary exposure to Cr(III) and the contribution of different <strong>food</strong>s is presented divided by age<br />
class and individual dietary survey. It is important to mention that some dietary surveys (DIPP and<br />
FINDIET 2007) reported the consumption data at the disaggregated level (e.g. reporting the amount of<br />
flour instead of the amount of bread), which could have influence on the contribution of specific <strong>food</strong><br />
categories to the dietary exposure to Cr(III). Before calculating the dietary exposure, the available<br />
<strong>food</strong>s were grouped to explain their contribution to the total exposure to Cr(III). Although some <strong>food</strong><br />
commodities such as tea, coffee and cocoa are described in more than one <strong>food</strong> category (described<br />
within ‘Vegetables and vegetable products’ but also within ‘Non-alcoholic beverages’), they were all<br />
grouped as ‘Non-alcoholic beverages’ when describing the contribution to the dietary exposure to<br />
Cr(III). Appendix E shows the different groups that were created.<br />
6.1.2.1. Infants and toddlers<br />
The results for infants should be cautiously interpreted as only two dietary surveys are available. Mean<br />
dietary exposure to Cr(III) for infants ranged between 1.5 µg/kg b.w. per day and 3.6 µg/kg b.w. per<br />
day (minimum LB and maximum UB). The 95 th percentile dietary exposure for the single qualifying<br />
study was 4.8 μg/kg b.w. per day (LB) and 9.4 μg/kg b.w. per day (UB).<br />
In the infant population the exposure to Cr(III) came basically from two different <strong>food</strong> categories.<br />
‘Foods for infants and small children’ made the highest contribution (34-53 % of the total) followed<br />
by ‘Milk and dairy products’ (13-18 % of the total) (Figure 10).<br />
As in previous scientific <strong>opinion</strong>s, a mean consumption of human milk of 800 mL per day and a<br />
maximum of 1200 mL per day (EFSA CONTAM Panel, 2011) was considered representative for a<br />
breast-fed infant of three months and 6.1 kg b.w. For the occurrence value, an average Cr(III)<br />
EFSA Journal 2014;12(3):3595 49