efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table J12: Epithelial carcinoma in the duodenum, jejunum or ileum carcinoma in male and female
mice combined. The benchmark dose (BMD 10 ) and the 95 % benchmark dose lower confidence limit
(BMDL 10 ) values are given for a BMR of 10 % extra risk with characteristics of the model fit. The
selected model based on the model selection used in PROAST is highlighted in bold. Numerical results
of the fit of the probit model were inconsistent.
Models
N of
parameters
Loglikelihood
Accepted
BMD 10
(mg/kg b.w.
per day)
BMDL 10
(mg/kg b.w.
per day)
BMDU 10
(mg/kg b.w.
per day)
null 1 -96.29 – – – –
full 10 -85.80 - - - -
one-stage 2 -88.05 yes 6.34 4.16 11.5
two-stage 3 -88.05 yes 6.34 4.16 11.5
log-logist 3 -88.02 yes 6.36 3.94 16.5
Weibull 3 -88.02 yes 6.37 3.98 16.2
log-prob 3 -88.03 yes 6.38 3.81 18.5
gamma 3 -88.02 yes 6.38 4.00 15.9
logistic 2 -88.02 yes 7.32 5.90 10.7
probit - - - - - -
b.w.: body weight.
EFSA Journal 2014;12(3):3595 241