efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Weibull Model with 0.95 Confidence Level
0.6
Weibull
BMD Lower Bound
0.5
0.4
Fraction Affected
0.3
0.2
0.1
0
16:23 01/20 2014
BMDL BMD
0 1 2 3 4 5 6 7 8 9
dose
Figure J8: Fit of the Weibull model to the dose-response data on carcinoma or adenoma in the
duodenum, jejunum or ileum female mice
Table J9: Epithelial carcinoma or adenoma in the duodenum, jejunum or ileum in male and female
mice combined. The benchmark dose (BMD 10 ) and the 95 % benchmark dose lower confidence limit
(BMDL 10 ) values are given for a BMR of 10 % extra risk with characteristics of the model fit. The
selected model based on the model selection used in PROAST is highlighted in bold.
Models
N of
parameters
Loglikelihood
Accepted
BMD 10
(mg/kg b.w.
per day)
BMDL 10
(mg/kg b.w.
per day)
BMDU 10
(mg/kg b.w.
per day)
null 1 -216.49 – – – –
full 10 -168.64 - - - -
one-stage 2 -172.72 yes 1.41 1.15 1.77
two-stage 3 -172.72 yes 1.41 1.15 1.75
log-logist 3 -172.72 yes 1.56 1.04 2.22
Weibull 3 -172.65 yes 1.53 1.00 2.21
log-prob 3 -171.96 yes 1.60 1.06 2.27
Gamma 3 -172.6 yes 1.56 1.02 2.25
Logistic 2 -179.62 No 3.10 2.71 -
probit 2 -178.22 No 2.86 2.50 -
b.w.: body weight.
EFSA Journal 2014;12(3):3595 237