efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
0.6
Quantal Linear Model with 0.95 Confidence Level
Quantal Linear
BMD Lower Bound
0.5
0.4
Fraction Affected
0.3
0.2
0.1
0
BMDL
BMD
16:05 01/20 2014
0 1 2 3 4 5 6
dose
Figure J7: Fit of the Quantal Linear model to the dose-response data on epithelial carcinoma or
adenoma combined in the duodenum, jejunum or ileum in male mice
Table J8: Epithelial carcinoma or adenoma combined in the duodenum, jejunum or ileum in female
mice. The benchmark dose (BMD 10 ) and the 95 % benchmark dose lower confidence limit (BMDL 10 )
values are given for a BMR of 10 % extra risk with characteristics of the model fit. The model with
lowest BMDL 10 is highlighted in bold.
Models
Restriction
N of
parameters
Minus
Loglikelihood
P-value
Accepted
BMD 10
(mg/kg
b.w. per
day)
Full model na 5 85.19 – – – –
Null (reduced) model na 1 116.32 - - - -
BMDL 10
(mg/kg
b.w. per
day)
Probit na 2 94.88 < 10-3 no 2.30 2.51
LogProbit none 3 86.88 0.34 yes 1.19 0.70
Logistic na 2 95.78 < 10-3 no 3.26 2.72
LogLogistic none 3 87.22 0.25 yes 1.19 0.66
Quantal-Linear na 1 87.75 0.27 yes 1.30 1.02
Multistage Cancer na 1 87.75 0.27 yes 1.30 1.02
Multistage none 3 87.14 0.27 yes 1.00 0.67
Weibull none 3 87.64 0.18 yes 1.15 0.61
Gamma none 3 87.69 0.17 yes 1.18 0.61
na: not applicable; b.w.: body weight.
EFSA Journal 2014;12(3):3595 236