efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table J6: Squamous cell carcinoma of the oral mucosa in male and female rats combined using
PROAST The benchmark dose (BMD 10 ) and the 95 % benchmark dose lower confidence limit
(BMDL 10 ) values are given for a BMR of 10 % extra risk with characteristics of the model fit. The
selected model based on the model selection used in PROAST is highlighted in bold.
Models
N of
parameters
Loglikelihood
Accepted
BMD 10
(mg/kg b.w.
per day)
BMDL 10
(mg/kg b.w.
per day)
BMDU 10
(mg/kg b.w.
per day)
null 1 -80.77 – – – –
full 10 -53.09 - - - -
one-stage 2 -58.89 yes 5.09 3.57 7.62
two-stage 3 -58.89 yes 5.09 3.57 7.62
log-logist 3 -54.56 yes 5.01 4.11 5.96
Weibull 3 -54.56 yes 5.07 4.18 5.98
log-prob 3 -54.49 yes 4.80 3.90 5.85
gamma 3 -54.54 yes 4.96 4.09 5.93
logistic 2 -55.50 yes 5.67 5.01 6.27
probit 2 -55.17 yes 5.45 4.83 -
b.w.: body weight.
EFSA Journal 2014;12(3):3595 233