efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
LVM E2----
log-logist -- --
logistic -- --
0.00 0.10 0.20
0 1 2 3 4 5 6 7
LVM H3----
0 1 2 3 4 5 6 7
0.00 0.10 0.20
0 1 2 3 4 5 6 7
one-stage -- --
0.00 0.10 0.20
0 1 2 3 4 5 6 7
two-stage -- --
0.00 0.10 0.20
0.00 0.10 0.20
Weibull -- --
0.00 0.10 0.20
0 1 2 3 4 5 6 7
log-prob -- --
0.00 0.10 0.20
0 1 2 3 4 5 6 7
0.00 0.10 0.20
0.00 0.10 0.20
0 1 2 3 4 5 6 7
probit -- --
0.00 0.10 0.20
0 1 2 3 4 5 6 7
gamma -- --
0 1 2 3 4 5 6 7
0 1 2 3 4 5 6 7
a) Result of PROAST for all models
Quantal Linear Model, with BMR of 10% Extra Risk for the BMD and 0.95 Lower Confidence Limit for the BMDL
0.4
0.35
Quantal Linear
BMD Lower Bound
0.3
0.25
Fraction Affected
0.2
0.15
0.1
0.05
0
15:23 01/20 2014
BMDL
BMD
0 2 4 6 8 10
b) Result of BMDS when pooling the data of males and female for the quantal linear model
Figure J3: Fit of all models used in PROAST to the dose-response data on the incidence of squamous
cell carcinoma or papilloma in oral mucosa or tongue in rats. Note that the models denoted LVM E2 and
H3 are not recommended by EFSA (2009c).
dose
EFSA Journal 2014;12(3):3595 230