efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table J3: Squamous cell carcinoma or papilloma of the oral mucosa or tongue in male and female rats
combined using PROAST.The benchmark dose (BMD 10 ) and the 95 % benchmark dose lower
confidence limits (BMDL 10 , BMDU 10 values are given for a BMR of 10 % extra risk with
characteristics of the model fit. The selected model based on the model selection in PROAST is
highlighted in bold.
Models
N of
parameters
Loglikelihood
Accepted
BMD 10
(mg/kg b.w.
per day)
BMDL 10
(mg/kg b.w.
per day)
BMDU 10
(mg/kg b.w.
per day)
null 1 -93.28 – – – –
full 10 -69.70 - - - -
one-stage 2 -77.01 yes 4.85 3.36 7.55
two-stage 3 -77.01 yes 4.85 - -
log-logist 3 -73.08 yes 5.25 4.22 6.14
Weibull 3 -73.08 yes 5.30 4.29 6.27
log-prob 3 -73.04 yes 5.02 4.01 6.22
gamma 3 -73.06 yes 5.18 4.20 6.24
logistic 2 -73.47 yes 5.35 4.71 6.18
probit 2 -73.66 yes 5.14 4.44 -
EFSA Journal 2014;12(3):3595 229