efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table J2: Squamous cell carcinoma or papilloma in oral mucosa or tongue in female rats. The
benchmark dose (BMD 10 ) and the 95 % benchmark dose lower confidence limit (BMDL 10 ) values are
given for a BMR of 10 % extra risk with characteristics of the model fit. The model with lowest
BMDL 10 is highlighted in bold.
Models
Restriction
N of
parameters
Minus
Loglikelihood
P-
value
Accepted
BMD 10
(mg/kg
b.w. per
day)
BMDL 10
(mg/kg
b.w. per
day)
Full model na 5 44.55 – – – –
Null (reduced) model - 1 56.74 - - - -
Probit na 2 45.72 0.50 yes 4.92 4.01
LogProbit none 3 45.43 0.41 yes 4.58 3.20
Logistic na 2 45.67 0.52 yes 5.17 4.31
LogLogistic none 2 45.50 0.39 yes 4.87 3.34
Quantal-Linear na 2 47.22 0.15 yes 4.11 2.61
Multistage Cancer na 2 45.57 0.50 yes 4.73 3.52
Multistage none 2 45.36 0.44 yes 4.96 3.65
Weibull none 3 45.51 0.38 yes 4.95 3.40
Gamma none 3 45.48 0.39 yes 4.82 3.38
b.w.: body weight; na: not applicable.
0.4
0.35
Quantal Linear Model with 0.95 Confidence Level
Quantal Linear
BMD Lower Bound
0.3
0.25
Fraction Affected
0.2
0.15
0.1
0.05
0
11:50 06/10 2013
BMDL
BMD
0 1 2 3 4 5 6 7 8 9
dose
Figure J2: Fit of the quantal-linear model to the dose-response data on the incidence of squamous cell
carcinoma or papilloma in oral mucosa or tongue in female rats.
EFSA Journal 2014;12(3):3595 228