efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table H6: Developmental and reproductive toxicity studies with Cr(VI) compounds (continued)
Study* NOAEL LOAEL Effect Reference
Adult female Swiss mice
Oral (drinking water)
0, 2000 or 5000 mg potassium dichromate/L
for 12 weeks
X untreated M (10 days)
Sacrifice F 1 wk after mating period for
examination of uterine contents
Additional animals were not mated and
sacrificed at end of treatment period for
determinayion of b.w. and organ weights
Maternal
toxicity:
2000 mg/L
106 mg
Cr(VI)/kg b.w.
per day
Developmental
toxicity:
-
Maternal
toxicity:
5000 mg/L
265 mg
Cr(VI)/kg
b.w. per day
Developmental
toxicity:
2000 mg/L
106 mg
Cr(VI)/kg
b.w. per day
Dams:
Increase ovarian weights at HD.
Number of pregnant animals/total mated F: 17/18, 14/15 and 9/11.
Litter data:
Reduction of number of implantations/litter, number of viable
foetuses.
Increase number of litters with resorptions.
Elbetieha and
Al-Hamood
(1997)
Doses: 0, 106 and 265 mg Cr(VI)/kg b.w.
per day (b)
EFSA Journal 2014;12(3):3595 217