efsa-opinion-chromium-food-drinking-water

Chromium in food and bottled water
Table H6: Developmental and reproductive toxicity studies with Cr(VI) compounds (continued)
Study* NOAEL LOAEL Effect Reference
9-week exposure Male and female BALB/c
No effect on spermatogenesis has been reported.
NTP (1996a,
mice + 8-week recovery
1997)
Oral (diet)
Potassium dichromate 0, 15, 50, 100 and 400
mg/kg food, corresponding to 0, 4, 13, 28,
115 mg potassium dichromate/kg b.w. per day
Doses:
0, 1.4, 4.6, 9.9, 40.7 mg Cr(VI)/kg b.w. per
day (a)
-week exposure Male and female Sprague-
Dawley rats+ 8-week recovery
Oral (diet)
Potassium dichromate 0, 15, 50, 100 and 400
mg/kg food corresponding to 0, 5.3, 17.7,
35.3, 141 mg Cr(VI)/kg food
Doses:
0, 0.4, 1.1, 2.3, 9.2 mg Cr(VI)/kg b.w. per
day (a)
Systematic tox:
15 mg/kg food
1.4 mg
Cr(VI)/kg b.w.
per day
Reproduction
tox:
40.7 mg
Cr(VI)/kg b.w.
per day
Systematic tox:
100 mg/kg food
2.3 mg
Cr(VI)/kg b.w.
per day
Reproduction
tox:
9.2 mg
Cr(VI)/kg b.w.
per day
Systematic
tox:
50 mg/kg food
4.6 mg
Cr(VI)/kg
b.w. per day
Reproduction
tox: -
Systematic
tox:
400 mg/kg
food
9.2 mg
Cr(VI)/kg
b.w. per day
Reproduction
tox: -
Adult male New Zealand white rabbits
Oral (gavage)
0, 5 mg potassium dichromate/kg b.w. per day
for 10 weeks
Doses: 0, 1.8 mg Cr(VI)/kg b.w. per day (a) - 5 mg/kg b.w.
potassium
dichromate
1.8 mg
Cr(VI)/kg
b.w. per day
No effect on testis, epididymus or spermatogenesis has been reported.
No adverse clinical signs. Decrease b.w., mean testes and epididymis
weights.
Reduction mean plasma testosterone.
Increases in reaction time, pH and % of dead sperm.
Decreases in packed sperm volume, sperm concentratin, total sperm
output, sperm motility, total motile sperm, % normal sperm, total
functional sperm fraction.
Seminal plasma parameters were also affected.
NTP (1996b,
1997)
Yousef et al.
(2006)
EFSA Journal 2014;12(3):3595 207