efsa-opinion-chromium-food-drinking-water
efsa-opinion-chromium-food-drinking-water
efsa-opinion-chromium-food-drinking-water
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Chromium in <strong>food</strong> and bottled <strong>water</strong><br />
Table H6: Developmental and reproductive toxicity studies with Cr(VI) compounds<br />
Study* NOAEL LOAEL Effect Reference<br />
Multigeneration reproductive toxicity<br />
Continuous breeding study 2-generation<br />
BALB/c mice<br />
Oral (diet) potassium dichromate<br />
0, 100, 200 and 400 mg/kg diet<br />
F0: expo: 1 week before mating, continuous<br />
mating for 12 weeks (20 pairs)<br />
F0: Parental:<br />
13.6 mg/ kg b.w.<br />
per day Cr(VI)<br />
Reproduction:<br />
30.3 mg/kg b.w.<br />
per day Cr(VI)<br />
F0: Parental:<br />
30.3 mg/ kg<br />
b.w. per day<br />
Cr(VI)<br />
Reproduction:<br />
-<br />
No treatment-related effects on fertility or reproductive performance.<br />
No effect on oestrous cyclicity of F1 animals.<br />
Parents:<br />
Slight decrease mean b.w. of HD F0 & F1 M & F.<br />
Decrease mean absolute liver weights in HD F0 M &F<br />
NTP (1997)<br />
F0: 0, 19.4, 38.6 and 85.7 mg potassium<br />
dichromate/kg b.w. per day.<br />
Doses: 0, 6.9, 13.6, 30.3 mg Cr(VI)/ kg b.w.<br />
per day (a )<br />
Litters examined PND 1.<br />
F1 litters reared by dams until weaning on<br />
PND 21, then separated, allowed to mature<br />
for about 74 days, 20 pairs allowed to mate<br />
and produce F2<br />
F1: Parental:<br />
200 ppm (16.1<br />
mg Cr(VI)/kg<br />
b.w. per day<br />
Reproduction:<br />
400 ppm (37 mg<br />
Cr(VI)/kg b.w.<br />
per day<br />
F1: Parental:<br />
400 ppm (37<br />
mg Cr(VI)/kg<br />
b.w. per day<br />
Reproduction:<br />
-<br />
Treatment-related changes in haematology (decrease MCV, MCH<br />
and Hb) for F1 animals.<br />
F1:0, 22.4, 45.5, 104.9 mg potassium<br />
dichromate/kg b.w. per day.<br />
Doses: 0, 7.9, 16.1, 37<br />
mg Cr(VI)/ kg b.w. per day (a)<br />
F2 litters reared by dams until weaning on<br />
PND 21 and then sacrificed<br />
EFSA Journal 2014;12(3):3595 203