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Disclaimer<br />

This presentation has been prepared by <strong>Glenmark</strong><br />

Pharmaceuticals Ltd. All information, statements and analysis<br />

made in this presentation describing company’s objectives,<br />

projections and estimates are forward looking statements and<br />

progressive within the meaning of applicable security Laws<br />

and Regulations. The analysis contained herein is based on<br />

numerous assumptions. Actual result may vary from those<br />

expressed or implied depending upon economic conditions,<br />

government policies and other incidental factors. No<br />

representation or warranty, either express or implied, is<br />

provided in relation to this presentation. This presentation<br />

should not be regarded by recipients as a substitute for the<br />

exercise of their own judgment.


Contents<br />

Background<br />

Strategy and Business Units<br />

Business Unit Overview<br />

Financials and Projections<br />

Summary


Background<br />

History<br />

Identity / Scope<br />

Global Footprint<br />

Financial<br />

Performance<br />

Market<br />

Capitalisation<br />

29-year old company<br />

Went public on Indian bourses in 1999<br />

Integrated, operating in Research,<br />

Manufacturing & Marketing of Pharmaceuticals<br />

Business interests span formulations and bulk<br />

activities<br />

Headquartered in Mumbai, India<br />

Operates in over 80 countries<br />

About 42% of revenues in FY 2006 from outside<br />

India<br />

Results in FY 2006 [ending March 31, 2006]:<br />

• Consolidated revenues of ~ $171 Mn<br />

• Consolidated Profit after Tax of ~ $20.5 Mn<br />

~USD 888 Mn [as at May 3, 2006]


Strategy and Business<br />

Units


Strategic roadmap: Transform into a specialty company<br />

through research<br />

Learning from Trends The transformation plan<br />

• Growing through generics alone is not a<br />

long-term value creator<br />

• Differentiation is key – but close to<br />

impossible in the generic space<br />

• Niche therapy segments offer good<br />

opportunity for value growth in generics<br />

space<br />

• Ownership of IP is critical to<br />

differentiation and value growth<br />

• NCE research is a large opportunity; but<br />

success in biologics can help leap-frog<br />

industry evolution<br />

• Taking proprietary molecules through all<br />

development phases is beyond our<br />

current skill-set and risk-appetite<br />

• Several markets are below the radar<br />

screen for bigger branded pharma<br />

players<br />

• Focus on building IP assets today, the key<br />

engine for this transformation<br />

• Out-license IP to drive/fund drug<br />

development<br />

• Retain/acquire IP rights for markets under<br />

the “radar” screen<br />

• In parallel, seek out such markets with<br />

growth potential and build a branded generic<br />

marketing foot-print in areas of dermatology,<br />

respiratory and oncology<br />

• Build and launch portfolios of generic<br />

products in the US niche segments like<br />

Dermatology and Controlled Substances<br />

• Subsequently, transform branded generics<br />

to specialty businesses: launch <strong>Glenmark</strong>brand<br />

novel drugs


Execute through Business Units aligned to Strategy<br />

Organized by Business Units<br />

CEO<br />

R&D<br />

Generic Formulations API<br />

Biologics<br />

(Swiss)<br />

India<br />

Formulati<br />

ons<br />

Less<br />

Regulated<br />

Markets<br />

Latin<br />

America<br />

NCE USA EU API


Build proprietary pipeline of NCEs/Biologics in high<br />

growth areas with good licensing potential<br />

RESEARCH FOCUS<br />

NCE RESEARCH BIOLOGICS<br />

Metabolic Disorders<br />

• Diabetes (Type II)<br />

• Obesity<br />

Inflammation<br />

• Asthma/COPD<br />

•Pain<br />

UNDISCLOSED THERAPIES AND<br />

TARGETS<br />

NCE Research – In Mumbai, India<br />

• Focused capability building over 5 years –<br />

170 scientists, spend ~5% of revenues<br />

• Eminent scientific advisory board<br />

• Five validated targets; 3 more planned<br />

• 6 leads – 2 in Ph II, 2 entering Ph I shortly<br />

and 2 in Pre-clinical<br />

• Target: One NCE into clinics every year<br />

Biologics Research – In Switzerland<br />

• Lab commissioned –15+ researchers<br />

by 2006<br />

• Invest to build capability until 2009-10<br />

• Start with bio-improvics; new drugs by<br />

2008<br />

• Target : Ph 1 on first lead by 2009<br />

License out the leads to partners for the markets of North America, Europe and Japan;<br />

retain marketing rights for rest of the world


Research and Development


NCE Research & Development<br />

Plan to progress 6 compounds in clinical trials in FY 2007<br />

Compound Target Primary Indications Status Target<br />

Launch<br />

GRC 3886<br />

(Oglemilast)<br />

PDE 4<br />

Asthma, COPD<br />

Ph II 2009/10<br />

GRC 8200 DPP IV Diabetes (Type II) Ph II 2010<br />

GRC 6211 VR 1 Osteoarthritis, Migraine,<br />

Incontinence, Asthma<br />

GRC 10622 CB 2 Neuropathic and<br />

inflammatory pain<br />

Ph I in<br />

Sept,06<br />

GRC 10389 CB 1 Obesity Ph I in Q4,<br />

FY07<br />

GRC 4039 PDE 4 Rheumatoid Arthritis,<br />

Inflammation<br />

2011<br />

Ph I in Nov,06 2012<br />

Ph I in<br />

Q1,FY08<br />

2011<br />

2012<br />

<strong>Glenmark</strong> will target concluding 2 licensing collaborations in FY 2007


NCE Pipeline<br />

Lead Target Indication Stage Status<br />

GRC 3886<br />

(Oglemilast)<br />

GRC 8200<br />

PDE 4<br />

DPP IV<br />

Asthma,<br />

COPD<br />

Diabetes<br />

(Type II)<br />

Ph II • Currently 2 Ph II trials underway for “exercise induced<br />

asthma” and “antigen challenge”; enrollment complete<br />

for the first study, top line results likely by Nov FY07<br />

• Phase II B for Asthma, COPD likely to begin Jan FY07<br />

• $ 30 Mn expected from Forest Inc. this year<br />

• In discussions with potential European Partners<br />

Ph II • Currently 2 Ph II trials underway in South Africa and<br />

India<br />

• Plan to file IND with USFDA in Feb/March FY07<br />

• Currently in advanced discussions with big pharma<br />

company for licensing for US, Europe, Japan and cocommercialization<br />

in RoW with <strong>Glenmark</strong> having<br />

exclusive rights for India.<br />

• Expect to conclude a deal in FY07


NCE Pipeline<br />

Lead Target Indication Stage Status<br />

GRC 6211 VR 1 Osteoarthriti<br />

s, Migraine,<br />

Incontinenc<br />

e, Asthma<br />

GRC 10622 CB 2 Neuropathic<br />

and<br />

inflammator<br />

y pain<br />

Ph I in<br />

Sept,06<br />

Ph I in<br />

Nov,06<br />

• Exciting target – after Merck licensed compound from<br />

Neurogen (currently in Ph I) and Pfizer licensed<br />

compound from Renovis (currently in pre-clinicals)<br />

• <strong>Glenmark</strong> currently in discussions for potential<br />

licensing. Timing of licensing would depend on the deal<br />

terms and ability to get co-promotion rights in some of<br />

the regulated markets. Expect to finalize partner by<br />

end-FY 07<br />

• <strong>Glenmark</strong> could be 2 nd in class with this compound<br />

• Likely to be first/second in class with an oral CB2<br />

Agonist. Currently Pharmos has an IV compound in Ph<br />

II and GSK has an oral compound in Ph I<br />

• Very exciting target as non-narcotic, peripherally acting,<br />

excellent pain-control and without addiction potential<br />

associated with Opoids. Potential applications in<br />

Rheumatoid Arthritis.<br />

• Currently in discussion with several big-pharma<br />

companies for potential licensing – expect to finalize<br />

partner by end FY07


NCE Pipeline<br />

Lead Target Indication Stage Status<br />

GRC 10389 CB 1 Obesity Ph I in<br />

Q4,<br />

FY07<br />

GRC 4039 PDE 4 Rheumatoi<br />

d Arthritis,<br />

Inflammatio<br />

n<br />

Ph I in<br />

Q1 FY08<br />

• Timelines delayed by 3-6 months for lead-optimization<br />

to differentiate us from existing drugs in development<br />

• Though Rimonabant (Sanofi-Aventis) is approved in<br />

EU, not an ideal candidate due to safety aspects<br />

• <strong>Glenmark</strong>’s lead target profile with clearly differentiate<br />

us on aspects of safety and drug metabolism<br />

• Though lead will enter Ph I in end-FY07, we expect to<br />

be third/fourth in class with a clear differential over<br />

existing compounds<br />

• After the withdrawal/setback of COX-2’s and the void<br />

that exists in RA therapy, we believe this could be a<br />

potential block-buster opportunity<br />

• The lead is also showing promise in Animal models in<br />

RA and other inflammatory conditions


Biologics research in Switzerland in early phase<br />

Swiss Presence<br />

• Diversifying research activities<br />

to cover biologics<br />

• Bioimprovics and New biologics<br />

in the future – biosimilars to<br />

build skill-sets in the near term<br />

• Biologics Research Centre<br />

established<br />

• Employed scientists with<br />

Biologics Research experience<br />

from Switzerland and Europe


Generic Formulations


Overview: Build/consolidate “branded generic” marketing<br />

footprint: Emphasis on the top 15 RoW countries<br />

RoW accounts ~12% of Global Pharma<br />

Market…<br />

…but 15 country markets contribute ~ 90%<br />

of ROW Market<br />

(2005 sales in $ Bn)<br />

265<br />

$ 21 bn<br />

Acquire<br />

• Africa: Egypt<br />

• AsiaPac/ME: China,<br />

Indonesia<br />

170<br />

6<br />

60 64<br />

90%<br />

$ 16 bn<br />

$ 27 bn<br />

Enter<br />

or<br />

Ally<br />

Grow<br />

• AsiaPac/ME: Australia,<br />

Saudi Arabia, S Korea<br />

• Africa: SA, Nigeria<br />

• Lat Am: Brazil, Argentina<br />

• AsiaPac/ME: Philippines,<br />

India, S Lanka, Malaysia,<br />

Russia<br />

US EU Japan ROW<br />

These 15 country markets are jointly growing at an annual rate of over 15% that will put<br />

them at 20% of the Global Pharma market by 2012


Overview: Acquire branded generic footprint in EU;<br />

market generics in the US market through own front-end<br />

EU Market<br />

US Market<br />

• Focus on select branded generic markets:<br />

Spain, Italy, Central and Eastern European<br />

Countries<br />

• Acquire privately held front ends<br />

– Euro 8-12 Mn Sales, cash generating<br />

– Pipeline in place for next 2-3 years<br />

– Good local brand equity<br />

– High overlap in prescriber base with<br />

our research focus<br />

• File and launch branded generics through<br />

own front-ends; also provide dossiers to<br />

partners for non-core markets<br />

• Partner with players to fund high cost<br />

developments – share marketing rights<br />

• Remain focused on generics<br />

• Market products to distributors, chains,<br />

wholesalers through own front-end<br />

• Combination of Make/Partner/Buy to build<br />

depth of portfolio rapidly<br />

– Own development<br />

– Product development alliances<br />

– Acquire registrations<br />

– Licensing marketing rights<br />

• Focus own development on specific niches<br />

with greater margins/sustainability:<br />

Dermatology and controlled substances<br />

• Use own API for cost advantage


India Formulations<br />

Current Status: FY 2006<br />

Revenue growth of 30% over FY 2005, 39% growth in March 2006 [ORG-<br />

IMS]<br />

Ranked #2 in dermatology (after GSK), strong presence in over 10<br />

segments including female healthcare, paediatrics, respiratory, antiinfectives,<br />

cardiovascular, diabetology<br />

Increased focus on chronic lifestyle diseases<br />

Launched 45 new products and novel combinations including 15 first<br />

generics such as Strontium Ranelate, Diacerin, Eplerenone, Acitretin, S-<br />

ibuprofen<br />

Created 7 retail divisions, 1 institutional division for improved focus<br />

Grew field force (currently 1700 medical representatives) and increased<br />

focus on productivity improvements<br />

Driving supply chain cost down; new plant at Baddi for tax-efficiencies<br />

Commenced in-licensing and co-marketing tie-ups for novel products


India Formulations<br />

Segment Contribution to Revenue: Diversified across therapies<br />

Segment Contribution<br />

ORG MAT Mar 2005<br />

Alimentary T. &<br />

Metabolism<br />

Blood + B. Forming<br />

Organs<br />

Segment Contribution<br />

ORG MAT Mar 2006<br />

15% 3% 15%<br />

1%<br />

13% 5%<br />

12%<br />

4%<br />

32%<br />

Cardiovascular<br />

System<br />

Dermatologicals<br />

G. U. System & Sex<br />

Hormones<br />

Systemic Anti-<br />

Infectives<br />

7%<br />

14%<br />

17%<br />

4%<br />

3%<br />

16%<br />

32%<br />

1%<br />

Musculo-Skeletal<br />

System<br />

Respiratory<br />

System<br />

Sensory Organs<br />

6%


India Formulations<br />

Moving forward, the plan…<br />

Grow revenues by 10% p.a.<br />

Initiate presence in new segments: Oncology, Probiotics<br />

Strengthen presence in respiratory, pain management and metabolic<br />

diseases – in preparation for own NCE launches<br />

Grow mass-market division: Milieus through increased product launches,<br />

sales force hires and geographic expansion<br />

Increase in-licensing efforts for novel products to augment own pipeline<br />

Continue launching differentiated branded generics; focus on building<br />

power brands<br />

Improve cost-efficiencies and cash-cycle management


Less Regulated Markets<br />

Status in FY 2006<br />

Posted 25% growth in revenues<br />

Acquisition in South Africa – entry point<br />

to the largest African market; key<br />

requirement to expand presence in<br />

Africa<br />

Expansion to 7 other countries during<br />

the year<br />

Completed over 400 filings and received<br />

over 300 approvals for products across<br />

markets<br />

Consolidated position in existing<br />

markets: increased field force, launched<br />

many new products, reviewed portfolio<br />

to meet local requirements<br />

Plan going forward…<br />

Consolidate position in Russia<br />

Expand in South Africa – use the India<br />

advantage to file several products<br />

Focus on high potential country markets<br />

Diversify portfolio to include an oncology<br />

line – leverage the acquisition of<br />

Servycal in Argentina<br />

Continue registration of products across<br />

geographies<br />

Achieve over 40% growth in revenues<br />

over FY 2006<br />

Evaluate acquisition candidates in highpotential<br />

RoW markets


Latin America<br />

Status in FY 2006<br />

Acquired a company (Servycal) in Argentina: Provides opportunity to build an<br />

Oncology franchise across Latin America, going forward<br />

Expanded field force and also commenced commercial operations in several<br />

additional countries : Presence in 10 countries (including Brazil and Argentina) in<br />

Latin America<br />

Focused on specific therapeutic segments: Respiratory, Dermatology, Gynaecology.<br />

Grew by 197% over FY 2005 in Brazil<br />

Filed 19 dossiers in the key market of Brazil; obtained 11 product approvals and<br />

launched the products towards latter half of the year<br />

Completed the integration with India: ANVISA approval for Goa and Nasik plants,<br />

and 72-bed clinical trial unit for bio-equivalences


Latin America<br />

Going forward<br />

Expand presence in Oncology to other Latin American markets: use<br />

Argentina as the hub<br />

File over 50 dossiers in markets across Latin America with about 33 in<br />

Brazil. Launch 27 new products in Brazil.<br />

Margin expansion through increasing revenue for products filed from<br />

Indian parent<br />

Divisionalisation for greater focus – focus on high margin segments<br />

Achieve 100% growth in revenues over FY 2006


USA – Generic Formulations<br />

Progress till date<br />

Rapidly built up a generic sales front end in the USA with investments in distribution,<br />

finance systems and sales team<br />

Organic and inorganic build-up of portfolio<br />

• Filed 24 ANDAs with US FDA (including partner filings) till date<br />

• 10 Generics on market – own and partnered<br />

• Focus on niche segment of controlled substances and dermatology<br />

• 5 controlled substances licensed: 2 on market and 3 to be launched by<br />

November 2006<br />

• Paul Cap partnerships to finance product development in dermatology<br />

• Strategic co-development tie-ups concluded with Shasun and InvaGen: Together<br />

accounting for 20 additional filings to which <strong>Glenmark</strong> has marketing access<br />

• Excellent sales performance – locked in excess of 20-25% of the US market on most<br />

products within first year of launch<br />

• Achieved operating cash break-even in Q4, FY06 – within 3 years of set-up


USA – Generic Formulations<br />

Going forward: Multi-pronged build-out of Product Portfolio<br />

Oral solids: File 15-20 ANDAs in FY 07; Includes 3-5 XRs and healthy & exciting<br />

mix of P-II, P-III & at least 3 FTF/P-IV opportunities<br />

Niche topical generics: File 6 products in FY 07, working on 20+ steroidal, nonsteroidal<br />

and combination topicals. Tie-up with Paul Royalty Fund to finance<br />

derm product development<br />

Niche controlled substances: Launched 2 controlled substances out of five<br />

products licensed from two US based firms; remaining to be launched by<br />

November 2006. Segment offers lower competitive pressures. Further licensing<br />

efforts ongoing.<br />

Partnerships: Already announced partnerships will file over 8 generics with the<br />

USFDA in FY 2007<br />

Current status Target for FY 2007<br />

Marketed 10<br />

Marketed 18-22<br />

Under Approval 20<br />

Under approval 38-40<br />

Total Filings 30<br />

Total Filings 28-35<br />

Own filings 20<br />

Own filings 20-25


Europe / UK – Start-up phase<br />

Strategy & Progress<br />

Entry through a niche / branded strategy<br />

• Developing niche generic products, and partnering & creating alliances with<br />

European companies<br />

• Expanding Inorganically in select branded generics markets in the EU<br />

Establish front-end<br />

• EU headquarters, <strong>Glenmark</strong> Pharmaceuticals [UK] Ltd., set up in 2004<br />

• Team building in progress<br />

• Potential front-end acquisitions under review: Italy, Spain, CE and EE countries<br />

are the current focus


Active Pharmaceutical<br />

Ingredients


Active Pharmaceutical Ingredients<br />

Status in FY 2006<br />

Plan going forward…<br />

Revenue decline (12%) driven by:<br />

capacity diversion for captive APIs<br />

across US, India and LRM<br />

decline in prices in some key APIs<br />

Revenue growth in excess of 30%<br />

Complete capacity expansion in<br />

Ankleshwar, start construction in<br />

Aurangabad<br />

discontinuation of Valdecoxib<br />

File 12-14 DMFs per year<br />

Mix of revenues from segments:<br />

India and co-marketing – 48%<br />

Regulated APIs – 22%<br />

Commercial supplies to regulated<br />

markets to increase dramatically with<br />

several ANDA’s/Dossiers filed and<br />

pending from out 3rd party customers<br />

Rest of world – 30%<br />

Commenced commercial supplies of<br />

DMFs during year; several samples,<br />

validation, pivotal batches to global<br />

generic players for their ANDA/Dossier<br />

filings<br />

Develop several APIs annually to<br />

provide cost and timing advantage to<br />

complement our US and EU generic<br />

filings<br />

Continue to be a preferred 3rd party API<br />

supplier to the generic industry<br />

Filed 7 DMFs in the year<br />

Capacity de-bottlenecking initiated for<br />

Ankleshwar, commenced preconstruction<br />

work at new site<br />

Aurangabad


Financials and Projections


Financials and Projections<br />

Performance in FY 2006<br />

(In USD Million)<br />

FY 2006 FY 2005<br />

Audited<br />

Audited<br />

Operating income (A) 171.09<br />

139.87<br />

Expenditure (B) 140.11<br />

104.27<br />

EBITDA (Operations) (C =A-B) 30.98<br />

35.60<br />

EBT (Operations) (D) 22.41<br />

27.90<br />

Other Income (E) 2.90<br />

1.19<br />

PBT (F=D+E) 25.31<br />

29.09<br />

PAT (G) 19.87<br />

24.48<br />

Basic Earnings per share (in rupees) 7.28<br />

8.97<br />

Diluted Earnings per share (in<br />

rupees) 6.41<br />

8.16<br />

Note : 1. Average conversion rate for FY 2005-06 of Rs. 44.28 / USD 1.00<br />

2. Average conversion rate for FY 2004-05 of Rs. 44.94 / USD 1.00


Financials and Projections<br />

Revenues<br />

In USD Mn<br />

171<br />

Projections (in Mn USD)<br />

277 368 CAGR ~ 46.6%<br />

Business Mix<br />

22<br />

14<br />

7<br />

22<br />

89<br />

17<br />

34<br />

40<br />

98<br />

33<br />

37<br />

35<br />

35<br />

55<br />

108<br />

48<br />

47<br />

75<br />

NCE<br />

API<br />

India Formulation<br />

ROW<br />

Latam<br />

USA<br />

FY 2006 FY 2007 FY 2008<br />

Net Profits<br />

20.5 55-60<br />

70-75 CAGR ~ 84-91%<br />

* In USD Mn [Assumed exchange rate of ~44 INR/USD]


Summary


Summary-Key target milestones<br />

Research<br />

Conclude at least 2 licensing deals for NCEs<br />

Complete Phase II for GRC 8200 and GRC 3886; initiate Phase I trials on 3 NCE<br />

compounds<br />

Formulations<br />

Launch oncology and probiotic portfolios in India<br />

In-license novel products/co-marketing deals<br />

Roll out Oncology to LRM and Latin American markets<br />

Market 18-24 ANDAs in the US market<br />

File 15-20 solid dose ANDAs and another >6 topicals; include XRs and P-IV<br />

opportunities<br />

APIs<br />

File 12-14 DMFs<br />

Commence construction in Aurangabad, expand Ankhleshwar


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