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Review of Eccrine Sweat Gland and Nephron Function with Implications for
Targeted Treatment of Uraemia
Keller, R OMS1
University of New England, College of Osteopathic Medicine Biddeford, ME
The purpose of this literature review was to highlight similarities between the
nephron and eccrine sweat gland (ESG). The nephron has been very well
characterized in recent years. Individual mechanisms of solute movement for K+,
Na+, NH4+, urea, inorganic phosphate (Pi) and creatinine have been elucidated.
Many of the same solutes excreted in urine are also excreted in sweat. The ESG
has been shown to excrete Na+ and K+, but we were unable to find research
involving molecular mediators of nitrogenous compound excretion. Despite this,
nitrogenous compound concentration in sweat has been reported. First, we will
present a brief overview of nephron solute transport. Normal and diseased states
will be considered. Next, a detailed review of the ESG will be presented. Finally,
we will look into past attempts at thermally induced diaphoretic therapy. The
discussion will focus on next steps in research that would implicate the ESG as a
target for therapeutic use in patients with chronic uraemia.