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CHLOROTHALONIL - 25 - APPENDIX II END POINTS AND RELATED INFORMATION 3. Ecotoxicology 20 December 2004 Species time effect value mg a.i./L Mean of the log -1.1382 toxicity values Sample standard 0.5219 deviation Sample size 36 Long term toxicity Species time effect value in mg a.i./L Pimephales promelas 2- generati on NOEC 0.003 Oncorhynchus mykiss 21 days NOEC 0.003 geometric mean Navicula pelliculosa 120 NOEC 0.0035 hours Daphnia magna 21 days NOEC 0.0085 geometric mean Scenedesmus subspicatus 96h NOEC 0.020 geometric mean Anabaena flos-aquae 120 NOEC 0.020 hours Selenastrum capricornutum 72-96h NOEC 0.033 geometric mean Chironomus riparius 28 days NOEC 0.040 Lemna gibba 14 days NOEC 0.29 Sensitivity distribution normal HC5 0.001 of NOEC distributi (95% cf) on (0.0002 -0.003) values Mean of the log 1.1792 toxicity values Sample standard 0.6540
CHLOROTHALONIL - 26 - APPENDIX II END POINTS AND RELATED INFORMATION 3. Ecotoxicology 20 December 2004 Species time effect value in mg a.i./L deviation Sample size 9 • the average HC5 for the L(E)C50 is 0.01 mg/l (n=36); the average HC5 for the NOECs is 1 µg/l (n=9) • The number of acute samples vs. chronic samples (36 vs 9) and the spread of the HC5 estimates indicates that the acute HC5 is statistically the more reliable value. Given the rapid dissipation in the aquatic systems, chronic exposure due to the agricultural applications is considered less likely. The initial PEC is the protective estimation for the acute effects, because many toxicity data are based on nominal concentrations and because it cannot be excluded that pronounced effects may appear already after a short-term exposure. Outdoor microcosm study (without fish) • On basis of the most sensitive endpoints studied the overall NOEC in the microcosms is 10 µg chlorothalonil/L; • In shallow freshwater ecosystems an EAC of 30 µg chlorothalonil/L may allow sustainable populations of sensitive algae and invertebrates, since recovery of affected populations of algae and invertebrates was observed a few weeks after the last application.
Page 1 and 2: EUROPEAN COMMISSION HEALTH & CONSUM
Page 3 and 4: - 3 - By letter 6 March 1998 Zeneca
Page 5 and 6: - 5 - Annex I to Directive 91/414/E
Page 7 and 8: - 7 - 4. Identity and Physical/chem
Page 9 and 10: - 9 - 8. Information on studies wit
Page 11 and 12: CHLOROTHALONIL Melting point 252 °
Page 13 and 14: CHLOROTHALONIL - 4 - APPENDIX II EN
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