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CHLOROTHALONIL - 9 - APPENDIX II END POINTS AND RELATED INFORMATION 1. Toxicology and metabolism 20 December 2004 R182281 (SDS-3701) Value Study Safety factor ADI 0.01 mg/kg bw/day AOEL Not relevant ARfD (acute reference dose) 0.01 mg/kg bw/day 90-day/1- year dog 90-day/1- year dog 100 100 R611965 (SDS-46851) Value Study Safety factor ADI AOEL 0.5 mg/kg bw/day Not relevant ARfD (acute reference dose) 0.5 mg/kg bw/day 90-day dog 90-day dog 100 100 R417888 Value Study Safety factor ADI 0.06 mg/kg bw/day 90-day rat 1000 AOEL Not relevant ARfD (acute reference dose) Not relevant
CHLOROTHALONIL - 10 - APPENDIX II END POINTS AND RELATED INFORMATION 1. Toxicology and metabolism 20 December 2004 Dermal absorption liquid formulation: Concentrate liquid formulation: 0.02% based on in vivo rat and in vitro human/rat data Spray dilution liquid formulation: 0.34% based on in vivo rat and in vitro human/rat data granular formulation: Concentrate formulation: 0.1% based on in vivo rat and in vitro human/rat data Spray dilution: 1.2% based on in vivo rat and in vitro human/rat data
Page 1 and 2: EUROPEAN COMMISSION HEALTH & CONSUM
Page 3 and 4: - 3 - By letter 6 March 1998 Zeneca
Page 5 and 6: - 5 - Annex I to Directive 91/414/E
Page 7 and 8: - 7 - 4. Identity and Physical/chem
Page 9 and 10: - 9 - 8. Information on studies wit
Page 11 and 12: CHLOROTHALONIL Melting point 252 °
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