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CHLOROTHALONIL - 167 - APPENDIX IIIB List of studies 20 December 2004 Annex point/ refere nce numb er Author(s) Yea r 6.8.1 Seville, A. 199 9 6.8.1 Duane, W.C. 6.8.1 Callander, R. D. 197 1 200 0 Title Source (where different from company) Company, Report No. GLP or GEP status (where relevant) Published or not GSH reactivity of chlorothalonil and its metabolite R611965 (SDS-46851 / CTB - MIII) generated by: Chemistry Design Group, Zeneca Agrochemicals Submitted by: Zeneca Agrochemicals Report no.: - Date: 25 October 1999b Not GLP, unpublished Submitted by SYN Reinvestigation of the degradation of chlorothalonil by bovine rumen fluid Generated by: Diamond Shamrock Corp., T.R. Evans research Centre, Painesville, Ohio Submitted by: Zeneca Agrochemicals Report no.: date: 17 December 1971 Not GLP, unpublished Submitted by SYN R417888: Bacterial mutation assay in S. typhimurium and E. coli Generated by: Central Toxicology Laboratory, Alderly Park Macclesfield Cheshire UK Submitted by: Zeneca Agrochemicals Report CTL/YV4341/Regulatory/Report Date: 22 March 2000 GLP, unpublished Submitted by SYN no.:

CHLOROTHALONIL - 168 - APPENDIX IIIB List of studies 20 December 2004 Annex point/ refere nce numb er Author(s) Yea r 6.8.1 Clay, P. 200 0 6.11.1 Kilgour, J.D. 6.11.1 Kilgour, J.D. 199 9 199 9 Title Source (where different from company) Company, Report No. GLP or GEP status (where relevant) Published or not R417888: L5178 TK+/- mouse lymphoma mutation assay Generated by: Central Toxicology Laboratory, Alderly Park Macclesfield Cheshire UK Submitted by: Zeneca Agrochemicals Report no.: CTL/VV0208/Regulatory/Report Date: 12 January 2000 GLP, unpublished Submitted by SYN Chlorothalonil 720 g/l SC: 4-Hour acute inhalation toxicity study in rats Generated by: Central Toxicology Laboratory Submitted by: Zeneca Agrochemicals Report No.: CTL/P/6311 Date: 12 July 1999 GLP, unpublished Submitted by SYN Chlorothalonil 500 g/l SC: 4-Hour acute inhalation toxicity study in rats Generated by: Central Toxicology Laboratory Submitted by: Zeneca Agrochemicals Report No.: CTL/P/6317 Date: 23 August 1999 GLP, unpublished Submitted by SYN

CHLOROTHALONIL<br />

- 168 -<br />

APPENDIX IIIB<br />

List of studies<br />

20 December 2004<br />

Annex<br />

point/<br />

refere<br />

nce<br />

numb<br />

er<br />

Auth<strong>or</strong>(s)<br />

Yea<br />

r<br />

6.8.1 Clay, P. 200<br />

0<br />

6.11.1 Kilgour,<br />

J.D.<br />

6.11.1 Kilgour,<br />

J.D.<br />

199<br />

9<br />

199<br />

9<br />

Title<br />

Source (where different from<br />

company)<br />

Company, Rep<strong>or</strong>t No.<br />

GLP <strong>or</strong> GEP status (where relevant)<br />

<strong>Published</strong> <strong>or</strong> <strong>not</strong><br />

R417888: L5178 TK+/- mouse<br />

lymphoma mutation assay<br />

Generated by: Central Toxicology<br />

Lab<strong>or</strong>at<strong>or</strong>y, Alderly Park Macclesfield<br />

Cheshire UK<br />

Submitted by: Zeneca Agrochemicals<br />

Rep<strong>or</strong>t<br />

no.:<br />

CTL/VV0208/Regulat<strong>or</strong>y/Rep<strong>or</strong>t<br />

Date: 12 January 2000<br />

GLP, unpublished<br />

Submitted by SYN<br />

Chl<strong>or</strong>othalonil 720 g/l SC: 4-Hour<br />

acute inhalation toxicity study in rats<br />

Generated by: Central Toxicology<br />

Lab<strong>or</strong>at<strong>or</strong>y<br />

Submitted by: Zeneca Agrochemicals<br />

Rep<strong>or</strong>t No.: CTL/P/6311<br />

Date: 12 July 1999<br />

GLP, unpublished<br />

Submitted by SYN<br />

Chl<strong>or</strong>othalonil 500 g/l SC: 4-Hour<br />

acute inhalation toxicity study in rats<br />

Generated by: Central Toxicology<br />

Lab<strong>or</strong>at<strong>or</strong>y<br />

Submitted by: Zeneca Agrochemicals<br />

Rep<strong>or</strong>t No.: CTL/P/6317<br />

Date: 23 August 1999<br />

GLP, unpublished<br />

Submitted by SYN

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