Published or not - fyto
Published or not - fyto Published or not - fyto
CHLOROTHALONIL - 7 - APPENDIX II END POINTS AND RELATED INFORMATION 1. Toxicology and metabolism 20 December 2004 R417888: - Acute oral toxicity: LD 50 > 2000 mg/kg bw - 90-d toxicity study: NOAEL > 59 mg/kg bw/d - Genotoxicity: no pointmutations in bacteria and mammalian cells, no chromosome aberrations Mechanistic data Medical data Kidney effects: the data indicate that kidney lesions are probably caused by thiol metabolites leading to celldegeneration and subsequent cellproliferation. Stomach-effects: the data indicate that stomach effects are caused by the irritating properties of the parent compound and were eliminated by glutathion conjugation In case of occupational exposure skin and eye irritation might occur. Summary (Annex IIA, point 5.10) Chlorothalonil Value Study Safety factor ADI 0.015 mg/kg bw/day AOEL 0.009 mg/kg bw/day ARfD (acute reference dose) 0.015 mg/kg bw/day 90-day rat 100 Chronic study rat; 30% oral absorption 100 28-day rat 100
CHLOROTHALONIL - 8 - APPENDIX II END POINTS AND RELATED INFORMATION 1. Toxicology and metabolism 20 December 2004
- Page 1 and 2: EUROPEAN COMMISSION HEALTH & CONSUM
- Page 3 and 4: - 3 - By letter 6 March 1998 Zeneca
- Page 5 and 6: - 5 - Annex I to Directive 91/414/E
- Page 7 and 8: - 7 - 4. Identity and Physical/chem
- Page 9 and 10: - 9 - 8. Information on studies wit
- Page 11 and 12: CHLOROTHALONIL Melting point 252 °
- Page 13 and 14: CHLOROTHALONIL - 4 - APPENDIX II EN
- Page 15: CHLOROTHALONIL - 6 - APPENDIX II EN
- Page 19 and 20: CHLOROTHALONIL - 10 - APPENDIX II E
- Page 21 and 22: CHLOROTHALONIL - 12 - APPENDIX II E
- Page 23 and 24: CHLOROTHALONIL - 14 - APPENDIX II E
- Page 25 and 26: CHLOROTHALONIL - 16 - APPENDIX II E
- Page 27 and 28: CHLOROTHALONIL - 18 - APPENDIX II E
- Page 29 and 30: CHLOROTHALONIL - 20 - APPENDIX II E
- Page 31 and 32: CHLOROTHALONIL 3 Ecotoxicology Terr
- Page 33 and 34: CHLOROTHALONIL - 24 - APPENDIX II E
- Page 35 and 36: CHLOROTHALONIL - 26 - APPENDIX II E
- Page 37 and 38: CHLOROTHALONIL - 28 - APPENDIX II E
- Page 39 and 40: CHLOROTHALONIL - 30 - APPENDIX II E
- Page 41 and 42: CHLOROTHALONIL - 32 - APPENDIX IIIA
- Page 43 and 44: CHLOROTHALONIL - 34 - APPENDIX IIIA
- Page 45 and 46: CHLOROTHALONIL - 36 - APPENDIX IIIA
- Page 47 and 48: CHLOROTHALONIL - 38 - APPENDIX IIIA
- Page 49 and 50: CHLOROTHALONIL - 40 - APPENDIX IIIA
- Page 51 and 52: CHLOROTHALONIL - 42 - APPENDIX IIIA
- Page 53 and 54: CHLOROTHALONIL - 44 - APPENDIX IIIA
- Page 55 and 56: CHLOROTHALONIL - 46 - APPENDIX IIIA
- Page 57 and 58: CHLOROTHALONIL - 48 - APPENDIX IIIA
- Page 59 and 60: CHLOROTHALONIL - 50 - APPENDIX IIIA
- Page 61 and 62: CHLOROTHALONIL - 52 - APPENDIX IIIA
- Page 63 and 64: CHLOROTHALONIL - 54 - APPENDIX IIIA
- Page 65 and 66: CHLOROTHALONIL - 56 - APPENDIX IIIA
CHLOROTHALONIL<br />
- 7 -<br />
APPENDIX II<br />
END POINTS AND RELATED INFORMATION<br />
1. Toxicology and metabolism<br />
20 December 2004<br />
R417888: - Acute <strong>or</strong>al toxicity: LD 50 > 2000<br />
mg/kg bw<br />
- 90-d toxicity study: NOAEL > 59<br />
mg/kg bw/d<br />
- Ge<strong>not</strong>oxicity: no pointmutations in<br />
bacteria and mammalian cells, no<br />
chromosome aberrations<br />
Mechanistic data<br />
Medical data<br />
Kidney effects: the data indicate that<br />
kidney lesions are probably caused by<br />
thiol metabolites leading to celldegeneration<br />
and subsequent cellproliferation.<br />
Stomach-effects: the data indicate<br />
that stomach effects are caused by<br />
the irritating properties of the parent<br />
compound and were eliminated by<br />
glutathion conjugation<br />
In case of occupational exposure skin<br />
and eye irritation might occur.<br />
Summary (Annex IIA, point<br />
5.10)<br />
Chl<strong>or</strong>othalonil Value Study Safety<br />
fact<strong>or</strong><br />
ADI 0.015<br />
mg/kg<br />
bw/day<br />
AOEL 0.009<br />
mg/kg<br />
bw/day<br />
ARfD (acute reference dose) 0.015<br />
mg/kg<br />
bw/day<br />
90-day rat 100<br />
Chronic<br />
study rat;<br />
30% <strong>or</strong>al<br />
abs<strong>or</strong>ption<br />
100<br />
28-day rat 100
Change language