Published or not - fyto
Published or not - fyto
Published or not - fyto
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
CHLOROTHALONIL<br />
- 6 -<br />
APPENDIX II<br />
END POINTS AND RELATED INFORMATION<br />
1. Toxicology and metabolism<br />
20 December 2004<br />
R611965 (SDS 46851):<br />
decreased foetal weight at maternal<br />
toxic doses NOAEL: 2.5 mg/kg<br />
bw/day.<br />
- Oral abs<strong>or</strong>ption: 22-26% (urinary<br />
excretion, rat)<br />
- Acute <strong>or</strong>al toxicity: LD 50 > 5000<br />
mg/kg bw<br />
- Sh<strong>or</strong>t-term toxicity: Overall NOAEL<br />
50 mg/kg bw/day.<br />
- Ge<strong>not</strong>oxicity: Several in vitro and<br />
in vivo ge<strong>not</strong>oxicity studies were<br />
perf<strong>or</strong>med with SDS-46851. All<br />
studies, including two point<br />
mutation assays, a sister<br />
chromatid exchange assay (in<br />
CHO-cells), a f<strong>or</strong>ward mutation<br />
assay (TK, mouse lymphoma<br />
cells), an unscheduled DNA<br />
synthesis assay (rat hepatocytes),<br />
and two micronucleus tests in vivo<br />
(mice) were negative. Overall, it is<br />
concluded that SDS-46851 is nonge<strong>not</strong>oxic.<br />
- Chronic toxicity in rats: Overall<br />
NOAEL: 200 mg/kg bw/day, no<br />
carcinogenic potential.<br />
- Reproductive toxicity (rat): no<br />
reproductive toxicity at parental<br />
toxic doses, reproductive NOAEL:<br />
> 20.000 ppm (911 mg/kg bw/day)<br />
- Teratogenicity (rabbit): decreased<br />
live fetuses and decreased fetal<br />
weight at maternal toxic doses,<br />
developmental NOAEL: 500 mg/kg<br />
bw/day.
Change language