Published or not - fyto

CHLOROTHALONIL
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APPENDIX II
END POINTS AND RELATED INFORMATION
1. Toxicology and metabolism
20 December 2004
Lowest relevant
reproductive NOAEL /
NOEL:
Target / critical effect -
Developmental toxicity:
Lowest relevant
developmental NOAEL /
NOEL:
22.6 mg/kg bw/day, rat
decreased number of live fetuses (rat),
increased number of rudimentary ribs
(rabbit).
10 mg/kg bw/day, rabbit
Delayed neurotoxicity
no data; not required
Other toxicological
studies
Toxicological data on three
environmental metabolites were
submitted: SDS 3701, SDS 46851 and
R417888.
R182281 (SDS 3701): - Oral absorption 26-30% (urine
and tissue residues (rat))
- Acute oral toxicity: LD50:242
mg/kg bw
- Short-term toxicity: overall NOAEL
(90-day/1-year dog): 50 ppm (1.25
mg/kg bw/day)
- Genotoxicity:clastogenic in vitro, no
genotoxic potential in vivo
- Chronic toxicity in rats: NOAEL 3.0
mg/kg bw/day, no indications for
carcinogenicity
- Reproductive toxicity (rat):
decreased body weight pups
(without parental toxicity) NOAEL:
1.5 mg/kg bw/day
- Teratogenicity (rabbit): increased
post implantation loss and