Published or not - fyto
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Published or not - fyto
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CHLOROTHALONIL<br />
- 4 -<br />
APPENDIX II<br />
END POINTS AND RELATED INFORMATION<br />
1. Toxicology and metabolism<br />
20 December 2004<br />
Eye irritation:<br />
Skin sensitization (test<br />
method used and result):<br />
irritant<br />
skin sensitizer (Maximisation test)<br />
Sh<strong>or</strong>t term toxicity<br />
Target / critical effect:<br />
Lowest relevant <strong>or</strong>al<br />
NOAEL / NOEL:<br />
Lowest relevant dermal<br />
NOAEL / NOEL:<br />
Lowest relevant inhalation<br />
NOAEL / NOEL:<br />
Ge<strong>not</strong>oxicity<br />
stomach and kidneys<br />
(histopathological changes and<br />
increased <strong>or</strong>gan weights in kidneys)<br />
1.5 mg/kg bw/day (90-day rat)<br />
< 60 mg/kg bw (21-day rat)<br />
no data; <strong>not</strong> required<br />
Some positive response in vitro<br />
(without activation). No convincing<br />
evidence f<strong>or</strong> ge<strong>not</strong>oxicity in vivo<br />
Long term toxicity and carcinogenicity<br />
Target / critical effect:<br />
Lowest relevant NOAEL:<br />
Carcinogenicity:<br />
kidney and (f<strong>or</strong>e)stomach (preneoplastic<br />
and neoplastic lesions)<br />
chronic study, rat :1.8 mg/kg bw/day<br />
Most relevant NOAEL f<strong>or</strong> setting the<br />
AOEL: 2.7 mg/kg bw/day<br />
f<strong>or</strong>e-stomach tumours in rats and<br />
mice, kidney tumours in rats<br />
Reproductive toxicity<br />
Target / critical effect -<br />
Reproduction:<br />
decreased pup weight and<br />
histopathological changes in stomach<br />
at parental toxic doses.
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