EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

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Hydrocarbon metabolites have been briefly assessed (Appendix 3) where there was potentially considered to be an issue with their PBT properties for certain HCB. This assessment indicates that metabolites are not P or B. 6.0 Toxicity Assessment of HCBs meeting P and B criteria To determine if a substance fulfills the toxicity criterion an evaluation of both aquatic toxicity and specific hazard classifications is required based on the following triggers: The long-term no-observed effect concentration for marine of freshwater organisms is less than 10 g/L, or the substance is classified as carcinogenic, (R45, R49), mutagenic (R46) , or toxic to reproduction (R60, R61), or there is other evidence of chronic toxicity (R48) A compilation of reliable chronic aquatic toxicity data for aliphatic hydrocarbons is provided in Tables 23 and 24 for algae (P. subcapita) and daphnia (D. magna), respectively. A comparison of observed chronic toxicity to measured water solubility presented in these tables indicates that a chronic toxicity cut-off for algae occurs at a solubility limit of ca. 6 g/L while a cut-off for daphnia occurs above 10 g/L. The observation that algae are more sensitive to daphnia is consistent with lower estimated critical body burden derived using the target lipid model. Critical body burdens for algae and daphnia were reported to be 48 and 115 mmol/kg lipid, respectively (McGrath et al. 2004). In the case of the C16 di-naphthenic structures, the water solubility is expected to be too low to pose a chronic toxicity concern. This is confirmed by measured slow-stir water solubility and chronic test data for 2,7-diisopropyldecalin which shows no chronic algal effects are observed at measured exposure concentrations exceeding the solubility limit (Table 23). Further, C17 and C18 di-naphthenic hydrocarbons will exhibit even lower water solubility and thus based on read across will also not fulfill the chronic aquatic toxicity criterion. In the case of the C16 poly-naphthenic structures, the water solubility is again expected to be too low to pose a chronic aquatic toxicity hazard. This is supported by measured slow-stir water solubility and target lipid model predictions for hexadecahydropyrene using the PETROTOX model (Redman, 2009). This structure serves as the worst case, most water soluble representative structure that occurs in this HCB. Predicted NOECs for algae, daphnia and trout are 5, 12 and 7 g/L, respectively. The measured water solubility of hexadecahydropyrene (4.7 g/L) falls just below the lowest toxicity value for algae. In addition, the measured solubility falls below the empirical chronic solubility cut-off for algae of ca. 6 g/L as previously discussed. Therefore, based on available data for hexadecahydropyrene and recognizing other C16 poly-naphthenic structures that fall into this HCB will exhibit lower aqueous solubilities, it may be concluded that C16 poly-naphthenics are unlikely to meet the aquatic toxicity criterion. Testing could help to verify this conclusion. Given C17 to C22 poly-naphthenic hydrocarbons will exhibit even 64
lower water solubility, it is possible to conclude, based on read across, that these HCBs will also not fulfill the chronic aquatic toxicity criterion. Slow-Stir Water Solubility Mean Measured Exposure Test Compound (g/L) (g/L) Algal Chronic Toxicity 2,6,10-trimethyldodecane 0.3 23 No n-octylcyclohexane 1.4 9 No 2,7 di-isopropyl decalin 1.8 5 No 2,6- dimethylundecane 2.7 16 No hexadecahydropyrene 4.7 not tested n-heptylcylohexane 6.2 64 Yes 2,6-dimethyldecane 11 19 Yes 2,2,4,6,6- pentamehtylheptane 2,2,4,6,6- pentamehtylheptane 23 6 No 23 146 Yes 2-isopropyl decalin 25 68 Yes Reference EMBSI, 2006c EMBSI, 2006d EMBSI, 2009c EMBSI, 2006d EMBSI, 2009p EMBSI, 2006e EMBSI, 2009c SafePharm, 2004a Tolls and van Dijk, 2002 EMBSI, 2009c Table 23. Chronic algal toxicity for selected hydrocarbons that may be used to readacross for the C16-18 poly-naphthenic hydrocarbons. Slow-Stir Water Solubility Mean Measured Exposure Daphnia Chronic Test Compound (g/L) (g/L) Toxicity n-octylcyclohexane 1.4 3 No 2,6-dimethylundecane 2.7 2 No 2,6-dimethylundecane 2.7 3 No hexadecahydropyrene 3.8 not tested Reference EMBSI, 2006f EMBSI, 2006f EMBSI, 2007d EMBSI, 2009p 65
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Gas Oils (Vacuum) 4 DNEL (inhalatio
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Industrial - Tabletting, CS100 Indo
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Combined Professional - Manual spra
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Industrial - Bulk transfers CS14 Da
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Professional - Maintenance and CS77
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Note: differentiated Industrial -SU
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Professional - Treatment and dispos
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Industrial - operation of open CS16
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Gas Oils (Vacuum) 4 DNEL (inhalatio
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Industrial - Tabletting, CS100 Indo
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Combined Professional - Manual spra
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Industrial - Bulk transfers CS14 Da
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Professional - Maintenance and CS77
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Note: differentiated Industrial -SU
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Professional - Treatment and dispos
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Industrial - operation of open CS16
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This tool is provided for informati
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An Evaluation of the Persistence, B
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Table of Contents Executive Summary
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2.0 Outline of PBT/vPvB Assessment
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3.0 Persistence Assessment of Petro
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100.0 Half-life predicted (days) 10
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2,3-dimethylheptane 9 7.7 6.2 7.4 2
Page 179 and 180: ioHCwin half-life (days) 10000.0 10
Page 181 and 182: criterion. It can be concluded that
Page 185 and 186: Hydrocarbon C nr BioHCwin Predicted
Page 187 and 188: ioHCwin half-life (days) 1000000.0
Page 191 and 192: Hydrocarbon C nr BioHCwin Predicted
Page 193 and 194: enzo[a]pyrene 20 421.6 16.5 Table 1
Page 195 and 196: (see Appendix 2). Since BCF predict
Page 197 and 198: 10000 BCF (Arnot) 1000 100 10 1 n-P
Page 199 and 200: exhibit BMFs near unity (Figure 28)
Page 201 and 202: 2,2,4,4,6,8,8- heptamethyl nonane 1
Page 203 and 204: Hydrocarbon C BMF BCF (Arnot) Dieta
Page 205 and 206: BCF (regression) 100000 10000 1000
Page 207 and 208: 4.5 Polynaphthenic hydrocarbons Reg
Page 209 and 210: Experimental BMF 10 1 Polynaphth. D
Page 211 and 212: enzene n-octylbenzene 14 0.034 403
Page 213 and 214: 10000 1000 BCF (Arnot) 100 10 1 NMA
Page 215 and 216: and appears to be an outlier. This
Page 217 and 218: 4-ethylbiphenyl 14 863 1039 C Yakat
Page 219 and 220: 100000 BCF (regression) 10000 1000
Page 221 and 222: 10 Experimental BMF 1 0.1 NDiAr Die
Page 223 and 224: Hydrocarbon C BMF Arnot BCF Dietary
Page 225 and 226: Hydrocarbon C BMF Arnot BCF Dietary
Page 227 and 228: Acenaphthene Acenaphthylene Benz(a)
Page 229: 5.0 Summary of Persistence and Bioa
Page 233 and 234: properties of petroleum hydrocarbon
Page 235 and 236: 8.0 References Anonymous (2004). Fi
Page 237 and 238: EMBSI (2007c). Fish, dietary bioacc
Page 239 and 240: Prince RC, Walters CC. (2007). Biod
Page 241 and 242: Appendix 1. Hydrocarbon structures
Page 243 and 244: iP 14 2,4,10-Trimethylundecane CC(C
Page 245 and 246: MN 7 1,2-Dimethylcyclopentane CC1C(
Page 247 and 248: MN 14 n-Nonylcyclopentane CCCCCCCCC
Page 249 and 250: MN 29 MN 29 MN 30 n-Tetracosylcyclo
Page 251 and 252: hexahydroindane DN 20 2,4-dimethylo
Page 253 and 254: PN 27 Phenanthrene 2,6-dimethylhept
Page 255 and 256: MAr 13 1-Methyl-3-hexylbenzene Cc1c
Page 257 and 258: NMAr 12 n-Propylindan c1ccc2CC(CCC)
Page 259 and 260: NMAr 24 c1cc(CC(C)CCCC(C)CCCCC)c2CC
Page 261 and 262: NMAr 29 NMAr 29 NMAr 29 NMAr 29 NMA
Page 263 and 264: DAr 16 2-Hexylnaphthalene CCCCCCc1c
Page 265 and 266: NDAr 16 n-Butylacenaphthene c12cccc
Page 267 and 268: NDAr 26 Dimethyloctyl-1,2,3,6,7,8-
Page 269 and 270: PAr 19 Ethylbenzo(a)fluorene C3c1cc
Page 271 and 272: PAr 22 n-Pentylbenzo(a)fluorene C3c
Page 273 and 274: PAr 28 Isohexyl-octadecahydro-picen
Page 275 and 276: Appendix 3. CONCAWE Position Paper
Page 277 and 278: probabilities are adjusted to best
Page 279 and 280: 1.2.2 OASIS LMC Models: Toxicologic
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environmental chemicals (database o
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dihydrodiol. These dihydroxylated i
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Table 1 : PBT assessment of C15 str
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1: The following structures were pr
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Dimitrov SD, Dimitrova N, Mekenyan
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hydrocarbons and azaarenes original
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Verhaar HJM, van Leeuwen CJ, Hermen
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CONCAWE AQUATIC TOXICITY PREDICTION
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CONTENTS (Continued) Section Page 1
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1-2 The model predictions include m
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2-1 SECTION 2 2 SUMMARY OF COMPOSIT
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10-1 SECTION 10 10 SUMMARY OF COMPO
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EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

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