EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

Hydrocarbon metabolites have been briefly assessed (Appendix 3) where there was
potentially considered to be an issue with their PBT properties for certain HCB. This
assessment indicates that metabolites are not P or B.
6.0 Toxicity Assessment of HCBs meeting P and B criteria
To determine if a substance fulfills the toxicity criterion an evaluation of both aquatic
toxicity and specific hazard classifications is required based on the following triggers:
The long-term no-observed effect concentration for marine of freshwater organisms is
less than 10 g/L, or
the substance is classified as carcinogenic, (R45, R49), mutagenic (R46) , or toxic to
reproduction (R60, R61), or
there is other evidence of chronic toxicity (R48)
A compilation of reliable chronic aquatic toxicity data for aliphatic hydrocarbons is
provided in Tables 23 and 24 for algae (P. subcapita) and daphnia (D. magna),
respectively. A comparison of observed chronic toxicity to measured water solubility
presented in these tables indicates that a chronic toxicity cut-off for algae occurs at a
solubility limit of ca. 6 g/L while a cut-off for daphnia occurs above 10 g/L. The
observation that algae are more sensitive to daphnia is consistent with lower estimated
critical body burden derived using the target lipid model. Critical body burdens for algae
and daphnia were reported to be 48 and 115 mmol/kg lipid, respectively (McGrath et al.
2004).
In the case of the C16 di-naphthenic structures, the water solubility is expected to be too
low to pose a chronic toxicity concern. This is confirmed by measured slow-stir water
solubility and chronic test data for 2,7-diisopropyldecalin which shows no chronic algal
effects are observed at measured exposure concentrations exceeding the solubility limit
(Table 23). Further, C17 and C18 di-naphthenic hydrocarbons will exhibit even lower
water solubility and thus based on read across will also not fulfill the chronic aquatic
toxicity criterion.
In the case of the C16 poly-naphthenic structures, the water solubility is again expected
to be too low to pose a chronic aquatic toxicity hazard. This is supported by measured
slow-stir water solubility and target lipid model predictions for hexadecahydropyrene
using the PETROTOX model (Redman, 2009). This structure serves as the worst case,
most water soluble representative structure that occurs in this HCB. Predicted NOECs
for algae, daphnia and trout are 5, 12 and 7 g/L, respectively. The measured water
solubility of hexadecahydropyrene (4.7 g/L) falls just below the lowest toxicity value
for algae. In addition, the measured solubility falls below the empirical chronic solubility
cut-off for algae of ca. 6 g/L as previously discussed. Therefore, based on available
data for hexadecahydropyrene and recognizing other C16 poly-naphthenic structures that
fall into this HCB will exhibit lower aqueous solubilities, it may be concluded that C16
poly-naphthenics are unlikely to meet the aquatic toxicity criterion. Testing could help to
verify this conclusion. Given C17 to C22 poly-naphthenic hydrocarbons will exhibit even
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