EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

PolyAr = poly-aromatics consisting of three or more ring aromatics that may include
saturated rings
Note that for certain HCBs, none of the possible structures may exist, e.g. there are no C5
aromatics.
The strategy to assess PBT/vPvB properties of HCBs consists of the following steps:
QSAR models are applied to compute predictions of primary biodegradation halflives
(P) and fish bioconcentration factors (B) for the CONCAWE library of
representative structures (Appendix 1) as recommended by the REACH PBT
guidance (R.11). Two modules from EPISuite v4.00 were used to screen for
persistence and bioaccumulative properties, BioHCwin and BCFBAF.
Where available for hydrocarbons, experimental primary biodegradation half-lives in
un-acclimated freshwater or marine water as well as aqueous or dietary
bioaccumulation test data are compiled and compared to model predictions. In
addition, other relevant lab and field bioaccumulation studies are also considered to
assess the potential of petroleum hydrocarbons to biomagnify in the foodchain. This
information is an important compliment to bioconcentration data since
biomagnification is regarded as the principal determinant for identifying substances
posing a bioaccumulation concern (Weisbrod et al. 2009).
In some cases, experimental data for hydrocarbons that have atypical structures (e.g.
ethanediyl or isopropyl functional groups) are included in this analysis. This allows a
more through appraisal of the reasonableness of model predictions based on available
experimental information. However, such data are interpreted with caution, and
judged relative to the weight of evidence provided by more typical structures, in
deciding P and B properties of specific HCBs.
Finally, all the available information on persistence and bioaccumulation are
collectively reviewed to determine if a further assessment of toxicity was required. If
a HCB was found to meet the P and B criteria, toxicity was evaluated in accordance
with Annex XIII criteria. If necessary, the chronic aquatic toxicity for the structures
comprising the HCB was computed using the target lipid model included in the
PETROTOX model (Redman 2009).
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