EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

Vacuum Gas Oils, Hydrocracked Gas Oils, and Distillate Fuels
Endpoint 3
8.7.3 Onegeneration
reproductive toxicity
study
8.8 Toxicokinetics
8.8.1 Assessment of
the Toxicokinetic
behaviour of the
substance
8.9 Carcinogenicity
8.9.1 Carcinogenicity
study
Relevance
to
Category
Yes
Derived Category
Value
125 mg/kg
No data from
reproductive
studies
Comment
No No data Substances in this category are UVCBs.
It is not possible to apply standard
methodology for assessing absorption,
distribution and metabolism. Data on
constituents can be used as the basis
for understanding the toxicokinetics are
included in the dossier
Yes Carcinogenic Key study test data indicate low
carcinogenic potential in line with the
harmonised classification.
‣ Eco-toxicological Information (Section 9 of REACH Annexes VII-X)
Many of the standard test methods for environmental endpoints are not suitable for assessing the
hazards of complex UVCB petroleum substances. Hence it has been necessary to develop alternative
methodologies e.g. use of water accommodated fractions, which are more suitable for predicting the
hazard properties of complex petroleum substances, for classification purposes.
A number of environmental endpoints are not relevant to the overall UVCB petroleum substance. The
type, concentration, and physical-chemical properties of individual chemical constituents present will
influence the environmental distribution and fate of category members. Hence, an alternative strategy,
based on the ‘Hydrocarbon Block Method’, has been developed for assessing the environmental risk
related to the constituents present in UVCB petroleum substances (European Chemicals Bureau,
Technical Guidance Document on Risk Assessment, Part II, 2003).
For the purposes of ecological hazard endpoint evaluation, data on individual CAS Registry Numbers
from the category have been used. Unless specified, in all cases a ‘worst case’ approach has been
applied to identify a category value, with some being assigned on the basis of data available for
constituents. Table 3 summarises the data available
Table 3: Eco-toxicological endpoint category values for Vacuum or Hydrocracked Gas Oils &
Distillate Fuels.
Endpoint
9.1 Aquatic toxicity
9.1.1 Short-term toxicity
testing on invertebrates
(preferred species Daphnia)
Relevance to
Category
Yes
Derived Category
Value
EL50
68 mg/l
(48 h)
(Daphnia magna)
Comment
Based on key study.
9.1.2 Growth inhibition study
aquatic plants (algae
preferred)
Yes
IL50
22 mg/l
(72 h)
(Raphidocelis
subcapitata)
Based on key study.
9.1.3 Short-term toxicity Yes LL50 Based on key study.
2010-07-30 CSR Appendix 1