EU-SICHERHEITSDATENBLATT Dieselkraftstoff ... - Schmierstoffe

Vacuum Gas Oils, Hydrocracked Gas Oils, and Distillate Fuels
Table 2: Toxicological Endpoint Category Values for Vacuum Gas Oils, Hydrocracked Gas Oils &
Distillate Fuels.
Endpoint 3
8.1 Skin irritation or
skin Corrosion
8.1.1 In vivo skin
irritation
8.2 Eye irritation
8.2.1 In vivo eye
irritation
8.3 Skin
sensitisation
8.4 Mutagenicity
8.4.1 In vitro gene
mutation study In
Bacteria
8.4.2 In vitro
cytogenicity study in
mammalian cells
8.4.3 In vitro gene
mutation study in
mammalian cells
8.4.4 In vivo
cytogenicity
8.4.5 In vivo gene
Relevance
to
Category
Derived Category
Value
Comment
Yes Irritant Based on key study test data
Yes Mild irritant Based on key study test data
Yes Not sensitising Based on key study test data
Yes Positive Based on key study test data
Yes
Yes
Yes
No data
Positive &
Ambiguous
No data
Based on read across supporting
studies
Yes Negative Based on key study test data
mutation
8.5 Acute toxicity
8.5.1 By oral route Yes LD 50 : > 7600 mg/kg Based on key study test data
8.5.2 By inhalation Yes LC 50 : 4.1 mg/l Based on key study test data
8.5.3 By dermal
route
8.6 Repeated dose
toxicity
8.6.1 Short-term
repeated dose
toxicity study
(28 days)
8.6.2 Sub-chronic
toxicity study (90-
day)
Yes LD 50 : > 4300 mg/kg Based on key study test data
yes
yes
Dermal rat NOAEL
0.5 ml/kg
Inhalation rat
NOAEC >1710
mg/m 3
Based on key study test data
Based on test data from key studies
8.7 Reproductive
toxicity
8.7.1 Screening for
reproductive/
developmental
toxicity (OECD 421
or 422)
8.7.2 Pre-natal
developmental
Toxicity Study
No
Yes
Dermal rat, NOAEL
30 mg/kg/day
No data
Negative
Inhalation NOAEC
>401 ppm
Based on key studies test data
Dermal: NOAEL
developmental 125
mg/kg/day, NOAEL
maternal toxicity
3 In accordance with Annexes VII to X of REACH
2010-07-30 CSR Appendix 1