31.03.2014 Views

Making an impact - Cancer Research UK

Making an impact - Cancer Research UK

Making an impact - Cancer Research UK

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

<strong>Making</strong><br />

<strong>an</strong> <strong>impact</strong><br />

Annual Review 2009/10


C<strong>an</strong>cer patients <strong>an</strong>d their families<br />

are at the heart of everything we do.<br />

We have saved millions of lives with<br />

our groundbreaking work preventing,<br />

diagnosing <strong>an</strong>d treating c<strong>an</strong>cer.<br />

Our research is vital if we are<br />

to save more lives in the future.<br />

Harpal S Kumar<br />

Chief Executive Officer, C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

Contents<br />

01 Welcome to our review of the year<br />

02 About us<br />

<strong>Research</strong><br />

<strong>Research</strong> is our primary focus. We work in partnership<br />

with others to achieve the greatest <strong>impact</strong> in the global<br />

fight against c<strong>an</strong>cer.<br />

05 <strong>Making</strong> your support count – a year of progress<br />

07 Leading the way in radiotherapy<br />

08 Looking to tomorrow<br />

Information<br />

We provide life-ch<strong>an</strong>ging information to <strong>an</strong>yone affected<br />

by c<strong>an</strong>cer <strong>an</strong>d run awareness-raising initiatives so that<br />

c<strong>an</strong>cer c<strong>an</strong> be detected as early as possible <strong>an</strong>d to help<br />

people reduce their risk of the disease.<br />

10 Raising awareness <strong>an</strong>d saving lives<br />

Influencing public policy<br />

Our campaigning <strong>an</strong>d work to influence government<br />

policy keeps c<strong>an</strong>cer at the top of the political agenda.<br />

13 Campaigning for ch<strong>an</strong>ge<br />

Bringing our work together to save lives<br />

14 Diagnosing c<strong>an</strong>cer early<br />

16 Driving world-class c<strong>an</strong>cer research<br />

18 Our people<br />

20 Raising money to support our work<br />

22 How your donation helps us beat c<strong>an</strong>cer<br />

25 Meet our Executive Board<br />

27 Get involved <strong>an</strong>d find out more<br />

28 Th<strong>an</strong>k you<br />

29 More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

For more information about us <strong>an</strong>d our work visit<br />

aboutus.c<strong>an</strong>cerresearchuk.org/what-we-do<br />

We would like to say th<strong>an</strong>k you to all those who feature within<br />

this Annual Review.<br />

Cover: Anna Robinson, seven, was diagnosed with acute lymphoblastic<br />

leukaemia in J<strong>an</strong>uary 2006 after her mum took her to the doctors<br />

suffering with pains in her legs, appetite loss, exhaustion <strong>an</strong>d a high<br />

temperature. She was treated until 2008 at the Royal Victoria Infirmary<br />

in Newcastle <strong>an</strong>d is now doing well. Anna officially started<br />

the Middlesbrough Race for Life events in 2007 <strong>an</strong>d 2008.


Welcome to our review<br />

of the year<br />

Life-saving information<br />

Accurate <strong>an</strong>d straightforward information about c<strong>an</strong>cer helps<br />

people to recognise signs <strong>an</strong>d symptoms, encourages them to<br />

visit their GP as soon as possible, <strong>an</strong>d provides them with<br />

better underst<strong>an</strong>ding if they are going through a c<strong>an</strong>cer journey.<br />

Last year, more th<strong>an</strong> 37,000 people visited our C<strong>an</strong>cer<br />

Awareness Roadshow, which toured the <strong>UK</strong> offering<br />

information about c<strong>an</strong>cer <strong>an</strong>d how to prevent it. And our<br />

award-winning patient information website, C<strong>an</strong>cerHelp <strong>UK</strong>,<br />

regularly received over one million visits per month.<br />

It has been <strong>an</strong>other very successful year<br />

for C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>, with a number of<br />

achievements <strong>an</strong>d promising scientific progress.<br />

Th<strong>an</strong>ks to adv<strong>an</strong>ces in our underst<strong>an</strong>ding<br />

of c<strong>an</strong>cer, more new treatments are being<br />

developed at a faster pace th<strong>an</strong> ever before.<br />

We would like to th<strong>an</strong>k everyone who has helped make this<br />

possible. Our work is funded entirely by the public. All of our<br />

progress depends on the generosity of our supporters, the<br />

efforts of our fundraisers <strong>an</strong>d volunteers <strong>an</strong>d the dedication<br />

of our partners.<br />

World-class research<br />

More people are surviving c<strong>an</strong>cer th<strong>an</strong> ever before. People<br />

diagnosed with c<strong>an</strong>cer are now twice as likely to survive for at<br />

least ten years as those diagnosed in the early 1970s. Our work<br />

has been at the heart of this progress.<br />

In April we were delighted to report a major research<br />

breakthrough – a term we rarely use. A 16-year study that<br />

we helped fund showed that a one-off five-minute screening<br />

test could cut the risk of developing bowel c<strong>an</strong>cer by a third.<br />

The study also found that the test could reduce the number<br />

of deaths by 43%. Bowel c<strong>an</strong>cer is currently the <strong>UK</strong>’s second<br />

biggest c<strong>an</strong>cer killer.<br />

Thous<strong>an</strong>ds of c<strong>an</strong>cer deaths could be avoided each year if<br />

c<strong>an</strong>cer was diagnosed earlier. This year, we launched the<br />

research arm of the National Awareness <strong>an</strong>d Early Diagnosis<br />

Initiative (NAEDI), which will inform our early diagnosis work<br />

to ensure as m<strong>an</strong>y people as possible survive c<strong>an</strong>cer.<br />

New laws to protect our health<br />

Th<strong>an</strong>ks to our research <strong>an</strong>d campaigning, tobacco displays in<br />

shops <strong>an</strong>d cigarette vending machines will be removed from<br />

2011 onwards across the <strong>UK</strong> <strong>an</strong>d it will be illegal for under-18s<br />

to use sunbeds in Engl<strong>an</strong>d <strong>an</strong>d Wales. In 2010, we made sure<br />

c<strong>an</strong>cer was high on the agenda at the General Election,<br />

<strong>an</strong>d we are working with the new government to ensure<br />

that c<strong>an</strong>cer remains a priority.<br />

Working towards our vision<br />

Our five-year strategy <strong>an</strong>d ambitious goals continue to guide<br />

our work <strong>an</strong>d aspirations for the future. We have made some<br />

real progress this year. More treatments now exist with fewer<br />

side effects, the number of smokers is down <strong>an</strong>d more people<br />

are aware of the lifestyle factors that c<strong>an</strong> cause c<strong>an</strong>cer. For<br />

more information see our Annual Report <strong>an</strong>d Accounts at<br />

aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />

We continue to need your support<br />

Nine out of ten donations to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> are £10 or<br />

less. But big or small, we make sure they are used in the best<br />

possible way.<br />

We ensure that every penny possible is spent on research.<br />

Last year, for every pound that we received, excluding our retail<br />

chain, over 80 pence was available to spend on our work to<br />

beat c<strong>an</strong>cer. Despite the difficult fin<strong>an</strong>cial backdrop, we raised a<br />

record £446 million, th<strong>an</strong>ks to our generous supporters. But we<br />

receive no government funding for our research <strong>an</strong>d we have<br />

no endowment, me<strong>an</strong>ing that we have a continual need to raise<br />

funds if we are to make further progress through our<br />

life-saving work.<br />

We are proud of our achievements <strong>an</strong>d grateful to everyone<br />

who donated to our shops, took part in events or volunteered<br />

their time <strong>an</strong>d skills to us. There continue to be huge challenges<br />

ahead but, with your help, together we will beat c<strong>an</strong>cer.<br />

In 2009 a record number of patients took part in our clinical<br />

trials which help to develop new treatments <strong>an</strong>d set new<br />

st<strong>an</strong>dards of clinical practice.<br />

We continued to recruit <strong>an</strong>d retain the best scientists <strong>an</strong>d the<br />

quality of our research remains world-class, as measured by<br />

<strong>an</strong>other excellent year for honours with 50 of our scientists<br />

receiving 28 different awards.<br />

David Newbigging<br />

Chairm<strong>an</strong><br />

27 July 2010<br />

Harpal S Kumar<br />

Chief Executive Officer<br />

27 July 2010<br />

Annual Review / Welcome to our review of the year / 01


About us<br />

Every two minutes someone in the <strong>UK</strong> hears<br />

the words ‘it’s c<strong>an</strong>cer’. This devastating disease<br />

affects millions of lives every year worldwide<br />

<strong>an</strong>d we are here to make sure as m<strong>an</strong>y people<br />

as possible survive.<br />

Why are we here?<br />

We believe that research is the key to beating c<strong>an</strong>cer.<br />

Our work is entirely funded by the public – th<strong>an</strong>ks to their<br />

generosity <strong>an</strong>d support, our researchers lead the world in<br />

discovering new ways to prevent, diagnose <strong>an</strong>d treat c<strong>an</strong>cer.<br />

The ch<strong>an</strong>ces of surviving c<strong>an</strong>cer have doubled in the last<br />

40 years. More people are enjoying things they thought they<br />

might not live to see, <strong>an</strong>d we have been central to that<br />

progress. But for every person who survives c<strong>an</strong>cer, <strong>an</strong>other<br />

does not.<br />

We have made a huge number of import<strong>an</strong>t discoveries which<br />

have ch<strong>an</strong>ged the way c<strong>an</strong>cer is prevented, diagnosed <strong>an</strong>d<br />

treated. Yet our work remains essential because more th<strong>an</strong><br />

one in three of us will get c<strong>an</strong>cer at some point in our lives.<br />

What do we do?<br />

Our aim is simple: we w<strong>an</strong>t to save lives by reducing the<br />

number of people who get c<strong>an</strong>cer <strong>an</strong>d helping more to survive<br />

the disease. But because a breakthrough c<strong>an</strong> take decades<br />

of research, it’s a complex challenge.<br />

There are over 200 types of c<strong>an</strong>cer which all involve the<br />

uncontrolled, abnormal growth of some of the body’s cells.<br />

We work to underst<strong>an</strong>d how c<strong>an</strong>cers develop <strong>an</strong>d spread, <strong>an</strong>d<br />

design strategies to combat this. We are the only <strong>UK</strong> charity<br />

dedicated to beating all types of c<strong>an</strong>cer.<br />

We research ways of preventing c<strong>an</strong>cer <strong>an</strong>d detecting it early,<br />

when it c<strong>an</strong> usually be treated more successfully. Our work<br />

has already underpinned national screening programmes for<br />

breast, bowel <strong>an</strong>d cervical c<strong>an</strong>cer which are saving thous<strong>an</strong>ds<br />

of lives every year.<br />

We also raise awareness about c<strong>an</strong>cer, providing information<br />

about prevention, symptoms, treatment <strong>an</strong>d coping with the<br />

disease. And we campaign for new policies to ensure diagnosis<br />

is swift <strong>an</strong>d the best treatment <strong>an</strong>d care are available for all<br />

c<strong>an</strong>cer patients across the <strong>UK</strong>.<br />

<strong>Research</strong><br />

The breadth of our research is unparalleled – we fund the<br />

work of over 4,000 scientists, doctors <strong>an</strong>d nurses around the<br />

<strong>UK</strong>. We play a vital role in supporting around 200 clinical trials<br />

aimed at improving c<strong>an</strong>cer treatment <strong>an</strong>d testing exciting new<br />

radiotherapy techniques <strong>an</strong>d drugs.<br />

By funding all types of research – based in labs <strong>an</strong>d clinical<br />

departments in hospitals <strong>an</strong>d universities around the <strong>UK</strong><br />

– we build productive working relationships between scientists,<br />

c<strong>an</strong>cer doctors <strong>an</strong>d nurses. Our work <strong>an</strong>d expertise ensure<br />

that discoveries made on the laboratory bench are<br />

tr<strong>an</strong>sformed into pioneering, life-saving treatments.<br />

Th<strong>an</strong>ks to our research, around eight new c<strong>an</strong>cer drugs<br />

are tested in clinical trials every year for the first time.<br />

Information<br />

Every year we help millions of people find the information they<br />

need to prevent, underst<strong>an</strong>d <strong>an</strong>d cope with c<strong>an</strong>cer.<br />

We help people recognise c<strong>an</strong>cer symptoms <strong>an</strong>d encourage<br />

them to go to their GP promptly. We also offer information<br />

about the import<strong>an</strong>ce <strong>an</strong>d benefits of screening. We provide<br />

websites <strong>an</strong>d publications <strong>an</strong>d run health awareness campaigns<br />

aimed at health professionals <strong>an</strong>d the public which highlight the<br />

steps people c<strong>an</strong> take to help reduce their risk of c<strong>an</strong>cer.<br />

Influencing public policy<br />

We work with politici<strong>an</strong>s, civil serv<strong>an</strong>ts, policy-makers <strong>an</strong>d the<br />

media to ensure that c<strong>an</strong>cer stays at the top of their agenda,<br />

influencing legislation on import<strong>an</strong>t issues relating to c<strong>an</strong>cer.<br />

We petition for better information on screening <strong>an</strong>d rapid<br />

access to the best surgery, treatment <strong>an</strong>d medicines <strong>an</strong>d we<br />

run targeted campaigns for higher risk groups, such as over<br />

75s <strong>an</strong>d disadv<strong>an</strong>taged social groups. Our scientists <strong>an</strong>d<br />

doctors advise the parliaments in Westminster, Scotl<strong>an</strong>d,<br />

Wales <strong>an</strong>d Northern Irel<strong>an</strong>d on health <strong>an</strong>d scientific policy.<br />

Looking to the future<br />

For over 100 years we have worked to beat c<strong>an</strong>cer. We have<br />

helped to tr<strong>an</strong>sform the way c<strong>an</strong>cer is prevented, diagnosed<br />

<strong>an</strong>d treated <strong>an</strong>d our work has helped to save millions of lives,<br />

but we have so much more to do to achieve our vision of<br />

beating c<strong>an</strong>cer.<br />

When I was diagnosed with c<strong>an</strong>cer I thought my life was<br />

finished – now I’m doing well. I’m happy to support C<strong>an</strong>cer<br />

<strong>Research</strong> <strong>UK</strong> because future generations will benefit from<br />

the work that they do.<br />

Jayshree Jhala<br />

Breast c<strong>an</strong>cer survivor<br />

02 / Annual Review / About us


Maggie Harrison, 49<br />

Bowel c<strong>an</strong>cer survivor<br />

Maggie was initially treated for irritable bowel syndrome<br />

before she was diagnosed with bowel c<strong>an</strong>cer in 2006.<br />

She underwent surgery to have the c<strong>an</strong>cer <strong>an</strong>d part of her<br />

bowel removed, followed by six months of chemotherapy.<br />

Three years on, Maggie, from Barrow-in-Furness, is feeling<br />

fitter th<strong>an</strong> ever <strong>an</strong>d keen to spread the message about<br />

early detection.<br />

6.45am<br />

8.00am<br />

9.30am<br />

1.00pm<br />

7.30pm<br />

Get up with my husb<strong>an</strong>d John so we c<strong>an</strong> have<br />

breakfast together. I then exercise for about<br />

<strong>an</strong> hour. I’m in the best shape of my adult life.<br />

Call my mum. She was amazingly supportive<br />

when I was ill – we speak every day.<br />

I volunteer at my local community centre three<br />

mornings a week. We paint, draw, sew <strong>an</strong>d knit,<br />

all things I missed doing during chemotherapy.<br />

Four afternoons a week I work at my local<br />

hospital, inputting data.<br />

Amateur dramatics rehearsal. It gives me<br />

a great buzz.<br />

43%<br />

A 16-year study that we<br />

helped fund showed that a<br />

one-off five-minute<br />

screening test could cut the<br />

risk of developing bowel<br />

c<strong>an</strong>cer by a third, <strong>an</strong>d<br />

reduce deaths from the<br />

disease by 43%, saving<br />

thous<strong>an</strong>ds of lives.<br />

Annual Review / About us / 03


Tyler Strong, 7<br />

Little Star <strong>an</strong>d leukaemia survivor<br />

Tyler was diagnosed with acute lymphoblastic leukaemia<br />

when he was 18 months old. Suffering from appetite loss,<br />

listlessness <strong>an</strong>d infections, he was sent for a bone marrow<br />

test at M<strong>an</strong>chester Children’s Hospital. Once the diagnosis<br />

was confirmed, Tyler was given intense chemotherapy in<br />

two blocks eight weeks apart. He finished his treatment in<br />

March 2008, is now doing well <strong>an</strong>d helped us launch our<br />

new night-time walking marathon, Shine, in M<strong>an</strong>chester.<br />

Tyler was also nominated for our Little Star Award, which<br />

celebrates the courage of children with c<strong>an</strong>cer.<br />

7.45am<br />

9.00am<br />

5.00pm<br />

7.30pm<br />

8.30pm<br />

Breakfast. Then, after vetting his packed lunch<br />

(he’s quite fussy!), Tyler has a quick play. He likes<br />

Lego <strong>an</strong>d drawing on his whiteboard.<br />

School. Because he spent so much time<br />

in hospital away from his friends, it took<br />

Tyler some time to build up confidence,<br />

but he’s come on loads.<br />

Take Tyler to Beavers, which he loves.<br />

Dad picks him up <strong>an</strong>d he runs riot for half<br />

<strong>an</strong> hour before having a shower <strong>an</strong>d putting<br />

his pyjamas on.<br />

Bedtime – <strong>an</strong> hour later th<strong>an</strong> normal<br />

on Beavers day.<br />

£10.3m<br />

We are a major funder<br />

of research into children’s<br />

c<strong>an</strong>cer in the <strong>UK</strong>, <strong>an</strong>d we<br />

have supported m<strong>an</strong>y of the<br />

world’s most successful<br />

trials of treatments for this<br />

varied group of diseases,<br />

benefitting thous<strong>an</strong>ds<br />

of children like Tyler.<br />

04 / Annual Review / <strong>Research</strong>


<strong>Research</strong><br />

<strong>Making</strong> your support count – a year of progress<br />

We are a world leader in c<strong>an</strong>cer research.<br />

Our scientists make cutting-edge discoveries<br />

in the lab that help us underst<strong>an</strong>d more about<br />

c<strong>an</strong>cer every day – such as how it grows <strong>an</strong>d<br />

spreads, <strong>an</strong>d how our genes <strong>an</strong>d lifestyle<br />

choices c<strong>an</strong> increase our risk of developing the<br />

disease. Each of these adv<strong>an</strong>ces is <strong>an</strong>other<br />

step towards beating c<strong>an</strong>cer.<br />

We are const<strong>an</strong>tly searching for more effective treatments that<br />

accurately target c<strong>an</strong>cer <strong>an</strong>d have fewer side effects for patients.<br />

Our scientists <strong>an</strong>d doctors have contributed to most of the top<br />

drugs used to treat patients worldwide today. Th<strong>an</strong>ks to our<br />

leading role in developing treatments, hundreds of thous<strong>an</strong>ds<br />

of people have beaten the disease.<br />

Our researchers share their knowledge with c<strong>an</strong>cer experts<br />

across the world – they work together to fight c<strong>an</strong>cer <strong>an</strong>d save<br />

even more lives. Here are just a few highlights of our progress<br />

this year.<br />

Tackling p<strong>an</strong>creatic c<strong>an</strong>cer<br />

We have come one step closer to tackling p<strong>an</strong>creatic c<strong>an</strong>cer.<br />

Our researchers led <strong>an</strong> international team that discovered why<br />

some patients stop responding to a commonly-used drug called<br />

gemcitabine. They found that p<strong>an</strong>creatic tumour samples have<br />

poor networks of blood vessels, making it harder for the drug<br />

to reach the tumour <strong>an</strong>d treat the c<strong>an</strong>cer effectively.<br />

We’re extremely excited by these results, as they may help<br />

explain the disappointing response of m<strong>an</strong>y people with<br />

p<strong>an</strong>creatic c<strong>an</strong>cer to chemotherapy. Our new method<br />

of delivering chemotherapy to p<strong>an</strong>creatic tumours should<br />

make treatment more effective in the future.<br />

Dr David Tuveson<br />

Cambridge <strong>Research</strong> Institute<br />

Targeted screening for prostate c<strong>an</strong>cer<br />

Our scientists are at the forefront of efforts to identify the<br />

common variations in our genes that influence c<strong>an</strong>cer risk.<br />

Among several import<strong>an</strong>t discoveries this year, researchers in<br />

London <strong>an</strong>d Cambridge identified nine new genetic variations in<br />

the hum<strong>an</strong> genome that c<strong>an</strong> increase a m<strong>an</strong>’s risk of developing<br />

prostate c<strong>an</strong>cer. We hope that this discovery will enable more<br />

targeted screening.<br />

Saving precious time in the fight against ovari<strong>an</strong> c<strong>an</strong>cer<br />

Our research helps doctors choose the right drugs for individual<br />

patients, saving precious time <strong>an</strong>d avoiding unnecessary side<br />

effects. Our scientists discovered a pattern of genetic defects in<br />

tumours that could predict whether ovari<strong>an</strong> c<strong>an</strong>cer patients will<br />

respond to common chemotherapy drugs.<br />

Choosing the right drug for the right patient is crucial.<br />

We hope that a simple test based on our research may one<br />

day save patients from unnecessary treatments <strong>an</strong>d side<br />

effects. This will allow us to target the most effective drugs<br />

to those people who will really benefit.<br />

Dr Charles Sw<strong>an</strong>ton<br />

London <strong>Research</strong> Institute<br />

New hope for acute lymphoblastic leukaemia<br />

Our scientists in M<strong>an</strong>chester have brought hope to the one in<br />

five children with acute lymphoblastic leukaemia (ALL) who<br />

don’t respond to current treatments. They pinpointed a<br />

possible reason why some children become resist<strong>an</strong>t or allergic<br />

to asparaginase, a drug used to treat virtually every child with<br />

ALL in the <strong>UK</strong>. Although there’s still a lot to do, the new results<br />

could me<strong>an</strong> that even more children will be cured in the future.<br />

In the 1960s, only around a quarter of children with<br />

c<strong>an</strong>cer survived. Today, three-quarters survive, <strong>an</strong>d<br />

our work has been at the heart of this huge progress.<br />

Preventing bowel c<strong>an</strong>cer<br />

Could we find new ways to prevent one of the most common<br />

c<strong>an</strong>cers? Our research is bringing us nearer every day. Scientists<br />

in Dundee uncovered fascinating new insights into a gene called<br />

GSTP showing that it protects against bowel c<strong>an</strong>cer. And they<br />

are already investigating how to control it, to help stop the<br />

disease developing in the future.<br />

Improving breast c<strong>an</strong>cer survival<br />

Our scientists used cutting-edge filming techniques to unravel<br />

how single breast c<strong>an</strong>cer cells leave a tumour <strong>an</strong>d start to move<br />

<strong>an</strong>d spread around the body – something that until now has not<br />

been fully understood. This research will help scientists find ways<br />

to stop breast c<strong>an</strong>cer in its tracks <strong>an</strong>d help more people survive.<br />

My breast c<strong>an</strong>cer was caught early. I feel lucky because<br />

it c<strong>an</strong> be more difficult to treat c<strong>an</strong>cer once it has spread.<br />

I think it’s f<strong>an</strong>tastic news that researchers have found out<br />

how breast c<strong>an</strong>cer cells move around the body.<br />

Pamina Brassey<br />

West London<br />

Annual Review / <strong>Research</strong> / 05


120,000<br />

Around 120,000 c<strong>an</strong>cer<br />

patients in the <strong>UK</strong> benefit<br />

from radiotherapy each<br />

year, which is why we are<br />

investing heavily in<br />

research into the most<br />

effective ways to deliver it.<br />

Claire D<strong>an</strong>iels, 24<br />

Hodgkin’s lymphoma survivor<br />

Claire was 19 when she was diagnosed with Hodgkin’s<br />

lymphoma. She was initially treated with chemotherapy at<br />

M<strong>an</strong>chester’s Christie Hospital. But the c<strong>an</strong>cer returned <strong>an</strong>d<br />

Claire had further intense chemotherapy, radiotherapy <strong>an</strong>d<br />

a stem-cell tr<strong>an</strong>spl<strong>an</strong>t. In between treatments, Claire<br />

org<strong>an</strong>ised a student ball <strong>an</strong>d realised she w<strong>an</strong>ted to be <strong>an</strong><br />

event pl<strong>an</strong>ner. Now 24, she’s healthy <strong>an</strong>d works as a Special<br />

Events Executive for us.<br />

6.00am<br />

8.45am<br />

2.00pm<br />

8.00pm<br />

My alarm goes off. Eventually I get up <strong>an</strong>d leave<br />

for the train station in Cambridge at 7am.<br />

Get into work. I’m on the phone a lot, talking to<br />

different supporters <strong>an</strong>d looking for ways to raise<br />

money at our events.<br />

Meeting about our Emeralds & Ivy Ball, which<br />

promotes early diagnosis <strong>an</strong>d raises awareness.<br />

Walk home from the train station, my boyfriend<br />

Steve <strong>an</strong>d I have dinner together <strong>an</strong>d watch<br />

some TV.<br />

11.00pm Bed. I’m normally pretty tired. The commute<br />

isn’t ideal but I’m lucky I c<strong>an</strong> give something back.<br />

606 / / Annual Review / Contents / <strong>Research</strong>


<strong>Research</strong><br />

Leading the way in radiotherapy<br />

W. Gillies McKenna, Director of Gray Institute for Radiation Oncology & Biology<br />

You might be surprised to learn that<br />

radiotherapy, the longest established<br />

treatment for c<strong>an</strong>cer other th<strong>an</strong> surgery,<br />

still helps cure more people th<strong>an</strong> c<strong>an</strong>cer drugs.<br />

Today, radiotherapy is kinder to patients, <strong>an</strong>d<br />

every year, millions of patients benefit from<br />

this cornerstone of c<strong>an</strong>cer treatment.<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> helped establish the first treatment<br />

centres across the country as early as the 1920s, when<br />

radiotherapy research first beg<strong>an</strong> to take shape.<br />

Th<strong>an</strong>ks to the unwavering support of the public since those<br />

early days of research, we’ve continued to make excellent<br />

progress in radiotherapy. It is now used to treat m<strong>an</strong>y c<strong>an</strong>cers<br />

including breast, lung, bowel, brain <strong>an</strong>d prostate. And today,<br />

four in ten people who beat c<strong>an</strong>cer had radiotherapy as part<br />

of their treatment.<br />

As part of our five-year strategy, we aim to make radiotherapy<br />

more effective, targeting tumours more precisely with fewer<br />

<strong>an</strong>d less severe side effects for patients.<br />

I took part in the PARSPORT trial, funded by<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. The idea was to test a more precise<br />

radiotherapy technique for head <strong>an</strong>d neck c<strong>an</strong>cer. The results<br />

were f<strong>an</strong>tastic. I had virtually no side effects – I could eat,<br />

drink <strong>an</strong>d taste perfectly normally. Th<strong>an</strong>ks to the trial, I now<br />

lead a completely normal life again.<br />

David Jenkins<br />

Throat c<strong>an</strong>cer survivor<br />

London<br />

<strong>Making</strong> radiotherapy more effective<br />

In 2007 we launched the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>-MRC<br />

Gray Institute for Radiation Oncology & Biology in Oxford.<br />

Scientists there are making import<strong>an</strong>t adv<strong>an</strong>ces in radiotherapy<br />

research. They discovered that certain drugs c<strong>an</strong> be used to<br />

‘prepare’ tumours for radiotherapy by increasing their blood<br />

supply, which makes them more sensitive to treatment.<br />

In a different approach, <strong>an</strong>other team discovered a gene<br />

that could be blocked to make radiotherapy more effective.<br />

Both of these results from laboratory studies are crucial steps<br />

towards making radiotherapy even more effective for patients.<br />

Reducing side effects<br />

Improving radiotherapy also involves making it more tolerable<br />

for c<strong>an</strong>cer patients. We’re at the forefront of international<br />

efforts to develop a type of radiotherapy that c<strong>an</strong> be tailored<br />

to the size <strong>an</strong>d shape of a tumour. Called Intensity Modulated<br />

Radiotherapy (IMRT), this approach allows doctors to<br />

maximise the dose of radiation to the c<strong>an</strong>cer, while limiting<br />

damage to surrounding healthy tissue. Less damage me<strong>an</strong>s<br />

fewer side effects.<br />

This year, a trial funded by us showed that people with head<br />

<strong>an</strong>d neck c<strong>an</strong>cer given IMRT were much less likely to suffer<br />

from a dry mouth. This is the main side effect of treatment<br />

<strong>an</strong>d it often causes debilitating problems with speech <strong>an</strong>d<br />

eating <strong>an</strong>d also increases the ch<strong>an</strong>ce of ulcers <strong>an</strong>d infections.<br />

This work could soon lead to a ch<strong>an</strong>ge in how all head <strong>an</strong>d<br />

neck c<strong>an</strong>cer patients are treated in the <strong>UK</strong>.<br />

Doctors prescribe radiotherapy treatments in numbers<br />

of ‘Gray’ – the unit measuring how much radiation your<br />

body absorbs. This is named after Hal Gray, <strong>an</strong> early<br />

pioneer in radiotherapy, whose research we funded<br />

from the 1930s to the 1960s <strong>an</strong>d after whom the<br />

Oxford Institute is named.<br />

Less time in hospital, more time at home<br />

We’re helping to fund a pivotal trial, which recently showed<br />

that fewer but higher doses of radiotherapy are just as effective<br />

as st<strong>an</strong>dard radiotherapy for women with breast c<strong>an</strong>cer.<br />

That me<strong>an</strong>s fewer trips to hospital – <strong>an</strong>d more time at home.<br />

Cutting-edge treatments<br />

Our scientists are also exploring ingenious ways to help patients<br />

benefit more from radiotherapy. In M<strong>an</strong>chester, researchers<br />

are using ‘smart’ drugs to tr<strong>an</strong>sport radiotherapy directly<br />

to tumours. Early results in certain types of lymphoma are<br />

encouraging, <strong>an</strong>d we hope this treatment will reach clinics soon.<br />

Radiotherapy for the future<br />

Over the years we’ve made great leaps in underst<strong>an</strong>ding c<strong>an</strong>cer,<br />

<strong>an</strong>d radiotherapy technology has accelerated at <strong>an</strong> astonishing<br />

pace. But new technologies, <strong>an</strong>d better evidence of the way<br />

that radiotherapy <strong>an</strong>d other treatments c<strong>an</strong> be used together,<br />

are placing increased dem<strong>an</strong>ds on services. We need more<br />

radiotherapy machines, <strong>an</strong>d people to operate them, to reduce<br />

waiting times <strong>an</strong>d allow better access to treatment. We know<br />

that new radiotherapy technologies aren’t being rolled out<br />

in the <strong>UK</strong> as fast as they are in the rest of Europe.<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> is asking the government to take steps<br />

to tackle these issues <strong>an</strong>d, with the help of our supporters,<br />

we’ll continue to work hard to ensure that adv<strong>an</strong>ces in<br />

radiotherapy benefit patients <strong>an</strong>d that the <strong>UK</strong> remains<br />

a world leader in this field.<br />

For more information about our work in this area, visit<br />

www.c<strong>an</strong>cerhelp.org.uk/about-c<strong>an</strong>cer/treatment/<br />

radiotherapy<br />

Annual Review / <strong>Research</strong> / 07


<strong>Research</strong><br />

Looking to tomorrow<br />

To achieve our vision of beating c<strong>an</strong>cer,<br />

we c<strong>an</strong>not afford to st<strong>an</strong>d still. Every day<br />

our scientists <strong>an</strong>d doctors are studying all<br />

aspects of c<strong>an</strong>cer, from underst<strong>an</strong>ding the<br />

fine details of cell biology to c<strong>an</strong>cer risk<br />

factors in entire populations.<br />

Here are some of the projects we are currently funding,<br />

highlighting just a few of the m<strong>an</strong>y ways we are investing<br />

in the breakthroughs of tomorrow.<br />

New trial offers hope for children with c<strong>an</strong>cer<br />

Although rare, neuroblastoma is the most common c<strong>an</strong>cer in<br />

children under five besides c<strong>an</strong>cers of the blood. Six in ten<br />

children with neuroblastoma are successfully treated, but<br />

certain forms of the disease still remain difficult to treat.<br />

This year we launched a new international trial for children<br />

with a particularly difficult form of neuroblastoma, so we<br />

c<strong>an</strong> learn more about how to tackle the disease.<br />

Our doctors hope to save the lives of more children in the<br />

<strong>UK</strong> by using cutting-edge ‘immunotherapy’ – a treatment that<br />

boosts the immune system to help fight c<strong>an</strong>cer.<br />

Developing innovative ways to see c<strong>an</strong>cer inside the body<br />

Finding ways to see c<strong>an</strong>cer inside the body is vital for detecting<br />

the disease early – <strong>an</strong>d at a stage when treatment is more<br />

likely to be successful. Also, we need ways to rapidly monitor<br />

whether therapy is working, so we c<strong>an</strong> ensure people are<br />

getting the right treatment.<br />

Our scientists are developing techniques to see if c<strong>an</strong>cer<br />

treatments such as chemotherapy <strong>an</strong>d radiotherapy are<br />

working by looking at subst<strong>an</strong>ces found in <strong>an</strong>d around<br />

tumours. Crucially, they hope to detect these subst<strong>an</strong>ces<br />

known as ‘biomarkers’ at a very early stage. This will allow<br />

doctors to tell if a treatment is working without having<br />

to wait to see if a tumour shrinks.<br />

This work could ultimately me<strong>an</strong> more people with c<strong>an</strong>cer<br />

live for longer, <strong>an</strong>d with a better quality of life.<br />

We c<strong>an</strong> make <strong>an</strong> enormous difference through research.<br />

There are new drugs coming through <strong>an</strong>d we are seeing<br />

ch<strong>an</strong>ges in treatment approaches so we c<strong>an</strong> try to cure<br />

people without damaging other tissues. This is a really<br />

exciting time, <strong>an</strong>d if we have more money for research<br />

we will get much better treatments.<br />

Penelope Brock<br />

Consult<strong>an</strong>t in Paediatric Oncology, neuroblastoma<br />

Targeting leukaemia at the roots<br />

Of the millions of cells that make up a tumour, a rare kind<br />

– called c<strong>an</strong>cer stem cells – c<strong>an</strong> fuel c<strong>an</strong>cer growth but are<br />

particularly hard to treat. They not only produce ‘normal’<br />

c<strong>an</strong>cer cells that go on to divide m<strong>an</strong>y times, forming the<br />

bulk of a tumour, but also make new c<strong>an</strong>cer stem cells.<br />

Current chemotherapy <strong>an</strong>d radiotherapy treatments don’t<br />

destroy c<strong>an</strong>cer stem cells, which explains why some people’s<br />

c<strong>an</strong>cer c<strong>an</strong> come back over time.<br />

Our scientists are investigating c<strong>an</strong>cer stem cells in a type<br />

of leukaemia called CML. They are using sophisticated lab<br />

experiments to find the genes <strong>an</strong>d proteins that keep these<br />

stem cells alive. This is the first step towards developing new<br />

treatments that specifically target c<strong>an</strong>cer stem cells without<br />

harming healthy cells.<br />

We hope to discover drugs in the future that will completely<br />

eradicate this type of leukaemia.<br />

Predicting our risk of getting c<strong>an</strong>cer<br />

One of the biggest challenges we face is finding ways<br />

to predict each person’s individual risk of developing c<strong>an</strong>cer.<br />

This is because our risk depends on so m<strong>an</strong>y different things,<br />

including our age, lifestyle <strong>an</strong>d genes. If doctors c<strong>an</strong> identify<br />

people who are at a high risk of c<strong>an</strong>cer, they c<strong>an</strong> offer them<br />

tailored screening, monitoring, treatment <strong>an</strong>d lifestyle advice.<br />

Our researchers are developing computer programmes<br />

to help doctors assess a person’s risk of developing certain<br />

c<strong>an</strong>cers. They use information such as people’s genetic<br />

make-up <strong>an</strong>d family history to make predictions.<br />

One programme, called BOADICEA, is already being used in<br />

clinics to help identify women under 50 who are most at risk of<br />

breast c<strong>an</strong>cer. Our scientists are now fine-tuning this programme<br />

to make it as accurate as possible. They are also refining their<br />

risk assessment programme for ovari<strong>an</strong> c<strong>an</strong>cer, <strong>an</strong>d pl<strong>an</strong> to<br />

develop a br<strong>an</strong>d new programme for prostate c<strong>an</strong>cer.<br />

Some of our research objectives for 2010/11<br />

— Continue to fund the best research to deepen our<br />

underst<strong>an</strong>ding of c<strong>an</strong>cer, including increasing our focus<br />

on unravelling how our genes, lifestyle <strong>an</strong>d environment<br />

interact to cause c<strong>an</strong>cer.<br />

— Promote <strong>an</strong>d fund research on c<strong>an</strong>cers that have the<br />

poorest survival rates – such as oesophageal, lung <strong>an</strong>d<br />

p<strong>an</strong>creatic c<strong>an</strong>cer.<br />

— Work on new research <strong>an</strong>d initiatives in radiotherapy,<br />

surgery <strong>an</strong>d in combining treatments to boost survival.<br />

For more detailed information on these objectives visit<br />

aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />

08 / Annual Review / <strong>Research</strong>


Dr Penelope Brock, 56<br />

Consult<strong>an</strong>t in Paediatric Oncology, neuroblastoma<br />

Penelope works at Great Ormond Street Hospital in<br />

London. She is leading the <strong>UK</strong> part of <strong>an</strong> international clinical<br />

trial we are funding into a high-risk form of the childhood<br />

c<strong>an</strong>cer called neuroblastoma. The trial is looking at using a<br />

new kind of treatment called immunotherapy, which aims<br />

to trigger the body’s immune system to help stop the c<strong>an</strong>cer<br />

or prevent it from coming back.<br />

6.00am<br />

8.25am<br />

9.00am<br />

1.30pm<br />

3.00pm<br />

7.30pm<br />

My husb<strong>an</strong>d Paul wakes me with a cup of tea.<br />

Catch the train from Tonbridge to Waterloo<br />

East. Read the Metro <strong>an</strong>d then edit a draft<br />

trial report.<br />

Pick up a cappuccino, check my emails<br />

– reply to Europe<strong>an</strong> colleagues on the high-risk<br />

neuroblastoma trial.<br />

Start clinic. A busy day ahead – I have a<br />

telephone conference on a liver tumour trial<br />

<strong>an</strong>d I supervise junior doctors.<br />

Take s<strong>an</strong>dwich to ward round.<br />

See patients on the daycare ward.<br />

Eat supper <strong>an</strong>d enjoy the evening with<br />

my children, Ben <strong>an</strong>d Izzy.<br />

Over 4,000<br />

Th<strong>an</strong>ks to our supporters,<br />

we fund the work of over<br />

4,000 researchers, nurses<br />

<strong>an</strong>d doctors like Penelope<br />

in the <strong>UK</strong>.<br />

Annual Review / <strong>Research</strong> / 09


Information<br />

Raising awareness <strong>an</strong>d saving lives<br />

We provide information on every aspect<br />

of c<strong>an</strong>cer, from prevention <strong>an</strong>d detection<br />

to treatment <strong>an</strong>d care.<br />

Our award-winning website, C<strong>an</strong>cerHelp <strong>UK</strong>, helps people<br />

with c<strong>an</strong>cer underst<strong>an</strong>d their illness <strong>an</strong>d make informed<br />

decisions, by providing comprehensive information about<br />

c<strong>an</strong>cer <strong>an</strong>d its treatment.<br />

Our team of c<strong>an</strong>cer information nurses <strong>an</strong>swer questions by<br />

phone <strong>an</strong>d email <strong>an</strong>d the Spot C<strong>an</strong>cer Early <strong>an</strong>d Healthy Living<br />

sections of our website include information on how we c<strong>an</strong><br />

spot the signs <strong>an</strong>d symptoms of c<strong>an</strong>cer early <strong>an</strong>d make lifestyle<br />

ch<strong>an</strong>ges to reduce the risk of the disease. We also run<br />

awareness campaigns such as SunSmart, to prevent skin c<strong>an</strong>cer.<br />

Our information for health professionals includes newsletters<br />

for GPs <strong>an</strong>d practice nurses with information including risk<br />

factors, screening <strong>an</strong>d early detection as well as a dedicated<br />

section of our website providing up-to-date statistics <strong>an</strong>d key<br />

facts on c<strong>an</strong>cer. And to help people underst<strong>an</strong>d more about<br />

c<strong>an</strong>cer research <strong>an</strong>d the latest adv<strong>an</strong>ces, we also have <strong>an</strong><br />

award-winning science blog.<br />

scienceblog.c<strong>an</strong>cerresearchuk.org<br />

Raising awareness of signs <strong>an</strong>d symptoms<br />

We know that thous<strong>an</strong>ds of c<strong>an</strong>cer deaths could be avoided<br />

each year if people were diagnosed at <strong>an</strong> earlier stage.<br />

Together with the Department of Health <strong>an</strong>d National C<strong>an</strong>cer<br />

Action Team (NCAT), we formed the National Awareness<br />

<strong>an</strong>d Early Diagnosis Initiative (NAEDI). NAEDI’s work will help<br />

ensure doctors c<strong>an</strong> diagnose c<strong>an</strong>cer earlier, <strong>an</strong>d encourage<br />

people with symptoms that could be c<strong>an</strong>cer to seek advice<br />

quickly from a specialist. We targeted people at increased<br />

risk of certain c<strong>an</strong>cers in a variety of ways, raising awareness<br />

of symptoms <strong>an</strong>d encouraging them to visit the doctor.<br />

Our activities over the year included producing films that<br />

explained the symptoms of different c<strong>an</strong>cers <strong>an</strong>d running<br />

<strong>an</strong> online campaign to encourage over 50s – those most<br />

at risk – to view them, <strong>an</strong>d talking to the B<strong>an</strong>gladeshi<br />

community in Tower Hamlets about oral c<strong>an</strong>cer.<br />

Ch<strong>an</strong>ges to public attitudes along with ch<strong>an</strong>ges within the<br />

healthcare system will be fundamental to making a difference.<br />

C<strong>an</strong>cer is more likely to be treated successfully when it’s<br />

spotted early.<br />

Professor J<strong>an</strong>e Wardle<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s Health Behaviour <strong>Research</strong> Centre,<br />

University College London<br />

Our patient information website, C<strong>an</strong>cerHelp <strong>UK</strong>,<br />

is the most visited c<strong>an</strong>cer site in the <strong>UK</strong> <strong>an</strong>d regularly<br />

received over one million visits per month last year.<br />

Targeting lifestyle ch<strong>an</strong>ges<br />

Up to half of all c<strong>an</strong>cers could be prevented through lifestyle<br />

ch<strong>an</strong>ges. For example, keeping a healthy body weight c<strong>an</strong> greatly<br />

reduce the risk of c<strong>an</strong>cer. Similarly, enjoying the sun safely <strong>an</strong>d<br />

not using sunbeds actually reduces the risk of skin c<strong>an</strong>cer.<br />

During the year we worked with the British Heart Foundation<br />

<strong>an</strong>d Diabetes <strong>UK</strong> on the Active Fat campaign, which highlights<br />

how carrying excess weight around your middle c<strong>an</strong> increase<br />

the risk of c<strong>an</strong>cer, heart disease <strong>an</strong>d Type 2 diabetes. We also<br />

supported the NHS, who produced TV adverts about the<br />

risks of drinking too much alcohol.<br />

Our award-winning skindividual campaign encourages young<br />

people to use social networking sites to spread sun protection<br />

messages. According to our research, in the last six years the<br />

number of people who seek out shade, cover up <strong>an</strong>d avoid<br />

sunbeds, <strong>an</strong>d who know the import<strong>an</strong>ce of checking their<br />

moles, has increased signific<strong>an</strong>tly.<br />

Our C<strong>an</strong>cer Awareness Roadshow toured the <strong>UK</strong>, giving<br />

information <strong>an</strong>d support on c<strong>an</strong>cer. More th<strong>an</strong> 37,000 people<br />

visited in 2009, <strong>an</strong>d over 8,500 had consultations with our<br />

nurses. Nine out of ten of those interviewed said they would<br />

ch<strong>an</strong>ge their behaviour as a result of their visit.<br />

Informing people about clinical trials <strong>an</strong>d research<br />

Clinical trials are <strong>an</strong> essential part of our work to beat c<strong>an</strong>cer.<br />

But it is hard for patients to find out about research into<br />

treatment for their c<strong>an</strong>cer type.<br />

Our unique clinical trials database lists easy-to-read summaries<br />

of clinical trials, which patients c<strong>an</strong> print <strong>an</strong>d take to their own<br />

specialists. The revamped database is now easier to use th<strong>an</strong><br />

ever, listing around 350 open trials in the <strong>UK</strong>, as well as closed<br />

trials <strong>an</strong>d trial results.<br />

www.c<strong>an</strong>cerhelp.org.uk/trials<br />

Some of our information objectives for 2010/11<br />

— Drive progress on diagnosing c<strong>an</strong>cer earlier, including<br />

finding out more about why people experience delays<br />

between seeing their GP <strong>an</strong>d getting the hospital<br />

appointment they need.<br />

— Promote earlier diagnosis of breast, bowel <strong>an</strong>d lung<br />

c<strong>an</strong>cer in particular, <strong>an</strong>d support the NHS to do the same.<br />

Find out how to reduce your risk of c<strong>an</strong>cer at<br />

info.c<strong>an</strong>cerresearchuk.org/healthyliving<br />

10 / Annual Review / Information


Jayshree Jhala, 73<br />

Early detection campaigner <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />

Jayshree was diagnosed with breast c<strong>an</strong>cer following a<br />

mammogram when she was 69. She chose to have a<br />

mastectomy <strong>an</strong>d chemotherapy <strong>an</strong>d is now on a five-year<br />

course of tamoxifen. Jayshree promotes c<strong>an</strong>cer awareness<br />

in schools <strong>an</strong>d community centres in Luton to her local<br />

Asi<strong>an</strong> community.<br />

1,000<br />

Our specialist nurses<br />

respond to up to 1,000<br />

enquiries every month<br />

from people like Jayshree,<br />

affected by or concerned<br />

about c<strong>an</strong>cer. Around one<br />

in five of these enquiries<br />

is about breast c<strong>an</strong>cer.<br />

6.30am Wake up. I feed Simba, our Alsati<strong>an</strong>. He’s just<br />

over a year old <strong>an</strong>d like a lion.<br />

7.30am Prepare breakfast for my gr<strong>an</strong>dchildren Arjun<br />

<strong>an</strong>d Shiv – they’re the apples of my eye.<br />

10.00am Attend a cooking class, meeting, or do some<br />

paperwork. I work for Luton Primary Care Trust<br />

as a community food adviser.<br />

1.30pm Have my main meal with my husb<strong>an</strong>d, Govind.<br />

He has a c<strong>an</strong>cerous tumour near his urethra.<br />

We encourage each other to be positive <strong>an</strong>d<br />

get over our illnesses, so we c<strong>an</strong> still enjoy our<br />

lives together.<br />

7.00pm Have a snack with Govind. I used to swim in the<br />

evenings <strong>an</strong>d I’m building up the courage to go<br />

again after my mastectomy.<br />

8.00pm Watch TV, make a few phone calls <strong>an</strong>d relax<br />

with my family <strong>an</strong>d Simba before going to bed.<br />

Annual Review / Information / About us / 11


Justine Sheils, 39<br />

SunSmart campaigner <strong>an</strong>d skin c<strong>an</strong>cer survivor<br />

Sun-lover Justine regularly used t<strong>an</strong>ning beds from the age<br />

of 15, <strong>an</strong>d rarely applied sunscreen when on holiday. In 2004<br />

she noticed a mole on her chest but didn’t get it checked<br />

out for a further 18 months. When she did, a specialist<br />

diagnosed malign<strong>an</strong>t mel<strong>an</strong>oma. Liverpool-based Justine had<br />

the mole removed <strong>an</strong>d is now back to full health. She is a<br />

passionate supporter of our SunSmart campaign.<br />

£13.3m<br />

We are the largest funder<br />

of skin c<strong>an</strong>cer research in<br />

the <strong>UK</strong>. Our broad<br />

research programme<br />

r<strong>an</strong>ges from uncovering the<br />

causes of the disease to<br />

developing new treatments<br />

for people like Justine.<br />

5.00am<br />

8.00am<br />

4.00pm<br />

6.00pm<br />

Get up <strong>an</strong>d go for a 45-minute run – it helps get<br />

rid of all of my <strong>an</strong>xieties. When I was ill,<br />

my aim was to put my trainers back on.<br />

Start work at my local hospital where I’m <strong>an</strong><br />

administrator. I have gone part-time because<br />

I’ve realised what’s import<strong>an</strong>t in life.<br />

Finish work <strong>an</strong>d head home for some<br />

chill-out time.<br />

College. I’m training to be a sports therapist.<br />

I’ve realised that life’s too short to not follow<br />

your dreams.<br />

10.00pm Head to bed. I’m pretty exhausted<br />

on college nights.<br />

12 / Annual Review / Contents Influencing public policy


Influencing public policy<br />

Campaigning for ch<strong>an</strong>ge<br />

We need to make sure c<strong>an</strong>cer stays<br />

at the top of the national health agenda.<br />

Influencing politici<strong>an</strong>s is a vital part of this.<br />

We work with decision-makers in Westminster, the Scottish<br />

Parliament, the Welsh Assembly, the Northern Irel<strong>an</strong>d Assembly<br />

<strong>an</strong>d the Europe<strong>an</strong> Parliament. We make sure the views of<br />

patients, researchers, health professionals, volunteers <strong>an</strong>d<br />

supporters are heard at all levels of government.<br />

The 2010 General Election<br />

We knew that c<strong>an</strong>cer would be a big issue in the General<br />

Election. We w<strong>an</strong>ted to make sure all parties were backing<br />

steps to prevent c<strong>an</strong>cer <strong>an</strong>d detect it earlier as well as making<br />

sure the <strong>UK</strong> has the funding <strong>an</strong>d resources needed to carry out<br />

high quality research. We also w<strong>an</strong>ted to see MPs commit to<br />

improving access to treatment <strong>an</strong>d reducing inequalities between<br />

social groups, as we know that the risk of dying of c<strong>an</strong>cer is far<br />

greater in less affluent communities.<br />

We published a new m<strong>an</strong>ifesto <strong>an</strong>d a Guide to Campaigning<br />

about C<strong>an</strong>cer for prospective parliamentary c<strong>an</strong>didates (PPCs).<br />

We met key ministers, policy advisers, MPs <strong>an</strong>d PPCs, <strong>an</strong>d asked<br />

our supporters to contact c<strong>an</strong>didates in their constituency <strong>an</strong>d<br />

urge them to ‘Commit to Beat C<strong>an</strong>cer’ if elected.<br />

Over 1,000 parliamentary c<strong>an</strong>didates signed our pledge<br />

to help make the <strong>UK</strong>’s c<strong>an</strong>cer outcomes among the best<br />

in Europe <strong>an</strong>d more th<strong>an</strong> 250 of those have gone on<br />

to become MPs. Find out more at<br />

www.c<strong>an</strong>cercampaigns.org.uk/ourcampaigns/commit<br />

Pl<strong>an</strong>ning for the future of c<strong>an</strong>cer services<br />

National c<strong>an</strong>cer pl<strong>an</strong>s are a vital way to make sure we have<br />

the best c<strong>an</strong>cer services. They detail each government’s pl<strong>an</strong>s<br />

to invest in <strong>an</strong>d reform c<strong>an</strong>cer services, <strong>an</strong>d provide direction<br />

for using resources effectively. We monitor how these pl<strong>an</strong>s<br />

are implemented from spending commitments to passing new<br />

legislation – to ensure promises are kept on key issues.<br />

We wrote <strong>an</strong> in-depth report on how the c<strong>an</strong>cer pl<strong>an</strong>s<br />

in Engl<strong>an</strong>d, Scotl<strong>an</strong>d, Wales <strong>an</strong>d Northern Irel<strong>an</strong>d were<br />

implemented, <strong>an</strong>d what progress they have made.<br />

Our research included interviews with scientists, clinici<strong>an</strong>s<br />

<strong>an</strong>d NHS professionals. We reviewed information available<br />

to people with c<strong>an</strong>cer, to help us underst<strong>an</strong>d how people’s<br />

experiences have ch<strong>an</strong>ged since the c<strong>an</strong>cer pl<strong>an</strong>s have been<br />

in place. Results showed there has been progress in some<br />

areas. We will continue to push governments to ensure the<br />

best c<strong>an</strong>cer services are available to patients throughout the <strong>UK</strong>.<br />

Protecting young people<br />

Smoking is the single biggest preventable cause of c<strong>an</strong>cer in the<br />

world. A large number of studies have shown that quitting the<br />

habit c<strong>an</strong> greatly reduce the risk of smoking-related c<strong>an</strong>cers.<br />

The earlier you stop, the better. Reaching young people early<br />

so they don’t start smoking is <strong>an</strong> import<strong>an</strong>t part of our fight<br />

against c<strong>an</strong>cer.<br />

Over 12,000 of our supporters wrote to MPs <strong>an</strong>d MSPs backing<br />

our ‘Out of Sight, Out of Mind’ campaign, which called for a<br />

b<strong>an</strong> on tobacco marketing to young people. More th<strong>an</strong> 50,000<br />

people signed our petition. Our supporters helped convince<br />

MPs <strong>an</strong>d MSPs to vote to end the display of tobacco at the<br />

tills in shops <strong>an</strong>d supermarkets across the <strong>UK</strong> <strong>an</strong>d to stop<br />

cigarettes being sold in vending machines in Engl<strong>an</strong>d, Scotl<strong>an</strong>d,<br />

Wales <strong>an</strong>d Northern Irel<strong>an</strong>d. This will be phased in from 2011.<br />

Reducing the risk of skin c<strong>an</strong>cer<br />

Malign<strong>an</strong>t mel<strong>an</strong>oma – the most serious type of skin c<strong>an</strong>cer<br />

– is one of the most common c<strong>an</strong>cers in the <strong>UK</strong>. Using a<br />

sunbed once a month or more c<strong>an</strong> increase the risk of this<br />

type of c<strong>an</strong>cer by more th<strong>an</strong> half, <strong>an</strong>d the number of people<br />

who develop it is increasing.<br />

We met politici<strong>an</strong>s, civil serv<strong>an</strong>ts <strong>an</strong>d health campaigners to push<br />

for new laws to stop under-18s using sunbeds. We also w<strong>an</strong>ted<br />

to make sure all salons are staffed <strong>an</strong>d customers receive<br />

accurate health information. Th<strong>an</strong>ks to thous<strong>an</strong>ds of emails<br />

from our supporters, MPs <strong>an</strong>d Peers from all parties voted<br />

in favour of the Sunbeds Act, which will become law in 2011<br />

in Engl<strong>an</strong>d <strong>an</strong>d Wales.<br />

Some of our influencing public policy objectives for 2010/11<br />

— Raise awareness of the import<strong>an</strong>ce of radiotherapy<br />

as a c<strong>an</strong>cer treatment <strong>an</strong>d the need for better services.<br />

— Keep c<strong>an</strong>cer high on the agenda following the General<br />

Election <strong>an</strong>d prepare for elections in the Scottish<br />

Parliament, Welsh Assembly <strong>an</strong>d Northern<br />

Irel<strong>an</strong>d Assembly.<br />

To read more about the issues <strong>an</strong>d how you c<strong>an</strong><br />

call for ch<strong>an</strong>ge, visit<br />

www.c<strong>an</strong>cerresearchuk.org/publicpolicy<br />

Annual Review / Influencing public policy / 13


Bringing our work together to save lives<br />

Diagnosing c<strong>an</strong>cer early<br />

Sara Hiom, Director of Health Information, C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

If only my c<strong>an</strong>cer had been spotted earlier.<br />

We’re determined to make statements like this<br />

a thing of the past. Thous<strong>an</strong>ds of deaths could<br />

be avoided each year if c<strong>an</strong>cer was diagnosed<br />

<strong>an</strong>d subsequently treated at <strong>an</strong> earlier stage.<br />

This is probably the single biggest reason why<br />

c<strong>an</strong>cer survival rates in the <strong>UK</strong> are lower th<strong>an</strong><br />

in m<strong>an</strong>y other countries in Europe.<br />

At the moment, just over half of all people with c<strong>an</strong>cer are<br />

diagnosed at a stage when it c<strong>an</strong> be successfully treated.<br />

Our goal is to see this rise to two-thirds by 2020 by tackling<br />

late diagnosis through our research, our information <strong>an</strong>d<br />

influencing health policy.<br />

Our research underpins the national screening programmes<br />

for breast <strong>an</strong>d cervical c<strong>an</strong>cers. Both me<strong>an</strong> more women are<br />

diagnosed when treatment is likely to be successful. Since<br />

national breast screening beg<strong>an</strong> in 1988, around five million<br />

women in Engl<strong>an</strong>d have been screened <strong>an</strong>d over 100,000<br />

c<strong>an</strong>cers detected. And the cervical screening programme<br />

has prevented <strong>an</strong> epidemic of cervical c<strong>an</strong>cer. Th<strong>an</strong>ks to our<br />

supporters, we’re building on these successes.<br />

Our research<br />

In a major breakthrough this year, our scientists found that a<br />

one-off five minute screening test could prevent one-third of<br />

bowel c<strong>an</strong>cers <strong>an</strong>d reduce deaths by 43%. Bowel c<strong>an</strong>cer is the<br />

second biggest c<strong>an</strong>cer killer in the <strong>UK</strong>, <strong>an</strong>d the third most<br />

common c<strong>an</strong>cer. We’re now calling on <strong>UK</strong> governments to add<br />

the test to the national bowel c<strong>an</strong>cer screening programme.<br />

This could save thous<strong>an</strong>ds of lives <strong>an</strong>d spare families the <strong>an</strong>xiety<br />

<strong>an</strong>d suffering associated with a c<strong>an</strong>cer diagnosis.<br />

We’re also helping to fund a major trial to see whether a national<br />

screening programme for ovari<strong>an</strong> c<strong>an</strong>cer should be introduced<br />

which could detect the disease early enough to save lives.<br />

And as part of a national prostate c<strong>an</strong>cer trial, we’re supporting<br />

import<strong>an</strong>t research to help decide if the PSA blood test – which<br />

c<strong>an</strong> help identify prostate c<strong>an</strong>cer – could form the basis of a<br />

national screening programme.<br />

We’re leading the research arm of the National Awareness <strong>an</strong>d<br />

Early Diagnosis Initiative (NAEDI), a new National C<strong>an</strong>cer<br />

<strong>Research</strong> Institute partnership, formed to fund high-quality<br />

research in areas likely to have the greatest <strong>impact</strong> on tackling<br />

late diagnosis.<br />

Our information<br />

Together with the Department of Health <strong>an</strong>d the National<br />

C<strong>an</strong>cer Action Team, NAEDI coordinates activity to promote<br />

the earlier diagnosis of c<strong>an</strong>cer. We’ve been raising awareness<br />

of the import<strong>an</strong>ce of detecting c<strong>an</strong>cer at <strong>an</strong> early stage with<br />

the public <strong>an</strong>d GPs, as well as trying to better identify who<br />

is most at risk.<br />

We supported NHS Derby City in campaigning to raise<br />

awareness of bowel c<strong>an</strong>cer in communities with a greater th<strong>an</strong><br />

average risk of c<strong>an</strong>cer <strong>an</strong>d to encourage men over 50 to visit<br />

their GP if they notice <strong>an</strong>ything unusual, <strong>an</strong>d we worked with<br />

Merseyside <strong>an</strong>d Cheshire C<strong>an</strong>cer Network to tell older men<br />

about symptoms of skin c<strong>an</strong>cer.<br />

Early diagnosis is our next big challenge in c<strong>an</strong>cer <strong>an</strong>d<br />

will be crucial in bringing our survival rates up to the<br />

best in Europe.<br />

Professor Sir Mike Richards<br />

National C<strong>an</strong>cer Director<br />

Influencing health policy<br />

We w<strong>an</strong>t <strong>UK</strong> governments to make early diagnosis of c<strong>an</strong>cer<br />

a priority. During the election campaign we promoted the<br />

import<strong>an</strong>ce of early diagnosis to thous<strong>an</strong>ds of parliamentary<br />

c<strong>an</strong>didates. We called on politici<strong>an</strong>s to adopt the new bowel<br />

screening test <strong>an</strong>d we are urging them to increase the number<br />

of people invited for c<strong>an</strong>cer screening.<br />

We held a discussion day for people with c<strong>an</strong>cer <strong>an</strong>d their<br />

families to help underst<strong>an</strong>d their experiences of being diagnosed<br />

<strong>an</strong>d to inform our own work with policy-makers.<br />

The future<br />

We’re pushing for policies that encourage people to visit their<br />

GP with signs or symptoms of c<strong>an</strong>cer, <strong>an</strong>d for speedy referrals.<br />

We w<strong>an</strong>t policies that support GPs <strong>an</strong>d help the public to<br />

underst<strong>an</strong>d as much as possible about the benefits of<br />

early diagnosis.<br />

By catching c<strong>an</strong>cer earlier we c<strong>an</strong> help ensure that the <strong>UK</strong>’s<br />

outcomes are among the best in Europe <strong>an</strong>d globally<br />

– instead of being behind most Northern Europe<strong>an</strong> countries.<br />

For information on detecting c<strong>an</strong>cer early visit<br />

www.spotc<strong>an</strong>cerearly.com<br />

With our partners we are investing up to £7.5 million over five<br />

years in such research. For more information see<br />

www.naedi.org.uk<br />

14 / Annual Review / Diagnosing c<strong>an</strong>cer early


Calvin Wood, 68<br />

Prostate c<strong>an</strong>cer survivor<br />

Calvin, a gr<strong>an</strong>dfather of four, was diagnosed with prostate<br />

c<strong>an</strong>cer in 2001. He received hormone treatment – Casodex<br />

<strong>an</strong>d Zoladex – <strong>an</strong>d a six-week course of radiotherapy.<br />

Calvin now devotes much of his time to supporting other<br />

men with the disease. He set up a prostate c<strong>an</strong>cer support<br />

group at the hospital, on the Wirral, where he was treated,<br />

which now has more th<strong>an</strong> 180 members.<br />

8.00am<br />

Get up <strong>an</strong>d have breakfast with my wife.<br />

The mornings are my ‘free time’ for doing<br />

<strong>an</strong>y shopping or jobs around the house.<br />

10.00am Contact members of the prostate c<strong>an</strong>cer<br />

support group. It’s wonderful to help others<br />

in the same boat, particularly those struggling<br />

to come to terms with a diagnosis.<br />

2.00pm<br />

7.00pm<br />

Meetings. I’m treasurer of the National<br />

Conference of C<strong>an</strong>cer Self-Help Groups <strong>an</strong>d<br />

a trustee of the Clatterbridge Centre for<br />

Oncology. I feel I’m giving something back.<br />

Go for a meal with friends or catch up with<br />

family news. Having c<strong>an</strong>cer helps you focus<br />

on what’s import<strong>an</strong>t, like friends <strong>an</strong>d family.<br />

10.00pm Watch the news, then bed – 24 hours doesn’t<br />

seem long enough!<br />

Seven out<br />

of ten men<br />

now survive prostate<br />

c<strong>an</strong>cer for at least ten<br />

years, compared with only<br />

two out of ten in the 1970s.<br />

We fund research at all<br />

levels, from uncovering<br />

the disease’s causes to<br />

developing new treatments.<br />

Annual Review Annual / Diagnosing Review c<strong>an</strong>cer / About early us / 15


Driving world-class c<strong>an</strong>cer research<br />

The breadth of our work is<br />

unparalleled. We are tackling<br />

c<strong>an</strong>cer from all <strong>an</strong>gles <strong>an</strong>d<br />

support research in m<strong>an</strong>y<br />

different ways.<br />

To make sure adv<strong>an</strong>ces in c<strong>an</strong>cer<br />

research benefit as m<strong>an</strong>y people as<br />

quickly as possible, we fund scientists,<br />

doctors <strong>an</strong>d nurses across the <strong>UK</strong>.<br />

We have five core research Institutes,<br />

each specialising in different areas<br />

of c<strong>an</strong>cer. We also form lasting<br />

partnerships <strong>an</strong>d networks – with the<br />

NHS, universities <strong>an</strong>d other charities<br />

– both in the <strong>UK</strong> <strong>an</strong>d internationally.<br />

Our Centres<br />

As well as undertaking world-class<br />

research, our growing <strong>UK</strong>-wide network<br />

of Centres helps train the clinical <strong>an</strong>d<br />

scientific research workforce of the<br />

future. Each Centre is a ‘virtual hub’<br />

that unites researchers, patients <strong>an</strong>d<br />

fundraisers, giving them the opportunity<br />

to work together to raise awareness of<br />

c<strong>an</strong>cer research <strong>an</strong>d host events in the<br />

local community.<br />

We launched seven more Centres<br />

in 2009/10, bringing our total launched<br />

to ten, <strong>an</strong>d we pl<strong>an</strong> to have between<br />

15 <strong>an</strong>d 20 by the end of 2011. In this<br />

Annual Review we put the spotlight<br />

on just a few examples of the life-saving<br />

work happening at our Centres.<br />

For more information on our Institutes<br />

<strong>an</strong>d Centres visit<br />

science.c<strong>an</strong>cerresearchuk.org/research/<br />

how-we-deliver-our-research<br />

Belfast<br />

Teams at our Belfast Centre are<br />

leading research into bowel,<br />

oesophageal <strong>an</strong>d breast c<strong>an</strong>cers.<br />

They are also exploring the latest<br />

techniques in radiotherapy,<br />

improving c<strong>an</strong>cer diagnosis, <strong>an</strong>d<br />

developing more effective drugs<br />

with fewer side effects. The Centre<br />

brings together over 40 researchers<br />

from across Northern Irel<strong>an</strong>d.<br />

Ruth Boyd is a Senior <strong>Research</strong><br />

<strong>an</strong>d Information Nurse at Belfast<br />

City Hospital. Ruth is helping to<br />

recruit more c<strong>an</strong>cer patients to<br />

clinical trials which could benefit<br />

thous<strong>an</strong>ds of people in the future.<br />

Dundee<br />

<strong>Research</strong> at our Dundee Centre<br />

particularly focuses on skin, bowel,<br />

<strong>an</strong>d breast c<strong>an</strong>cers. Scientists are<br />

also carrying out world-class<br />

research to refine <strong>an</strong>d improve<br />

c<strong>an</strong>cer surgery.<br />

Professor Inke Näthke <strong>an</strong>d<br />

her team at the University<br />

of Dundee are carrying out<br />

work that could aid the early<br />

detection of bowel c<strong>an</strong>cer. She<br />

is investigating a gene called<br />

APC, which is faulty in m<strong>an</strong>y<br />

cases of the disease.<br />

This work is import<strong>an</strong>t as it<br />

may help us develop techniques<br />

for identifying pre-c<strong>an</strong>cerous<br />

tissue at <strong>an</strong> early stage when it<br />

still appears normal. This will give<br />

clinici<strong>an</strong>s a ch<strong>an</strong>ce to catch the<br />

disease in the early stages – when<br />

it c<strong>an</strong> be treated more effectively.<br />

Southampton<br />

Scientists <strong>an</strong>d doctors at our<br />

Southampton Centre are recognised<br />

internationally for their research into<br />

immunotherapy, a type of treatment<br />

that harnesses the power of the<br />

body’s own immune system to<br />

target c<strong>an</strong>cer.<br />

Professor Peter Johnson, our<br />

Chief Clinici<strong>an</strong> <strong>an</strong>d one of the<br />

leaders of the Southampton<br />

Centre, is <strong>an</strong> expert in lymphoma.<br />

He <strong>an</strong>d other researchers are<br />

developing a r<strong>an</strong>ge of <strong>an</strong>tibody<br />

<strong>an</strong>d immunotherapy treatments,<br />

some of which are being tested<br />

in early-stage clinical trials.<br />

Joining the network of<br />

Centres is very import<strong>an</strong>t for<br />

patients, doctors <strong>an</strong>d scientists in<br />

Southampton. It will strengthen<br />

the work we already do in bringing<br />

treatments straight from the<br />

laboratory to the clinic, <strong>an</strong>d help<br />

us to do more work in import<strong>an</strong>t<br />

areas such as surgery.<br />

Newcastle<br />

<strong>Research</strong>ers at the Newcastle<br />

Centre at the Northern Institute<br />

for C<strong>an</strong>cer <strong>Research</strong> specialise<br />

in discovering <strong>an</strong>d testing new<br />

treatments. Teams here have<br />

particular strengths in carrying out<br />

early-stage clinical trials of the latest<br />

treatments, <strong>an</strong>d specialise in m<strong>an</strong>y<br />

types of c<strong>an</strong>cer including childhood<br />

<strong>an</strong>d prostate c<strong>an</strong>cers.<br />

Professor Herbie Newell is <strong>an</strong><br />

expert in c<strong>an</strong>cer pharmacology<br />

– underst<strong>an</strong>ding how c<strong>an</strong>cer<br />

drugs work inside the body.<br />

He <strong>an</strong>d his team are currently<br />

working on targeted drugs that<br />

block the action of specific faulty<br />

proteins found within c<strong>an</strong>cer cells,<br />

stopping the disease in its tracks.<br />

The development of<br />

personalised treatment –<br />

treatment that is tailored to the<br />

requirements of <strong>an</strong> individual<br />

patient – is becoming a reality <strong>an</strong>d<br />

offers the opportunity to design<br />

new drugs that are truly selective<br />

for different forms of c<strong>an</strong>cer.<br />

16 / Annual Review / Contents Driving world-class c<strong>an</strong>cer research


Cardiff<br />

Teams at our Cardiff Centre are<br />

focusing on leukaemia as well as<br />

bowel, breast <strong>an</strong>d urological c<strong>an</strong>cers,<br />

such as prostate <strong>an</strong>d bladder c<strong>an</strong>cer.<br />

They are using laboratory discoveries<br />

to develop new ways to prevent,<br />

diagnose <strong>an</strong>d treat the disease.<br />

Recent work by Dr Dunc<strong>an</strong> Baird<br />

at Cardiff University takes us<br />

one step closer to a blood test<br />

that could predict how fast<br />

leukaemia will progress. Dr Baird<br />

is <strong>an</strong> expert on ‘telomeres’ – tiny<br />

structures that protect the ends<br />

of chromosomes, which hold<br />

our cells’ entire DNA blueprint.<br />

His team recently revealed how<br />

shortened <strong>an</strong>d fused telomeres<br />

are involved in the progression of<br />

leukaemia. This discovery may help<br />

doctors identify people with more<br />

adv<strong>an</strong>ced c<strong>an</strong>cer, so they c<strong>an</strong> select<br />

the best treatment.<br />

Beatson Institute<br />

Paterson Institute<br />

Gray Institute<br />

Cambridge <strong>Research</strong><br />

Institute<br />

London <strong>Research</strong><br />

Institute<br />

Key<br />

Centres – our ten Centres of research excellence<br />

Institutes – our five core-funded research Institutes<br />

Other locations – just some of the other locations around the <strong>UK</strong> where<br />

we fund our life-saving research or support clinical trials<br />

Annual Review / Driving world-class Annual Review c<strong>an</strong>cer / About research us / 17


Our people<br />

From our world-class scientists <strong>an</strong>d lab<br />

assist<strong>an</strong>ts to our volunteers, our doctors <strong>an</strong>d<br />

nurses to our staff, we rely on a wide variety<br />

of skills <strong>an</strong>d experience to help us beat c<strong>an</strong>cer.<br />

There are hundreds of thous<strong>an</strong>ds of people<br />

involved in helping us achieve our vision<br />

– they are all a vital part of our team, <strong>an</strong>d<br />

we need each <strong>an</strong>d every one of them.<br />

Here we highlight just a few of those that<br />

make our work possible.<br />

Senior scientist<br />

Professor Iain McNeish is a c<strong>an</strong>cer specialist at Barts <strong>an</strong>d<br />

the London School of Medicine, part of the Barts C<strong>an</strong>cer<br />

<strong>Research</strong> <strong>UK</strong> Centre. He specialises in the treatment of<br />

ovari<strong>an</strong> c<strong>an</strong>cer. His research aims to underst<strong>an</strong>d the biology<br />

of ovari<strong>an</strong> c<strong>an</strong>cer – in particular, the reasons why ovari<strong>an</strong><br />

c<strong>an</strong>cer cells c<strong>an</strong> become resist<strong>an</strong>t to chemotherapy.<br />

He w<strong>an</strong>ts to use this knowledge to design new types of<br />

treatment, such as gene therapy, to overcome resist<strong>an</strong>ce<br />

<strong>an</strong>d make treatment successful for more women.<br />

The research C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> does<br />

is high quality <strong>an</strong>d focused on the one mission<br />

– to beat c<strong>an</strong>cer.<br />

Professor Iain McNeish<br />

Ovari<strong>an</strong> c<strong>an</strong>cer specialist<br />

18 / Annual Review / Our people


Campaigning ambassador<br />

When Chris Geiger was diagnosed with non-Hodgkin’s<br />

lymphoma, he was given just months to live. That was 20 years<br />

ago. Chris is now a passionate campaigner <strong>an</strong>d ambassador for<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. He uses his personal experience to raise<br />

awareness of the amazing work that happens in our hospitals<br />

every day, <strong>an</strong>d the import<strong>an</strong>t role we play in supporting patients.<br />

Our expert bloggers<br />

Science writers Henry Scowcroft, Ed Yong, Kat Arney<br />

<strong>an</strong>d others write our award-winning science blog.<br />

They help people underst<strong>an</strong>d more about c<strong>an</strong>cer research<br />

<strong>an</strong>d the latest adv<strong>an</strong>ces, including work we fund, as well<br />

as explaining health myths <strong>an</strong>d media scares, <strong>an</strong>d providing<br />

links to other helpful resources. Read more at<br />

scienceblog.c<strong>an</strong>cerresearchuk.org<br />

Celebrity supporters<br />

Celebrities play <strong>an</strong> invaluable role when it comes to supporting<br />

<strong>an</strong>d promoting our work. Sir Richard Br<strong>an</strong>son, Sir Trevor<br />

MacDonald, Dame Judi Dench <strong>an</strong>d Honor Blackm<strong>an</strong> are<br />

among m<strong>an</strong>y others who have supported our campaigns, whilst<br />

legendary rocker Rod Stewart, Gary Barlow, Ke<strong>an</strong>e <strong>an</strong>d Lemar<br />

are among m<strong>an</strong>y who have performed or supported our music<br />

events. British F1 Star Lewis Hamilton along with singer Leona<br />

Lewis <strong>an</strong>d gold medallist Usain Bolt supported our Little Star<br />

Awards, which celebrate the courage of children with c<strong>an</strong>cer.<br />

Shop volunteer<br />

Breast c<strong>an</strong>cer survivor Doreen Walker volunteers<br />

two days a week at the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> shop on<br />

her local high street in Potters Bar. The gr<strong>an</strong>dmother<br />

of five sorts <strong>an</strong>d prices clothes, serves customers <strong>an</strong>d<br />

supervises the other volunteers.<br />

Relay For Life org<strong>an</strong>iser<br />

V<strong>an</strong>essa Babbage, who has been clear of breast c<strong>an</strong>cer<br />

for two years now, helped org<strong>an</strong>ise a Relay For Life<br />

fundraising event in Crystal Palace. She coordinated<br />

the survivors’ ceremony <strong>an</strong>d food for the day, then<br />

walked in the survivors’ lap of honour. The event raised<br />

£20,000 <strong>an</strong>d V<strong>an</strong>essa is chairing the committee to<br />

org<strong>an</strong>ise next year’s event.<br />

I’ve been on cloud nine since the Relay. It was<br />

just brilli<strong>an</strong>t for everyone in the local community to<br />

come together <strong>an</strong>d it’s so good to give something back<br />

to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. C<strong>an</strong>cer ch<strong>an</strong>ges you forever.<br />

I don’t worry about little things now because I know<br />

that what’s import<strong>an</strong>t is having a good quality of life.<br />

V<strong>an</strong>essa Babbage<br />

Breast c<strong>an</strong>cer survivor<br />

Clinical trial nurse<br />

Marylyn Pilkington is a Senior <strong>Research</strong> Nurse at the<br />

Sir Bobby Robson C<strong>an</strong>cer Trials <strong>Research</strong> Centre in<br />

Newcastle. She works with patients who are taking<br />

part in early-phase clinical trials – trials for drugs that<br />

have shown promise in the laboratory <strong>an</strong>d now need<br />

testing in the clinical setting. Marylyn gives patients the<br />

information they need to decide whether to take part,<br />

<strong>an</strong>d supports them throughout the treatment.<br />

I really enjoy the work <strong>an</strong>d w<strong>an</strong>t to give something<br />

back, <strong>an</strong>d I think that goes for the other volunteers<br />

who have all been touched by c<strong>an</strong>cer. I feel so fortunate<br />

that a routine screening helped to save my life. It never<br />

crossed my mind there would be a problem. But th<strong>an</strong>k<br />

goodness I was invited to go along that day.<br />

Doreen Walker<br />

Breast c<strong>an</strong>cer survivor<br />

All new c<strong>an</strong>cer drugs have to go through these<br />

early-phase trials. We’re hopeful that today’s trials<br />

will lead to the c<strong>an</strong>cer treatments of the future.<br />

Marylyn Pilkington<br />

Clinical trial nurse<br />

Annual Review / Our people / 19


Raising money to support our work<br />

Our life-saving work is only possible th<strong>an</strong>ks to<br />

the ongoing commitment <strong>an</strong>d generosity of<br />

our supporters, as we receive no government<br />

funding for our research.<br />

We would like to th<strong>an</strong>k them for helping us to raise a record<br />

£446 million. Here are just some of the ways they did it.<br />

Giving generously<br />

Our supporters set up regular donations by direct debit,<br />

donate online or give through a payroll scheme at work.<br />

Some people choose to give in celebration of a special<br />

event like a wedding, <strong>an</strong>niversary or birthday. Others donate<br />

in memory of a loved one. It’s also possible to give online<br />

to a specific research project through MyProjects.<br />

myprojects.c<strong>an</strong>cerresearchuk.org<br />

M<strong>an</strong>y people choose to continue their support for us by<br />

leaving a gift in their will. More th<strong>an</strong> a third of our work<br />

is made possible by legacies, <strong>an</strong>d last year we were left<br />

£157 million by generous donors.<br />

Joining a local group or org<strong>an</strong>ising your own fundraiser<br />

Across the <strong>UK</strong>, people support us by joining or forming<br />

local groups <strong>an</strong>d committees. We have nearly 900 groups,<br />

committees <strong>an</strong>d regular fundraisers all around the country.<br />

People also raise money individually – at school, home or<br />

work. Last year our supporters got involved in m<strong>an</strong>y ways,<br />

from hosting quiz nights <strong>an</strong>d fundraising dinners to coffee<br />

mornings <strong>an</strong>d head shaves.<br />

Getting active – taking part in <strong>an</strong> event or a challenge<br />

Our flagship, women-only event Race for Life has gone from<br />

strength to strength. In 2009, over 730,000 women came<br />

together at around 250 Race for Life events around the<br />

country. Together they raised <strong>an</strong> incredible £66 million.<br />

In April 2010 we launched Shine, our new night-time walking<br />

marathon. Shine was a great success, with more th<strong>an</strong> 7,500<br />

people talking part in our first event in M<strong>an</strong>chester, raising over<br />

£1.4 million for our life-saving work. For the first time people<br />

could choose which c<strong>an</strong>cer they w<strong>an</strong>ted to beat <strong>an</strong>d raise<br />

money specifically for that area of our work.<br />

We also held 22 Run10k events for men <strong>an</strong>d women at<br />

f<strong>an</strong>tastic locations across the country. And our overnight<br />

Relay For Life events, org<strong>an</strong>ised by volunteers, are a ch<strong>an</strong>ce<br />

for supporters to team up with friends, family or colleagues.<br />

We have hundreds of events <strong>an</strong>d challenges taking place across<br />

the <strong>UK</strong> for all fitness levels all year round. Find out more at<br />

supportus.c<strong>an</strong>cerresearchuk.org/events<br />

Supporting us on the high street<br />

We have over 570 shops around the <strong>UK</strong>, where you c<strong>an</strong> buy<br />

or donate goods. Despite it being a difficult year, our shops<br />

had their best week ever in December 2009, raising nearly<br />

£3 million. To make shopping even easier, we also have our<br />

own online shopping site selling a wide selection of products,<br />

including gifts <strong>an</strong>d flowers.<br />

www.shoptobeatc<strong>an</strong>cer.org.uk<br />

In partnership with business<br />

Our corporate supporters play a vital role in our work to beat<br />

c<strong>an</strong>cer. Employees org<strong>an</strong>ise <strong>an</strong>d take part in events <strong>an</strong>d give up<br />

their time to volunteer with us. Last year we raised more th<strong>an</strong><br />

£5 million from our partnerships with various org<strong>an</strong>isations –<br />

including TKMaxx, Superdrug <strong>an</strong>d E.On. And other partners<br />

such as Tesco <strong>an</strong>d Nivea sponsor our running events.<br />

I’ve taken part in Race for Life since my diagnosis in 2007.<br />

I walk it with my friends, <strong>an</strong>d my daughter runs it too. It’s part<br />

of our year now. My husb<strong>an</strong>d was marshalling at the last<br />

Race for Life at 6.30am on his 60th birthday! That’s what it’s all<br />

about – everyone coming together to support each other.<br />

Deborah Huggons<br />

Breast c<strong>an</strong>cer survivor<br />

Major supporters<br />

We are grateful to our major supporters: individuals,<br />

gr<strong>an</strong>t-making trusts <strong>an</strong>d foundations whose most generous<br />

contributions have helped to fund new buildings, items of<br />

equipment, Fellowship schemes <strong>an</strong>d new areas of scientific<br />

research. We are delighted to acknowledge m<strong>an</strong>y of our<br />

supporters on page 28.<br />

Special events<br />

Every year we have a packed diary of special events. These<br />

include the Bobby Moore Fund Sports Ball, Sound & Vision,<br />

a series of concerts at Abbey Road Studios, the Chelsea Flower<br />

Show – where a generous supporter funds <strong>an</strong> inspirational<br />

garden – <strong>an</strong>d our Christmas-time Emeralds & Ivy ball.<br />

Fundraising together – supporting foundations<br />

Last year we worked with Seve Ballesteros to create a new<br />

foundation to raise funds for brain c<strong>an</strong>cer research. And we<br />

became a beneficiary of the Dallaglio Foundation in memory of<br />

Lawrence Dallaglio’s mother who died of c<strong>an</strong>cer. This year we<br />

will continue to work in partnership with Seve <strong>an</strong>d Lawrence<br />

to deliver high-profile events, such as gala dinners <strong>an</strong>d celebrity<br />

music events, which will help fund our life-saving work.<br />

Fundraising for the future<br />

Give Ch<strong>an</strong>ge Make Ch<strong>an</strong>ge is a new way to give to charity<br />

while shopping online. Like a virtual charity-box, this novel<br />

idea allows people to round up their online shopping bill on<br />

partner websites <strong>an</strong>d donate their ‘electronic spare ch<strong>an</strong>ge’.<br />

We are working with WWF, Great Ormond Street Hospital<br />

<strong>an</strong>d the British Red Cross to launch the initiative.<br />

To find out more about how you c<strong>an</strong> support us see<br />

pages 26 <strong>an</strong>d 27, or visit<br />

www.c<strong>an</strong>cerresearchuk.org/supportus<br />

20 / Annual Review / Raising money to support our work


Deborah Huggons, 53<br />

Race for Life particip<strong>an</strong>t <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />

After noticing a lump in her breast, Deborah was<br />

diagnosed with breast c<strong>an</strong>cer in 2007. She had<br />

a mastectomy <strong>an</strong>d six months of chemotherapy.<br />

Deborah took part in the TACT-2 trial, which we helped<br />

fund. It compares different chemotherapy treatments<br />

to try to reduce side effects <strong>an</strong>d improve long-term<br />

benefits. Now back to full health, Deborah r<strong>an</strong> the<br />

Barnstaple Race for Life with her daughter Esme.<br />

7.00am The dashing around begins, trying to get my<br />

children out of bed <strong>an</strong>d on the school bus.<br />

8.30am Start work. I’m a careers advisor for young<br />

people with learning difficulties.<br />

1.00pm Grab a quick s<strong>an</strong>dwich.<br />

7.15pm When I get home it’s a bit m<strong>an</strong>ic. We spend<br />

m<strong>an</strong>y of our evenings taking our children to<br />

after-school activities. Having c<strong>an</strong>cer ch<strong>an</strong>ged<br />

my priorities. Now I’m more focused on<br />

my family.<br />

11.30pm Bed, but I have to have some quiet time first.<br />

200trials<br />

We currently support<br />

around 200 clinical trials<br />

across the <strong>UK</strong>. With the<br />

help of people like Deborah<br />

<strong>an</strong>d the vital funds raised<br />

by our supporters, trials<br />

like TACT-2 aim to make<br />

treatments more effective.<br />

Annual Review / Raising money Annual to Review support / our About work us / 21


How your donation helps<br />

us beat c<strong>an</strong>cer<br />

We rely entirely on the money you give<br />

us <strong>an</strong>d 90% of the donations we receive<br />

are £10 or under. Small donations c<strong>an</strong><br />

make a big difference.<br />

One gift of £10 could buy 300 glass slides for<br />

studying cells under the microscope. If 55,000<br />

people each give £10, they would pay for<br />

a research programme to test new drugs<br />

to treat women with breast c<strong>an</strong>cer.<br />

Total cost of research work done during the year – £334m<br />

£37.4m<br />

Includes cervical, kidney,<br />

stomach, sarcoma,<br />

testicular, pharyngeal<br />

<strong>an</strong>d over 100 other c<strong>an</strong>cers<br />

£41.4m<br />

Breast<br />

£4.8m<br />

Brain<br />

£6.1m<br />

Bladder<br />

£9.4m<br />

P<strong>an</strong>creatic<br />

£9.5m<br />

Non-Hodgkin’s<br />

Lymphoma<br />

£132.5m<br />

Basic research *<br />

£24.8m<br />

Bowel<br />

£10.6m<br />

Ovari<strong>an</strong><br />

£11.9m<br />

Lung<br />

£13.3m<br />

Skin<br />

£15.0m<br />

Leukaemia<br />

£17.3m<br />

Prostate<br />

*<br />

In basic research, our scientists are working in laboratories to underst<strong>an</strong>d<br />

exactly how normal cells work <strong>an</strong>d exactly how these processes go wrong<br />

in c<strong>an</strong>cer. This research is vital, increasing our underst<strong>an</strong>ding of the molecular<br />

basis of the disease <strong>an</strong>d laying the foundations for new ways to detect <strong>an</strong>d<br />

treat m<strong>an</strong>y different types of c<strong>an</strong>cer.<br />

22 / Annual Review / How your donation helps us beat c<strong>an</strong>cer<br />

157


Lun<br />

C<strong>an</strong>cer research is very expensive…<br />

The average cost to run just one trial or laboratory<br />

is around £1 million per year, <strong>an</strong>d research projects<br />

normally last several years. <strong>Research</strong> activities carried<br />

out in institutes, hospitals <strong>an</strong>d universities throughout<br />

the <strong>UK</strong> cost £334 million. This figure reflects the cost<br />

of research work done this year.<br />

14 1<br />

We also spent £14 million on 57 our information <strong>an</strong>d<br />

influencing work, raising awareness of c<strong>an</strong>cer risks,<br />

providing better information to people affected by<br />

c<strong>an</strong>cer <strong>an</strong>d influencing public health policies. Total<br />

C<strong>an</strong>cer research is a long-term<br />

87 expenditure<br />

investment. This 308<br />

£467m year,<br />

due to the difficult economic climate <strong>an</strong>d <strong>an</strong> overall<br />

308<br />

fall<br />

in voluntary giving to charities in the <strong>UK</strong>, it has been<br />

more import<strong>an</strong>t th<strong>an</strong> ever that we keep a small amount<br />

of funds in reserve. This way, we will be able to continue<br />

our vital work in order to achieve our future goals.<br />

…but small donations add up<br />

Our supporters defied the recession by giving more th<strong>an</strong><br />

ever. Our fundraising income was £446 million – £13 million<br />

more th<strong>an</strong> last year. This me<strong>an</strong>t we were able to commit<br />

more towards our life-saving work to beat c<strong>an</strong>cer.<br />

82<br />

65<br />

25<br />

Total<br />

fundraising<br />

income<br />

£446m<br />

94<br />

23<br />

157<br />

Legacies (People leaving us a gift in their will)<br />

Volunteer fundraising (Community fundraising<br />

– local events <strong>an</strong>d appeals, including Relay For Life)<br />

Direct giving (Regular <strong>an</strong>d one-off donations,<br />

payroll <strong>an</strong>d online products)<br />

Events (National events such as Race for Life,<br />

Run10k <strong>an</strong>d activities for the Booby Moore Fund)<br />

Shop income (Sales from donated goods <strong>an</strong>d our own products)<br />

Other income (Including major gifts, corporate partnerships<br />

<strong>an</strong>d shop donations)<br />

We will spend 80p in every £1 on fighting c<strong>an</strong>cer…<br />

For every pound we receive, excluding our retail chain,<br />

80p is available to spend on our life-saving research,<br />

providing information <strong>an</strong>d influencing public policy.<br />

…<strong>an</strong>d the other 20p works hard too<br />

The money we spend on fundraising activities helps us<br />

to raise more th<strong>an</strong> four times as much – for every £1 we<br />

spend on fundraising, excluding our retail chain, we raise<br />

over £4 more. And we are always looking for ways to<br />

make our fundraising operations more efficient.<br />

£1<br />

80p *<br />

• <strong>Research</strong><br />

• Public-facing information<br />

• Influencing public policy<br />

20p<br />

• Cost of generating funds<br />

(excluding retail)<br />

£1<br />

£1<br />

£1<br />

£1<br />

£1<br />

*<br />

Funds available to spend on our work to beat c<strong>an</strong>cer – 2009/10<br />

Annual Review / How your donation helps us beat c<strong>an</strong>cer / 23


Professor David Neal, 59<br />

Leading expert on prostate c<strong>an</strong>cer<br />

David is based at the Oncology Department of<br />

Addenbrooke’s Hospital, University of Cambridge. He leads<br />

the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> Uro-Oncology Group, which is<br />

looking into prostate c<strong>an</strong>cer screening <strong>an</strong>d other ways to<br />

beat the disease. A particular focus is identifying better ways<br />

of distinguishing aggressive c<strong>an</strong>cers from non-aggressive<br />

ones so treatment c<strong>an</strong> be better targeted.<br />

7.15am<br />

8.00am<br />

8.45am<br />

1.00pm<br />

6.30pm<br />

After cycling to work, I see a patient who has<br />

been admitted for robotic radical prostatectomy<br />

– a very precise way of removing c<strong>an</strong>cerous<br />

prostate gl<strong>an</strong>ds with the aid of a robot.<br />

Chair the urology departmental meeting<br />

to ensure we are doing our best to see people<br />

on time <strong>an</strong>d treat them promptly.<br />

Go to the operating theatre.<br />

Meet with my research group, who are funded<br />

by C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. We are studying<br />

adv<strong>an</strong>ced prostate c<strong>an</strong>cers to determine what<br />

new treatments might work in a disease that<br />

has become resist<strong>an</strong>t to conventional treatments.<br />

Go home <strong>an</strong>d have dinner. My wife <strong>an</strong>d I take<br />

our two dogs for a walk, <strong>an</strong>d I play the guitar<br />

before bed.<br />

£334m<br />

We support people like<br />

David, who is investigating<br />

the PSA test <strong>an</strong>d if it<br />

should form the basis<br />

of a national screening<br />

programme. This year<br />

we spent £334 million on<br />

research activity like this<br />

in hospitals, institutes <strong>an</strong>d<br />

universities across the <strong>UK</strong>.<br />

24 / Annual Review / Contents Meet our Executive Board


Meet our Executive Board<br />

Our supporters put a huge amount of time<br />

<strong>an</strong>d effort into raising money to help beat<br />

c<strong>an</strong>cer. Our Trustees, Executive Board, <strong>an</strong>d<br />

all of our staff work hard to make sure every<br />

penny raised is used as effectively as possible.<br />

The Directors who made up our Executive Board<br />

in 2009/10 were:<br />

1<br />

2 3 4<br />

1/ Harpal Kumar MA MEng MBA<br />

Chief Executive Officer <strong>an</strong>d Chairm<strong>an</strong> of the Executive Board<br />

Harpal leads C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> in our fight to beat c<strong>an</strong>cer.<br />

He chairs our Executive Board <strong>an</strong>d Scientific Executive<br />

Board <strong>an</strong>d leads m<strong>an</strong>y of our key programes <strong>an</strong>d initiatives.<br />

He co-chairs the National Awareness <strong>an</strong>d Early Diagnosis<br />

Initiative <strong>an</strong>d is a Board Member of the National C<strong>an</strong>cer<br />

<strong>Research</strong> Institute committees. He is also Deputy Chair<br />

of the Advisory Board for the C<strong>an</strong>cer Reform Strategy.<br />

2/ Aisling Burn<strong>an</strong>d MBE<br />

Executive Director, Policy <strong>an</strong>d Public Affairs<br />

Aisling is responsible for keeping c<strong>an</strong>cer on the political agenda<br />

across the <strong>UK</strong> <strong>an</strong>d in Europe. This includes developing our<br />

policies on c<strong>an</strong>cer, science <strong>an</strong>d other charity issues, <strong>an</strong>d working<br />

with our supporters to influence politici<strong>an</strong>s <strong>an</strong>d civil serv<strong>an</strong>ts.<br />

3/ Dr Lili<strong>an</strong> Clark PhD MBA<br />

Executive Director, Science Operations <strong>an</strong>d Funding<br />

Lili<strong>an</strong> is responsible for the funding <strong>an</strong>d administration of much<br />

of the research we support. She ensures that the research<br />

we fund is of the highest quality, <strong>an</strong>d aligned to our vision.<br />

4/ Dr Iain Foulkes PhD<br />

Executive Director, Strategy <strong>an</strong>d Pl<strong>an</strong>ning<br />

Iain helps shape C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s long-term strategic<br />

direction. He makes sure that, by having a clear <strong>an</strong>d effective<br />

strategy, we are in a position to meet our ambitious goals.<br />

5/ Professor Peter Johnson MA MD FRCP<br />

Chief Clinici<strong>an</strong><br />

Peter is responsible for our clinical activities – our clinical<br />

research, the gathering of clinical input to guide our policy<br />

<strong>an</strong>d much of our work on c<strong>an</strong>cer prevention, diagnosis <strong>an</strong>d<br />

treatment. He helps us to decide what direction we take in<br />

these areas <strong>an</strong>d makes sure we have the pl<strong>an</strong>s in place to carry<br />

out this work.<br />

6/ Professor Sir David L<strong>an</strong>e FRS FRSE<br />

Chief Scientist<br />

David is a leading c<strong>an</strong>cer research scientist, currently based<br />

in Singapore. He is responsible for helping to develop our<br />

scientific strategy ensuring that it is leading-edge <strong>an</strong>d<br />

monitoring its implementation. He also plays a key role<br />

in attracting the top scientists to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>.<br />

5 6 7 8<br />

9 10 11<br />

7/ Sarah Lyness MA<br />

Executive Director, Communications <strong>an</strong>d Information<br />

Sarah has helped make C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> a well-known<br />

name in the <strong>UK</strong>. She is responsible for informing people<br />

about c<strong>an</strong>cer <strong>an</strong>d the work we do to fight it.<br />

8/ Lynne Robb BSc ACA<br />

Chief Fin<strong>an</strong>cial Officer <strong>an</strong>d Executive Director,<br />

Corporate Resources<br />

Lynne’s role covers a wide r<strong>an</strong>ge of areas, including our<br />

fin<strong>an</strong>ces, our investments <strong>an</strong>d our legal position. She’s also<br />

responsible for our facilities <strong>an</strong>d for making sure we m<strong>an</strong>age<br />

the Charity in the most cost-effective way.<br />

9/ Elizabeth Sideris BA MSc<br />

Executive Director, Hum<strong>an</strong> Resources<br />

Elizabeth is responsible for C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s people.<br />

She supports our staff, making sure they’re always developing,<br />

<strong>an</strong>d looks for ways to make C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> <strong>an</strong> enjoyable<br />

<strong>an</strong>d rewarding place to work.<br />

10/ Dr Peter Sneddon PhD BSc DPhil(Oxon)<br />

Executive Director, Clinical <strong>an</strong>d Tr<strong>an</strong>slational<br />

Operations <strong>an</strong>d Funding<br />

Peter is responsible for the operation <strong>an</strong>d funding of clinical<br />

<strong>an</strong>d tr<strong>an</strong>slational research, which includes our vital clinical trials<br />

portfolio, our C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> Centres <strong>an</strong>d our drug<br />

discovery <strong>an</strong>d development work.<br />

11/ Richard C Taylor<br />

Executive Director, Fundraising <strong>an</strong>d Supporter Marketing<br />

Richard oversees our fundraising. He makes sure we have<br />

enough money coming in to fund our long-term goals. He leads<br />

a team to develop our five-year fundraising strategy <strong>an</strong>d ensures<br />

that our fundraising is as effective <strong>an</strong>d efficient as possible.<br />

For more information on our Executive Board visit<br />

www.c<strong>an</strong>cerresearchuk.org/executiveboard<br />

Annual Review / Meet our Executive Board / 25


Const<strong>an</strong>ce Hoey, 55<br />

Race for Life particip<strong>an</strong>t <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />

Const<strong>an</strong>ce discovered a lump under her right armpit<br />

while she was on holiday in May 2008. She underwent<br />

six months of chemotherapy <strong>an</strong>d surgery to remove both<br />

breasts <strong>an</strong>d 25 lymph nodes from each armpit, as well<br />

as radiotherapy. She was treated with Herceptin <strong>an</strong>d<br />

Arimidex, <strong>an</strong>d is now on Tamoxifen – all drugs that<br />

our research helped to develop. Now back at work<br />

as <strong>an</strong> administrative assist<strong>an</strong>t, Const<strong>an</strong>ce took part<br />

in the Birmingham Race for Life earlier this year.<br />

6.00am Wake up <strong>an</strong>d do 15 minutes of exercise. Then<br />

leave for work. I’ll have a light breakfast <strong>an</strong>d take<br />

my tablets when I get there.<br />

12.00pm I like to go for a walk at lunchtime.<br />

2.00pm Finish work. I’m not ready for full-time work yet.<br />

But I’m getting better <strong>an</strong>d stronger all the time.<br />

I might pop to the shops, prepare tea or potter<br />

in the garden.<br />

6.30pm Dinner with my husb<strong>an</strong>d Martin – he’s been<br />

a tower of strength. Afterwards we watch<br />

TV or a film together.<br />

10.00pm Try a little more exercise before going to bed.<br />

£41.4m<br />

This year we spent<br />

£41.4 million on life-saving<br />

breast c<strong>an</strong>cer research.<br />

Our work covers all<br />

aspects of the disease,<br />

from its molecular causes<br />

through to developing new<br />

drugs <strong>an</strong>d the psychological<br />

effects of treatment.<br />

26 / Annual Review / Contents Get involved <strong>an</strong>d find out more


Get involved <strong>an</strong>d find out more<br />

How you c<strong>an</strong> help<br />

Do your own fundraising or join a group<br />

Org<strong>an</strong>ise a quiz, a sweepstake, a party – whatever<br />

you enjoy doing, use it to raise funds to fight c<strong>an</strong>cer.<br />

If you don’t w<strong>an</strong>t to fundraise alone, join a group,<br />

or why not start your own? Find out more at<br />

supportus.c<strong>an</strong>cerresearchuk.org/fundraising<br />

Take part in <strong>an</strong> event<br />

Whether you w<strong>an</strong>t to walk, run, cycle or swim, we have <strong>an</strong><br />

event to suit you <strong>an</strong>d to help us beat c<strong>an</strong>cer. Get involved at<br />

supportus.c<strong>an</strong>cerresearchuk.org/events<br />

Give your time<br />

If you have the time, we have the volunteering opportunity –<br />

from helping out in a shop or at <strong>an</strong> event, to raising awareness<br />

about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> in your community. Find out more at<br />

supportus.c<strong>an</strong>cerresearchuk.org/volunteering<br />

Become a corporate partner<br />

Take part in staff fundraising, health promotion or commercial<br />

marketing partnerships <strong>an</strong>d we will support you every step<br />

of the way. For more information visit<br />

c<strong>an</strong>cerresearchuk.org/corporatepartnerships<br />

Visit our shops<br />

Donate your unw<strong>an</strong>ted items, or come in for a browse<br />

<strong>an</strong>d a bargain. You c<strong>an</strong> also shop from your sofa at<br />

www.shoptobeatc<strong>an</strong>cer.org.uk<br />

Make a donation – leave a lasting legacy<br />

Give monthly by direct debit or through payroll giving.<br />

Give in memory of a loved one or leave a life-saving legacy<br />

by remembering us in your will. However big or small,<br />

your donation will help us beat c<strong>an</strong>cer.<br />

www.c<strong>an</strong>cerresearchuk.org/donate<br />

It’s research that saved my life. There’s every ch<strong>an</strong>ce that<br />

someone you know will benefit directly from the money you<br />

give to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>.<br />

Const<strong>an</strong>ce Hoey<br />

Breast c<strong>an</strong>cer survivor<br />

Information about c<strong>an</strong>cer – prevention, treatment <strong>an</strong>d care<br />

Get reliable information about c<strong>an</strong>cer<br />

If you’re looking for information about c<strong>an</strong>cer that’s up to<br />

date <strong>an</strong>d easy to underst<strong>an</strong>d, visit our C<strong>an</strong>cerHelp <strong>UK</strong> website.<br />

You c<strong>an</strong> find out about c<strong>an</strong>cer trials <strong>an</strong>d research here too.<br />

www.c<strong>an</strong>cerhelp.org.uk<br />

Speak to a specialist c<strong>an</strong>cer nurse<br />

We have a team of specialist c<strong>an</strong>cer nurses who c<strong>an</strong> <strong>an</strong>swer<br />

your questions in confidence.<br />

Call free on 0808 800 4040, Monday to Friday, 9am to 5pm.<br />

Or email using the contact form at<br />

www.c<strong>an</strong>cerhelp.org.uk<br />

Talk to others affected by c<strong>an</strong>cer<br />

Our online discussion forum C<strong>an</strong>cer Chat is your space to talk<br />

to other people affected by c<strong>an</strong>cer, share experiences <strong>an</strong>d find<br />

information at<br />

www.c<strong>an</strong>cerchat.org.uk<br />

More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

Visit our website<br />

For everything there is to know about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>,<br />

the work we do, <strong>an</strong>d how you c<strong>an</strong> support us, visit<br />

www.c<strong>an</strong>cerresearchuk.org<br />

Join our Facebook page<br />

Meet other C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> supporters, give messages<br />

of support, post details of events <strong>an</strong>d share fundraising ideas<br />

www.facebook.com/c<strong>an</strong>cerresearchuk<br />

Ask us questions or tell us what you think<br />

If you have a question or a comment about our work,<br />

we’d love to hear from you.<br />

Call our Supporter Services team on 020 7121 6699<br />

or send us a message through our website.<br />

www.c<strong>an</strong>cerresearchuk.org/aboutus/contactus<br />

Donate to a project<br />

Choose the type of c<strong>an</strong>cer you w<strong>an</strong>t to beat <strong>an</strong>d donate<br />

to a specific project. Your reasons, your choice.<br />

Find out more at<br />

myprojects.c<strong>an</strong>cerresearchuk.org<br />

Campaign with us<br />

Help us keep c<strong>an</strong>cer at the top of the public agenda.<br />

Our supporters have successfully campaigned on issues<br />

from smokefree workplaces to improved c<strong>an</strong>cer screening<br />

programmes. Get involved at<br />

www.c<strong>an</strong>cercampaigns.org.uk<br />

Annual Review / Get involved <strong>an</strong>d find out more / 27


Th<strong>an</strong>k you<br />

We would like to th<strong>an</strong>k everyone who<br />

has helped C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> over the<br />

past year by investing their money, time<br />

<strong>an</strong>d skills to make our work possible.<br />

In particular we would like to th<strong>an</strong>k all the<br />

people that help us in our research by<br />

taking part in our clinical trials <strong>an</strong>d helping<br />

in our population studies. Their support<br />

has made a huge difference.<br />

We would also like to th<strong>an</strong>k the<br />

following org<strong>an</strong>isations <strong>an</strong>d individuals,<br />

including those who have chosen to<br />

remain <strong>an</strong>onymous – we are immensely<br />

grateful to everyone.<br />

Our Patron<br />

Her Majesty The Queen<br />

Our Joint Presidents<br />

HRH The Duke of Gloucester, KG, GCVO<br />

HRH Princess Alex<strong>an</strong>dra<br />

the Hon. Lady Ogilvy, KG, GCVO<br />

Our corporate partners<br />

AT&T<br />

Beiersdorf <strong>UK</strong> Ltd<br />

British Airways plc<br />

Cheltenham Racecourse<br />

Compass Group <strong>UK</strong> <strong>an</strong>d Irel<strong>an</strong>d Ltd<br />

Deloitte LLP<br />

Diamond Insur<strong>an</strong>ce<br />

docrafts®<br />

FlyBe Ltd<br />

The Football Association<br />

Hearst Digital<br />

HSBC B<strong>an</strong>k plc<br />

ICAP<br />

J Sainsbury plc<br />

JT Ellis & Co Ltd<br />

Ladbrokes in the Community<br />

Charitable Trust<br />

Live Nation (Music) <strong>UK</strong> Ltd<br />

Lloyds B<strong>an</strong>king Group plc<br />

The London Marriott Business Council<br />

Mackays Stores Ltd<br />

Molton Brown Ltd<br />

Network Rail Infrastructure Ltd<br />

The Pampered Chef Ltd<br />

Peacocks Stores Ltd<br />

Premier Foods plc<br />

The Royal B<strong>an</strong>k of Scotl<strong>an</strong>d Group plc<br />

Sony Music Entertainment <strong>UK</strong> Ltd<br />

Sportsdirect.com Retail Ltd<br />

The Stobart Group<br />

Tesco plc<br />

TK Maxx <strong>an</strong>d HomeSense<br />

Towergate Charitable Foundation<br />

Toyota Motor M<strong>an</strong>ufacturing (<strong>UK</strong>) Ltd<br />

<strong>UK</strong> Mail Group plc<br />

Wembley National Stadium<br />

West Ham United<br />

Wm Morrison Supermarkets plc<br />

Our major supporters<br />

Milly Apthorp Charitable Trust<br />

Celia Atkin<br />

Awareness<br />

James Baldwin Trust<br />

Mr Seve Ballesteros<br />

The B<strong>an</strong>d Trust<br />

The Barbour Trust<br />

Mark <strong>an</strong>d Rebecca Baron<br />

Dr Christopher Beels<br />

Robert <strong>an</strong>d Alison Bernays<br />

Tony Bramall Charitable Trust<br />

Bill Butlin Charity Trust<br />

David <strong>an</strong>d Jennifer Buxton<br />

Edward Cadbury Charitable Trust<br />

Bill C<strong>an</strong>non<br />

Catherine Cookson Charitable Trust<br />

Mr Keith C Cornwell<br />

Mr Lawrence Dallaglio OBE<br />

The D<strong>an</strong>ego Charitable Trust<br />

Dr Naim D<strong>an</strong>goor OBE<br />

DG Charitable Trust<br />

Mr & Mrs Martin Dawe<br />

Mr Cyril Dennis MBE<br />

Clive <strong>an</strong>d Greta Dorey<br />

Collette Dove<br />

Mr Sydney Draper<br />

Mr David Dutton<br />

The Alice Edwards Charitable<br />

Foundation<br />

Team Engl<strong>an</strong>d Footballers’ Charity<br />

Eveson Charitable Trust<br />

Doris Field Charitable Trust<br />

Donald Forrester Trust<br />

The Freemasons’ Gr<strong>an</strong>d Charity<br />

Friends Provident Foundation<br />

Mr Jonath<strong>an</strong> Goldstein<br />

Mike Gooley Trailfinders Charity<br />

Sir Donald Gordon<br />

JWC H<strong>an</strong>ds Charitable Trust<br />

Harhil Charitable Trust<br />

Mr Bob Harris<br />

Ada Hillard Charitable Trust<br />

The Marie Keating Foundation<br />

Mr Ron<strong>an</strong> Keating<br />

Robert <strong>an</strong>d Anna King<br />

The Jimmy Knapp C<strong>an</strong>cer Fund<br />

Mr Stephen Knott<br />

Kirby Laing Foundation<br />

Laing O’Rourke Plc<br />

Kathleen Laurence Charitable Trust<br />

Richard Lawes Foundation<br />

Mr Bri<strong>an</strong> Lay<br />

Leonora Children’s C<strong>an</strong>cer Fund<br />

Miss E M Lidbury Charitable Trust<br />

The Lipsaira Foundation<br />

Dr Iain MacKellar BVSc MRCVS<br />

The Mayfair Committee<br />

The McGrath Charitable Trust<br />

Fiona McHugh <strong>an</strong>d Gertie McHugh,<br />

B. & M. McHugh Limited<br />

Debs McLe<strong>an</strong><br />

Barbara McLell<strong>an</strong><br />

Laurence Misener Charitable Trust<br />

Steph<strong>an</strong>ie Moore OBE<br />

The Musgrave Charitable Trust Ltd<br />

The Myristica Trust<br />

The North Sea Flight 85N<br />

Memorial Fund<br />

Oak Foundation<br />

Parthenon Trust<br />

Peacock Trust<br />

Plaw Hatch Hall Trust<br />

Lee <strong>an</strong>d Caroline Portnoi<br />

Mr Glenn Poulter<br />

Nigel <strong>an</strong>d Sus<strong>an</strong> Pritchard<br />

Juliette Proudlove Memorial Fund<br />

R<strong>an</strong>worth Trust<br />

Gerald Ronson Foundation<br />

Mr Justin Rose<br />

Mrs Sue Scott<br />

Mr Nigel Seabold<br />

ShareGift<br />

The Gill Gurdit Singh Fund<br />

Phillip <strong>an</strong>d Vivien Sober<br />

Mrs John Somers<br />

Peter <strong>an</strong>d Beryl Stevens<br />

Rhoddy <strong>an</strong>d Georgina Swire<br />

Mr John Thomson<br />

Timp<strong>an</strong>y Charitable Trust<br />

The Toby Charitable Trust<br />

Mr <strong>an</strong>d Mrs Robin Tomkins<br />

John <strong>an</strong>d Ann-Margaret Walton<br />

Garfield Weston Foundation<br />

Pamela Williams Charitable Trust<br />

Foster Wood Foundation<br />

Mrs Humphrey Wood MBE<br />

Mr Thomas Wood<br />

Lennox <strong>an</strong>d Wyfold Foundation<br />

Yelsel Trust<br />

Zochonis Charitable Trust<br />

Our Trustees<br />

David Newbigging OBE Chairm<strong>an</strong><br />

Dr Mel<strong>an</strong>ie G Lee CBE BSc DSc(Hon)<br />

FMedSci Deputy Chairm<strong>an</strong><br />

Professor Anton Berns PhD<br />

(appointed 30 March 2010)<br />

Professor Colin C Bird CBE FRSE<br />

Dr Philip H M Campbell BSc MSc PhD<br />

DSc FInstP FRAS<br />

Sir James Crosby BA FFA<br />

Liz A Hewitt FCA BSc(Econ) FRSA<br />

Roger Matthews ACA BSocSci<br />

Dame Bridget Ogilvie AC DBE FRS<br />

Dr Keith F Palmer OBE Treasurer<br />

Michael Pragnell MA(Oxon)<br />

MBA(INSEAD)<br />

(appointed 30 March 2010)<br />

Leah J Sowden FCA CTA DChA<br />

Professor Jeffrey Tobias MD<br />

FRCP FRCR<br />

Professor Sir Kenneth Calm<strong>an</strong> KCB DL<br />

FRSE (retired 31 December 2009)<br />

28 / Annual Review / Th<strong>an</strong>k you


More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

For everything there is to know about<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> visit<br />

www.c<strong>an</strong>cerresearchuk.org<br />

We are committed to a series of social <strong>an</strong>d<br />

environmental goals. You c<strong>an</strong> find out more<br />

about these at<br />

aboutus.c<strong>an</strong>cerresearchuk.org/sustainability<br />

A great deal of c<strong>an</strong>cer research is carried out without<br />

using <strong>an</strong>imals, but in certain areas <strong>an</strong>imal research remains<br />

essential if we are to underst<strong>an</strong>d, prevent <strong>an</strong>d cure c<strong>an</strong>cer.<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> only uses <strong>an</strong>imals when there<br />

is no alternative.<br />

C<strong>an</strong>cer patients <strong>an</strong>d their families are at the heart of<br />

everything we do. We believe that all our research is vital<br />

if we are to save the lives of more patients in the future.<br />

C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> is a member of the Association of<br />

Medical <strong>Research</strong> Charities <strong>an</strong>d endorses the AMRC's<br />

position on the use of <strong>an</strong>imals in medical research.<br />

A PDF of both our Annual Review <strong>an</strong>d Annual Report<br />

<strong>an</strong>d Accounts c<strong>an</strong> be downloaded at<br />

aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />

Registered charity number in Engl<strong>an</strong>d <strong>an</strong>d Wales 1089464<br />

Registered charity number in Scotl<strong>an</strong>d SC041666<br />

Registered comp<strong>an</strong>y number 4325234<br />

Copyright © 2010 C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

Design: NB Studio<br />

Photography: Spike Watson<br />

Printed on 9 Lives Offset 100% recycled paper with<br />

environmentally credible printing technology <strong>an</strong>d using<br />

inks made from vegetable based oils. Printer is carbon<br />

neutral <strong>an</strong>d ISO14001 <strong>an</strong>d EMAS registered.


C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />

Registered address:<br />

61 Lincoln’s Inn Fields<br />

London WC2A 3PX<br />

T +44(0)20 7242 0200<br />

www.c<strong>an</strong>cerresearchuk.org<br />

LF013

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!