Making an impact - Cancer Research UK
Making an impact - Cancer Research UK
Making an impact - Cancer Research UK
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<strong>Making</strong><br />
<strong>an</strong> <strong>impact</strong><br />
Annual Review 2009/10
C<strong>an</strong>cer patients <strong>an</strong>d their families<br />
are at the heart of everything we do.<br />
We have saved millions of lives with<br />
our groundbreaking work preventing,<br />
diagnosing <strong>an</strong>d treating c<strong>an</strong>cer.<br />
Our research is vital if we are<br />
to save more lives in the future.<br />
Harpal S Kumar<br />
Chief Executive Officer, C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />
Contents<br />
01 Welcome to our review of the year<br />
02 About us<br />
<strong>Research</strong><br />
<strong>Research</strong> is our primary focus. We work in partnership<br />
with others to achieve the greatest <strong>impact</strong> in the global<br />
fight against c<strong>an</strong>cer.<br />
05 <strong>Making</strong> your support count – a year of progress<br />
07 Leading the way in radiotherapy<br />
08 Looking to tomorrow<br />
Information<br />
We provide life-ch<strong>an</strong>ging information to <strong>an</strong>yone affected<br />
by c<strong>an</strong>cer <strong>an</strong>d run awareness-raising initiatives so that<br />
c<strong>an</strong>cer c<strong>an</strong> be detected as early as possible <strong>an</strong>d to help<br />
people reduce their risk of the disease.<br />
10 Raising awareness <strong>an</strong>d saving lives<br />
Influencing public policy<br />
Our campaigning <strong>an</strong>d work to influence government<br />
policy keeps c<strong>an</strong>cer at the top of the political agenda.<br />
13 Campaigning for ch<strong>an</strong>ge<br />
Bringing our work together to save lives<br />
14 Diagnosing c<strong>an</strong>cer early<br />
16 Driving world-class c<strong>an</strong>cer research<br />
18 Our people<br />
20 Raising money to support our work<br />
22 How your donation helps us beat c<strong>an</strong>cer<br />
25 Meet our Executive Board<br />
27 Get involved <strong>an</strong>d find out more<br />
28 Th<strong>an</strong>k you<br />
29 More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />
For more information about us <strong>an</strong>d our work visit<br />
aboutus.c<strong>an</strong>cerresearchuk.org/what-we-do<br />
We would like to say th<strong>an</strong>k you to all those who feature within<br />
this Annual Review.<br />
Cover: Anna Robinson, seven, was diagnosed with acute lymphoblastic<br />
leukaemia in J<strong>an</strong>uary 2006 after her mum took her to the doctors<br />
suffering with pains in her legs, appetite loss, exhaustion <strong>an</strong>d a high<br />
temperature. She was treated until 2008 at the Royal Victoria Infirmary<br />
in Newcastle <strong>an</strong>d is now doing well. Anna officially started<br />
the Middlesbrough Race for Life events in 2007 <strong>an</strong>d 2008.
Welcome to our review<br />
of the year<br />
Life-saving information<br />
Accurate <strong>an</strong>d straightforward information about c<strong>an</strong>cer helps<br />
people to recognise signs <strong>an</strong>d symptoms, encourages them to<br />
visit their GP as soon as possible, <strong>an</strong>d provides them with<br />
better underst<strong>an</strong>ding if they are going through a c<strong>an</strong>cer journey.<br />
Last year, more th<strong>an</strong> 37,000 people visited our C<strong>an</strong>cer<br />
Awareness Roadshow, which toured the <strong>UK</strong> offering<br />
information about c<strong>an</strong>cer <strong>an</strong>d how to prevent it. And our<br />
award-winning patient information website, C<strong>an</strong>cerHelp <strong>UK</strong>,<br />
regularly received over one million visits per month.<br />
It has been <strong>an</strong>other very successful year<br />
for C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>, with a number of<br />
achievements <strong>an</strong>d promising scientific progress.<br />
Th<strong>an</strong>ks to adv<strong>an</strong>ces in our underst<strong>an</strong>ding<br />
of c<strong>an</strong>cer, more new treatments are being<br />
developed at a faster pace th<strong>an</strong> ever before.<br />
We would like to th<strong>an</strong>k everyone who has helped make this<br />
possible. Our work is funded entirely by the public. All of our<br />
progress depends on the generosity of our supporters, the<br />
efforts of our fundraisers <strong>an</strong>d volunteers <strong>an</strong>d the dedication<br />
of our partners.<br />
World-class research<br />
More people are surviving c<strong>an</strong>cer th<strong>an</strong> ever before. People<br />
diagnosed with c<strong>an</strong>cer are now twice as likely to survive for at<br />
least ten years as those diagnosed in the early 1970s. Our work<br />
has been at the heart of this progress.<br />
In April we were delighted to report a major research<br />
breakthrough – a term we rarely use. A 16-year study that<br />
we helped fund showed that a one-off five-minute screening<br />
test could cut the risk of developing bowel c<strong>an</strong>cer by a third.<br />
The study also found that the test could reduce the number<br />
of deaths by 43%. Bowel c<strong>an</strong>cer is currently the <strong>UK</strong>’s second<br />
biggest c<strong>an</strong>cer killer.<br />
Thous<strong>an</strong>ds of c<strong>an</strong>cer deaths could be avoided each year if<br />
c<strong>an</strong>cer was diagnosed earlier. This year, we launched the<br />
research arm of the National Awareness <strong>an</strong>d Early Diagnosis<br />
Initiative (NAEDI), which will inform our early diagnosis work<br />
to ensure as m<strong>an</strong>y people as possible survive c<strong>an</strong>cer.<br />
New laws to protect our health<br />
Th<strong>an</strong>ks to our research <strong>an</strong>d campaigning, tobacco displays in<br />
shops <strong>an</strong>d cigarette vending machines will be removed from<br />
2011 onwards across the <strong>UK</strong> <strong>an</strong>d it will be illegal for under-18s<br />
to use sunbeds in Engl<strong>an</strong>d <strong>an</strong>d Wales. In 2010, we made sure<br />
c<strong>an</strong>cer was high on the agenda at the General Election,<br />
<strong>an</strong>d we are working with the new government to ensure<br />
that c<strong>an</strong>cer remains a priority.<br />
Working towards our vision<br />
Our five-year strategy <strong>an</strong>d ambitious goals continue to guide<br />
our work <strong>an</strong>d aspirations for the future. We have made some<br />
real progress this year. More treatments now exist with fewer<br />
side effects, the number of smokers is down <strong>an</strong>d more people<br />
are aware of the lifestyle factors that c<strong>an</strong> cause c<strong>an</strong>cer. For<br />
more information see our Annual Report <strong>an</strong>d Accounts at<br />
aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />
We continue to need your support<br />
Nine out of ten donations to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> are £10 or<br />
less. But big or small, we make sure they are used in the best<br />
possible way.<br />
We ensure that every penny possible is spent on research.<br />
Last year, for every pound that we received, excluding our retail<br />
chain, over 80 pence was available to spend on our work to<br />
beat c<strong>an</strong>cer. Despite the difficult fin<strong>an</strong>cial backdrop, we raised a<br />
record £446 million, th<strong>an</strong>ks to our generous supporters. But we<br />
receive no government funding for our research <strong>an</strong>d we have<br />
no endowment, me<strong>an</strong>ing that we have a continual need to raise<br />
funds if we are to make further progress through our<br />
life-saving work.<br />
We are proud of our achievements <strong>an</strong>d grateful to everyone<br />
who donated to our shops, took part in events or volunteered<br />
their time <strong>an</strong>d skills to us. There continue to be huge challenges<br />
ahead but, with your help, together we will beat c<strong>an</strong>cer.<br />
In 2009 a record number of patients took part in our clinical<br />
trials which help to develop new treatments <strong>an</strong>d set new<br />
st<strong>an</strong>dards of clinical practice.<br />
We continued to recruit <strong>an</strong>d retain the best scientists <strong>an</strong>d the<br />
quality of our research remains world-class, as measured by<br />
<strong>an</strong>other excellent year for honours with 50 of our scientists<br />
receiving 28 different awards.<br />
David Newbigging<br />
Chairm<strong>an</strong><br />
27 July 2010<br />
Harpal S Kumar<br />
Chief Executive Officer<br />
27 July 2010<br />
Annual Review / Welcome to our review of the year / 01
About us<br />
Every two minutes someone in the <strong>UK</strong> hears<br />
the words ‘it’s c<strong>an</strong>cer’. This devastating disease<br />
affects millions of lives every year worldwide<br />
<strong>an</strong>d we are here to make sure as m<strong>an</strong>y people<br />
as possible survive.<br />
Why are we here?<br />
We believe that research is the key to beating c<strong>an</strong>cer.<br />
Our work is entirely funded by the public – th<strong>an</strong>ks to their<br />
generosity <strong>an</strong>d support, our researchers lead the world in<br />
discovering new ways to prevent, diagnose <strong>an</strong>d treat c<strong>an</strong>cer.<br />
The ch<strong>an</strong>ces of surviving c<strong>an</strong>cer have doubled in the last<br />
40 years. More people are enjoying things they thought they<br />
might not live to see, <strong>an</strong>d we have been central to that<br />
progress. But for every person who survives c<strong>an</strong>cer, <strong>an</strong>other<br />
does not.<br />
We have made a huge number of import<strong>an</strong>t discoveries which<br />
have ch<strong>an</strong>ged the way c<strong>an</strong>cer is prevented, diagnosed <strong>an</strong>d<br />
treated. Yet our work remains essential because more th<strong>an</strong><br />
one in three of us will get c<strong>an</strong>cer at some point in our lives.<br />
What do we do?<br />
Our aim is simple: we w<strong>an</strong>t to save lives by reducing the<br />
number of people who get c<strong>an</strong>cer <strong>an</strong>d helping more to survive<br />
the disease. But because a breakthrough c<strong>an</strong> take decades<br />
of research, it’s a complex challenge.<br />
There are over 200 types of c<strong>an</strong>cer which all involve the<br />
uncontrolled, abnormal growth of some of the body’s cells.<br />
We work to underst<strong>an</strong>d how c<strong>an</strong>cers develop <strong>an</strong>d spread, <strong>an</strong>d<br />
design strategies to combat this. We are the only <strong>UK</strong> charity<br />
dedicated to beating all types of c<strong>an</strong>cer.<br />
We research ways of preventing c<strong>an</strong>cer <strong>an</strong>d detecting it early,<br />
when it c<strong>an</strong> usually be treated more successfully. Our work<br />
has already underpinned national screening programmes for<br />
breast, bowel <strong>an</strong>d cervical c<strong>an</strong>cer which are saving thous<strong>an</strong>ds<br />
of lives every year.<br />
We also raise awareness about c<strong>an</strong>cer, providing information<br />
about prevention, symptoms, treatment <strong>an</strong>d coping with the<br />
disease. And we campaign for new policies to ensure diagnosis<br />
is swift <strong>an</strong>d the best treatment <strong>an</strong>d care are available for all<br />
c<strong>an</strong>cer patients across the <strong>UK</strong>.<br />
<strong>Research</strong><br />
The breadth of our research is unparalleled – we fund the<br />
work of over 4,000 scientists, doctors <strong>an</strong>d nurses around the<br />
<strong>UK</strong>. We play a vital role in supporting around 200 clinical trials<br />
aimed at improving c<strong>an</strong>cer treatment <strong>an</strong>d testing exciting new<br />
radiotherapy techniques <strong>an</strong>d drugs.<br />
By funding all types of research – based in labs <strong>an</strong>d clinical<br />
departments in hospitals <strong>an</strong>d universities around the <strong>UK</strong><br />
– we build productive working relationships between scientists,<br />
c<strong>an</strong>cer doctors <strong>an</strong>d nurses. Our work <strong>an</strong>d expertise ensure<br />
that discoveries made on the laboratory bench are<br />
tr<strong>an</strong>sformed into pioneering, life-saving treatments.<br />
Th<strong>an</strong>ks to our research, around eight new c<strong>an</strong>cer drugs<br />
are tested in clinical trials every year for the first time.<br />
Information<br />
Every year we help millions of people find the information they<br />
need to prevent, underst<strong>an</strong>d <strong>an</strong>d cope with c<strong>an</strong>cer.<br />
We help people recognise c<strong>an</strong>cer symptoms <strong>an</strong>d encourage<br />
them to go to their GP promptly. We also offer information<br />
about the import<strong>an</strong>ce <strong>an</strong>d benefits of screening. We provide<br />
websites <strong>an</strong>d publications <strong>an</strong>d run health awareness campaigns<br />
aimed at health professionals <strong>an</strong>d the public which highlight the<br />
steps people c<strong>an</strong> take to help reduce their risk of c<strong>an</strong>cer.<br />
Influencing public policy<br />
We work with politici<strong>an</strong>s, civil serv<strong>an</strong>ts, policy-makers <strong>an</strong>d the<br />
media to ensure that c<strong>an</strong>cer stays at the top of their agenda,<br />
influencing legislation on import<strong>an</strong>t issues relating to c<strong>an</strong>cer.<br />
We petition for better information on screening <strong>an</strong>d rapid<br />
access to the best surgery, treatment <strong>an</strong>d medicines <strong>an</strong>d we<br />
run targeted campaigns for higher risk groups, such as over<br />
75s <strong>an</strong>d disadv<strong>an</strong>taged social groups. Our scientists <strong>an</strong>d<br />
doctors advise the parliaments in Westminster, Scotl<strong>an</strong>d,<br />
Wales <strong>an</strong>d Northern Irel<strong>an</strong>d on health <strong>an</strong>d scientific policy.<br />
Looking to the future<br />
For over 100 years we have worked to beat c<strong>an</strong>cer. We have<br />
helped to tr<strong>an</strong>sform the way c<strong>an</strong>cer is prevented, diagnosed<br />
<strong>an</strong>d treated <strong>an</strong>d our work has helped to save millions of lives,<br />
but we have so much more to do to achieve our vision of<br />
beating c<strong>an</strong>cer.<br />
When I was diagnosed with c<strong>an</strong>cer I thought my life was<br />
finished – now I’m doing well. I’m happy to support C<strong>an</strong>cer<br />
<strong>Research</strong> <strong>UK</strong> because future generations will benefit from<br />
the work that they do.<br />
Jayshree Jhala<br />
Breast c<strong>an</strong>cer survivor<br />
02 / Annual Review / About us
Maggie Harrison, 49<br />
Bowel c<strong>an</strong>cer survivor<br />
Maggie was initially treated for irritable bowel syndrome<br />
before she was diagnosed with bowel c<strong>an</strong>cer in 2006.<br />
She underwent surgery to have the c<strong>an</strong>cer <strong>an</strong>d part of her<br />
bowel removed, followed by six months of chemotherapy.<br />
Three years on, Maggie, from Barrow-in-Furness, is feeling<br />
fitter th<strong>an</strong> ever <strong>an</strong>d keen to spread the message about<br />
early detection.<br />
6.45am<br />
8.00am<br />
9.30am<br />
1.00pm<br />
7.30pm<br />
Get up with my husb<strong>an</strong>d John so we c<strong>an</strong> have<br />
breakfast together. I then exercise for about<br />
<strong>an</strong> hour. I’m in the best shape of my adult life.<br />
Call my mum. She was amazingly supportive<br />
when I was ill – we speak every day.<br />
I volunteer at my local community centre three<br />
mornings a week. We paint, draw, sew <strong>an</strong>d knit,<br />
all things I missed doing during chemotherapy.<br />
Four afternoons a week I work at my local<br />
hospital, inputting data.<br />
Amateur dramatics rehearsal. It gives me<br />
a great buzz.<br />
43%<br />
A 16-year study that we<br />
helped fund showed that a<br />
one-off five-minute<br />
screening test could cut the<br />
risk of developing bowel<br />
c<strong>an</strong>cer by a third, <strong>an</strong>d<br />
reduce deaths from the<br />
disease by 43%, saving<br />
thous<strong>an</strong>ds of lives.<br />
Annual Review / About us / 03
Tyler Strong, 7<br />
Little Star <strong>an</strong>d leukaemia survivor<br />
Tyler was diagnosed with acute lymphoblastic leukaemia<br />
when he was 18 months old. Suffering from appetite loss,<br />
listlessness <strong>an</strong>d infections, he was sent for a bone marrow<br />
test at M<strong>an</strong>chester Children’s Hospital. Once the diagnosis<br />
was confirmed, Tyler was given intense chemotherapy in<br />
two blocks eight weeks apart. He finished his treatment in<br />
March 2008, is now doing well <strong>an</strong>d helped us launch our<br />
new night-time walking marathon, Shine, in M<strong>an</strong>chester.<br />
Tyler was also nominated for our Little Star Award, which<br />
celebrates the courage of children with c<strong>an</strong>cer.<br />
7.45am<br />
9.00am<br />
5.00pm<br />
7.30pm<br />
8.30pm<br />
Breakfast. Then, after vetting his packed lunch<br />
(he’s quite fussy!), Tyler has a quick play. He likes<br />
Lego <strong>an</strong>d drawing on his whiteboard.<br />
School. Because he spent so much time<br />
in hospital away from his friends, it took<br />
Tyler some time to build up confidence,<br />
but he’s come on loads.<br />
Take Tyler to Beavers, which he loves.<br />
Dad picks him up <strong>an</strong>d he runs riot for half<br />
<strong>an</strong> hour before having a shower <strong>an</strong>d putting<br />
his pyjamas on.<br />
Bedtime – <strong>an</strong> hour later th<strong>an</strong> normal<br />
on Beavers day.<br />
£10.3m<br />
We are a major funder<br />
of research into children’s<br />
c<strong>an</strong>cer in the <strong>UK</strong>, <strong>an</strong>d we<br />
have supported m<strong>an</strong>y of the<br />
world’s most successful<br />
trials of treatments for this<br />
varied group of diseases,<br />
benefitting thous<strong>an</strong>ds<br />
of children like Tyler.<br />
04 / Annual Review / <strong>Research</strong>
<strong>Research</strong><br />
<strong>Making</strong> your support count – a year of progress<br />
We are a world leader in c<strong>an</strong>cer research.<br />
Our scientists make cutting-edge discoveries<br />
in the lab that help us underst<strong>an</strong>d more about<br />
c<strong>an</strong>cer every day – such as how it grows <strong>an</strong>d<br />
spreads, <strong>an</strong>d how our genes <strong>an</strong>d lifestyle<br />
choices c<strong>an</strong> increase our risk of developing the<br />
disease. Each of these adv<strong>an</strong>ces is <strong>an</strong>other<br />
step towards beating c<strong>an</strong>cer.<br />
We are const<strong>an</strong>tly searching for more effective treatments that<br />
accurately target c<strong>an</strong>cer <strong>an</strong>d have fewer side effects for patients.<br />
Our scientists <strong>an</strong>d doctors have contributed to most of the top<br />
drugs used to treat patients worldwide today. Th<strong>an</strong>ks to our<br />
leading role in developing treatments, hundreds of thous<strong>an</strong>ds<br />
of people have beaten the disease.<br />
Our researchers share their knowledge with c<strong>an</strong>cer experts<br />
across the world – they work together to fight c<strong>an</strong>cer <strong>an</strong>d save<br />
even more lives. Here are just a few highlights of our progress<br />
this year.<br />
Tackling p<strong>an</strong>creatic c<strong>an</strong>cer<br />
We have come one step closer to tackling p<strong>an</strong>creatic c<strong>an</strong>cer.<br />
Our researchers led <strong>an</strong> international team that discovered why<br />
some patients stop responding to a commonly-used drug called<br />
gemcitabine. They found that p<strong>an</strong>creatic tumour samples have<br />
poor networks of blood vessels, making it harder for the drug<br />
to reach the tumour <strong>an</strong>d treat the c<strong>an</strong>cer effectively.<br />
We’re extremely excited by these results, as they may help<br />
explain the disappointing response of m<strong>an</strong>y people with<br />
p<strong>an</strong>creatic c<strong>an</strong>cer to chemotherapy. Our new method<br />
of delivering chemotherapy to p<strong>an</strong>creatic tumours should<br />
make treatment more effective in the future.<br />
Dr David Tuveson<br />
Cambridge <strong>Research</strong> Institute<br />
Targeted screening for prostate c<strong>an</strong>cer<br />
Our scientists are at the forefront of efforts to identify the<br />
common variations in our genes that influence c<strong>an</strong>cer risk.<br />
Among several import<strong>an</strong>t discoveries this year, researchers in<br />
London <strong>an</strong>d Cambridge identified nine new genetic variations in<br />
the hum<strong>an</strong> genome that c<strong>an</strong> increase a m<strong>an</strong>’s risk of developing<br />
prostate c<strong>an</strong>cer. We hope that this discovery will enable more<br />
targeted screening.<br />
Saving precious time in the fight against ovari<strong>an</strong> c<strong>an</strong>cer<br />
Our research helps doctors choose the right drugs for individual<br />
patients, saving precious time <strong>an</strong>d avoiding unnecessary side<br />
effects. Our scientists discovered a pattern of genetic defects in<br />
tumours that could predict whether ovari<strong>an</strong> c<strong>an</strong>cer patients will<br />
respond to common chemotherapy drugs.<br />
Choosing the right drug for the right patient is crucial.<br />
We hope that a simple test based on our research may one<br />
day save patients from unnecessary treatments <strong>an</strong>d side<br />
effects. This will allow us to target the most effective drugs<br />
to those people who will really benefit.<br />
Dr Charles Sw<strong>an</strong>ton<br />
London <strong>Research</strong> Institute<br />
New hope for acute lymphoblastic leukaemia<br />
Our scientists in M<strong>an</strong>chester have brought hope to the one in<br />
five children with acute lymphoblastic leukaemia (ALL) who<br />
don’t respond to current treatments. They pinpointed a<br />
possible reason why some children become resist<strong>an</strong>t or allergic<br />
to asparaginase, a drug used to treat virtually every child with<br />
ALL in the <strong>UK</strong>. Although there’s still a lot to do, the new results<br />
could me<strong>an</strong> that even more children will be cured in the future.<br />
In the 1960s, only around a quarter of children with<br />
c<strong>an</strong>cer survived. Today, three-quarters survive, <strong>an</strong>d<br />
our work has been at the heart of this huge progress.<br />
Preventing bowel c<strong>an</strong>cer<br />
Could we find new ways to prevent one of the most common<br />
c<strong>an</strong>cers? Our research is bringing us nearer every day. Scientists<br />
in Dundee uncovered fascinating new insights into a gene called<br />
GSTP showing that it protects against bowel c<strong>an</strong>cer. And they<br />
are already investigating how to control it, to help stop the<br />
disease developing in the future.<br />
Improving breast c<strong>an</strong>cer survival<br />
Our scientists used cutting-edge filming techniques to unravel<br />
how single breast c<strong>an</strong>cer cells leave a tumour <strong>an</strong>d start to move<br />
<strong>an</strong>d spread around the body – something that until now has not<br />
been fully understood. This research will help scientists find ways<br />
to stop breast c<strong>an</strong>cer in its tracks <strong>an</strong>d help more people survive.<br />
My breast c<strong>an</strong>cer was caught early. I feel lucky because<br />
it c<strong>an</strong> be more difficult to treat c<strong>an</strong>cer once it has spread.<br />
I think it’s f<strong>an</strong>tastic news that researchers have found out<br />
how breast c<strong>an</strong>cer cells move around the body.<br />
Pamina Brassey<br />
West London<br />
Annual Review / <strong>Research</strong> / 05
120,000<br />
Around 120,000 c<strong>an</strong>cer<br />
patients in the <strong>UK</strong> benefit<br />
from radiotherapy each<br />
year, which is why we are<br />
investing heavily in<br />
research into the most<br />
effective ways to deliver it.<br />
Claire D<strong>an</strong>iels, 24<br />
Hodgkin’s lymphoma survivor<br />
Claire was 19 when she was diagnosed with Hodgkin’s<br />
lymphoma. She was initially treated with chemotherapy at<br />
M<strong>an</strong>chester’s Christie Hospital. But the c<strong>an</strong>cer returned <strong>an</strong>d<br />
Claire had further intense chemotherapy, radiotherapy <strong>an</strong>d<br />
a stem-cell tr<strong>an</strong>spl<strong>an</strong>t. In between treatments, Claire<br />
org<strong>an</strong>ised a student ball <strong>an</strong>d realised she w<strong>an</strong>ted to be <strong>an</strong><br />
event pl<strong>an</strong>ner. Now 24, she’s healthy <strong>an</strong>d works as a Special<br />
Events Executive for us.<br />
6.00am<br />
8.45am<br />
2.00pm<br />
8.00pm<br />
My alarm goes off. Eventually I get up <strong>an</strong>d leave<br />
for the train station in Cambridge at 7am.<br />
Get into work. I’m on the phone a lot, talking to<br />
different supporters <strong>an</strong>d looking for ways to raise<br />
money at our events.<br />
Meeting about our Emeralds & Ivy Ball, which<br />
promotes early diagnosis <strong>an</strong>d raises awareness.<br />
Walk home from the train station, my boyfriend<br />
Steve <strong>an</strong>d I have dinner together <strong>an</strong>d watch<br />
some TV.<br />
11.00pm Bed. I’m normally pretty tired. The commute<br />
isn’t ideal but I’m lucky I c<strong>an</strong> give something back.<br />
606 / / Annual Review / Contents / <strong>Research</strong>
<strong>Research</strong><br />
Leading the way in radiotherapy<br />
W. Gillies McKenna, Director of Gray Institute for Radiation Oncology & Biology<br />
You might be surprised to learn that<br />
radiotherapy, the longest established<br />
treatment for c<strong>an</strong>cer other th<strong>an</strong> surgery,<br />
still helps cure more people th<strong>an</strong> c<strong>an</strong>cer drugs.<br />
Today, radiotherapy is kinder to patients, <strong>an</strong>d<br />
every year, millions of patients benefit from<br />
this cornerstone of c<strong>an</strong>cer treatment.<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> helped establish the first treatment<br />
centres across the country as early as the 1920s, when<br />
radiotherapy research first beg<strong>an</strong> to take shape.<br />
Th<strong>an</strong>ks to the unwavering support of the public since those<br />
early days of research, we’ve continued to make excellent<br />
progress in radiotherapy. It is now used to treat m<strong>an</strong>y c<strong>an</strong>cers<br />
including breast, lung, bowel, brain <strong>an</strong>d prostate. And today,<br />
four in ten people who beat c<strong>an</strong>cer had radiotherapy as part<br />
of their treatment.<br />
As part of our five-year strategy, we aim to make radiotherapy<br />
more effective, targeting tumours more precisely with fewer<br />
<strong>an</strong>d less severe side effects for patients.<br />
I took part in the PARSPORT trial, funded by<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. The idea was to test a more precise<br />
radiotherapy technique for head <strong>an</strong>d neck c<strong>an</strong>cer. The results<br />
were f<strong>an</strong>tastic. I had virtually no side effects – I could eat,<br />
drink <strong>an</strong>d taste perfectly normally. Th<strong>an</strong>ks to the trial, I now<br />
lead a completely normal life again.<br />
David Jenkins<br />
Throat c<strong>an</strong>cer survivor<br />
London<br />
<strong>Making</strong> radiotherapy more effective<br />
In 2007 we launched the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>-MRC<br />
Gray Institute for Radiation Oncology & Biology in Oxford.<br />
Scientists there are making import<strong>an</strong>t adv<strong>an</strong>ces in radiotherapy<br />
research. They discovered that certain drugs c<strong>an</strong> be used to<br />
‘prepare’ tumours for radiotherapy by increasing their blood<br />
supply, which makes them more sensitive to treatment.<br />
In a different approach, <strong>an</strong>other team discovered a gene<br />
that could be blocked to make radiotherapy more effective.<br />
Both of these results from laboratory studies are crucial steps<br />
towards making radiotherapy even more effective for patients.<br />
Reducing side effects<br />
Improving radiotherapy also involves making it more tolerable<br />
for c<strong>an</strong>cer patients. We’re at the forefront of international<br />
efforts to develop a type of radiotherapy that c<strong>an</strong> be tailored<br />
to the size <strong>an</strong>d shape of a tumour. Called Intensity Modulated<br />
Radiotherapy (IMRT), this approach allows doctors to<br />
maximise the dose of radiation to the c<strong>an</strong>cer, while limiting<br />
damage to surrounding healthy tissue. Less damage me<strong>an</strong>s<br />
fewer side effects.<br />
This year, a trial funded by us showed that people with head<br />
<strong>an</strong>d neck c<strong>an</strong>cer given IMRT were much less likely to suffer<br />
from a dry mouth. This is the main side effect of treatment<br />
<strong>an</strong>d it often causes debilitating problems with speech <strong>an</strong>d<br />
eating <strong>an</strong>d also increases the ch<strong>an</strong>ce of ulcers <strong>an</strong>d infections.<br />
This work could soon lead to a ch<strong>an</strong>ge in how all head <strong>an</strong>d<br />
neck c<strong>an</strong>cer patients are treated in the <strong>UK</strong>.<br />
Doctors prescribe radiotherapy treatments in numbers<br />
of ‘Gray’ – the unit measuring how much radiation your<br />
body absorbs. This is named after Hal Gray, <strong>an</strong> early<br />
pioneer in radiotherapy, whose research we funded<br />
from the 1930s to the 1960s <strong>an</strong>d after whom the<br />
Oxford Institute is named.<br />
Less time in hospital, more time at home<br />
We’re helping to fund a pivotal trial, which recently showed<br />
that fewer but higher doses of radiotherapy are just as effective<br />
as st<strong>an</strong>dard radiotherapy for women with breast c<strong>an</strong>cer.<br />
That me<strong>an</strong>s fewer trips to hospital – <strong>an</strong>d more time at home.<br />
Cutting-edge treatments<br />
Our scientists are also exploring ingenious ways to help patients<br />
benefit more from radiotherapy. In M<strong>an</strong>chester, researchers<br />
are using ‘smart’ drugs to tr<strong>an</strong>sport radiotherapy directly<br />
to tumours. Early results in certain types of lymphoma are<br />
encouraging, <strong>an</strong>d we hope this treatment will reach clinics soon.<br />
Radiotherapy for the future<br />
Over the years we’ve made great leaps in underst<strong>an</strong>ding c<strong>an</strong>cer,<br />
<strong>an</strong>d radiotherapy technology has accelerated at <strong>an</strong> astonishing<br />
pace. But new technologies, <strong>an</strong>d better evidence of the way<br />
that radiotherapy <strong>an</strong>d other treatments c<strong>an</strong> be used together,<br />
are placing increased dem<strong>an</strong>ds on services. We need more<br />
radiotherapy machines, <strong>an</strong>d people to operate them, to reduce<br />
waiting times <strong>an</strong>d allow better access to treatment. We know<br />
that new radiotherapy technologies aren’t being rolled out<br />
in the <strong>UK</strong> as fast as they are in the rest of Europe.<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> is asking the government to take steps<br />
to tackle these issues <strong>an</strong>d, with the help of our supporters,<br />
we’ll continue to work hard to ensure that adv<strong>an</strong>ces in<br />
radiotherapy benefit patients <strong>an</strong>d that the <strong>UK</strong> remains<br />
a world leader in this field.<br />
For more information about our work in this area, visit<br />
www.c<strong>an</strong>cerhelp.org.uk/about-c<strong>an</strong>cer/treatment/<br />
radiotherapy<br />
Annual Review / <strong>Research</strong> / 07
<strong>Research</strong><br />
Looking to tomorrow<br />
To achieve our vision of beating c<strong>an</strong>cer,<br />
we c<strong>an</strong>not afford to st<strong>an</strong>d still. Every day<br />
our scientists <strong>an</strong>d doctors are studying all<br />
aspects of c<strong>an</strong>cer, from underst<strong>an</strong>ding the<br />
fine details of cell biology to c<strong>an</strong>cer risk<br />
factors in entire populations.<br />
Here are some of the projects we are currently funding,<br />
highlighting just a few of the m<strong>an</strong>y ways we are investing<br />
in the breakthroughs of tomorrow.<br />
New trial offers hope for children with c<strong>an</strong>cer<br />
Although rare, neuroblastoma is the most common c<strong>an</strong>cer in<br />
children under five besides c<strong>an</strong>cers of the blood. Six in ten<br />
children with neuroblastoma are successfully treated, but<br />
certain forms of the disease still remain difficult to treat.<br />
This year we launched a new international trial for children<br />
with a particularly difficult form of neuroblastoma, so we<br />
c<strong>an</strong> learn more about how to tackle the disease.<br />
Our doctors hope to save the lives of more children in the<br />
<strong>UK</strong> by using cutting-edge ‘immunotherapy’ – a treatment that<br />
boosts the immune system to help fight c<strong>an</strong>cer.<br />
Developing innovative ways to see c<strong>an</strong>cer inside the body<br />
Finding ways to see c<strong>an</strong>cer inside the body is vital for detecting<br />
the disease early – <strong>an</strong>d at a stage when treatment is more<br />
likely to be successful. Also, we need ways to rapidly monitor<br />
whether therapy is working, so we c<strong>an</strong> ensure people are<br />
getting the right treatment.<br />
Our scientists are developing techniques to see if c<strong>an</strong>cer<br />
treatments such as chemotherapy <strong>an</strong>d radiotherapy are<br />
working by looking at subst<strong>an</strong>ces found in <strong>an</strong>d around<br />
tumours. Crucially, they hope to detect these subst<strong>an</strong>ces<br />
known as ‘biomarkers’ at a very early stage. This will allow<br />
doctors to tell if a treatment is working without having<br />
to wait to see if a tumour shrinks.<br />
This work could ultimately me<strong>an</strong> more people with c<strong>an</strong>cer<br />
live for longer, <strong>an</strong>d with a better quality of life.<br />
We c<strong>an</strong> make <strong>an</strong> enormous difference through research.<br />
There are new drugs coming through <strong>an</strong>d we are seeing<br />
ch<strong>an</strong>ges in treatment approaches so we c<strong>an</strong> try to cure<br />
people without damaging other tissues. This is a really<br />
exciting time, <strong>an</strong>d if we have more money for research<br />
we will get much better treatments.<br />
Penelope Brock<br />
Consult<strong>an</strong>t in Paediatric Oncology, neuroblastoma<br />
Targeting leukaemia at the roots<br />
Of the millions of cells that make up a tumour, a rare kind<br />
– called c<strong>an</strong>cer stem cells – c<strong>an</strong> fuel c<strong>an</strong>cer growth but are<br />
particularly hard to treat. They not only produce ‘normal’<br />
c<strong>an</strong>cer cells that go on to divide m<strong>an</strong>y times, forming the<br />
bulk of a tumour, but also make new c<strong>an</strong>cer stem cells.<br />
Current chemotherapy <strong>an</strong>d radiotherapy treatments don’t<br />
destroy c<strong>an</strong>cer stem cells, which explains why some people’s<br />
c<strong>an</strong>cer c<strong>an</strong> come back over time.<br />
Our scientists are investigating c<strong>an</strong>cer stem cells in a type<br />
of leukaemia called CML. They are using sophisticated lab<br />
experiments to find the genes <strong>an</strong>d proteins that keep these<br />
stem cells alive. This is the first step towards developing new<br />
treatments that specifically target c<strong>an</strong>cer stem cells without<br />
harming healthy cells.<br />
We hope to discover drugs in the future that will completely<br />
eradicate this type of leukaemia.<br />
Predicting our risk of getting c<strong>an</strong>cer<br />
One of the biggest challenges we face is finding ways<br />
to predict each person’s individual risk of developing c<strong>an</strong>cer.<br />
This is because our risk depends on so m<strong>an</strong>y different things,<br />
including our age, lifestyle <strong>an</strong>d genes. If doctors c<strong>an</strong> identify<br />
people who are at a high risk of c<strong>an</strong>cer, they c<strong>an</strong> offer them<br />
tailored screening, monitoring, treatment <strong>an</strong>d lifestyle advice.<br />
Our researchers are developing computer programmes<br />
to help doctors assess a person’s risk of developing certain<br />
c<strong>an</strong>cers. They use information such as people’s genetic<br />
make-up <strong>an</strong>d family history to make predictions.<br />
One programme, called BOADICEA, is already being used in<br />
clinics to help identify women under 50 who are most at risk of<br />
breast c<strong>an</strong>cer. Our scientists are now fine-tuning this programme<br />
to make it as accurate as possible. They are also refining their<br />
risk assessment programme for ovari<strong>an</strong> c<strong>an</strong>cer, <strong>an</strong>d pl<strong>an</strong> to<br />
develop a br<strong>an</strong>d new programme for prostate c<strong>an</strong>cer.<br />
Some of our research objectives for 2010/11<br />
— Continue to fund the best research to deepen our<br />
underst<strong>an</strong>ding of c<strong>an</strong>cer, including increasing our focus<br />
on unravelling how our genes, lifestyle <strong>an</strong>d environment<br />
interact to cause c<strong>an</strong>cer.<br />
— Promote <strong>an</strong>d fund research on c<strong>an</strong>cers that have the<br />
poorest survival rates – such as oesophageal, lung <strong>an</strong>d<br />
p<strong>an</strong>creatic c<strong>an</strong>cer.<br />
— Work on new research <strong>an</strong>d initiatives in radiotherapy,<br />
surgery <strong>an</strong>d in combining treatments to boost survival.<br />
For more detailed information on these objectives visit<br />
aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />
08 / Annual Review / <strong>Research</strong>
Dr Penelope Brock, 56<br />
Consult<strong>an</strong>t in Paediatric Oncology, neuroblastoma<br />
Penelope works at Great Ormond Street Hospital in<br />
London. She is leading the <strong>UK</strong> part of <strong>an</strong> international clinical<br />
trial we are funding into a high-risk form of the childhood<br />
c<strong>an</strong>cer called neuroblastoma. The trial is looking at using a<br />
new kind of treatment called immunotherapy, which aims<br />
to trigger the body’s immune system to help stop the c<strong>an</strong>cer<br />
or prevent it from coming back.<br />
6.00am<br />
8.25am<br />
9.00am<br />
1.30pm<br />
3.00pm<br />
7.30pm<br />
My husb<strong>an</strong>d Paul wakes me with a cup of tea.<br />
Catch the train from Tonbridge to Waterloo<br />
East. Read the Metro <strong>an</strong>d then edit a draft<br />
trial report.<br />
Pick up a cappuccino, check my emails<br />
– reply to Europe<strong>an</strong> colleagues on the high-risk<br />
neuroblastoma trial.<br />
Start clinic. A busy day ahead – I have a<br />
telephone conference on a liver tumour trial<br />
<strong>an</strong>d I supervise junior doctors.<br />
Take s<strong>an</strong>dwich to ward round.<br />
See patients on the daycare ward.<br />
Eat supper <strong>an</strong>d enjoy the evening with<br />
my children, Ben <strong>an</strong>d Izzy.<br />
Over 4,000<br />
Th<strong>an</strong>ks to our supporters,<br />
we fund the work of over<br />
4,000 researchers, nurses<br />
<strong>an</strong>d doctors like Penelope<br />
in the <strong>UK</strong>.<br />
Annual Review / <strong>Research</strong> / 09
Information<br />
Raising awareness <strong>an</strong>d saving lives<br />
We provide information on every aspect<br />
of c<strong>an</strong>cer, from prevention <strong>an</strong>d detection<br />
to treatment <strong>an</strong>d care.<br />
Our award-winning website, C<strong>an</strong>cerHelp <strong>UK</strong>, helps people<br />
with c<strong>an</strong>cer underst<strong>an</strong>d their illness <strong>an</strong>d make informed<br />
decisions, by providing comprehensive information about<br />
c<strong>an</strong>cer <strong>an</strong>d its treatment.<br />
Our team of c<strong>an</strong>cer information nurses <strong>an</strong>swer questions by<br />
phone <strong>an</strong>d email <strong>an</strong>d the Spot C<strong>an</strong>cer Early <strong>an</strong>d Healthy Living<br />
sections of our website include information on how we c<strong>an</strong><br />
spot the signs <strong>an</strong>d symptoms of c<strong>an</strong>cer early <strong>an</strong>d make lifestyle<br />
ch<strong>an</strong>ges to reduce the risk of the disease. We also run<br />
awareness campaigns such as SunSmart, to prevent skin c<strong>an</strong>cer.<br />
Our information for health professionals includes newsletters<br />
for GPs <strong>an</strong>d practice nurses with information including risk<br />
factors, screening <strong>an</strong>d early detection as well as a dedicated<br />
section of our website providing up-to-date statistics <strong>an</strong>d key<br />
facts on c<strong>an</strong>cer. And to help people underst<strong>an</strong>d more about<br />
c<strong>an</strong>cer research <strong>an</strong>d the latest adv<strong>an</strong>ces, we also have <strong>an</strong><br />
award-winning science blog.<br />
scienceblog.c<strong>an</strong>cerresearchuk.org<br />
Raising awareness of signs <strong>an</strong>d symptoms<br />
We know that thous<strong>an</strong>ds of c<strong>an</strong>cer deaths could be avoided<br />
each year if people were diagnosed at <strong>an</strong> earlier stage.<br />
Together with the Department of Health <strong>an</strong>d National C<strong>an</strong>cer<br />
Action Team (NCAT), we formed the National Awareness<br />
<strong>an</strong>d Early Diagnosis Initiative (NAEDI). NAEDI’s work will help<br />
ensure doctors c<strong>an</strong> diagnose c<strong>an</strong>cer earlier, <strong>an</strong>d encourage<br />
people with symptoms that could be c<strong>an</strong>cer to seek advice<br />
quickly from a specialist. We targeted people at increased<br />
risk of certain c<strong>an</strong>cers in a variety of ways, raising awareness<br />
of symptoms <strong>an</strong>d encouraging them to visit the doctor.<br />
Our activities over the year included producing films that<br />
explained the symptoms of different c<strong>an</strong>cers <strong>an</strong>d running<br />
<strong>an</strong> online campaign to encourage over 50s – those most<br />
at risk – to view them, <strong>an</strong>d talking to the B<strong>an</strong>gladeshi<br />
community in Tower Hamlets about oral c<strong>an</strong>cer.<br />
Ch<strong>an</strong>ges to public attitudes along with ch<strong>an</strong>ges within the<br />
healthcare system will be fundamental to making a difference.<br />
C<strong>an</strong>cer is more likely to be treated successfully when it’s<br />
spotted early.<br />
Professor J<strong>an</strong>e Wardle<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s Health Behaviour <strong>Research</strong> Centre,<br />
University College London<br />
Our patient information website, C<strong>an</strong>cerHelp <strong>UK</strong>,<br />
is the most visited c<strong>an</strong>cer site in the <strong>UK</strong> <strong>an</strong>d regularly<br />
received over one million visits per month last year.<br />
Targeting lifestyle ch<strong>an</strong>ges<br />
Up to half of all c<strong>an</strong>cers could be prevented through lifestyle<br />
ch<strong>an</strong>ges. For example, keeping a healthy body weight c<strong>an</strong> greatly<br />
reduce the risk of c<strong>an</strong>cer. Similarly, enjoying the sun safely <strong>an</strong>d<br />
not using sunbeds actually reduces the risk of skin c<strong>an</strong>cer.<br />
During the year we worked with the British Heart Foundation<br />
<strong>an</strong>d Diabetes <strong>UK</strong> on the Active Fat campaign, which highlights<br />
how carrying excess weight around your middle c<strong>an</strong> increase<br />
the risk of c<strong>an</strong>cer, heart disease <strong>an</strong>d Type 2 diabetes. We also<br />
supported the NHS, who produced TV adverts about the<br />
risks of drinking too much alcohol.<br />
Our award-winning skindividual campaign encourages young<br />
people to use social networking sites to spread sun protection<br />
messages. According to our research, in the last six years the<br />
number of people who seek out shade, cover up <strong>an</strong>d avoid<br />
sunbeds, <strong>an</strong>d who know the import<strong>an</strong>ce of checking their<br />
moles, has increased signific<strong>an</strong>tly.<br />
Our C<strong>an</strong>cer Awareness Roadshow toured the <strong>UK</strong>, giving<br />
information <strong>an</strong>d support on c<strong>an</strong>cer. More th<strong>an</strong> 37,000 people<br />
visited in 2009, <strong>an</strong>d over 8,500 had consultations with our<br />
nurses. Nine out of ten of those interviewed said they would<br />
ch<strong>an</strong>ge their behaviour as a result of their visit.<br />
Informing people about clinical trials <strong>an</strong>d research<br />
Clinical trials are <strong>an</strong> essential part of our work to beat c<strong>an</strong>cer.<br />
But it is hard for patients to find out about research into<br />
treatment for their c<strong>an</strong>cer type.<br />
Our unique clinical trials database lists easy-to-read summaries<br />
of clinical trials, which patients c<strong>an</strong> print <strong>an</strong>d take to their own<br />
specialists. The revamped database is now easier to use th<strong>an</strong><br />
ever, listing around 350 open trials in the <strong>UK</strong>, as well as closed<br />
trials <strong>an</strong>d trial results.<br />
www.c<strong>an</strong>cerhelp.org.uk/trials<br />
Some of our information objectives for 2010/11<br />
— Drive progress on diagnosing c<strong>an</strong>cer earlier, including<br />
finding out more about why people experience delays<br />
between seeing their GP <strong>an</strong>d getting the hospital<br />
appointment they need.<br />
— Promote earlier diagnosis of breast, bowel <strong>an</strong>d lung<br />
c<strong>an</strong>cer in particular, <strong>an</strong>d support the NHS to do the same.<br />
Find out how to reduce your risk of c<strong>an</strong>cer at<br />
info.c<strong>an</strong>cerresearchuk.org/healthyliving<br />
10 / Annual Review / Information
Jayshree Jhala, 73<br />
Early detection campaigner <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />
Jayshree was diagnosed with breast c<strong>an</strong>cer following a<br />
mammogram when she was 69. She chose to have a<br />
mastectomy <strong>an</strong>d chemotherapy <strong>an</strong>d is now on a five-year<br />
course of tamoxifen. Jayshree promotes c<strong>an</strong>cer awareness<br />
in schools <strong>an</strong>d community centres in Luton to her local<br />
Asi<strong>an</strong> community.<br />
1,000<br />
Our specialist nurses<br />
respond to up to 1,000<br />
enquiries every month<br />
from people like Jayshree,<br />
affected by or concerned<br />
about c<strong>an</strong>cer. Around one<br />
in five of these enquiries<br />
is about breast c<strong>an</strong>cer.<br />
6.30am Wake up. I feed Simba, our Alsati<strong>an</strong>. He’s just<br />
over a year old <strong>an</strong>d like a lion.<br />
7.30am Prepare breakfast for my gr<strong>an</strong>dchildren Arjun<br />
<strong>an</strong>d Shiv – they’re the apples of my eye.<br />
10.00am Attend a cooking class, meeting, or do some<br />
paperwork. I work for Luton Primary Care Trust<br />
as a community food adviser.<br />
1.30pm Have my main meal with my husb<strong>an</strong>d, Govind.<br />
He has a c<strong>an</strong>cerous tumour near his urethra.<br />
We encourage each other to be positive <strong>an</strong>d<br />
get over our illnesses, so we c<strong>an</strong> still enjoy our<br />
lives together.<br />
7.00pm Have a snack with Govind. I used to swim in the<br />
evenings <strong>an</strong>d I’m building up the courage to go<br />
again after my mastectomy.<br />
8.00pm Watch TV, make a few phone calls <strong>an</strong>d relax<br />
with my family <strong>an</strong>d Simba before going to bed.<br />
Annual Review / Information / About us / 11
Justine Sheils, 39<br />
SunSmart campaigner <strong>an</strong>d skin c<strong>an</strong>cer survivor<br />
Sun-lover Justine regularly used t<strong>an</strong>ning beds from the age<br />
of 15, <strong>an</strong>d rarely applied sunscreen when on holiday. In 2004<br />
she noticed a mole on her chest but didn’t get it checked<br />
out for a further 18 months. When she did, a specialist<br />
diagnosed malign<strong>an</strong>t mel<strong>an</strong>oma. Liverpool-based Justine had<br />
the mole removed <strong>an</strong>d is now back to full health. She is a<br />
passionate supporter of our SunSmart campaign.<br />
£13.3m<br />
We are the largest funder<br />
of skin c<strong>an</strong>cer research in<br />
the <strong>UK</strong>. Our broad<br />
research programme<br />
r<strong>an</strong>ges from uncovering the<br />
causes of the disease to<br />
developing new treatments<br />
for people like Justine.<br />
5.00am<br />
8.00am<br />
4.00pm<br />
6.00pm<br />
Get up <strong>an</strong>d go for a 45-minute run – it helps get<br />
rid of all of my <strong>an</strong>xieties. When I was ill,<br />
my aim was to put my trainers back on.<br />
Start work at my local hospital where I’m <strong>an</strong><br />
administrator. I have gone part-time because<br />
I’ve realised what’s import<strong>an</strong>t in life.<br />
Finish work <strong>an</strong>d head home for some<br />
chill-out time.<br />
College. I’m training to be a sports therapist.<br />
I’ve realised that life’s too short to not follow<br />
your dreams.<br />
10.00pm Head to bed. I’m pretty exhausted<br />
on college nights.<br />
12 / Annual Review / Contents Influencing public policy
Influencing public policy<br />
Campaigning for ch<strong>an</strong>ge<br />
We need to make sure c<strong>an</strong>cer stays<br />
at the top of the national health agenda.<br />
Influencing politici<strong>an</strong>s is a vital part of this.<br />
We work with decision-makers in Westminster, the Scottish<br />
Parliament, the Welsh Assembly, the Northern Irel<strong>an</strong>d Assembly<br />
<strong>an</strong>d the Europe<strong>an</strong> Parliament. We make sure the views of<br />
patients, researchers, health professionals, volunteers <strong>an</strong>d<br />
supporters are heard at all levels of government.<br />
The 2010 General Election<br />
We knew that c<strong>an</strong>cer would be a big issue in the General<br />
Election. We w<strong>an</strong>ted to make sure all parties were backing<br />
steps to prevent c<strong>an</strong>cer <strong>an</strong>d detect it earlier as well as making<br />
sure the <strong>UK</strong> has the funding <strong>an</strong>d resources needed to carry out<br />
high quality research. We also w<strong>an</strong>ted to see MPs commit to<br />
improving access to treatment <strong>an</strong>d reducing inequalities between<br />
social groups, as we know that the risk of dying of c<strong>an</strong>cer is far<br />
greater in less affluent communities.<br />
We published a new m<strong>an</strong>ifesto <strong>an</strong>d a Guide to Campaigning<br />
about C<strong>an</strong>cer for prospective parliamentary c<strong>an</strong>didates (PPCs).<br />
We met key ministers, policy advisers, MPs <strong>an</strong>d PPCs, <strong>an</strong>d asked<br />
our supporters to contact c<strong>an</strong>didates in their constituency <strong>an</strong>d<br />
urge them to ‘Commit to Beat C<strong>an</strong>cer’ if elected.<br />
Over 1,000 parliamentary c<strong>an</strong>didates signed our pledge<br />
to help make the <strong>UK</strong>’s c<strong>an</strong>cer outcomes among the best<br />
in Europe <strong>an</strong>d more th<strong>an</strong> 250 of those have gone on<br />
to become MPs. Find out more at<br />
www.c<strong>an</strong>cercampaigns.org.uk/ourcampaigns/commit<br />
Pl<strong>an</strong>ning for the future of c<strong>an</strong>cer services<br />
National c<strong>an</strong>cer pl<strong>an</strong>s are a vital way to make sure we have<br />
the best c<strong>an</strong>cer services. They detail each government’s pl<strong>an</strong>s<br />
to invest in <strong>an</strong>d reform c<strong>an</strong>cer services, <strong>an</strong>d provide direction<br />
for using resources effectively. We monitor how these pl<strong>an</strong>s<br />
are implemented from spending commitments to passing new<br />
legislation – to ensure promises are kept on key issues.<br />
We wrote <strong>an</strong> in-depth report on how the c<strong>an</strong>cer pl<strong>an</strong>s<br />
in Engl<strong>an</strong>d, Scotl<strong>an</strong>d, Wales <strong>an</strong>d Northern Irel<strong>an</strong>d were<br />
implemented, <strong>an</strong>d what progress they have made.<br />
Our research included interviews with scientists, clinici<strong>an</strong>s<br />
<strong>an</strong>d NHS professionals. We reviewed information available<br />
to people with c<strong>an</strong>cer, to help us underst<strong>an</strong>d how people’s<br />
experiences have ch<strong>an</strong>ged since the c<strong>an</strong>cer pl<strong>an</strong>s have been<br />
in place. Results showed there has been progress in some<br />
areas. We will continue to push governments to ensure the<br />
best c<strong>an</strong>cer services are available to patients throughout the <strong>UK</strong>.<br />
Protecting young people<br />
Smoking is the single biggest preventable cause of c<strong>an</strong>cer in the<br />
world. A large number of studies have shown that quitting the<br />
habit c<strong>an</strong> greatly reduce the risk of smoking-related c<strong>an</strong>cers.<br />
The earlier you stop, the better. Reaching young people early<br />
so they don’t start smoking is <strong>an</strong> import<strong>an</strong>t part of our fight<br />
against c<strong>an</strong>cer.<br />
Over 12,000 of our supporters wrote to MPs <strong>an</strong>d MSPs backing<br />
our ‘Out of Sight, Out of Mind’ campaign, which called for a<br />
b<strong>an</strong> on tobacco marketing to young people. More th<strong>an</strong> 50,000<br />
people signed our petition. Our supporters helped convince<br />
MPs <strong>an</strong>d MSPs to vote to end the display of tobacco at the<br />
tills in shops <strong>an</strong>d supermarkets across the <strong>UK</strong> <strong>an</strong>d to stop<br />
cigarettes being sold in vending machines in Engl<strong>an</strong>d, Scotl<strong>an</strong>d,<br />
Wales <strong>an</strong>d Northern Irel<strong>an</strong>d. This will be phased in from 2011.<br />
Reducing the risk of skin c<strong>an</strong>cer<br />
Malign<strong>an</strong>t mel<strong>an</strong>oma – the most serious type of skin c<strong>an</strong>cer<br />
– is one of the most common c<strong>an</strong>cers in the <strong>UK</strong>. Using a<br />
sunbed once a month or more c<strong>an</strong> increase the risk of this<br />
type of c<strong>an</strong>cer by more th<strong>an</strong> half, <strong>an</strong>d the number of people<br />
who develop it is increasing.<br />
We met politici<strong>an</strong>s, civil serv<strong>an</strong>ts <strong>an</strong>d health campaigners to push<br />
for new laws to stop under-18s using sunbeds. We also w<strong>an</strong>ted<br />
to make sure all salons are staffed <strong>an</strong>d customers receive<br />
accurate health information. Th<strong>an</strong>ks to thous<strong>an</strong>ds of emails<br />
from our supporters, MPs <strong>an</strong>d Peers from all parties voted<br />
in favour of the Sunbeds Act, which will become law in 2011<br />
in Engl<strong>an</strong>d <strong>an</strong>d Wales.<br />
Some of our influencing public policy objectives for 2010/11<br />
— Raise awareness of the import<strong>an</strong>ce of radiotherapy<br />
as a c<strong>an</strong>cer treatment <strong>an</strong>d the need for better services.<br />
— Keep c<strong>an</strong>cer high on the agenda following the General<br />
Election <strong>an</strong>d prepare for elections in the Scottish<br />
Parliament, Welsh Assembly <strong>an</strong>d Northern<br />
Irel<strong>an</strong>d Assembly.<br />
To read more about the issues <strong>an</strong>d how you c<strong>an</strong><br />
call for ch<strong>an</strong>ge, visit<br />
www.c<strong>an</strong>cerresearchuk.org/publicpolicy<br />
Annual Review / Influencing public policy / 13
Bringing our work together to save lives<br />
Diagnosing c<strong>an</strong>cer early<br />
Sara Hiom, Director of Health Information, C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />
If only my c<strong>an</strong>cer had been spotted earlier.<br />
We’re determined to make statements like this<br />
a thing of the past. Thous<strong>an</strong>ds of deaths could<br />
be avoided each year if c<strong>an</strong>cer was diagnosed<br />
<strong>an</strong>d subsequently treated at <strong>an</strong> earlier stage.<br />
This is probably the single biggest reason why<br />
c<strong>an</strong>cer survival rates in the <strong>UK</strong> are lower th<strong>an</strong><br />
in m<strong>an</strong>y other countries in Europe.<br />
At the moment, just over half of all people with c<strong>an</strong>cer are<br />
diagnosed at a stage when it c<strong>an</strong> be successfully treated.<br />
Our goal is to see this rise to two-thirds by 2020 by tackling<br />
late diagnosis through our research, our information <strong>an</strong>d<br />
influencing health policy.<br />
Our research underpins the national screening programmes<br />
for breast <strong>an</strong>d cervical c<strong>an</strong>cers. Both me<strong>an</strong> more women are<br />
diagnosed when treatment is likely to be successful. Since<br />
national breast screening beg<strong>an</strong> in 1988, around five million<br />
women in Engl<strong>an</strong>d have been screened <strong>an</strong>d over 100,000<br />
c<strong>an</strong>cers detected. And the cervical screening programme<br />
has prevented <strong>an</strong> epidemic of cervical c<strong>an</strong>cer. Th<strong>an</strong>ks to our<br />
supporters, we’re building on these successes.<br />
Our research<br />
In a major breakthrough this year, our scientists found that a<br />
one-off five minute screening test could prevent one-third of<br />
bowel c<strong>an</strong>cers <strong>an</strong>d reduce deaths by 43%. Bowel c<strong>an</strong>cer is the<br />
second biggest c<strong>an</strong>cer killer in the <strong>UK</strong>, <strong>an</strong>d the third most<br />
common c<strong>an</strong>cer. We’re now calling on <strong>UK</strong> governments to add<br />
the test to the national bowel c<strong>an</strong>cer screening programme.<br />
This could save thous<strong>an</strong>ds of lives <strong>an</strong>d spare families the <strong>an</strong>xiety<br />
<strong>an</strong>d suffering associated with a c<strong>an</strong>cer diagnosis.<br />
We’re also helping to fund a major trial to see whether a national<br />
screening programme for ovari<strong>an</strong> c<strong>an</strong>cer should be introduced<br />
which could detect the disease early enough to save lives.<br />
And as part of a national prostate c<strong>an</strong>cer trial, we’re supporting<br />
import<strong>an</strong>t research to help decide if the PSA blood test – which<br />
c<strong>an</strong> help identify prostate c<strong>an</strong>cer – could form the basis of a<br />
national screening programme.<br />
We’re leading the research arm of the National Awareness <strong>an</strong>d<br />
Early Diagnosis Initiative (NAEDI), a new National C<strong>an</strong>cer<br />
<strong>Research</strong> Institute partnership, formed to fund high-quality<br />
research in areas likely to have the greatest <strong>impact</strong> on tackling<br />
late diagnosis.<br />
Our information<br />
Together with the Department of Health <strong>an</strong>d the National<br />
C<strong>an</strong>cer Action Team, NAEDI coordinates activity to promote<br />
the earlier diagnosis of c<strong>an</strong>cer. We’ve been raising awareness<br />
of the import<strong>an</strong>ce of detecting c<strong>an</strong>cer at <strong>an</strong> early stage with<br />
the public <strong>an</strong>d GPs, as well as trying to better identify who<br />
is most at risk.<br />
We supported NHS Derby City in campaigning to raise<br />
awareness of bowel c<strong>an</strong>cer in communities with a greater th<strong>an</strong><br />
average risk of c<strong>an</strong>cer <strong>an</strong>d to encourage men over 50 to visit<br />
their GP if they notice <strong>an</strong>ything unusual, <strong>an</strong>d we worked with<br />
Merseyside <strong>an</strong>d Cheshire C<strong>an</strong>cer Network to tell older men<br />
about symptoms of skin c<strong>an</strong>cer.<br />
Early diagnosis is our next big challenge in c<strong>an</strong>cer <strong>an</strong>d<br />
will be crucial in bringing our survival rates up to the<br />
best in Europe.<br />
Professor Sir Mike Richards<br />
National C<strong>an</strong>cer Director<br />
Influencing health policy<br />
We w<strong>an</strong>t <strong>UK</strong> governments to make early diagnosis of c<strong>an</strong>cer<br />
a priority. During the election campaign we promoted the<br />
import<strong>an</strong>ce of early diagnosis to thous<strong>an</strong>ds of parliamentary<br />
c<strong>an</strong>didates. We called on politici<strong>an</strong>s to adopt the new bowel<br />
screening test <strong>an</strong>d we are urging them to increase the number<br />
of people invited for c<strong>an</strong>cer screening.<br />
We held a discussion day for people with c<strong>an</strong>cer <strong>an</strong>d their<br />
families to help underst<strong>an</strong>d their experiences of being diagnosed<br />
<strong>an</strong>d to inform our own work with policy-makers.<br />
The future<br />
We’re pushing for policies that encourage people to visit their<br />
GP with signs or symptoms of c<strong>an</strong>cer, <strong>an</strong>d for speedy referrals.<br />
We w<strong>an</strong>t policies that support GPs <strong>an</strong>d help the public to<br />
underst<strong>an</strong>d as much as possible about the benefits of<br />
early diagnosis.<br />
By catching c<strong>an</strong>cer earlier we c<strong>an</strong> help ensure that the <strong>UK</strong>’s<br />
outcomes are among the best in Europe <strong>an</strong>d globally<br />
– instead of being behind most Northern Europe<strong>an</strong> countries.<br />
For information on detecting c<strong>an</strong>cer early visit<br />
www.spotc<strong>an</strong>cerearly.com<br />
With our partners we are investing up to £7.5 million over five<br />
years in such research. For more information see<br />
www.naedi.org.uk<br />
14 / Annual Review / Diagnosing c<strong>an</strong>cer early
Calvin Wood, 68<br />
Prostate c<strong>an</strong>cer survivor<br />
Calvin, a gr<strong>an</strong>dfather of four, was diagnosed with prostate<br />
c<strong>an</strong>cer in 2001. He received hormone treatment – Casodex<br />
<strong>an</strong>d Zoladex – <strong>an</strong>d a six-week course of radiotherapy.<br />
Calvin now devotes much of his time to supporting other<br />
men with the disease. He set up a prostate c<strong>an</strong>cer support<br />
group at the hospital, on the Wirral, where he was treated,<br />
which now has more th<strong>an</strong> 180 members.<br />
8.00am<br />
Get up <strong>an</strong>d have breakfast with my wife.<br />
The mornings are my ‘free time’ for doing<br />
<strong>an</strong>y shopping or jobs around the house.<br />
10.00am Contact members of the prostate c<strong>an</strong>cer<br />
support group. It’s wonderful to help others<br />
in the same boat, particularly those struggling<br />
to come to terms with a diagnosis.<br />
2.00pm<br />
7.00pm<br />
Meetings. I’m treasurer of the National<br />
Conference of C<strong>an</strong>cer Self-Help Groups <strong>an</strong>d<br />
a trustee of the Clatterbridge Centre for<br />
Oncology. I feel I’m giving something back.<br />
Go for a meal with friends or catch up with<br />
family news. Having c<strong>an</strong>cer helps you focus<br />
on what’s import<strong>an</strong>t, like friends <strong>an</strong>d family.<br />
10.00pm Watch the news, then bed – 24 hours doesn’t<br />
seem long enough!<br />
Seven out<br />
of ten men<br />
now survive prostate<br />
c<strong>an</strong>cer for at least ten<br />
years, compared with only<br />
two out of ten in the 1970s.<br />
We fund research at all<br />
levels, from uncovering<br />
the disease’s causes to<br />
developing new treatments.<br />
Annual Review Annual / Diagnosing Review c<strong>an</strong>cer / About early us / 15
Driving world-class c<strong>an</strong>cer research<br />
The breadth of our work is<br />
unparalleled. We are tackling<br />
c<strong>an</strong>cer from all <strong>an</strong>gles <strong>an</strong>d<br />
support research in m<strong>an</strong>y<br />
different ways.<br />
To make sure adv<strong>an</strong>ces in c<strong>an</strong>cer<br />
research benefit as m<strong>an</strong>y people as<br />
quickly as possible, we fund scientists,<br />
doctors <strong>an</strong>d nurses across the <strong>UK</strong>.<br />
We have five core research Institutes,<br />
each specialising in different areas<br />
of c<strong>an</strong>cer. We also form lasting<br />
partnerships <strong>an</strong>d networks – with the<br />
NHS, universities <strong>an</strong>d other charities<br />
– both in the <strong>UK</strong> <strong>an</strong>d internationally.<br />
Our Centres<br />
As well as undertaking world-class<br />
research, our growing <strong>UK</strong>-wide network<br />
of Centres helps train the clinical <strong>an</strong>d<br />
scientific research workforce of the<br />
future. Each Centre is a ‘virtual hub’<br />
that unites researchers, patients <strong>an</strong>d<br />
fundraisers, giving them the opportunity<br />
to work together to raise awareness of<br />
c<strong>an</strong>cer research <strong>an</strong>d host events in the<br />
local community.<br />
We launched seven more Centres<br />
in 2009/10, bringing our total launched<br />
to ten, <strong>an</strong>d we pl<strong>an</strong> to have between<br />
15 <strong>an</strong>d 20 by the end of 2011. In this<br />
Annual Review we put the spotlight<br />
on just a few examples of the life-saving<br />
work happening at our Centres.<br />
For more information on our Institutes<br />
<strong>an</strong>d Centres visit<br />
science.c<strong>an</strong>cerresearchuk.org/research/<br />
how-we-deliver-our-research<br />
Belfast<br />
Teams at our Belfast Centre are<br />
leading research into bowel,<br />
oesophageal <strong>an</strong>d breast c<strong>an</strong>cers.<br />
They are also exploring the latest<br />
techniques in radiotherapy,<br />
improving c<strong>an</strong>cer diagnosis, <strong>an</strong>d<br />
developing more effective drugs<br />
with fewer side effects. The Centre<br />
brings together over 40 researchers<br />
from across Northern Irel<strong>an</strong>d.<br />
Ruth Boyd is a Senior <strong>Research</strong><br />
<strong>an</strong>d Information Nurse at Belfast<br />
City Hospital. Ruth is helping to<br />
recruit more c<strong>an</strong>cer patients to<br />
clinical trials which could benefit<br />
thous<strong>an</strong>ds of people in the future.<br />
Dundee<br />
<strong>Research</strong> at our Dundee Centre<br />
particularly focuses on skin, bowel,<br />
<strong>an</strong>d breast c<strong>an</strong>cers. Scientists are<br />
also carrying out world-class<br />
research to refine <strong>an</strong>d improve<br />
c<strong>an</strong>cer surgery.<br />
Professor Inke Näthke <strong>an</strong>d<br />
her team at the University<br />
of Dundee are carrying out<br />
work that could aid the early<br />
detection of bowel c<strong>an</strong>cer. She<br />
is investigating a gene called<br />
APC, which is faulty in m<strong>an</strong>y<br />
cases of the disease.<br />
This work is import<strong>an</strong>t as it<br />
may help us develop techniques<br />
for identifying pre-c<strong>an</strong>cerous<br />
tissue at <strong>an</strong> early stage when it<br />
still appears normal. This will give<br />
clinici<strong>an</strong>s a ch<strong>an</strong>ce to catch the<br />
disease in the early stages – when<br />
it c<strong>an</strong> be treated more effectively.<br />
Southampton<br />
Scientists <strong>an</strong>d doctors at our<br />
Southampton Centre are recognised<br />
internationally for their research into<br />
immunotherapy, a type of treatment<br />
that harnesses the power of the<br />
body’s own immune system to<br />
target c<strong>an</strong>cer.<br />
Professor Peter Johnson, our<br />
Chief Clinici<strong>an</strong> <strong>an</strong>d one of the<br />
leaders of the Southampton<br />
Centre, is <strong>an</strong> expert in lymphoma.<br />
He <strong>an</strong>d other researchers are<br />
developing a r<strong>an</strong>ge of <strong>an</strong>tibody<br />
<strong>an</strong>d immunotherapy treatments,<br />
some of which are being tested<br />
in early-stage clinical trials.<br />
Joining the network of<br />
Centres is very import<strong>an</strong>t for<br />
patients, doctors <strong>an</strong>d scientists in<br />
Southampton. It will strengthen<br />
the work we already do in bringing<br />
treatments straight from the<br />
laboratory to the clinic, <strong>an</strong>d help<br />
us to do more work in import<strong>an</strong>t<br />
areas such as surgery.<br />
Newcastle<br />
<strong>Research</strong>ers at the Newcastle<br />
Centre at the Northern Institute<br />
for C<strong>an</strong>cer <strong>Research</strong> specialise<br />
in discovering <strong>an</strong>d testing new<br />
treatments. Teams here have<br />
particular strengths in carrying out<br />
early-stage clinical trials of the latest<br />
treatments, <strong>an</strong>d specialise in m<strong>an</strong>y<br />
types of c<strong>an</strong>cer including childhood<br />
<strong>an</strong>d prostate c<strong>an</strong>cers.<br />
Professor Herbie Newell is <strong>an</strong><br />
expert in c<strong>an</strong>cer pharmacology<br />
– underst<strong>an</strong>ding how c<strong>an</strong>cer<br />
drugs work inside the body.<br />
He <strong>an</strong>d his team are currently<br />
working on targeted drugs that<br />
block the action of specific faulty<br />
proteins found within c<strong>an</strong>cer cells,<br />
stopping the disease in its tracks.<br />
The development of<br />
personalised treatment –<br />
treatment that is tailored to the<br />
requirements of <strong>an</strong> individual<br />
patient – is becoming a reality <strong>an</strong>d<br />
offers the opportunity to design<br />
new drugs that are truly selective<br />
for different forms of c<strong>an</strong>cer.<br />
16 / Annual Review / Contents Driving world-class c<strong>an</strong>cer research
Cardiff<br />
Teams at our Cardiff Centre are<br />
focusing on leukaemia as well as<br />
bowel, breast <strong>an</strong>d urological c<strong>an</strong>cers,<br />
such as prostate <strong>an</strong>d bladder c<strong>an</strong>cer.<br />
They are using laboratory discoveries<br />
to develop new ways to prevent,<br />
diagnose <strong>an</strong>d treat the disease.<br />
Recent work by Dr Dunc<strong>an</strong> Baird<br />
at Cardiff University takes us<br />
one step closer to a blood test<br />
that could predict how fast<br />
leukaemia will progress. Dr Baird<br />
is <strong>an</strong> expert on ‘telomeres’ – tiny<br />
structures that protect the ends<br />
of chromosomes, which hold<br />
our cells’ entire DNA blueprint.<br />
His team recently revealed how<br />
shortened <strong>an</strong>d fused telomeres<br />
are involved in the progression of<br />
leukaemia. This discovery may help<br />
doctors identify people with more<br />
adv<strong>an</strong>ced c<strong>an</strong>cer, so they c<strong>an</strong> select<br />
the best treatment.<br />
Beatson Institute<br />
Paterson Institute<br />
Gray Institute<br />
Cambridge <strong>Research</strong><br />
Institute<br />
London <strong>Research</strong><br />
Institute<br />
Key<br />
Centres – our ten Centres of research excellence<br />
Institutes – our five core-funded research Institutes<br />
Other locations – just some of the other locations around the <strong>UK</strong> where<br />
we fund our life-saving research or support clinical trials<br />
Annual Review / Driving world-class Annual Review c<strong>an</strong>cer / About research us / 17
Our people<br />
From our world-class scientists <strong>an</strong>d lab<br />
assist<strong>an</strong>ts to our volunteers, our doctors <strong>an</strong>d<br />
nurses to our staff, we rely on a wide variety<br />
of skills <strong>an</strong>d experience to help us beat c<strong>an</strong>cer.<br />
There are hundreds of thous<strong>an</strong>ds of people<br />
involved in helping us achieve our vision<br />
– they are all a vital part of our team, <strong>an</strong>d<br />
we need each <strong>an</strong>d every one of them.<br />
Here we highlight just a few of those that<br />
make our work possible.<br />
Senior scientist<br />
Professor Iain McNeish is a c<strong>an</strong>cer specialist at Barts <strong>an</strong>d<br />
the London School of Medicine, part of the Barts C<strong>an</strong>cer<br />
<strong>Research</strong> <strong>UK</strong> Centre. He specialises in the treatment of<br />
ovari<strong>an</strong> c<strong>an</strong>cer. His research aims to underst<strong>an</strong>d the biology<br />
of ovari<strong>an</strong> c<strong>an</strong>cer – in particular, the reasons why ovari<strong>an</strong><br />
c<strong>an</strong>cer cells c<strong>an</strong> become resist<strong>an</strong>t to chemotherapy.<br />
He w<strong>an</strong>ts to use this knowledge to design new types of<br />
treatment, such as gene therapy, to overcome resist<strong>an</strong>ce<br />
<strong>an</strong>d make treatment successful for more women.<br />
The research C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> does<br />
is high quality <strong>an</strong>d focused on the one mission<br />
– to beat c<strong>an</strong>cer.<br />
Professor Iain McNeish<br />
Ovari<strong>an</strong> c<strong>an</strong>cer specialist<br />
18 / Annual Review / Our people
Campaigning ambassador<br />
When Chris Geiger was diagnosed with non-Hodgkin’s<br />
lymphoma, he was given just months to live. That was 20 years<br />
ago. Chris is now a passionate campaigner <strong>an</strong>d ambassador for<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. He uses his personal experience to raise<br />
awareness of the amazing work that happens in our hospitals<br />
every day, <strong>an</strong>d the import<strong>an</strong>t role we play in supporting patients.<br />
Our expert bloggers<br />
Science writers Henry Scowcroft, Ed Yong, Kat Arney<br />
<strong>an</strong>d others write our award-winning science blog.<br />
They help people underst<strong>an</strong>d more about c<strong>an</strong>cer research<br />
<strong>an</strong>d the latest adv<strong>an</strong>ces, including work we fund, as well<br />
as explaining health myths <strong>an</strong>d media scares, <strong>an</strong>d providing<br />
links to other helpful resources. Read more at<br />
scienceblog.c<strong>an</strong>cerresearchuk.org<br />
Celebrity supporters<br />
Celebrities play <strong>an</strong> invaluable role when it comes to supporting<br />
<strong>an</strong>d promoting our work. Sir Richard Br<strong>an</strong>son, Sir Trevor<br />
MacDonald, Dame Judi Dench <strong>an</strong>d Honor Blackm<strong>an</strong> are<br />
among m<strong>an</strong>y others who have supported our campaigns, whilst<br />
legendary rocker Rod Stewart, Gary Barlow, Ke<strong>an</strong>e <strong>an</strong>d Lemar<br />
are among m<strong>an</strong>y who have performed or supported our music<br />
events. British F1 Star Lewis Hamilton along with singer Leona<br />
Lewis <strong>an</strong>d gold medallist Usain Bolt supported our Little Star<br />
Awards, which celebrate the courage of children with c<strong>an</strong>cer.<br />
Shop volunteer<br />
Breast c<strong>an</strong>cer survivor Doreen Walker volunteers<br />
two days a week at the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> shop on<br />
her local high street in Potters Bar. The gr<strong>an</strong>dmother<br />
of five sorts <strong>an</strong>d prices clothes, serves customers <strong>an</strong>d<br />
supervises the other volunteers.<br />
Relay For Life org<strong>an</strong>iser<br />
V<strong>an</strong>essa Babbage, who has been clear of breast c<strong>an</strong>cer<br />
for two years now, helped org<strong>an</strong>ise a Relay For Life<br />
fundraising event in Crystal Palace. She coordinated<br />
the survivors’ ceremony <strong>an</strong>d food for the day, then<br />
walked in the survivors’ lap of honour. The event raised<br />
£20,000 <strong>an</strong>d V<strong>an</strong>essa is chairing the committee to<br />
org<strong>an</strong>ise next year’s event.<br />
I’ve been on cloud nine since the Relay. It was<br />
just brilli<strong>an</strong>t for everyone in the local community to<br />
come together <strong>an</strong>d it’s so good to give something back<br />
to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. C<strong>an</strong>cer ch<strong>an</strong>ges you forever.<br />
I don’t worry about little things now because I know<br />
that what’s import<strong>an</strong>t is having a good quality of life.<br />
V<strong>an</strong>essa Babbage<br />
Breast c<strong>an</strong>cer survivor<br />
Clinical trial nurse<br />
Marylyn Pilkington is a Senior <strong>Research</strong> Nurse at the<br />
Sir Bobby Robson C<strong>an</strong>cer Trials <strong>Research</strong> Centre in<br />
Newcastle. She works with patients who are taking<br />
part in early-phase clinical trials – trials for drugs that<br />
have shown promise in the laboratory <strong>an</strong>d now need<br />
testing in the clinical setting. Marylyn gives patients the<br />
information they need to decide whether to take part,<br />
<strong>an</strong>d supports them throughout the treatment.<br />
I really enjoy the work <strong>an</strong>d w<strong>an</strong>t to give something<br />
back, <strong>an</strong>d I think that goes for the other volunteers<br />
who have all been touched by c<strong>an</strong>cer. I feel so fortunate<br />
that a routine screening helped to save my life. It never<br />
crossed my mind there would be a problem. But th<strong>an</strong>k<br />
goodness I was invited to go along that day.<br />
Doreen Walker<br />
Breast c<strong>an</strong>cer survivor<br />
All new c<strong>an</strong>cer drugs have to go through these<br />
early-phase trials. We’re hopeful that today’s trials<br />
will lead to the c<strong>an</strong>cer treatments of the future.<br />
Marylyn Pilkington<br />
Clinical trial nurse<br />
Annual Review / Our people / 19
Raising money to support our work<br />
Our life-saving work is only possible th<strong>an</strong>ks to<br />
the ongoing commitment <strong>an</strong>d generosity of<br />
our supporters, as we receive no government<br />
funding for our research.<br />
We would like to th<strong>an</strong>k them for helping us to raise a record<br />
£446 million. Here are just some of the ways they did it.<br />
Giving generously<br />
Our supporters set up regular donations by direct debit,<br />
donate online or give through a payroll scheme at work.<br />
Some people choose to give in celebration of a special<br />
event like a wedding, <strong>an</strong>niversary or birthday. Others donate<br />
in memory of a loved one. It’s also possible to give online<br />
to a specific research project through MyProjects.<br />
myprojects.c<strong>an</strong>cerresearchuk.org<br />
M<strong>an</strong>y people choose to continue their support for us by<br />
leaving a gift in their will. More th<strong>an</strong> a third of our work<br />
is made possible by legacies, <strong>an</strong>d last year we were left<br />
£157 million by generous donors.<br />
Joining a local group or org<strong>an</strong>ising your own fundraiser<br />
Across the <strong>UK</strong>, people support us by joining or forming<br />
local groups <strong>an</strong>d committees. We have nearly 900 groups,<br />
committees <strong>an</strong>d regular fundraisers all around the country.<br />
People also raise money individually – at school, home or<br />
work. Last year our supporters got involved in m<strong>an</strong>y ways,<br />
from hosting quiz nights <strong>an</strong>d fundraising dinners to coffee<br />
mornings <strong>an</strong>d head shaves.<br />
Getting active – taking part in <strong>an</strong> event or a challenge<br />
Our flagship, women-only event Race for Life has gone from<br />
strength to strength. In 2009, over 730,000 women came<br />
together at around 250 Race for Life events around the<br />
country. Together they raised <strong>an</strong> incredible £66 million.<br />
In April 2010 we launched Shine, our new night-time walking<br />
marathon. Shine was a great success, with more th<strong>an</strong> 7,500<br />
people talking part in our first event in M<strong>an</strong>chester, raising over<br />
£1.4 million for our life-saving work. For the first time people<br />
could choose which c<strong>an</strong>cer they w<strong>an</strong>ted to beat <strong>an</strong>d raise<br />
money specifically for that area of our work.<br />
We also held 22 Run10k events for men <strong>an</strong>d women at<br />
f<strong>an</strong>tastic locations across the country. And our overnight<br />
Relay For Life events, org<strong>an</strong>ised by volunteers, are a ch<strong>an</strong>ce<br />
for supporters to team up with friends, family or colleagues.<br />
We have hundreds of events <strong>an</strong>d challenges taking place across<br />
the <strong>UK</strong> for all fitness levels all year round. Find out more at<br />
supportus.c<strong>an</strong>cerresearchuk.org/events<br />
Supporting us on the high street<br />
We have over 570 shops around the <strong>UK</strong>, where you c<strong>an</strong> buy<br />
or donate goods. Despite it being a difficult year, our shops<br />
had their best week ever in December 2009, raising nearly<br />
£3 million. To make shopping even easier, we also have our<br />
own online shopping site selling a wide selection of products,<br />
including gifts <strong>an</strong>d flowers.<br />
www.shoptobeatc<strong>an</strong>cer.org.uk<br />
In partnership with business<br />
Our corporate supporters play a vital role in our work to beat<br />
c<strong>an</strong>cer. Employees org<strong>an</strong>ise <strong>an</strong>d take part in events <strong>an</strong>d give up<br />
their time to volunteer with us. Last year we raised more th<strong>an</strong><br />
£5 million from our partnerships with various org<strong>an</strong>isations –<br />
including TKMaxx, Superdrug <strong>an</strong>d E.On. And other partners<br />
such as Tesco <strong>an</strong>d Nivea sponsor our running events.<br />
I’ve taken part in Race for Life since my diagnosis in 2007.<br />
I walk it with my friends, <strong>an</strong>d my daughter runs it too. It’s part<br />
of our year now. My husb<strong>an</strong>d was marshalling at the last<br />
Race for Life at 6.30am on his 60th birthday! That’s what it’s all<br />
about – everyone coming together to support each other.<br />
Deborah Huggons<br />
Breast c<strong>an</strong>cer survivor<br />
Major supporters<br />
We are grateful to our major supporters: individuals,<br />
gr<strong>an</strong>t-making trusts <strong>an</strong>d foundations whose most generous<br />
contributions have helped to fund new buildings, items of<br />
equipment, Fellowship schemes <strong>an</strong>d new areas of scientific<br />
research. We are delighted to acknowledge m<strong>an</strong>y of our<br />
supporters on page 28.<br />
Special events<br />
Every year we have a packed diary of special events. These<br />
include the Bobby Moore Fund Sports Ball, Sound & Vision,<br />
a series of concerts at Abbey Road Studios, the Chelsea Flower<br />
Show – where a generous supporter funds <strong>an</strong> inspirational<br />
garden – <strong>an</strong>d our Christmas-time Emeralds & Ivy ball.<br />
Fundraising together – supporting foundations<br />
Last year we worked with Seve Ballesteros to create a new<br />
foundation to raise funds for brain c<strong>an</strong>cer research. And we<br />
became a beneficiary of the Dallaglio Foundation in memory of<br />
Lawrence Dallaglio’s mother who died of c<strong>an</strong>cer. This year we<br />
will continue to work in partnership with Seve <strong>an</strong>d Lawrence<br />
to deliver high-profile events, such as gala dinners <strong>an</strong>d celebrity<br />
music events, which will help fund our life-saving work.<br />
Fundraising for the future<br />
Give Ch<strong>an</strong>ge Make Ch<strong>an</strong>ge is a new way to give to charity<br />
while shopping online. Like a virtual charity-box, this novel<br />
idea allows people to round up their online shopping bill on<br />
partner websites <strong>an</strong>d donate their ‘electronic spare ch<strong>an</strong>ge’.<br />
We are working with WWF, Great Ormond Street Hospital<br />
<strong>an</strong>d the British Red Cross to launch the initiative.<br />
To find out more about how you c<strong>an</strong> support us see<br />
pages 26 <strong>an</strong>d 27, or visit<br />
www.c<strong>an</strong>cerresearchuk.org/supportus<br />
20 / Annual Review / Raising money to support our work
Deborah Huggons, 53<br />
Race for Life particip<strong>an</strong>t <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />
After noticing a lump in her breast, Deborah was<br />
diagnosed with breast c<strong>an</strong>cer in 2007. She had<br />
a mastectomy <strong>an</strong>d six months of chemotherapy.<br />
Deborah took part in the TACT-2 trial, which we helped<br />
fund. It compares different chemotherapy treatments<br />
to try to reduce side effects <strong>an</strong>d improve long-term<br />
benefits. Now back to full health, Deborah r<strong>an</strong> the<br />
Barnstaple Race for Life with her daughter Esme.<br />
7.00am The dashing around begins, trying to get my<br />
children out of bed <strong>an</strong>d on the school bus.<br />
8.30am Start work. I’m a careers advisor for young<br />
people with learning difficulties.<br />
1.00pm Grab a quick s<strong>an</strong>dwich.<br />
7.15pm When I get home it’s a bit m<strong>an</strong>ic. We spend<br />
m<strong>an</strong>y of our evenings taking our children to<br />
after-school activities. Having c<strong>an</strong>cer ch<strong>an</strong>ged<br />
my priorities. Now I’m more focused on<br />
my family.<br />
11.30pm Bed, but I have to have some quiet time first.<br />
200trials<br />
We currently support<br />
around 200 clinical trials<br />
across the <strong>UK</strong>. With the<br />
help of people like Deborah<br />
<strong>an</strong>d the vital funds raised<br />
by our supporters, trials<br />
like TACT-2 aim to make<br />
treatments more effective.<br />
Annual Review / Raising money Annual to Review support / our About work us / 21
How your donation helps<br />
us beat c<strong>an</strong>cer<br />
We rely entirely on the money you give<br />
us <strong>an</strong>d 90% of the donations we receive<br />
are £10 or under. Small donations c<strong>an</strong><br />
make a big difference.<br />
One gift of £10 could buy 300 glass slides for<br />
studying cells under the microscope. If 55,000<br />
people each give £10, they would pay for<br />
a research programme to test new drugs<br />
to treat women with breast c<strong>an</strong>cer.<br />
Total cost of research work done during the year – £334m<br />
£37.4m<br />
Includes cervical, kidney,<br />
stomach, sarcoma,<br />
testicular, pharyngeal<br />
<strong>an</strong>d over 100 other c<strong>an</strong>cers<br />
£41.4m<br />
Breast<br />
£4.8m<br />
Brain<br />
£6.1m<br />
Bladder<br />
£9.4m<br />
P<strong>an</strong>creatic<br />
£9.5m<br />
Non-Hodgkin’s<br />
Lymphoma<br />
£132.5m<br />
Basic research *<br />
£24.8m<br />
Bowel<br />
£10.6m<br />
Ovari<strong>an</strong><br />
£11.9m<br />
Lung<br />
£13.3m<br />
Skin<br />
£15.0m<br />
Leukaemia<br />
£17.3m<br />
Prostate<br />
*<br />
In basic research, our scientists are working in laboratories to underst<strong>an</strong>d<br />
exactly how normal cells work <strong>an</strong>d exactly how these processes go wrong<br />
in c<strong>an</strong>cer. This research is vital, increasing our underst<strong>an</strong>ding of the molecular<br />
basis of the disease <strong>an</strong>d laying the foundations for new ways to detect <strong>an</strong>d<br />
treat m<strong>an</strong>y different types of c<strong>an</strong>cer.<br />
22 / Annual Review / How your donation helps us beat c<strong>an</strong>cer<br />
157
Lun<br />
C<strong>an</strong>cer research is very expensive…<br />
The average cost to run just one trial or laboratory<br />
is around £1 million per year, <strong>an</strong>d research projects<br />
normally last several years. <strong>Research</strong> activities carried<br />
out in institutes, hospitals <strong>an</strong>d universities throughout<br />
the <strong>UK</strong> cost £334 million. This figure reflects the cost<br />
of research work done this year.<br />
14 1<br />
We also spent £14 million on 57 our information <strong>an</strong>d<br />
influencing work, raising awareness of c<strong>an</strong>cer risks,<br />
providing better information to people affected by<br />
c<strong>an</strong>cer <strong>an</strong>d influencing public health policies. Total<br />
C<strong>an</strong>cer research is a long-term<br />
87 expenditure<br />
investment. This 308<br />
£467m year,<br />
due to the difficult economic climate <strong>an</strong>d <strong>an</strong> overall<br />
308<br />
fall<br />
in voluntary giving to charities in the <strong>UK</strong>, it has been<br />
more import<strong>an</strong>t th<strong>an</strong> ever that we keep a small amount<br />
of funds in reserve. This way, we will be able to continue<br />
our vital work in order to achieve our future goals.<br />
…but small donations add up<br />
Our supporters defied the recession by giving more th<strong>an</strong><br />
ever. Our fundraising income was £446 million – £13 million<br />
more th<strong>an</strong> last year. This me<strong>an</strong>t we were able to commit<br />
more towards our life-saving work to beat c<strong>an</strong>cer.<br />
82<br />
65<br />
25<br />
Total<br />
fundraising<br />
income<br />
£446m<br />
94<br />
23<br />
157<br />
Legacies (People leaving us a gift in their will)<br />
Volunteer fundraising (Community fundraising<br />
– local events <strong>an</strong>d appeals, including Relay For Life)<br />
Direct giving (Regular <strong>an</strong>d one-off donations,<br />
payroll <strong>an</strong>d online products)<br />
Events (National events such as Race for Life,<br />
Run10k <strong>an</strong>d activities for the Booby Moore Fund)<br />
Shop income (Sales from donated goods <strong>an</strong>d our own products)<br />
Other income (Including major gifts, corporate partnerships<br />
<strong>an</strong>d shop donations)<br />
We will spend 80p in every £1 on fighting c<strong>an</strong>cer…<br />
For every pound we receive, excluding our retail chain,<br />
80p is available to spend on our life-saving research,<br />
providing information <strong>an</strong>d influencing public policy.<br />
…<strong>an</strong>d the other 20p works hard too<br />
The money we spend on fundraising activities helps us<br />
to raise more th<strong>an</strong> four times as much – for every £1 we<br />
spend on fundraising, excluding our retail chain, we raise<br />
over £4 more. And we are always looking for ways to<br />
make our fundraising operations more efficient.<br />
£1<br />
80p *<br />
• <strong>Research</strong><br />
• Public-facing information<br />
• Influencing public policy<br />
20p<br />
• Cost of generating funds<br />
(excluding retail)<br />
£1<br />
£1<br />
£1<br />
£1<br />
£1<br />
*<br />
Funds available to spend on our work to beat c<strong>an</strong>cer – 2009/10<br />
Annual Review / How your donation helps us beat c<strong>an</strong>cer / 23
Professor David Neal, 59<br />
Leading expert on prostate c<strong>an</strong>cer<br />
David is based at the Oncology Department of<br />
Addenbrooke’s Hospital, University of Cambridge. He leads<br />
the C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> Uro-Oncology Group, which is<br />
looking into prostate c<strong>an</strong>cer screening <strong>an</strong>d other ways to<br />
beat the disease. A particular focus is identifying better ways<br />
of distinguishing aggressive c<strong>an</strong>cers from non-aggressive<br />
ones so treatment c<strong>an</strong> be better targeted.<br />
7.15am<br />
8.00am<br />
8.45am<br />
1.00pm<br />
6.30pm<br />
After cycling to work, I see a patient who has<br />
been admitted for robotic radical prostatectomy<br />
– a very precise way of removing c<strong>an</strong>cerous<br />
prostate gl<strong>an</strong>ds with the aid of a robot.<br />
Chair the urology departmental meeting<br />
to ensure we are doing our best to see people<br />
on time <strong>an</strong>d treat them promptly.<br />
Go to the operating theatre.<br />
Meet with my research group, who are funded<br />
by C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>. We are studying<br />
adv<strong>an</strong>ced prostate c<strong>an</strong>cers to determine what<br />
new treatments might work in a disease that<br />
has become resist<strong>an</strong>t to conventional treatments.<br />
Go home <strong>an</strong>d have dinner. My wife <strong>an</strong>d I take<br />
our two dogs for a walk, <strong>an</strong>d I play the guitar<br />
before bed.<br />
£334m<br />
We support people like<br />
David, who is investigating<br />
the PSA test <strong>an</strong>d if it<br />
should form the basis<br />
of a national screening<br />
programme. This year<br />
we spent £334 million on<br />
research activity like this<br />
in hospitals, institutes <strong>an</strong>d<br />
universities across the <strong>UK</strong>.<br />
24 / Annual Review / Contents Meet our Executive Board
Meet our Executive Board<br />
Our supporters put a huge amount of time<br />
<strong>an</strong>d effort into raising money to help beat<br />
c<strong>an</strong>cer. Our Trustees, Executive Board, <strong>an</strong>d<br />
all of our staff work hard to make sure every<br />
penny raised is used as effectively as possible.<br />
The Directors who made up our Executive Board<br />
in 2009/10 were:<br />
1<br />
2 3 4<br />
1/ Harpal Kumar MA MEng MBA<br />
Chief Executive Officer <strong>an</strong>d Chairm<strong>an</strong> of the Executive Board<br />
Harpal leads C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> in our fight to beat c<strong>an</strong>cer.<br />
He chairs our Executive Board <strong>an</strong>d Scientific Executive<br />
Board <strong>an</strong>d leads m<strong>an</strong>y of our key programes <strong>an</strong>d initiatives.<br />
He co-chairs the National Awareness <strong>an</strong>d Early Diagnosis<br />
Initiative <strong>an</strong>d is a Board Member of the National C<strong>an</strong>cer<br />
<strong>Research</strong> Institute committees. He is also Deputy Chair<br />
of the Advisory Board for the C<strong>an</strong>cer Reform Strategy.<br />
2/ Aisling Burn<strong>an</strong>d MBE<br />
Executive Director, Policy <strong>an</strong>d Public Affairs<br />
Aisling is responsible for keeping c<strong>an</strong>cer on the political agenda<br />
across the <strong>UK</strong> <strong>an</strong>d in Europe. This includes developing our<br />
policies on c<strong>an</strong>cer, science <strong>an</strong>d other charity issues, <strong>an</strong>d working<br />
with our supporters to influence politici<strong>an</strong>s <strong>an</strong>d civil serv<strong>an</strong>ts.<br />
3/ Dr Lili<strong>an</strong> Clark PhD MBA<br />
Executive Director, Science Operations <strong>an</strong>d Funding<br />
Lili<strong>an</strong> is responsible for the funding <strong>an</strong>d administration of much<br />
of the research we support. She ensures that the research<br />
we fund is of the highest quality, <strong>an</strong>d aligned to our vision.<br />
4/ Dr Iain Foulkes PhD<br />
Executive Director, Strategy <strong>an</strong>d Pl<strong>an</strong>ning<br />
Iain helps shape C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s long-term strategic<br />
direction. He makes sure that, by having a clear <strong>an</strong>d effective<br />
strategy, we are in a position to meet our ambitious goals.<br />
5/ Professor Peter Johnson MA MD FRCP<br />
Chief Clinici<strong>an</strong><br />
Peter is responsible for our clinical activities – our clinical<br />
research, the gathering of clinical input to guide our policy<br />
<strong>an</strong>d much of our work on c<strong>an</strong>cer prevention, diagnosis <strong>an</strong>d<br />
treatment. He helps us to decide what direction we take in<br />
these areas <strong>an</strong>d makes sure we have the pl<strong>an</strong>s in place to carry<br />
out this work.<br />
6/ Professor Sir David L<strong>an</strong>e FRS FRSE<br />
Chief Scientist<br />
David is a leading c<strong>an</strong>cer research scientist, currently based<br />
in Singapore. He is responsible for helping to develop our<br />
scientific strategy ensuring that it is leading-edge <strong>an</strong>d<br />
monitoring its implementation. He also plays a key role<br />
in attracting the top scientists to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>.<br />
5 6 7 8<br />
9 10 11<br />
7/ Sarah Lyness MA<br />
Executive Director, Communications <strong>an</strong>d Information<br />
Sarah has helped make C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> a well-known<br />
name in the <strong>UK</strong>. She is responsible for informing people<br />
about c<strong>an</strong>cer <strong>an</strong>d the work we do to fight it.<br />
8/ Lynne Robb BSc ACA<br />
Chief Fin<strong>an</strong>cial Officer <strong>an</strong>d Executive Director,<br />
Corporate Resources<br />
Lynne’s role covers a wide r<strong>an</strong>ge of areas, including our<br />
fin<strong>an</strong>ces, our investments <strong>an</strong>d our legal position. She’s also<br />
responsible for our facilities <strong>an</strong>d for making sure we m<strong>an</strong>age<br />
the Charity in the most cost-effective way.<br />
9/ Elizabeth Sideris BA MSc<br />
Executive Director, Hum<strong>an</strong> Resources<br />
Elizabeth is responsible for C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>’s people.<br />
She supports our staff, making sure they’re always developing,<br />
<strong>an</strong>d looks for ways to make C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> <strong>an</strong> enjoyable<br />
<strong>an</strong>d rewarding place to work.<br />
10/ Dr Peter Sneddon PhD BSc DPhil(Oxon)<br />
Executive Director, Clinical <strong>an</strong>d Tr<strong>an</strong>slational<br />
Operations <strong>an</strong>d Funding<br />
Peter is responsible for the operation <strong>an</strong>d funding of clinical<br />
<strong>an</strong>d tr<strong>an</strong>slational research, which includes our vital clinical trials<br />
portfolio, our C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> Centres <strong>an</strong>d our drug<br />
discovery <strong>an</strong>d development work.<br />
11/ Richard C Taylor<br />
Executive Director, Fundraising <strong>an</strong>d Supporter Marketing<br />
Richard oversees our fundraising. He makes sure we have<br />
enough money coming in to fund our long-term goals. He leads<br />
a team to develop our five-year fundraising strategy <strong>an</strong>d ensures<br />
that our fundraising is as effective <strong>an</strong>d efficient as possible.<br />
For more information on our Executive Board visit<br />
www.c<strong>an</strong>cerresearchuk.org/executiveboard<br />
Annual Review / Meet our Executive Board / 25
Const<strong>an</strong>ce Hoey, 55<br />
Race for Life particip<strong>an</strong>t <strong>an</strong>d breast c<strong>an</strong>cer survivor<br />
Const<strong>an</strong>ce discovered a lump under her right armpit<br />
while she was on holiday in May 2008. She underwent<br />
six months of chemotherapy <strong>an</strong>d surgery to remove both<br />
breasts <strong>an</strong>d 25 lymph nodes from each armpit, as well<br />
as radiotherapy. She was treated with Herceptin <strong>an</strong>d<br />
Arimidex, <strong>an</strong>d is now on Tamoxifen – all drugs that<br />
our research helped to develop. Now back at work<br />
as <strong>an</strong> administrative assist<strong>an</strong>t, Const<strong>an</strong>ce took part<br />
in the Birmingham Race for Life earlier this year.<br />
6.00am Wake up <strong>an</strong>d do 15 minutes of exercise. Then<br />
leave for work. I’ll have a light breakfast <strong>an</strong>d take<br />
my tablets when I get there.<br />
12.00pm I like to go for a walk at lunchtime.<br />
2.00pm Finish work. I’m not ready for full-time work yet.<br />
But I’m getting better <strong>an</strong>d stronger all the time.<br />
I might pop to the shops, prepare tea or potter<br />
in the garden.<br />
6.30pm Dinner with my husb<strong>an</strong>d Martin – he’s been<br />
a tower of strength. Afterwards we watch<br />
TV or a film together.<br />
10.00pm Try a little more exercise before going to bed.<br />
£41.4m<br />
This year we spent<br />
£41.4 million on life-saving<br />
breast c<strong>an</strong>cer research.<br />
Our work covers all<br />
aspects of the disease,<br />
from its molecular causes<br />
through to developing new<br />
drugs <strong>an</strong>d the psychological<br />
effects of treatment.<br />
26 / Annual Review / Contents Get involved <strong>an</strong>d find out more
Get involved <strong>an</strong>d find out more<br />
How you c<strong>an</strong> help<br />
Do your own fundraising or join a group<br />
Org<strong>an</strong>ise a quiz, a sweepstake, a party – whatever<br />
you enjoy doing, use it to raise funds to fight c<strong>an</strong>cer.<br />
If you don’t w<strong>an</strong>t to fundraise alone, join a group,<br />
or why not start your own? Find out more at<br />
supportus.c<strong>an</strong>cerresearchuk.org/fundraising<br />
Take part in <strong>an</strong> event<br />
Whether you w<strong>an</strong>t to walk, run, cycle or swim, we have <strong>an</strong><br />
event to suit you <strong>an</strong>d to help us beat c<strong>an</strong>cer. Get involved at<br />
supportus.c<strong>an</strong>cerresearchuk.org/events<br />
Give your time<br />
If you have the time, we have the volunteering opportunity –<br />
from helping out in a shop or at <strong>an</strong> event, to raising awareness<br />
about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> in your community. Find out more at<br />
supportus.c<strong>an</strong>cerresearchuk.org/volunteering<br />
Become a corporate partner<br />
Take part in staff fundraising, health promotion or commercial<br />
marketing partnerships <strong>an</strong>d we will support you every step<br />
of the way. For more information visit<br />
c<strong>an</strong>cerresearchuk.org/corporatepartnerships<br />
Visit our shops<br />
Donate your unw<strong>an</strong>ted items, or come in for a browse<br />
<strong>an</strong>d a bargain. You c<strong>an</strong> also shop from your sofa at<br />
www.shoptobeatc<strong>an</strong>cer.org.uk<br />
Make a donation – leave a lasting legacy<br />
Give monthly by direct debit or through payroll giving.<br />
Give in memory of a loved one or leave a life-saving legacy<br />
by remembering us in your will. However big or small,<br />
your donation will help us beat c<strong>an</strong>cer.<br />
www.c<strong>an</strong>cerresearchuk.org/donate<br />
It’s research that saved my life. There’s every ch<strong>an</strong>ce that<br />
someone you know will benefit directly from the money you<br />
give to C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>.<br />
Const<strong>an</strong>ce Hoey<br />
Breast c<strong>an</strong>cer survivor<br />
Information about c<strong>an</strong>cer – prevention, treatment <strong>an</strong>d care<br />
Get reliable information about c<strong>an</strong>cer<br />
If you’re looking for information about c<strong>an</strong>cer that’s up to<br />
date <strong>an</strong>d easy to underst<strong>an</strong>d, visit our C<strong>an</strong>cerHelp <strong>UK</strong> website.<br />
You c<strong>an</strong> find out about c<strong>an</strong>cer trials <strong>an</strong>d research here too.<br />
www.c<strong>an</strong>cerhelp.org.uk<br />
Speak to a specialist c<strong>an</strong>cer nurse<br />
We have a team of specialist c<strong>an</strong>cer nurses who c<strong>an</strong> <strong>an</strong>swer<br />
your questions in confidence.<br />
Call free on 0808 800 4040, Monday to Friday, 9am to 5pm.<br />
Or email using the contact form at<br />
www.c<strong>an</strong>cerhelp.org.uk<br />
Talk to others affected by c<strong>an</strong>cer<br />
Our online discussion forum C<strong>an</strong>cer Chat is your space to talk<br />
to other people affected by c<strong>an</strong>cer, share experiences <strong>an</strong>d find<br />
information at<br />
www.c<strong>an</strong>cerchat.org.uk<br />
More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />
Visit our website<br />
For everything there is to know about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong>,<br />
the work we do, <strong>an</strong>d how you c<strong>an</strong> support us, visit<br />
www.c<strong>an</strong>cerresearchuk.org<br />
Join our Facebook page<br />
Meet other C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> supporters, give messages<br />
of support, post details of events <strong>an</strong>d share fundraising ideas<br />
www.facebook.com/c<strong>an</strong>cerresearchuk<br />
Ask us questions or tell us what you think<br />
If you have a question or a comment about our work,<br />
we’d love to hear from you.<br />
Call our Supporter Services team on 020 7121 6699<br />
or send us a message through our website.<br />
www.c<strong>an</strong>cerresearchuk.org/aboutus/contactus<br />
Donate to a project<br />
Choose the type of c<strong>an</strong>cer you w<strong>an</strong>t to beat <strong>an</strong>d donate<br />
to a specific project. Your reasons, your choice.<br />
Find out more at<br />
myprojects.c<strong>an</strong>cerresearchuk.org<br />
Campaign with us<br />
Help us keep c<strong>an</strong>cer at the top of the public agenda.<br />
Our supporters have successfully campaigned on issues<br />
from smokefree workplaces to improved c<strong>an</strong>cer screening<br />
programmes. Get involved at<br />
www.c<strong>an</strong>cercampaigns.org.uk<br />
Annual Review / Get involved <strong>an</strong>d find out more / 27
Th<strong>an</strong>k you<br />
We would like to th<strong>an</strong>k everyone who<br />
has helped C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> over the<br />
past year by investing their money, time<br />
<strong>an</strong>d skills to make our work possible.<br />
In particular we would like to th<strong>an</strong>k all the<br />
people that help us in our research by<br />
taking part in our clinical trials <strong>an</strong>d helping<br />
in our population studies. Their support<br />
has made a huge difference.<br />
We would also like to th<strong>an</strong>k the<br />
following org<strong>an</strong>isations <strong>an</strong>d individuals,<br />
including those who have chosen to<br />
remain <strong>an</strong>onymous – we are immensely<br />
grateful to everyone.<br />
Our Patron<br />
Her Majesty The Queen<br />
Our Joint Presidents<br />
HRH The Duke of Gloucester, KG, GCVO<br />
HRH Princess Alex<strong>an</strong>dra<br />
the Hon. Lady Ogilvy, KG, GCVO<br />
Our corporate partners<br />
AT&T<br />
Beiersdorf <strong>UK</strong> Ltd<br />
British Airways plc<br />
Cheltenham Racecourse<br />
Compass Group <strong>UK</strong> <strong>an</strong>d Irel<strong>an</strong>d Ltd<br />
Deloitte LLP<br />
Diamond Insur<strong>an</strong>ce<br />
docrafts®<br />
FlyBe Ltd<br />
The Football Association<br />
Hearst Digital<br />
HSBC B<strong>an</strong>k plc<br />
ICAP<br />
J Sainsbury plc<br />
JT Ellis & Co Ltd<br />
Ladbrokes in the Community<br />
Charitable Trust<br />
Live Nation (Music) <strong>UK</strong> Ltd<br />
Lloyds B<strong>an</strong>king Group plc<br />
The London Marriott Business Council<br />
Mackays Stores Ltd<br />
Molton Brown Ltd<br />
Network Rail Infrastructure Ltd<br />
The Pampered Chef Ltd<br />
Peacocks Stores Ltd<br />
Premier Foods plc<br />
The Royal B<strong>an</strong>k of Scotl<strong>an</strong>d Group plc<br />
Sony Music Entertainment <strong>UK</strong> Ltd<br />
Sportsdirect.com Retail Ltd<br />
The Stobart Group<br />
Tesco plc<br />
TK Maxx <strong>an</strong>d HomeSense<br />
Towergate Charitable Foundation<br />
Toyota Motor M<strong>an</strong>ufacturing (<strong>UK</strong>) Ltd<br />
<strong>UK</strong> Mail Group plc<br />
Wembley National Stadium<br />
West Ham United<br />
Wm Morrison Supermarkets plc<br />
Our major supporters<br />
Milly Apthorp Charitable Trust<br />
Celia Atkin<br />
Awareness<br />
James Baldwin Trust<br />
Mr Seve Ballesteros<br />
The B<strong>an</strong>d Trust<br />
The Barbour Trust<br />
Mark <strong>an</strong>d Rebecca Baron<br />
Dr Christopher Beels<br />
Robert <strong>an</strong>d Alison Bernays<br />
Tony Bramall Charitable Trust<br />
Bill Butlin Charity Trust<br />
David <strong>an</strong>d Jennifer Buxton<br />
Edward Cadbury Charitable Trust<br />
Bill C<strong>an</strong>non<br />
Catherine Cookson Charitable Trust<br />
Mr Keith C Cornwell<br />
Mr Lawrence Dallaglio OBE<br />
The D<strong>an</strong>ego Charitable Trust<br />
Dr Naim D<strong>an</strong>goor OBE<br />
DG Charitable Trust<br />
Mr & Mrs Martin Dawe<br />
Mr Cyril Dennis MBE<br />
Clive <strong>an</strong>d Greta Dorey<br />
Collette Dove<br />
Mr Sydney Draper<br />
Mr David Dutton<br />
The Alice Edwards Charitable<br />
Foundation<br />
Team Engl<strong>an</strong>d Footballers’ Charity<br />
Eveson Charitable Trust<br />
Doris Field Charitable Trust<br />
Donald Forrester Trust<br />
The Freemasons’ Gr<strong>an</strong>d Charity<br />
Friends Provident Foundation<br />
Mr Jonath<strong>an</strong> Goldstein<br />
Mike Gooley Trailfinders Charity<br />
Sir Donald Gordon<br />
JWC H<strong>an</strong>ds Charitable Trust<br />
Harhil Charitable Trust<br />
Mr Bob Harris<br />
Ada Hillard Charitable Trust<br />
The Marie Keating Foundation<br />
Mr Ron<strong>an</strong> Keating<br />
Robert <strong>an</strong>d Anna King<br />
The Jimmy Knapp C<strong>an</strong>cer Fund<br />
Mr Stephen Knott<br />
Kirby Laing Foundation<br />
Laing O’Rourke Plc<br />
Kathleen Laurence Charitable Trust<br />
Richard Lawes Foundation<br />
Mr Bri<strong>an</strong> Lay<br />
Leonora Children’s C<strong>an</strong>cer Fund<br />
Miss E M Lidbury Charitable Trust<br />
The Lipsaira Foundation<br />
Dr Iain MacKellar BVSc MRCVS<br />
The Mayfair Committee<br />
The McGrath Charitable Trust<br />
Fiona McHugh <strong>an</strong>d Gertie McHugh,<br />
B. & M. McHugh Limited<br />
Debs McLe<strong>an</strong><br />
Barbara McLell<strong>an</strong><br />
Laurence Misener Charitable Trust<br />
Steph<strong>an</strong>ie Moore OBE<br />
The Musgrave Charitable Trust Ltd<br />
The Myristica Trust<br />
The North Sea Flight 85N<br />
Memorial Fund<br />
Oak Foundation<br />
Parthenon Trust<br />
Peacock Trust<br />
Plaw Hatch Hall Trust<br />
Lee <strong>an</strong>d Caroline Portnoi<br />
Mr Glenn Poulter<br />
Nigel <strong>an</strong>d Sus<strong>an</strong> Pritchard<br />
Juliette Proudlove Memorial Fund<br />
R<strong>an</strong>worth Trust<br />
Gerald Ronson Foundation<br />
Mr Justin Rose<br />
Mrs Sue Scott<br />
Mr Nigel Seabold<br />
ShareGift<br />
The Gill Gurdit Singh Fund<br />
Phillip <strong>an</strong>d Vivien Sober<br />
Mrs John Somers<br />
Peter <strong>an</strong>d Beryl Stevens<br />
Rhoddy <strong>an</strong>d Georgina Swire<br />
Mr John Thomson<br />
Timp<strong>an</strong>y Charitable Trust<br />
The Toby Charitable Trust<br />
Mr <strong>an</strong>d Mrs Robin Tomkins<br />
John <strong>an</strong>d Ann-Margaret Walton<br />
Garfield Weston Foundation<br />
Pamela Williams Charitable Trust<br />
Foster Wood Foundation<br />
Mrs Humphrey Wood MBE<br />
Mr Thomas Wood<br />
Lennox <strong>an</strong>d Wyfold Foundation<br />
Yelsel Trust<br />
Zochonis Charitable Trust<br />
Our Trustees<br />
David Newbigging OBE Chairm<strong>an</strong><br />
Dr Mel<strong>an</strong>ie G Lee CBE BSc DSc(Hon)<br />
FMedSci Deputy Chairm<strong>an</strong><br />
Professor Anton Berns PhD<br />
(appointed 30 March 2010)<br />
Professor Colin C Bird CBE FRSE<br />
Dr Philip H M Campbell BSc MSc PhD<br />
DSc FInstP FRAS<br />
Sir James Crosby BA FFA<br />
Liz A Hewitt FCA BSc(Econ) FRSA<br />
Roger Matthews ACA BSocSci<br />
Dame Bridget Ogilvie AC DBE FRS<br />
Dr Keith F Palmer OBE Treasurer<br />
Michael Pragnell MA(Oxon)<br />
MBA(INSEAD)<br />
(appointed 30 March 2010)<br />
Leah J Sowden FCA CTA DChA<br />
Professor Jeffrey Tobias MD<br />
FRCP FRCR<br />
Professor Sir Kenneth Calm<strong>an</strong> KCB DL<br />
FRSE (retired 31 December 2009)<br />
28 / Annual Review / Th<strong>an</strong>k you
More about C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong><br />
For everything there is to know about<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> visit<br />
www.c<strong>an</strong>cerresearchuk.org<br />
We are committed to a series of social <strong>an</strong>d<br />
environmental goals. You c<strong>an</strong> find out more<br />
about these at<br />
aboutus.c<strong>an</strong>cerresearchuk.org/sustainability<br />
A great deal of c<strong>an</strong>cer research is carried out without<br />
using <strong>an</strong>imals, but in certain areas <strong>an</strong>imal research remains<br />
essential if we are to underst<strong>an</strong>d, prevent <strong>an</strong>d cure c<strong>an</strong>cer.<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> only uses <strong>an</strong>imals when there<br />
is no alternative.<br />
C<strong>an</strong>cer patients <strong>an</strong>d their families are at the heart of<br />
everything we do. We believe that all our research is vital<br />
if we are to save the lives of more patients in the future.<br />
C<strong>an</strong>cer <strong>Research</strong> <strong>UK</strong> is a member of the Association of<br />
Medical <strong>Research</strong> Charities <strong>an</strong>d endorses the AMRC's<br />
position on the use of <strong>an</strong>imals in medical research.<br />
A PDF of both our Annual Review <strong>an</strong>d Annual Report<br />
<strong>an</strong>d Accounts c<strong>an</strong> be downloaded at<br />
aboutus.c<strong>an</strong>cerresearchuk.org/our-<strong>an</strong>nual-publications<br />
Registered charity number in Engl<strong>an</strong>d <strong>an</strong>d Wales 1089464<br />
Registered charity number in Scotl<strong>an</strong>d SC041666<br />
Registered comp<strong>an</strong>y number 4325234<br />
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