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聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展

聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展

聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展

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[20 ] Theo JC , Marc CM , Bijsterbosch MK, et al. Drug targeting<br />

by neo2lipoproteins [J ]. J Controlled Release , 1996 , 41<br />

(1) :85 - 90.<br />

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droplets effects results of hepatic arterial chemotherapy with<br />

an anticancer agent in water2in2oil2in2water emulsion to hep2<br />

atocellular carcinoma [J ]. J Pharmacol Exp Ther , 1999 ,<br />

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166<br />

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Foreign Medical Sciences Section on Pharmacy 2001 Jun ; 28 (3)<br />

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[6<br />

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] Li [7 ] [1 ] Endoh H , Kawaguchi T , Seki T , et al. Controlled release<br />

<br />

of 52fluoro22 deoxyuridine by the combination of prodrug and<br />

<br />

,<br />

/ ( ) polymer matrix[J ]. Chem Pharm Bull (Tokyo) , 1991 , 39<br />

(2) :458 - 464.<br />

<br />

<br />

,<br />

acterization of poly(lactic2co2glycolic acid) microspheres for<br />

<br />

,<br />

targeted delivery of a novel anticancer agent , taxol [J ].<br />

, ,<br />

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Chem Pharm Bull (Tokyo) , 1996 , 44(10) :1935 - 1940.<br />

2. 3. 2 <br />

,<br />

<br />

,<br />

lease of a water2soluble GP b/ a antagonist from copoly<br />

, ( DL2lactic/ glycolic) acid microspheres[J ]. Int J Pharm ,<br />

,<br />

1997 , 146(2) :147 - 157.<br />

[15<br />

] <br />

[4 ] Celebi N , Erden N , T rkyilmaz A. The preparation and<br />

evaluation of salbutamol sulphate containing PLGA<br />

2. 4 <br />

micro2<br />

<br />

, ,<br />

[15<br />

<br />

] Pharm , 1996 , 136(1/ 2) :89 - 100.<br />

<br />

,<br />

[5 ] Herrmann J , Bodmeier R. The effect of particle microstruc2<br />

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ture on the somatostatin release from poly(lactide) micro2<br />

[2<br />

<br />

] ,PLGA DCM 30 %<br />

spheres prepared by a W/ O/ W solvent evaporation method<br />

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70 %<br />

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,IPM <br />

<br />

[J ]. W/ O/ W <br />

, 1997 , 32(10) :595 - 597.<br />

[11<br />

(somatostatin) <br />

] ,<br />

() [7 ] Li WI , Anderson KW , Mehta RC , et al. Prediction of sol2<br />

<br />

( vent removal profile and effect on properties for<br />

pH 2 . 2 ,3 . 0 , 4 . 0 , 5 . 0) <br />

peptide2<br />

loaded PLGA microspheres prepared by solvent2extraction<br />

(NaCl ,CaCl 2 ) <br />

<br />

(3) :199 - 214.<br />

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[8 ] <br />

,<br />

L2<br />

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,<br />

colic acid) microspheres containing tumor necrosis factor2al2<br />

<br />

pha (TNF2 ) [J ]. Int J Pharm , 1998 , 160(2) :145 - 156.<br />

<br />

PVA NaCl [9 ] Bodmeier R , Wang H , Dixon DJ , et al. Polymeric micro2<br />

Reich [16 ] <br />

,<br />

spheres prepared by spraying into compressed carbon dioxide<br />

PLGA ,<br />

DCM [10 ] Shenderova A , Burke TG, Schwendeman SP. Stabilization<br />

<br />

, <br />

of 102hydroxycamptothecin in poly(lactide2co2glycolide) mi2<br />

3 <br />

(10) :1406 - 1414.<br />

PLA PLGA <br />

<br />

[2 ] Wang YM , Sato H , Adachi I , et al. Preparation and char2<br />

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spheres with factorial design2based studies [ J ]. Int J<br />

[J ]. J Controlled Release , 1995 , 36(1/ 2) :63 - 71.<br />

evaporation method [J ]. J Controlled Release , 1995 , 37<br />

Iwata M , Tanaka T , Nakamura Y, et al. Selection of sol2<br />

vent system for the preparation of Poly( D , L2lactic2co2gly2<br />

[J ]. Pharm Res , 1995 ,12(8) :1211 - 1217.<br />

crosphere delivery vehicles [ J ]. Pharm Res , 1997 , 14<br />

[11 ] Corre PL , Guevello PL , Gajan V , et al. Preparation and<br />

<br />

,<br />

characterization of bupivacaine2loaded polylactide and poly2<br />

<br />

,<br />

lactide2co2glycolide microspheres[J ]. Int J Pharm , 1994 ,<br />

<br />

107 (1) :41 - 49.<br />

,<br />

[12 ] Delgado A , Evora C , Llabr s M. Effect of storage on the


2001 6 <br />

28 3 <br />

167<br />

<br />

stability of DL2PLA microspheres containing methadone[J ].<br />

Int J Pharm , 1998 , 166(2) :223 - 225.<br />

[13 ] Schrier JA , DeLuca PP. Recombinant human bone morpho2<br />

genetic protein22 binding and incorporation in PLGA micro2<br />

sphere delivery systems[J ]. Pharm Dev Technol , 1999 , 4<br />

(4) :611 - 612.<br />

[14 ] Ertl B , Platzer P , Wirth M , et al. Poly ( D , L2lactic2co2<br />

glycolic acid) microspheres for sustained delivery and stabi2<br />

lization of camptothecin[J ]. J Controlled Release , 1999 , 61<br />

(3) :305 - 317.<br />

[15 ] O Donnell PB , McGinity JW. Influence of processing of the<br />

stability and release properties of biodegradable microspheres<br />

containing thioridazine hydrochloride[J ]. Eur J Pharm Bio2<br />

pharm , 1998 , 45(1) :83 - 94.<br />

[16 ] Reich G. Ultrasound2induced degradation of PLA and PLGA<br />

during microsphere processing : influence of formulation vari2<br />

ables[J ]. Eur J Pharm Biopharm , 1998 , 45 (2) : 165 -<br />

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