聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展
聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展
聚乳酸、聚乳酸乙醇酸共聚物微球的制备及影响其质量因素的研究进展
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164<br />
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Foreign Medical Sciences Section on Pharmacy 2001 Jun ; 28 (3)<br />
[20 ] Theo JC , Marc CM , Bijsterbosch MK, et al. Drug targeting<br />
by neo2lipoproteins [J ]. J Controlled Release , 1996 , 41<br />
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droplets effects results of hepatic arterial chemotherapy with<br />
an anticancer agent in water2in2oil2in2water emulsion to hep2<br />
atocellular carcinoma [J ]. J Pharmacol Exp Ther , 1999 ,<br />
289 (2) :816 - 819.<br />
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166<br />
<br />
Foreign Medical Sciences Section on Pharmacy 2001 Jun ; 28 (3)<br />
,W/ O/ O/ O <br />
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, O/ W <br />
<br />
,<br />
,<br />
[6<br />
<br />
] Li [7 ] [1 ] Endoh H , Kawaguchi T , Seki T , et al. Controlled release<br />
<br />
of 52fluoro22 deoxyuridine by the combination of prodrug and<br />
<br />
,<br />
/ ( ) polymer matrix[J ]. Chem Pharm Bull (Tokyo) , 1991 , 39<br />
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<br />
,<br />
acterization of poly(lactic2co2glycolic acid) microspheres for<br />
<br />
,<br />
targeted delivery of a novel anticancer agent , taxol [J ].<br />
, ,<br />
, <br />
Chem Pharm Bull (Tokyo) , 1996 , 44(10) :1935 - 1940.<br />
2. 3. 2 <br />
,<br />
<br />
,<br />
lease of a water2soluble GP b/ a antagonist from copoly<br />
, ( DL2lactic/ glycolic) acid microspheres[J ]. Int J Pharm ,<br />
,<br />
1997 , 146(2) :147 - 157.<br />
[15<br />
] <br />
[4 ] Celebi N , Erden N , T rkyilmaz A. The preparation and<br />
evaluation of salbutamol sulphate containing PLGA<br />
2. 4 <br />
micro2<br />
<br />
, ,<br />
[15<br />
<br />
] Pharm , 1996 , 136(1/ 2) :89 - 100.<br />
<br />
,<br />
[5 ] Herrmann J , Bodmeier R. The effect of particle microstruc2<br />
,<br />
ture on the somatostatin release from poly(lactide) micro2<br />
[2<br />
<br />
] ,PLGA DCM 30 %<br />
spheres prepared by a W/ O/ W solvent evaporation method<br />
<br />
( IPM) 3<br />
<br />
70 %<br />
,IPM 50 %[6 ] , , , . <br />
,IPM <br />
<br />
[J ]. W/ O/ W <br />
, 1997 , 32(10) :595 - 597.<br />
[11<br />
(somatostatin) <br />
] ,<br />
() [7 ] Li WI , Anderson KW , Mehta RC , et al. Prediction of sol2<br />
<br />
( vent removal profile and effect on properties for<br />
pH 2 . 2 ,3 . 0 , 4 . 0 , 5 . 0) <br />
peptide2<br />
loaded PLGA microspheres prepared by solvent2extraction<br />
(NaCl ,CaCl 2 ) <br />
<br />
(3) :199 - 214.<br />
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[8 ] <br />
,<br />
L2<br />
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,<br />
colic acid) microspheres containing tumor necrosis factor2al2<br />
<br />
pha (TNF2 ) [J ]. Int J Pharm , 1998 , 160(2) :145 - 156.<br />
<br />
PVA NaCl [9 ] Bodmeier R , Wang H , Dixon DJ , et al. Polymeric micro2<br />
Reich [16 ] <br />
,<br />
spheres prepared by spraying into compressed carbon dioxide<br />
PLGA ,<br />
DCM [10 ] Shenderova A , Burke TG, Schwendeman SP. Stabilization<br />
<br />
, <br />
of 102hydroxycamptothecin in poly(lactide2co2glycolide) mi2<br />
3 <br />
(10) :1406 - 1414.<br />
PLA PLGA <br />
<br />
[2 ] Wang YM , Sato H , Adachi I , et al. Preparation and char2<br />
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spheres with factorial design2based studies [ J ]. Int J<br />
[J ]. J Controlled Release , 1995 , 36(1/ 2) :63 - 71.<br />
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Iwata M , Tanaka T , Nakamura Y, et al. Selection of sol2<br />
vent system for the preparation of Poly( D , L2lactic2co2gly2<br />
[J ]. Pharm Res , 1995 ,12(8) :1211 - 1217.<br />
crosphere delivery vehicles [ J ]. Pharm Res , 1997 , 14<br />
[11 ] Corre PL , Guevello PL , Gajan V , et al. Preparation and<br />
<br />
,<br />
characterization of bupivacaine2loaded polylactide and poly2<br />
<br />
,<br />
lactide2co2glycolide microspheres[J ]. Int J Pharm , 1994 ,<br />
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107 (1) :41 - 49.<br />
,<br />
[12 ] Delgado A , Evora C , Llabr s M. Effect of storage on the
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<br />
stability of DL2PLA microspheres containing methadone[J ].<br />
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[13 ] Schrier JA , DeLuca PP. Recombinant human bone morpho2<br />
genetic protein22 binding and incorporation in PLGA micro2<br />
sphere delivery systems[J ]. Pharm Dev Technol , 1999 , 4<br />
(4) :611 - 612.<br />
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glycolic acid) microspheres for sustained delivery and stabi2<br />
lization of camptothecin[J ]. J Controlled Release , 1999 , 61<br />
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stability and release properties of biodegradable microspheres<br />
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pharm , 1998 , 45(1) :83 - 94.<br />
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during microsphere processing : influence of formulation vari2<br />
ables[J ]. Eur J Pharm Biopharm , 1998 , 45 (2) : 165 -<br />
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