CellActive - SHAPE - Kinetik

CellActive ® - SHAPE
Fights Against Cellulite

CellActive ® - SHAPE
CellActive ® - SHAPE visibly improves the appearance of
cellulite. The active substance combination of Indian forskolin,
natural caffeine and the Essential Cell Boost-
Factor activates fat breakdown, promotes the removal of
waste substances and improves tissue firmness.
Confirmed efficacy
(A) Stimulation of the lipolysis activity – in vitro study on human
adipocytes
(B) Reduced fat infiltration in the dermis – in vivo study with ultrasound echography
Active principle
CellActive ® - SHAPE is a 3-component effective ingredient combination.
Natural caffeine activates fat splitting
(lipolysis). It increases the cAMP level
by inhibiting the phosphodiesterase.
This activates fat breakdown in adipocytes
by accelerating the splitting of
triacylglycerides into free fatty acids
Indian forskolin promotes detoxification.
It has a dilating effect on blood
and lymph vessels. This accelerates
the removal of released fatty acids
and promotes the discharge of excess
tissue liquids
Essential Cell Boost-Factor promotes
the formation of cell adhesion
proteins and strengthens the firmness
of the skin
Cellulite with typical “wave” structure
Wavy
skin surface
CellActive ® - SHAPE
improves the appearance of cellulite by:
Super elastic
connective tissue
Enlarged fat cells
causes bulging
(arrows)
(a)
(b)
(c)
Breaking down fats to reduce protuberances of fat tissue in the
dermis and epidermis (see arrow). The typical wave structure of
cellulite is reduced
Improving microcirculation so that broken down fatty acids can
leave the tissue quicker. Improved lymphatic flow takes the pressure
from the tissue
Tightening the epidermis and smoothing the surface

Fights Against Cellulite
Studies of efficacy
In vitro study lipolysis activity
Test with CellActive ® - SHAPE on human adipocytes
In vivo study relief—LASER profilometry
Test with 4% CellActive ® - SHAPE
Released free fatty acids in µmol
700
600
500
400
300
200
100
9
527
436
28
600
596
D0
0
Control
CellActive ® -
SHAPE
1%
CellActive ® -
SHAPE
0.1%
CellActive ® -
SHAPE
0.01%
Theophyllin
Isoproterenol
D56
Measurement parameters: Amount of released fatty
acids from adipocytes by the lipolysis of triacylglycerides
Method: Treatment with 1 %, 0.1 % and 0.01 % CellActive
® - SHAPE (2h / 37°C), positive controls with theophylline
(1 mM), isoproterenol (1 μM)
Results: Increase of lipolysis activity, comparably
strong effect as seen in theophylline and isoproterenol
In vivo study fat infiltration in the dermis ultrasound
echography
D0 untreated
D56 untreated
Messparameter: Hydratation des Stratum Corneum
Methode: Behandlung mit 2% und 4% CellActive ® -
HYDRO; 21 Testpersonen; Alter: 30 Jahre; Messgerät:
Corneometer
Ergebnis: Steigerung der Hydratation um 23% gegenüber
Placebo; Wirksamkeit in Gelen bestätigt
Measurement parameters: Surface relief of cellulite
Method: Treatment with 4% CellActive ® - SHAPE on cellulite
area of the upper thigh, duration: 56 days; 25 test persons,
aged 31; measuring method: LASER-profilometry
Results: 13% smoothing of the surface profile compared
to untreated skin
D0 CellActive ® - SHAPE
D56 CellActive ® - SHAPE
Concentrations
1 - 4%
Applications
Body care products for treating cellulite and to achieve a
fine silhouette. For use in emulsions O/W and W/O as well
as in gels
INCI
EU: Aqua, Alcohol denat., Caffeine, Coleus Forskohlii Root
Extract, Chlorella Vulgaris/Lupinus Albus Protein Ferment
USA/Japan: Water, Alcohol denat., Caffeine, Coleus Forskohlii
Root Extract, Chlorella Vulgaris/Lupinus Albus Protein
Ferment
Measurement parameters: Compactness and thickness
of the epidermis and dermis in 2-dimensional
depiction
Method: Treatment with 4% CellActive ® - SHAPE on
cellulite area of the upper thigh, duration: 56 days; 25
test persons, aged 31; measuring device: DermaScan-C
method (ultrasound echography). Black areas
depict tissue rich in fat
Results: Improvement of the compactness and thickness
of the epidermis and dermis. Average of 10% less
fat infiltration
Additional information
Preservatives: Free of preservatives
Animal testing: Not tested on animals. No ingredients are
of animal origin
Toxicology: Non-toxic for humans and environmentally
safe: GMO-free, BSE-free, CMR-free, pesticide-free, mineral
oil-free, free of heavy metals

RAHN AG
Dörflistrasse 120
CH-8050 Zürich
Tel. +41 44 315 42 00
Fax +41 44 315 42 45
Cosmetics@rahn-group.com
www.rahn-group.com
RAHN GmbH
Hahnstrasse 70
DE-60528 Frankfurt am Main
Tel. 0800 1 816 015
Fax 0800 1 816 016
RAHN (UK) Ltd.
75 Park Road
GB-Peterborough PE1 2TN
Tel. 0800 0 323 743
Fax 0800 0 323 744
RAHN USA Corp.
1005 North Commons Drive
Aurora US-Illinois 60504
Tel. +1 630 851 42 20
Fax +1 630 851 48 63
Disclaimer
Utilisation of this document or parts thereof as well as product names for commercial or industrial applications is subject to explicit written approval by RAHN AG. This information is based on our own experience
to date and we believe it to be reliable. It is intended only as a guide to use at your discretion and risk. We cannot guarantee favourable results and assume no liability in connection with its use, or the
use of the methods or products described. None of this information is to be taken as a license to operate under, or a recommendation to infringe patents.
Version: 11/2008