Atlas Automated Synthesis System (PDF) - John Morris Scientific

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Applications Atlas has the following applications in discovery and process development: l Reaction development l Reaction optimisation l Process screening l Synthesis automation l Scale-up chemistry l Crystallisation l Parallel chemistry l High throughput chemistry l Calorimetry l Biochemistry l Fermentation l Cell culture Atlas offers discovery and process chemists many advantages: l Greater system utility and flexibility l Simple functionality Above: Atlas is an automated synthesis system for research and development chemists. Left: The Atlas base is controlled using the twist and click knob. l A rationalisation in the number of synthesis systems required l An overall reduction in capital costs
What is Atlas? The Atlas system A fully modular system Atlas is a high performance, low cost synthesis system that is flexible and truly easy to use. The intelligent base can be configured to control one or many reactions at scales from µl to 2 litres in vials, flasks or jacketed reactors. Easy stirrer seal Chemically resistant, auto aligning stirrer seal and guide Atlas is a low cost modular synthesis system, that is simple to use and quick to set up. Using a fully modular approach, the atlas base unit can be configured into a wide range of systems. Atlas benefits l l l l l l l l Easy to use: twist & click knob, large display and intuitive Automated: walk away synthesis Automatic data capture: download all data to a USB stick in .csv format High performance hotplate or circulator temperature control: rapid heating to 280°C and accurate control High performance magnetic or overhead stirring: 1200RPM magnetic or 1000RPM powerful overhead stirrer Quick: everything clicks together quickly and easily without tools Small footprint: 23cm (9”) square easily fits in fume cupboards Robust: specifically designed for use in chemical laboratories Jacketed reactor systems Jacketed vessels from 100ml to 2 litres can be controlled in a fully automated fashion. They can be easily changed due to the quick release vessel clamp, auto aligning stirrer, quick connect fluid hoses and semi-automatic circulator fluid drain. Without PC control, the intelligent base can control circulator or reaction temperature, overhead stirrer speed and reagent addition from a pump. Data from sensors such as thermocouples, pH sensors, turbidity probes and stirrers are recorded by the base and can be downloaded to a USB stick. Vial and round bottom flask systems A variety of dry bath options fit onto the hotplate and magnetic stirrer for single round bottom flasks or parallel flasks or vials. For cooled reactions, the hotplate can be removed and a cold plate fitted. The single atlas dry bath has concentric cups allowing round bottom flasks from 50ml to 1 litre to be heated or cooled. A triple dry bath is available for flasks from 50ml to 250ml and 6 or 12 vials can be heated with a reflux head. The base can automatically run reaction profiles and add reagents. Atlas systems The atlas base can be configured into a variety of different systems for different applications such as discovery or process chemistry. In every case, the hardware clicks into place in seconds without the need for tools and can be controlled in three ways: 1) Turn the control knob to change hotplate or circulator fluid temperature and magnetic or overhead stirrer speed. Connect many bases for parallel chemistry in a master-slave fashion. 2) Edit and run profiles automatically from the base to control heating, cooling, stirring and reagent addition. Connect many bases in parallel to run one profile on all. 3) Use full PC software for complex recipe control, real time data plotting and control of third party hardware. The software can also control many bases at a time with different profiles. PC control Atlas and third party hardware can be controlled using the Atlas software Quick stirrer set up The stirrer post clicks into the base in seconds Powerful stirring Compact, auto aligning stirrer up to 1,000RPM Quick connections Thermo fluid connections made in seconds Quick clamp Vessel necks are clamped and aligned with one turn Wide range of sensors Thermocouples, pH sensors, turbidity probes etc. with localised calibration Quick clamp No tools required to change jacketed vessels in seconds Wide range of stirrers Different styles and lengths available Oil drain unit Press button to drain thermo fluid Jacketed vessels 100ml, 250ml, 500ml, 1 litre, 2 litre and custom profiles Base Unit To make choosing a system easier, there are three Atlas systems named Lithium and Sodium for round bottom flasks (magnetically and overhead stirred respectively) and Potassium for jacketed vessels. Add a hotplate and magnetic stirrer Add a triple dry bath... ...or single dry bath with temperature probe Atlas software can be used for more advanced control and real time data plotting. Add overhead stirring and a syringe pump Lithium system Sodium system Potassium system Atlas software running a Potassium system Far left: Automated heating/ stirring profiles with temperature controlled reagent addition can be run without PC control. Left: Jacketed vessels can be changed in seconds using the quick clamp. Round bottom flasks 50ml, 100ml, 250ml, 500ml and 1 litre Hotplate/coldplate Hotplate (RT to 280°C) or coldplate (-25 to 200°C) Parallel chemistry 1 Dry baths are available for 3 round bottom flasks, 6 vials, 12 vials or custom arrangements Atlas systems Lithium Sodium Potassium Base unit l l l Hotplate l l Magnetic stirrer l l o Scorpion overhead stirrer o l l Stirrer, stirrer seal and guide o l l Below: The cool wall nested dry bath is safe, clean and efficient. USB download Download data to USB stick Multiple sensors Multiple sensors can be used with the triple socket Magnetc stirring Up to 1200rpm Jacketed vessel, lid and seal o o l Jacketed vessel clamp and support rods o o l Reaction vessel drip tray o o l Stacking dry bath l l Quick clamp and support rods l l o Triple dry bath Triple clamp Vial dry bath with reflux head o o o Oil drain unit o o l Parallel chemistry 2 Many bases can be connected together in master/slave mode Simple control Twist & click knob to change temperature/stirrer speed or edit and run automated experiments Oil pipes from reactor to oil drain unit o o l Temperature node and probe o l l Triple node socket and node extension l Computer software o o o Standard l Optiono Many other options and extras exist for Atlas, this table is only a summary.
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