Atlas Automated Synthesis System (PDF) - John Morris Scientific

atlas
automated
synthesis system
Atlas simply does it all

Applications
Atlas has the following applications in
discovery and process development:
l Reaction development
l Reaction optimisation
l Process screening
l Synthesis automation
l Scale-up chemistry
l Crystallisation
l Parallel chemistry
l High throughput chemistry
l Calorimetry
l Biochemistry
l Fermentation
l Cell culture
Atlas offers discovery and process
chemists many advantages:
l Greater system utility and flexibility
l Simple functionality
Above: Atlas is an
automated synthesis
system for research and
development chemists.
Left: The Atlas base is
controlled using the twist
and click knob.
l A rationalisation in the number of synthesis
systems required
l An overall reduction in capital costs

What is Atlas?
The Atlas system
A fully modular system
Atlas is a high performance, low cost synthesis
system that is flexible and truly easy to use. The
intelligent base can be configured to control one or
many reactions at scales from µl to 2 litres in vials,
flasks or jacketed reactors.
Easy stirrer seal
Chemically resistant,
auto aligning stirrer seal
and guide
Atlas is a low cost modular
synthesis system, that is
simple to use and quick to
set up. Using a fully modular
approach, the atlas base unit
can be configured into a
wide range of systems.
Atlas benefits
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Easy to use: twist & click knob, large display
and intuitive
Automated: walk away synthesis
Automatic data capture: download all data
to a USB stick in .csv format
High performance hotplate or circulator
temperature control: rapid heating to 280°C
and accurate control
High performance magnetic or overhead
stirring: 1200RPM magnetic or 1000RPM
powerful overhead stirrer
Quick: everything clicks together quickly and
easily without tools
Small footprint: 23cm (9”) square easily fits in
fume cupboards
Robust: specifically designed for use in
chemical laboratories
Jacketed reactor systems
Jacketed vessels from 100ml to 2 litres can be
controlled in a fully automated fashion. They can
be easily changed due to the quick release vessel
clamp, auto aligning stirrer, quick connect fluid
hoses and semi-automatic circulator fluid drain.
Without PC control, the intelligent base can
control circulator or reaction temperature,
overhead stirrer speed and reagent addition from
a pump. Data from sensors such as thermocouples,
pH sensors, turbidity probes and stirrers are
recorded by the base and can be downloaded
to a USB stick.
Vial and round bottom flask systems
A variety of dry bath options fit onto the hotplate
and magnetic stirrer for single round bottom
flasks or parallel flasks or vials. For cooled
reactions, the hotplate can be removed and a
cold plate fitted. The single atlas dry bath has
concentric cups allowing round bottom flasks
from 50ml to 1 litre to be heated or cooled. A
triple dry bath is available for flasks from 50ml
to 250ml and 6 or 12 vials can be heated with a
reflux head. The base can automatically run
reaction profiles and add reagents.
Atlas systems
The atlas base can be configured into a variety
of different systems for different applications
such as discovery or process chemistry. In every
case, the hardware clicks into place in seconds
without the need for tools and can be controlled
in three ways:
1) Turn the control knob to change hotplate or
circulator fluid temperature and magnetic or
overhead stirrer speed. Connect many bases for
parallel chemistry in a master-slave fashion.
2) Edit and run profiles automatically from the
base to control heating, cooling, stirring and
reagent addition. Connect many bases in
parallel to run one profile on all.
3) Use full PC software for complex recipe control,
real time data plotting and control of third
party hardware. The software can also control
many bases at a time with different profiles.
PC control
Atlas and third party
hardware can be controlled
using the Atlas software
Quick stirrer set up
The stirrer post clicks into
the base in seconds
Powerful stirring
Compact, auto aligning
stirrer up to 1,000RPM
Quick connections
Thermo fluid connections
made in seconds
Quick clamp
Vessel necks are clamped
and aligned with one turn
Wide range of sensors
Thermocouples, pH sensors,
turbidity probes etc. with
localised calibration
Quick clamp
No tools required to change
jacketed vessels in seconds
Wide range of stirrers
Different styles and lengths
available
Oil drain unit
Press button to drain
thermo fluid
Jacketed vessels
100ml, 250ml, 500ml, 1 litre,
2 litre and custom profiles
Base Unit
To make choosing a system
easier, there are three Atlas
systems named Lithium and
Sodium for round bottom
flasks (magnetically and
overhead stirred
respectively) and Potassium
for jacketed vessels.
Add a hotplate and
magnetic stirrer
Add a triple
dry bath...
...or single dry
bath with
temperature probe
Atlas software can be used
for more advanced control
and real time data plotting.
Add overhead
stirring and a
syringe pump
Lithium system Sodium system Potassium system Atlas software
running a
Potassium system
Far left: Automated
heating/ stirring profiles
with temperature controlled
reagent addition can be run
without PC control.
Left: Jacketed vessels can
be changed in seconds using
the quick clamp.
Round bottom flasks
50ml, 100ml, 250ml, 500ml
and 1 litre
Hotplate/coldplate
Hotplate (RT to 280°C) or
coldplate (-25 to 200°C)
Parallel chemistry 1
Dry baths are available
for 3 round bottom flasks,
6 vials, 12 vials or custom
arrangements
Atlas systems Lithium Sodium Potassium
Base unit l l l
Hotplate l l Magnetic stirrer l l o
Scorpion overhead stirrer o l l
Stirrer, stirrer seal and guide o l l
Below: The cool wall nested
dry bath is safe, clean and
efficient.
USB download
Download data to USB stick
Multiple sensors
Multiple sensors can be
used with the triple socket
Magnetc stirring
Up to 1200rpm
Jacketed vessel, lid and seal o o l
Jacketed vessel clamp and support rods o o l
Reaction vessel drip tray o o l
Stacking dry bath l l Quick clamp and support rods l l o
Triple dry bath Triple clamp Vial dry bath with reflux head o o o
Oil drain unit o o l
Parallel chemistry 2
Many bases can be
connected together in
master/slave mode
Simple control
Twist & click knob to
change temperature/stirrer
speed or edit and run
automated experiments
Oil pipes from reactor to oil drain unit o o l
Temperature node and probe o l l
Triple node socket and node extension l
Computer software o o o
Standard l
Optiono
Many other options and extras exist for Atlas, this table is only a summary.

Distributor
Syrris Ltd.
27 Jarman Way, Royston, Hertfordshire
SG8 5HW, United Kingdom
T: +44 (0)1763 242555
F: +44 (0)1763 242992
E: info@syrris.com
W: www.syrris.com
Syrris Inc. (North America)
29 Albion Place
Charlestown, MA 02129
T: 617 848 2997
F: 617 532 1033
E: info-usa@syrris.com
W: www.syrris.com