XXII. BIOCHEMICKÝ ZJAZD - Jesseniova lekárska fakulta

Posters
91.
ANTIOXIDANT RESPONSE TO TREATMENT WITH NATUraL COMPOUNDS
AND AN NO DONOR IN EXPERIMENTAL HYPERTENSION
Ima Dovinová 1 , Zuzana Pakanová 2 , StanislavaVranková 1 , Oľga Pecháňová 1 ,
Soňa Čačányiová 1 , František Kristek 1 and Helena Paulíková 2
1
Institute of Normal and Pathological Physiology, SAS, Bratislava;
2
Department of Biochemistry and Microbiology, Faculty of Chemical and Food
Technology STU, Bratislava
SOD enzymes play an important role in cardiovascular tissue by protecting NO against
oxidative inactivation by superoxide. Both NO and superoxide are free radicals with
unpaired electrons and can react with one another. Studies with pharmacologically inhibited
SOD1 and SOD3 showed that NO cannot be released from endothelium without
oxidative degradation, that is, SOD enzymes play an important role in vasodilatation and
in protection of NO in blood vessel walls.
In this study, we observed the effect of flavonoids (Alibernet red wine extract), melatonin,
and an NO-donor, PETN, on antioxidant response of blood vessels and the heart in
animal hypertension models, SHR and SHR-cp.
The experiments show that in young hypertensive rats the Alibernet extract increased
the activity of SOD and NOS in the left ventricle of SHR and the total antioxidant status
in plasma.
In adult hypertensive rats, the NO donor, PETN, increased SOD and GPx activities and
decreased left ventricle damage.
The results indicate that the most remarkable effects of the Alibernet red wine extract
in young hypertensive rats, and of the PETN NO donor in adult hypertensive rats are
related to protective effects of SOD enzymes in the heart.
Ackowledgement: The work was supported by VEGA Grant No 2/0066/08.
XXII. Biochemistry Congress, Martin
215