XXII. BIOCHEMICKÝ ZJAZD - Jesseniova lekárska fakulta

Posters
62.
THE effECT of naTUral POLYPHENOLS ON aDIPONECTINE LEvEL IN
paTIENTS SUfferING frOM erECTILE DYSfUNCTION
Monika Dvořáková 1 , Jana Muchová 1 , Branislav Trebatický 2 ,
Ján Breza 2 and Zdeňka Ďuračková 1
1
Department of Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty,
Bratislava, Slovakia, 2 Department of Urology, Faculty of Medicine,
Comenius University, Bratislava, Slovakia
As patients suffering from erectile dysfunction (ED) are considered patients with temporary or
permanent impotence. In the pathophysiology of ED psychological as well as organic factors
(or both together) can take a part. The main role in the erection process plays a relaxation
of smooth muscles inside the arterial system and cavernous tissue. It is controlled by spinal
reflex and can be initialized by visual, osmatic or imaginary stimulation. The most important
blood vessels relaxant is NO. By effect of free radicals, NO becomes more inactivated, what
leads to lowered tissue relaxation caused by change in cGMP/cAMP ratio. Pycnogenol ®
(Pyc) as a mixture of natural polyphenols and polyphenolic extract from gingko biloba leafs
(EGb761) stimulate a constitutive NO synthase, induce vasodilatation and improve the
microcirculation in the blood. Adiponectin is a protein hormone that modulates glucose
regulation and fatty acid catabolism. Levels of the hormone are inversely correlated with body
fat percentage. Levels of adiponectin are reduced in diabetics compared to non-diabetics.
Weight reduction significantly increases circulating levels. Hypoadiponectinemia is an
independent risk factor for developing of e.g. metabolic syndrome, cardiovascular disease
and diabetes mellitus, which are often found as disorders associated to ED. To our double
blind, randomized, placebo controlled study 52 patients suffering from ED were included.
Patients were investigated before, one and three months after supplements administration
and after termination of drugs supplementation. In addition, ED group of patients was split
to diabetes and nondiabets groups to compare adiponectin levels. No change after Pyc or
Egb 761 administration has been found in comparison to placebo group. Similarly, there has
not been found a difference in ED patients with diabetes and ED patients without diabetes
mellitus. ED patients have decreased levels of adiponectine compared to reference values.
But what is the reason of this decrease is hard to say because of the complexity of the disease.
Ackowledgement: This study was supported by VEGA grants of Ministry of Education of the
Slovak Republic, and Mind and Health, civil association.
184 XXII. Biochemistry Congress, Martin