Development of a Novel Mass Spectrometric ... - Jacobs University
Development of a Novel Mass Spectrometric ... - Jacobs University
Development of a Novel Mass Spectrometric ... - Jacobs University
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Introduction<br />
Figure 1-2 Range <strong>of</strong> ionisation techniques employed with different types <strong>of</strong><br />
compounds<br />
As explained earlier chromatography coupled to MS can solve analytical problems<br />
<strong>of</strong> mixtures containing several dozens or hundreds analytes, however the study <strong>of</strong><br />
real complex mixture comprising thousands <strong>of</strong> analytes is still in an area <strong>of</strong> MS<br />
only. MS can provide detailed molecular-level information for hydrocarbon<br />
complex mixtures.<br />
Therefore, better methods that characterise complex mixtures have been most<br />
recently driven by the development <strong>of</strong> improved mass spectrometry methods. For<br />
example the emerging field <strong>of</strong> Petroleomics has provided a series <strong>of</strong> novel data<br />
interpretation strategies to extract chemical and other relevant information from<br />
such enormously complex data. 42 Under this concept and with the help <strong>of</strong><br />
developed technological devices available for research groups, studies have<br />
examined hydrocarbon complex mixtures and their model compounds by<br />
revolutionised methodologies. These experiments argued ionisability and<br />
volatility 43 <strong>of</strong> hydrocarbon molecules using a high resolution detector are to play<br />
an important role in extending the applicability <strong>of</strong> MS for complex hydrocarbon<br />
mixture analyses. Although such experiments are considered intriguing steps<br />
towards hydrocarbon complex mixture, however they are not without problems. To<br />
understand the problems and limitations <strong>of</strong> hydrocarbon analyses in MS, a critical<br />
10