Design and development of fast Melting Tablets of ... - ISCA
Design and development of fast Melting Tablets of ... - ISCA
Design and development of fast Melting Tablets of ... - ISCA
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Research Journal <strong>of</strong> Chemical Sciences<br />
Batches<br />
Table-4: Physical parameters <strong>of</strong> Fast melting tablets <strong>of</strong> Terbutaline Sulphate<br />
Thickness<br />
(mm)<br />
n = 3<br />
Hardness<br />
(Kg/cm 2 )<br />
n = 3<br />
F1 2.7 ±0.1 2.43<br />
F2 2.8 ±0.1 2.45<br />
F3 2.7±0.1 2.41<br />
F4 2.9±0.1 2.42<br />
F5 3.0±0.1 2.45<br />
F6 3.5±0.1 2.50<br />
Friabilit<br />
y (%)<br />
n = 3<br />
0.51 ±<br />
0.1<br />
0.56 ±<br />
0.1<br />
0.54 ±<br />
0.1<br />
0.51 ±<br />
0.1<br />
0.51 ±<br />
0.1<br />
0.50 ±<br />
0.1<br />
Weight<br />
Variatio<br />
n (mg)<br />
n = 3<br />
Wetting<br />
time<br />
(sec)<br />
Disintegratio<br />
n time (sec)<br />
150.15 52 59<br />
151.5 59 68<br />
151.1 70 75<br />
149.5 49 52<br />
152.0 55 64<br />
155.11 56 63<br />
Figure-1: Drug release pr<strong>of</strong>ile <strong>of</strong> Fast melting tablet <strong>of</strong> Terbutaline Sulphate<br />
Vol. 1 (1) April (2011)<br />
Res.J.Chem.Sci.<br />
Drug content<br />
uniformity<br />
(%)<br />
98.97<br />
98.95<br />
98.76<br />
99.81<br />
98.69<br />
98.95<br />
120<br />
% cumulative drug relese v/s time for <strong>fast</strong> melting tablet <strong>of</strong> terbutaline<br />
Sulphate<br />
% cumulative release <strong>of</strong> terbutaline sulphate from formulation<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
0 1 2<br />
3 4 5<br />
F1<br />
F2<br />
F3<br />
F4<br />
F5<br />
F6<br />
Time in min<br />
110 108
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