Marvin Jiwan's Presentation - Irish Phytochemical Food Network

Academic Qualifications
•BSc Food Science 1981
National University of Ireland, Cork
•MS Human Nutrition 1983
University of Minnesota, USA
•PhD Nutritional Biochemistry 1987
Cornell University, USA
Brief Outline of Career History
•1988 – 1989 Post-doctoral Research Fellow,
Institute of Cellular and Molecular Pathology,
University of Louvain, Belgium
•1990 – 1999 Lecturer in Nutrition,
Department of Nutrition, UCC
•1999 – 2005 Senior Lecturer in Nutrition,
Department of Food and Nutritional Sciences, UCC
•2006 - now Associate Professor,
Department of Food and Nutritional Sciences, UCC

Postdoctoral Researchers 2
Dr. Aisling Aherne
Dr. Yvonne O’Callaghan
Research Assistants 3
Trevor Daly
Olivia Kenny
Marvin Jiwan
Postgraduate students 6
Current funding from:
SFI Investigator Award
Department of Agriculture, Fisheries and Food
Irish Food Industry
Enterprise Ireland
Safefood

•Bioactivity of dietary constituents.
•Bioavailability of dietary phytochemicals.
•Cytotoxic, genotoxic and cell signalling effects of cholesterol and
phytosterol oxidation products.
•Longitudinal study of changes in anthropometric measures, dietary intake
and physical activity in school-going adolescents
•Ecotoxicology. Collaborative work with biologists and ecologists
involving use of cytotoxicity and genotoxicity assays in cell culture
systems

Gastric Phase
Homogenised
Pepsin
Acidified to pH 2
Duodenal Phase
Increase pH to 5.3
with NaHCO 3
Pancreatin
Bile Salts
Increase pH to 7.4
with NaOH
Cholesterol esterase
Ultracentrifugation at
53,000 rpm

Apical Chamber

Apical Chamber
Basolateral Chamber

O’Sullivan L, Ryan L, O’Brien, NM (2007) Comparison of the uptake and secretion of
carotene and xanthophyll carotenoids by Caco-2 intestinal cells. British Journal of
Nutrition 98, 38-44.
O’Sullivan L, Ryan L, Aherne SA, O’Brien NM (2008) Cellular transport of lutein is
greater from uncooked rather than cooked spinach irrespective of whether it is fresh,
frozen or canned. Nutrition Research 28, 532-538.
O’Sullivan L, Aherne-Bruce SA, O’Brien NM. Investigation of -carotene and lutein
transport in Caco-2 cells: carotenoid-carotenoid interactions and transport inhibition by
ezetimibe. International Journal of Vitamin and Nutrition Research (in press)
Kenny O, Callaghan YO, O’Brien NM (2008). Effects of ingredient incorporation into
sausage meat on the micellarisation and uptake of -tocopherol by Caco-2 human
intestinal cells. Food Sci. Tech. Int. 14, 79-86.