Effect of Zinc Supplementation on Adenosine Deaminase ... - medIND

Indian Medical Gazette — OCTOBER 2013 379
activity in LL cases by the effect <strong>of</strong> oral zinc therapy
indicating an improvement in several immune parameters 6 .
Some experimental studies have concluded that it is possible
to restore the enzyme activity in aged skin fibroblasts to
normal levels by raising the zinc concentration in the culture
medium to four or five times the control normal plasma
zinc level 10 while others suggested that though ZnCl 2
has
enhancement effects on ADA activity in a dose dependent
manner, it might show toxicity with deleterious effects in
higher concentrations 21 . The above results matched with
the present study which depicts that oral zinc therapy plays
an important role in specific immune defences and
microbicidal activity in both types <strong>of</strong> leprosy more so in
the TT than LL group by significantly enhancing the ADA
activity in the cases.
Summary
ADA as a marker <strong>of</strong> CMI, consistent with lymphocyte
and macrophage activity was found to be raised in leprosy
patients in comparison to controls. Its concentration runs
parallel with the immunological response <strong>of</strong> the patients
against antigenic stimulation. Administration <strong>of</strong> zinc brings
about stimulation <strong>of</strong> a variety <strong>of</strong> immunological functions
involved in host defense like T-lymphocyte and macrophage
activation indicated by a rise in serum ADA levels after
supplementation in leprosy patients. <strong>Zinc</strong> having the ability
to enhance cell mediated immunity, could reduce the
incidence <strong>of</strong> reaction and minimize the morbidity <strong>of</strong> the
disease. In addition to various drugs and other primary
immunomodulators, it has an immense immunotherapeutic
role in treating leprosy cases and maybe used as an adjunct
to chemotherapy to enhance bacterial killing as well as
bacterial clearance and hence shorten the treatment period.
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