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english questionnaire - World Health Organization

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Dr. Lisa C. du Toit<br />

Mr. Pradeep Kumar<br />

Prof. Ashraf<br />

Coovadia<br />

Wits University,<br />

Department of<br />

Pharmacy and<br />

Pharmacology, South<br />

Africa<br />

Wits University,<br />

Department of<br />

Pharmacy and<br />

Pharmacology, South<br />

Africa<br />

Wits University,<br />

Department Clinical<br />

Medicine, South Africa<br />

journal ‘Recent Patents in Drug Delivery<br />

Formulation’ and co-author of several book<br />

chapters and more than 100 internationally<br />

peer-reviewed scientific papers. He is<br />

responsible for the technical aspects pertaining<br />

to the WaferMat formulation up to Stage 4.<br />

Co-Investigator - Dr. Lisa du Toit is a recent PhD<br />

graduate and Pharmaceutical Chemist who is<br />

Head of the Division of Pharmaceutical<br />

Chemistry at Wits University in Johannesburg,<br />

South Africa. She has long been an expert on<br />

dosage form design and has expertise on pK/PD<br />

studies. She is responsible for coordinating the<br />

in vivo animal studies pertaining to the<br />

WaferMat formulation. She will be involved in<br />

Stage 1 in terms of textural profiling to<br />

determine the physicomechanical performance<br />

of the preliminary system, in vitro drug release<br />

studies and preparation of the WaferMat as well<br />

as Stage 2 for drug loading efficiency, matrix<br />

erosion and pre-optimized drug release studies.<br />

Input at Stage 3 and 4 is also required.<br />

Co-Investigator - Mr. Pradeep Kumar is a PhD<br />

candidate and a Lecturer in Pharmaceutics as<br />

well as a Molecular Mechanist and Image<br />

Analyst. He has experience with formulation<br />

design in paediatrics and co-authored over 25<br />

peer-reviewed papers. He is responsible for<br />

molecular blue-printing the WaferMat<br />

formulation. He will be involved in Stage 1 for<br />

mechanistic elucidation and energetic profiling<br />

of the permeation enhancers within the<br />

WaferMat formulation and assessment of the<br />

WaferMat molecular stability via structure and<br />

electrostatic potential mapping as well as Stage<br />

2 in terms of molecular transitions of the<br />

WaferMat for ora-compatibility and durability.<br />

Input at Stage 3 and 4 is also required.<br />

Co-Investigator – Prof. Ashraf Coovadia is Head<br />

of the Empilweni Services and Research Unit in<br />

the Department of Paediatrics and Child <strong>Health</strong><br />

at Rahima Moosa Mother and Child Hospital in<br />

Johannesburg, South Africa. The hospital is the<br />

one of the largest hospitals that deals with<br />

challenges of providing efficacious treatment to<br />

the largest global population of paediatric<br />

patients suffering with infectious diseases<br />

including HIV. He has longstanding expertise in<br />

clinical practice in paediatrics with HIV and has<br />

presented many keynotes on paediatric HIV<br />

13

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