Publikationliste Stefan Uhlig

Publikationliste Stefan Uhlig 

Originalarbeiten 

1. Uhlig, S., A. Wendel. 1990. Glutathione enhancement 

in various mouse organs and protection by 

glutathione isopropyl ester against liver injury. Biochem. 

Pharmacol. 39: 1877-1881. 

2. Görgen, I., T. Hartung, M. Leist, M. Niehörster, G. 

Tiegs, S. Uhlig, F. Weitzel, A. Wendel. 1992. Granulocyte 

colony-stimulating factor treatment protects 

rodents against lipopolysaccharide-induced toxicity 

via suppression of systemic tumor necrosis factora. 

J. Immunol. 149: 918-924. 

3. Uhlig, S., L. Wollin. 1994. An improved set-up for 

the isolated perfused rat lung. J. Pharmacol. Tox. 

Meth. 31: 85-94. 

4. Uhlig, S., L. Wollin, A. Wendel. 1994. Contributions 

of thromboxane and leukotrienes to platelet-activating 

factor-induced impairment of lung function 

in the rat. J. Appl. Physiol. 77: 262-269. 

5. Tiegs, G., J. Barsig, B. Matiba, S. Uhlig, A. Wendel. 

1994. Potentiation by GM-CSF of LPS toxicity in 

mice. J. Clin. Invest. 93: 2616-2622. 

6. Uhlig, S., F. Brasch, L. Wollin, H. Fehrenbach, J. Richter, 

A. Wendel. 1995. Functional and fine structural 

changes in isolated lungs challenged with endotoxin 

ex vivo and in vitro. Am. J. Pathol. 146: 1235-1247. 

7. Uhlig, S., O. Heiny. 1995. Measuring the weight of 

the isolated perfused rat lung during negative pressure 

ventilation. J. Pharmacol. Tox. Meth. 33: 147- 

152. 

8. Bundschuh, D., S. Uhlig, M. Leist, A. Sauer, A. Wendel. 

1995. Isolation of rat primary lung cells. In vitro 

Cell Dev. Biol. Anim. 31: 684-691. 

9. Uhlig, S., A. v. Bethmann, R. Featherstone, A. Wendel. 

1995. Pharmacological characterization of endothelin 

receptor responses in the isolated perfused rat lung. 

Am. J. Respir. Crit. Care Med. 152: 1449-1460. 

10. Uhlig, S., A. v. Bethmann. 1995. Endothelin-induced 

bronchoconstriction in perfused rat lungs is partly 

mediated by thromboxane. J. Cardiovasc. Pharmacol. 

26: S111-S114. 

11. Bohlinger, I., M. Leist, J. Barsig, S. Uhlig, G. Tiegs, A. 

Wendel. 1995. Interleukin-1 and nitric oxide protect 

against tumor necrosis factor α-induced liver injury 

through distinct pathways. Hepatology 22: 1829- 

1837. 

12. Gantner, F., S. Uhlig, A. Wendel. 1995. Quinine 

potently inhibits release of tumor necrosis factor, 

apoptosis, necrosis and mortality in a murine model 

of septic liver failure. Eur. J. Pharmacol. 294: 353-355. 

13. Uhlig, S., R. Nüsing, A. von Bethmann, R. L. Featherstone, 

T. Klein, F. Brasch, K.-M Müller, V. Ullrich, 

A. Wendel. 1996. Cyclooxygenase-2 dependent 

broncho constriction in perfused rat lungs exposed 

to endotoxin. Mol. Med. 2: 373-383. 

14. Uhlig, S., R. Featherstone, O. Wilhelms, A. Wendel. 

1996. Effects of urodilatin on platelet-activating 

factor-induced bronchoconstriction, vasoconstriction 

and edema formation in perfused rat lung. 

Naunyn Schmiedeberg’s Arch. Pharmacol. 354: 684- 

688. 

15. Martin, C., S. Uhlig, V. Ullrich. 1996. Videomicroscopy 

of methacholine-induced contraction of individual 

airways in precision-cut lung slices. Eur. Resp. 

J. 9: 2479-2487. 

16. von Bethmann, A. N., F. Brasch, K. Müller, A. Wendel, 

S. Uhlig. 1996. Prolonged hyperventilation is 

required for release of tumor necrosis factor α but 

not IL-6. Appl. Cardiopulm. Pathol. 6: 171-177. 

17. Künstle, G., M. Leist, S. Uhlig, L. Revesz, R, 

Feifel, A. MacKenzie, A. Wendel. 1997. ICEprotease 

inhibitors block murine liver injury 

and apoptosis caused by CD95 or by TNF-a. 

Immunol. Lett. 55: 5-10. 

18. Held, H-D., A. Wendel, S. Uhlig. 1997. Phosphodiesterase 

inhibitors prevent endothelin-1-induced vasoconstriction, 

bronchoconstriction and thromboxane 

release in perfused rat lung. Biochem. Biophys. 

Res. Commun. 231: 22-25. 

19. Held, H-D., M. Raschak, S. Uhlig. 1997. Rat big 

endothelin-1-induced bronchoconstriction and 

vasoconstriction in the isolated perfused rat lung: 

role of endothelin converting enzyme and neutral 

endopeptidase 24.11. Naunyn Schmiedeberg’s Arch. 

Pharmacol. 355: 619-624. 

20. Uhlig, S., A. v. Bethmann. 1997. Determination of 

vascular compliance, interstitial compliance and 

capillary filtration coefficient in rat isolated perfused 

lungs. J. Pharm. Tox. Meth. 37: 119-127. 

21. Uhlig, S., R. Featherstone. 1997. Interaction of endothelin 

receptor responses in the isolated perfused 

rat lung. Naunyn Schmiedeberg’s Arch. Pharmacol. 

356: 392-397. 

22. Uhlig, S., R. Featherstone, R. Nüsing, H. Held, C. 

Schudt, A. Wendel. 1997. Attenuation by phosphodiesterase 

inhibitors of LPS-induced thromboxane 

release and bronchoconstriction in rat lungs. J. 

Pharmacol. Exp. Therap. 283: 1453-1459. 

Uhlig Publikationen 

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23. von Bethmann, A., F. Brasch, R. Nüsing, K. 

Vogt, D. Volk, K-M. Müller, A. Wendel, S. 

Uhlig. 1998. Hyperventilation induces release 

of cytokines from perfused mouse lung. 


24. Weisser, M., G. Tiegs, A. Wendel, S. Uhlig. 1998. 

Quantification of apoptotic and lytic cell death by 

video microscopy in combination with artificial 

neural networks. Cytometry 31: 20-28. 

25. Fehrenbach, H., F. Brasch, S. Uhlig, M. Weisser, C. 

Stamme, A. Wendel, J. Richter. 1998. Early alterations 

in intracellular and alveolar surfactant of the 

rat lung in response to endotoxin. Am. J. Respir. Crit. 

Care Med. 157: 1630-1639 

26. Held, H-D., C. Martin, S. Uhlig. 1999. 

Characterization of airway and vascular responses 

in murine lungs. Brit. J. Pharmacol. 126: 1191-1199. 

27. Stamme, C., D. S. Bundschuh, T. Hartung, U. Gebert, 

L. Wollin, R. Nüsing, A. Wendel, S. Uhlig. 1999. Temporal 

sequence of pulmonary and systemic inflammatory 

responses to graded polymicrobial peritonitis 

in mice. Infect. Immun. 67: 5642-5650. 

28. Falk, S., R. Göggel, U. Heydasch, F. Brasch, 

K. M. Müller, A. Wendel, S. Uhlig. 1999. 

Quinolines attenuate PAF-induced pressor responses 

and edema formation. Am. J. Respir. Crit. Care 

Med. 160: 1734-1742. 

29. Verbrugge, S. J. C, S. Uhlig, S. J. C. M. M. Neggers, C. 

Martin, H.-D. Held, J. J. Haitsma, B. Lachmann. 1999. 

Different ventilation strategies affect lung function 

but do not increase tumor necrosis factor-α and 

prostacyclin production in lavaged rat lungs in vivo. 

Anesthesiology 91: 1834-1843. 

30. Held, H.-D., S. Uhlig. 2000. Comparison of basal lung 

mechanics as well as airway and pulmonary vascular 

responsiveness among different inbred mouse 

strains. J. Appl. Physiol. 88: 2192-2198. 

31. C. Martin, V. Ullrich, S. Uhlig. 2000. Differential effects 

of thromboxane and endothelin on large and 

small airways in precision-cut lung slices. Eur. Respir. 

J. 16: 316-323. 

32. Martin, C., H.-D. Held, S. Uhlig. 2000. Differential 

effects of the mixed ETA/ETB-receptor antagonist 

bosentan on endothelin-induced bronchoconstriction, 

vasoconstriction and prostacyclin release. 

Naunyn Schmiedeberg’s Arch. Pharmacol. 362: 128- 

136. 

33. Wagner, F., S. Rottem, H.-D. Held, S. Uhlig, U. 

Zähringer. 2000. Ether lipids in the cell membrane 

of Mycoplasma fermentans. Eur. J. Biochem. 267: 

6276-6286. 

34. Held, H.-D., S. Uhlig. 2000. Mechanisms of endotoxin-induced 

airway and pulmonary vascular hyperreactivity 

in mice. Am. J. Respir. Crit. Care Med. 162: 

1547-1552 

35. Haitsma, J.J., S. Uhlig, R. Göggel, S. J. Verbrugge, U. 

Lachmann, B.Lachmann. 2000. Ventilator-induced 

lung injury leads to loss of alveolar and systemic 

compartmentalization of TNF-α. Intens. Care Med. 

26: 1515-1522 

36. Uhlig, S., A. Wohlsen, F. Brasch. 2000. Can airways 

close completely? J. Appl. Physiol. 89: 2521-2522 (Letter). 

37. Martin, C, S. Uhlig, V. Ullrich. 2001. Cytokine-induced 

bronchoconstriction in precision-cut lung 

slices is dependent upon cylooxygenase-2 and 

thromboxane receptor activation. Am. J. Respir. Cell. 

Mol. Biol. 24: 139-145. 

38. Wollin, L., S. Uhlig, R. Nüsing, A.Wendel. 2001. GM- 

CSF potentiates LPS-induced bronchoconstriction 

by a neutrophil and COX-2 dependent mechanism. 


39. Held, H.-D., S. Boettcher, L. Hamann, S. Uhlig. 2001. 

Ventilation-induced chemokine and cytokine release 

is associated with activation of NF-κB and is 

blocked by steroids. Am. J. Respir. Crit. Care Med 

162: 711-716. 

40. Martin, C., A. Wohlsen, S. Uhlig. 2001. 

Changes in airway resistance by simultaneous exposure 

to TNFα and IL-1β. Am. J. Physiol. Lung Cell. 

Mol. Physiol. 280: L595-L601. 

41. Wohlsen, A., S. Uhlig, C. Martin. 2001. The early allergic 

response in small airways. Am. J. Respir. Crit. 

Care Med. 163: 1462-1469. 

42. Ehlers, S., J. Benini, H.-D. Held, C. Röck, G. Alber, S. 

Uhlig. 2001. αβTCR+ cells and IFNγ, but not iNOS, 

are critical for granuloma necrosis in a mouse model 

of mycobacteria-induced pulmonary immunopathology. 

J. Exp. Med. 194: 1847-1859. 

43. Martin, C., R. Göggel, V. Dal Piaz, C. Vergelli, M. P. 

Giovannoni, M. Ernst, S.Uhlig. 2002. Airway relaxant 

and anti-inflammatory properties of a PDE-IV 

inhibitor with low affinity for the high-affinity rolipram 

binding site. Naunyn Schmiedeberg’s Arch. 

Pharmacol. 365: 284-289. 

44. Haitsma, J. J., S. Uhlig, U. Lachmann, S. J. Verbrugge, 

D. L.H. Poelma, B. Lachmann. 2002. Exogenous surfactant 

reduces ventilator-induced decompartmentalization 

of tumor necrosis factor α in the absence 

of positive end-expiratory pressure. Intens. Care 

Med. 28: 1131-1137. 


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45. Göggel, R., S. Hoffmann, R. Nüsing, S. Narumiya, S. 

Uhlig. 2002. PAF-induced pulmonary edema is mediated 

by PGE2 and subsequent activation of voltage-gated 

potassium channels. Am. J. Respir. Crit. 

Care Med. 166: 657-662. 

46. Uhlig, U., J. J. Haitsma, D. L. Poelma, B.Lachmann, 

S.Uhlig. 2002. Ventilation-induced activation of the 

MAP kinase pathway. Eur. Respir. J. 20: 946-956. 

47. Stamme, C., F. Brasch, A. von Bethmann, S. Uhlig. 

2002. Effect of surfactant on ventilation-induced 

mediator release in isolated perfused mouse lungs. 

Pulm. Pharmacol. Therap. 15: 455-461. 

48. Wohlsen, A., C. Martin, E. Vollmer, D. Branscheid, H. 

Magnussen, W. M. Becker, U. Lepp, S. Uhlig. 2003. 

The early allergic response in small airways of human 

precision-cut lung slices. Eur. Respir. J. 21: 1024- 

1032. 

49. Göggel, R., W. Pittermann, W. Aulmann, S. Uhlig. 

2003. Assessment of the acute pulmonary toxicity 

of lamp oil aspiration in the isolated perfused rat 

lung. Food Chem. Toxicol. 41:1029-33. 

50. Kübler, W. M., U. Uhlig, T. Goldmann, G. Schael, 

A. Kerem, K. Exner, C. Martin, E. Vollmer, S. Uhlig. 

2003. Stretch activates nitric oxide production in 

pulmonary vascular endothelial cells in situ. Am. J. 

Respir. Crit. Care Med. 168: 1391-98. 

51. Lee, J.H., J. de Azavedo, A. A. Khine, J. Schwartz, S. 

Uhlig, A. S. Slutsky, H. Zhang. 2003. Modulation of 

bacterial growth by TNF in vitro and in vivo. Am. J. 

Respir. Crit. Care Med. 168: 1462-70 . 

52. Haitsma, J. J., S. Uhlig, S. J. Verbrugge, R. Göggel, D. 

L. Poelma, B. Lachmann. 2003. Injurious ventilation 

strategies cause systemic release of IL-6 and MIP-2 in 

rats in vivo. Clin. Physiol. Funct. Imaging. 23: 349-53. 

53. Uhlig, U., H. Fehrenbach, R. A. Lachmann, T. Goldmann, 

E. Vollmer, B. Lachmann, S. Uhlig. 2004. A 

phosphoinositide 3-OH kinase inhibitor prevents 

ventilation-induced, but not LPS-induced NF-κB 

activation and cytokine release. Am. J. Respir. Crit. 

Care Med. 169: 201-8. 

54. Lee, J.H., L. Del Sorbo, S. Uhlig, G. A. Porro, T. 

Whitehead, S. Voglis, M. Liu, A.S. Slutsky, H. Zhang. 

2004. Intercellular adhesion molecule-1 mediates 

cellular cross-talk between parenchymal and immune 

cells after lipopolysaccharide neutralization. 

J. Immunol. 172: 608-16. 

55. 55. Wrigge H., U. Uhlig, J. Zinserling, E. Behrends- 

Callsen, G. Ottersbach, M. Fischer, S. Uhlig, C. 

Putensen. 2004. Effects of mechanical ventilation 

strategy on pulmonary and systemic inflammatory 

response to major surgery. Anesth. Analg. 98: 775- 

781. 

56. Göggel, R., S. Winoto-Morbach, G. Vielhaber, 

K. Lindner, Y. Imai, L. Brade, A. S. Slutsky, H. 

Brade, S. Schütze , E. Gulbins, S. Uhlig. 2004. 

PAF-mediated pulmonary edema: a new role 

for acid sphingomyelinase and ceramide. 

Nat. Med. 10: 155-160. 

57. Hasegawa J., K. F. Wagner, D. Karp, D. Li, J. Shibata, 

M. Heringlake, L. Bahlmann, R. Depping, J. Fandrey, 

P. Schmucker, S. Uhlig. 2004. Altered pulmonary 

vascular reactivity in mice with excessive erythrocytosis. 


58. Martin, C., R. Göggel, A. Ressmyer, S. Uhlig. Pressor 

responses to platelet-activating factor and thromboxane 

are mediated by Rho-kinase. Am. J. Physiol. 

Lung Cell. Mol. Physiol. 287: L250-L257. 

59. Uhlig, U, S. Uhlig, D. Branscheid, P. Zabel, E. Vollmer, 

T. Goldmann. 2004. HOPE-technique enables Western 

blot analysis from paraffin-embedded tissues. 

Pathol. Res. Pract. 200: 469-472. 

60. dos Santos, C. C., B. Han, C. F. Andrade, X. Bai, S. 

Uhlig, R. Hubmayr, M. Tsang, M. Lodyga, S. Keshavjee, 

A. S. Slutsky, M. Liu. 2004. DNA Microarray 

analysis of gene expression in alveolar epithelial cells 

in response to TNFa, LPS and cyclic stretch. Physiol. 

Genomics 19: 331-42. 

61. Göggel, R., S. Uhlig. 2005. The IP3-pathway mediates 

platelet-activating factor-induced pulmonary 

edema. Eur. Respir. J. 25: 849-857. 

62. Lindner, K., U. Uhlig, S. Uhlig. 2005. Ceramide alters 

endothelial cell permeability by a non-apoptotic 

mechanism. Brit. J. Pharmacol. 145: 132-140. 

63. Imai, Y., K. Kuba, S. Rao, Y. Huan, F. Guo, B. Guan, P. 

Yang, R. Sarao, T. Wada, H. Leong-Poi, M.A. Crackower, 

A. Fukamizu, C.C. Hui, L. Hein, S. Uhlig, A. 

Slutsky, C. Jiang, J. M. Penninger. 2005. Angiotensinconverting 

enzyme 2 protects from severe acute 

lung failure. Nature 436: 112-116. 

64. Yamane, M., M. Liu, H. Kaneda, S. Uhlig, T.K. Waddell, 

S. Keshavjee. 2005. Reperfusion-induced gene 

expression profiles in rat lung transplantation. Am. 

J. Tansplant. 5: 2160-2169. 

65. Wrigge, H., U. Uhlig, G. Baumgarten, J. Menzenbach, 

J. Zinserling, M. Ernst, D. Drömann, A. Welz, 

S. Uhlig, C. Putensen. 2005. Mechanical ventilation 

strategies and inflammatory responses to cardiac 

surgery: a prospective randomized clinical trial. Intens. 

Care Med. 31: 1379-8. 

66. Karagiannidisa, C., G. Hense, C. Martin, M. Epstein, 

B. Rückert, P.-Y. Mantel, G. Menz, S. Uhlig, K. Blaser, 

C.B. Schmidt-Weber. 2006. Overlapping functions 

but differential expression of activin A and TGF-a 

in asthma. J. Allergy Clin. Immunol. 117: 111-8. 


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67. Jin, J., H. Zeng, K-W. Schmid, M. Toetsch, S. Uhlig, T. 

Möröy. 2006. The zinc finger protein gfi1 acts upstream 

of TNF to attenuate endotoxin-mediated 

inflammatory responses in the lung. Eur. J. Immunol. 

36: 421-430. 

68. Dolinay, T., N. Kaminski, M. Felgendreher, 

H. P. Kim, P. Reynolds, S.C. Watkins, D. Karp, 

S. Uhlig*, A.M.K. Choi*. 2006. Gene expression 

profiling of target genes in ventilator-induced 

lung injury. Physiol. Genomics 26: 68-75. 

*, equal contribution from both laboratories. 

69. Erpenbeck V.J., M. Ziegert, D. Cavalet-Blanco, C. 

Martin, R. Baelder, T. Glaab, A. Braun, W. Steinhilber, 

B. Luettig, S. Uhlig, H. G. Hoymann, N. Krug, J. M. 

Hohlfeld. Surfactant protein D inhibits early airway 

response in Aspergillus fumigatus-sensitized mice. 

Clin. Exp. Allergy 36: 940-40. 

70. Heinzelmann, F., V. Jendrossek, K. Lauber, R. Boras, T. 

Eldh, K. Nowak, R. Handrick, M. Henkel, C. Martin, 

S. Uhlig, D. Köhler, H. K. Eltzschig, W. Budach, C. 

Belka. 2006. Irradiation-induced pneumonitis mediated 

by the CD95/CD95-ligand system. J. Natl. Canc. 

Inst. 98: 1248-1251. 

71. Ressmeyer, A.R., A.K., Larsson, S.E. Dahlèn, S. Uhlig, 

C. Martin. 2006. Characterization of guinea pig precision-cut 

lung slices. Eur. Respir. J. 28: 603-611. 

72. Uhlig, U., D. Drömann, T. Goldmann, H. Dombrowsky, 

E. Vollmer, P. Zabel, S. Uhlig. 2006. Pulmonary 

responses to overventilation in late multiple 

organ failure. Anesthesiology 105: 1192-1200. 

73. Sausbier, M., X-B. Zhou, C. Beier, U. Sausbier, D. Wolpers, 

S. Maget, C. Martin, A. Dietrich, A-R. Ressmeyer, 

H. Renz , J. Schlossmann, F. Hofmann, W. Neuhuber, 

T. Gudermann, S. Uhlig, M. Korth, P. Ruth. 2007. 

Reduced rather than enhanced cholinergic airway 

constriction in mice with ablation of the large conductance 

Ca 2+ -activated K + channel. FASEB J, 21: 812- 

822. 

74. von Bismarck, P., C-F. G Wistädt, K. Klemm, S. Winoto-Morbach, 

U. Uhlig, S. Schütze, S. Uhlig, B. Lachmann, 

M. F. Krause. 2007. Surfactant “fortification” 

by topical inhibition of nuclear factor-kB activity in 

a newborn piglet lavage model. Crit. Care Med. 35: 

2309-2318. 

75. Dombrowsky, H., S. Uhlig. 2007. Effects of steroids 

on ventilation-induced histone acetylation and 

gene transcription. Eur. Respir. J. 30: 865-877. 

76. Dembinski, R., S. Terbeck, N. Hochhausen, C. Dassow, 

S. Uhlig, M. Schneider, A. Schachtrupp. D. Henzler, 

R. Rossaint, R. Kuhlen. Pumpless extracorporeal 

lung assist for protective mechanical ventilation in 

experimental lung injury. Crit. Care Med. 35: 2309- 

2318. 

77. Vaschetto, R., J. Kuiper, J. Chiang, J. Haitsma, J. Juco, 

S. Uhlig, F. Plötz, F. Corte, H. Zhang, A. Slutsky. 

2008. Inhibition of poly(adenosine diphosphateribose) 

polymerase attenuates ventilator-induced 

lung injury. Anesthesiology 108: 261-8. 

78. von Bismarck, P., C.-F. G. Wistädt, K. Klemm, S. 

Winoto-Morbach, U. Uhlig, S. Schütze, D. Adam B. 

Lachmann, S. Uhlig, M. F. Krause. 2008. Improved 

pulmonary function by acid sphingomyelinase inhibition 

in a newborn piglet lavage model. Am. J. 

Respir. J. Crit. Care Med. 177: 1233-1241. 

79. Meier, T., A. Lange, H. Papenberg, M. Ziemann, C. Fentrop, 

U. Uhlig, P. Schmucker, S. Uhlig*, C. Stamme. Pulmonary 

cytokine responses during mechanical ventilation 

of non-injured lungs with and without endexpiratory 

pressure. Anesth. Analg. 107: 1265-1275. 

*, corresponding author. 

80. Henjakovic. M., K. Sewald, S. Switalla, D. Kaiser, M. 

Müller, T. Z. Veres, C. Martin, S. Uhlig, N. Krug, A. 

Braun. 2008. Ex vivo testing of immune responses in 

precision cut lung slices. Toxicol. Appl. Pharmacol. 

231: 68-76. 

81. Henjakovic M., C. Martin, H. G. Hoymann, K. 

Sewald, A. Ressmeyer, C. Dassow, G. Pohlmann, N. 

Krug, S. Uhlig, A. Braun. 2008. Ex vivo lung function 

measurements in precision cut lung slice (PCLS) 

from chemical allergen sensitized mice represent 

a suitable alternative to in vivo studies. Toxicol. Sci. 

106: 444-453. 

82. Spieth, P.M., A.R. Carvalho, P. Pelosi, C. Hoehn, C. 

Meissner, M. Kasper, M. Hübler, M. von Neindorff, 

C. Dassow, M. Barrenschee, S. Uhlig, T. Koch, M. 

Gama de Abreu. 2009. Variable tidal volumes improve 

different lung protective ventilation strategies 

in experimental lung injury. Am J. Respir. Crit. 

Care Med. 179: 684-693. 

83. Roth, A.G., D. Drescher, Y. Yang, S. Redmer, S. Uhlig, 

C. Arenz. 2009. Bisphosphonates are Potent and Selective 

Inhibitors of Acid Sphingomyelinase. Angew. 

Chem. Int. Ed. Engl. 48: 7560-7563. 

84. Dombrowsky, H., M. Barrenschee, M. Kunze, S. 

Uhlig. 2009. Conserved responses to trichostatin 

A in rodent lungs exposed to endotoxin or stretch. 

Pulm. Pharmacol. 22: 593-602. 


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85. Pruessmeyer, J., C. Martin, F.M. Hess, N. Schwarz, S. 

Schmidt, T. Kogel, N. Hoettecke, B. Schmidt, A. Sechi, 

S. Uhlig, A. Ludwig. 2010. ADAM17 mediates 

constitutive and regulated shedding of syndecan-1 

and -4 by epithelial cells. J. Biol. Chem. 285: 555-64. 

86. Rüter,D., H.-P. Hauber, D. Drömann, P. Zabel, S. 

Uhlig*. 2010. Low frequency ultrasound permeates 

the human thorax: a novel way of non-invasive lung 

testing. Ultraschall Med - Eur. J. Ultrasound. 31: 53- 

62. 

87. Yang, Y., J. Yin, W. Baumgartner, R. Samapati, E.A. 

Solymosi, E. Reppien, W. Kübler, S. Uhlig. 2010. 

Platelet-activating factor reduces endothelial NO 

production - Role of acid sphingomyelinase. Eur. 

Respir. J. 36: 417-427. 

88. Lautenschläger, I., H. Dombrowsky, I. Frerichs, S-C. 

Kuchenbecker, S. Bade, H. Schultz, P. Zabel, J. Scholz, 

N. Weiler, S. Uhlig. 2010. A Model of the Isolated 

Perfused Rat Small Intestine. Am. J. Physiol. Gastrointest. 

Liver Physiol. 298: G304-G313 

89. Dassow, C., L. Wiechert, C. Martin, S. Schumann, G. 

Müller-Newen, O. Pack, J. Guttmann, W.A. Wall, S. 

Uhlig. 2010. Biaxial distension of precision-cut lung 

slices. J. Appl. Physiol. 108: 713-721. 

90. Schwarz, N., J. Pruessmeyer, M.F. Hess, D. Dreymüller, 

E. Pantaler, R. Windoffer, M. Voss, A. Sarabi, C. 

Weber, A. Sechi, S. Uhlig, A. Ludwig. 2010. Requirements 

for leukocyte transmigration via the transmembrane 

chemokine CX3CL1. Cell. Mol. Life Sci. 

67: 4233-4248. 

91. Barrenschee, M., D. Lex, S. Uhlig. 2010. Effects of 

the TLR2 agonists MALP-2 and Pam3Cys in isolated 

mouse lungs. PLoS ONE 5(11): e13889. 

92. Spieth, P.M., A.R. Carvalho, A. Güldner, M. Kasper, 

R. Schubert, N.C. Carvalho, A. Beda, C. Dassow, S. 

Uhlig, T. Koch, P. Pelosi, de Abreu, M.G. 2011. Pressure 

support improves oxygenation and lung protection 

compared to pressure-controlled ventilation 

and is further improved by random variation 

of pressure support. Crit Care Med. 39: 746-755. 

93. Schlepütz, M., S. Uhlig, C. Martin. 2011. Electric 

field stimulation of precision cut lung slices. J. Appl. 

Physiol. 110: 545-554. 

94. Rausch, S., C. Martin, S. Uhlig, W.A. Wall. 2011. Material 

model of lung parenchyma based on living 

precision-cut lung slices. J. Mech. Behav. Biomed. 4: 

583-592. 

95. Spieth P.M., A. Güldner, A. R. Carvalho, M. Kasper, 

P. Pelosi, S. Uhlig, T. Koch, M. Gama de Abreu. 2011. 

Open lung approach vs acute respiratory distress 

syndrome network ventilation in experimental 

acute lung injury. Brit. J. Anaesth. 107: 388-97. 

96. Dombrowsky, H., I. Lautenschläger, N. Zehethofer, 

B. Lindner, H. Schultz, S. Uhlig, I. Frerichs, N. Weiler. 

Ingestion of n-3 fatty acids augments basal and 

platelet activating factor-induced permeability to 

dextran in the rat mesenteric vascular bed. J. Nutrition 

141:1635-42. 

97. Seehase S, M. Schlepütz, S. Switalla, K. Mätz-Rensing, 

F.J. Kaup, M. Zöller, C. Schlumbohm, E. Fuchs, 

HD. Lauenstein, C. Winkler, AR. Kuehl, S. Uhlig, A. 

Braun, K. Sewald, C. Martin. 2011. Bronchoconstriction 

in non-human primates: A species comparison. 

J. Appl. Physiol. 111: 791-798. 

98. Reiss, L.K., A. Kowallik, S. Uhlig. 2011. Recurrent 

recruitment manoeuvres improve lung mechanics 

and minimizes lung injury during mechanical ventilation 

of healthy mice. PLoS ONE 6(9):e24527. 

99. Kunzmann, S., J.J. Collins, Y. Yang, S. Uhlig, S. Kallapur, 

C.P. Speer, A.H. Jobe, B.W. Kramer. 2011. Antenatal 

inflammation reduces Cav-1 expression and 

influences multiple signaling pathways in preterm 

fetal lungs. Am J Respir Cell Mol Biol. 45: 969-976. 

100. Klug, K., S. Ehlers, S. Uhlig, N. Reiling. 2011. Mitogenactivated 

protein kinases p38 and ERK1/2 regulated 

control of M. avium replication in primary murine 

macrophages is independent of TNF and IL-10. Innate 

immunity 17: 470-485. 

101. Inhalative IL-10 attenuates pulmonary inflammation 

following hemorrhagic shock without major 

alterations of the systemic inflammatory response. 

2012. Kobbe, P., P. Lichte, H. Schreiber, L. K. Reiss, 

S. Uhlig, H.-C. Pape, R. Pfeifer. Med. Inflammation 

2012: 512974. 

102. Rieg, A.D., R. Rossaint, S. Uhlig, C. Martin. 2011. Differential 

effects of cardiovascular agents in the pulmonary 

artery and vein - implications for pharmacological 

therapy. PLoS One 6(12): e29698. 

103. Samapati, R. Y. Yang, J. Yin, C. Stoerger, C. Arenz, 

A. Dietrich, T. Gudermann, D. Adam, S. Wu, M. 

Freichel, V. Flockerzi, S. Uhlig*, W. M. Kübler*. 2012. 

Lung endothelial Ca 2+ and permeability response 

to PAF is mediated by acid sphingomyelinase and 

TRPC6. Am. J. Respir. Crit. Care Med. 185: 160-170, 

* shared last authorship. Selected for cover. 

104. Morenz, K., H. Biller, F. Wolfram, S. Leonhardt, 

D. Rüter, T. Glaab, S. Uhlig*, J. Hohlfeld. 

2012. Detection of air trapping in chronic obstructive 

pulmonary disease by low frequency 

ultrasound. BMC Pulm. Med. 16; 12(1);8 

*, corresponding author 


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105. Dreymueller, D., C. Martin, T. Kogel, J. Pruessmeyer, 

F.M. Hess, K. Horiuchi, S. Uhlig, A. Ludwig. 2012. 

Lung endothelial ADAM17 regulates the acute inflammatory 

response to lipopolysaccharide. EMBO 

Mol. Med. 5: 412-423. 

106. Cioffi, D.L., S. Wu, H. Chen, M. Alexeyev, C. M. St. 

Croix, B. R. Pitt, S. Uhlig, T. Stevens. 2012. Orai1 

determines calcium selectivity of an endogenous 

TRPC heterotetramer channel. Circ. Res. 110: 1435- 

1444. 

107. Siegl, S., S. Uhlig. 2012. Using the one-lung method 

to link p38 to pro-inflammatory gene expression 

during overventilation in C57BL/6 and BALB/c mice. 

PLoS ONE 7(7): e41464. 

108. Preuß, S., S. Stadelmann, F.D. Omam, J. Scheiermann, 

S. Winoto-Morbach S, P. von Bismarck, F. Knerlich- 

Lukoschus, D. Lex, S. Adam-Klages, D. Wesch, J. 

Held-Feindt, S. Uhlig, S. Schütze, M.F. Krause. 2012. 

Inositol-trisphosphate reduces alveolar apoptosis 

and pulmonary edema in neonatal lung injury. Am. 

J. Respir. Cell. Mol. Biol. 47: 158-169 . 

109. Schlepütz, M., A. Rieg, S. Seehase, J. Spillner, A. 

Perez-Bouza, T. Braunschweig, T. Schroeder, M. Bernau, 

V. Lambermont, C. Schlumbohm, K. Sewald, 

R. Autschbach, A. Braun, B.W. Kramer, S. Uhlig, C. 

Martin. 2012. Mechanisms of neuronal airway control 

in human and other species. A comparative 

study using precision-cut lung slices (PCLS). PLoS 

One 7(10):e47344. 

110. Preuß, S., F.D. Omam, J. Scheiermann, S. Stadelmann, 

S. Winoto-Morbach, P. von Bismarck, S. Adam-Klages, 

F. Knerlich-Lukoschus, D. Lex, D. Wesch , J. Held- 

Feindt, S. Uhlig, S. Schütze, M.F. Krause. 2012. Topical 

application of phosphatidyl-inositol-3,5-bisphosphate 

for acute lung injury in neonatal swine. J. Cell. 

Mol. Med. 16: 2813-26. 

111. Ichikawa, A., M. Morita, K. Kuba, S. Chida, H. Tezuka, 

H. Hara, T. Sasaki, T. Ohteki, V.M. Ranieri, C.C. 

dos Santos, Y. Kawaoka, S. Akira, A.D. Luster, B. Lu, 

J.M. Penninger, S. Uhlig, A.S. Slutsky, Y. Imai. 2013. 

CXCL10-CXCR3 enhances the development of 

neutrophil-mediated fulminant lung injury of viral 

and non-viral origin. Am. J. Respir. Crit. Care Med. 

87: 65-77. 

112. Engel, M., R.M. Nowacki, L.K. Reiss, S. Uhlig, C.H. 

Willems, N. Kloosterboer, J.F. van Iwaarden, A.C. 

Sewing, M. Seehase, V.A. Lambermont, J.J. Collins, 

L.J. Zimmermann, G.D. Vos, B.W. Kramer. 2013. 

Comparison of recruitment manoeuvres in ventilated 

sheep with Acute Respiratory Distress Syndrome. 

Lung 191: 77-86. 

113. Larsson, A.K., S.-E Dahlén, A.-R. Kühl, D. Lex, S. 

Uhlig, C. Martin. 2013. Modulation of antigen-induced 

responses by serotonin and prostaglandin E2 

via EP1 and EP4 receptors in the peripheral rat lung. 

Eur. J. Pharmacol. 699: 141-149. 

114. Rieg AD, Rossaint R, Verjans E, Maihöfer NA, Uhlig 

S, Martin C. 2013. Levosimendan relaxes pulmonary 

arteries and veins in precision-cut lung slices - the 

role of KATP-Channels, cAMP and cGMP. PLoS One 

18;8(6):e66195. 

115. Verjans, E., K. Ohl, Y.Yu, R. Lippe, A. Schippers, J. 

Roth, N. Wagner, S. Uhlig, K. Tenbrock, C. Martin. 

2013. Overexpression of CREMα in T cells aggravates 

LPS-induced acute lung injury. J. Immunol. 

191:1316-23. 

116. Bruells, C.S., A.J. Smuder, L. K. Reiss, M.B. Hudson, 

W.B. Nelson, M.P. Wiggs, K.J. Sollanek, R. Rossaint, 

S. Uhlig, S.K. Powers. 2013. Negative pressure ventilation 

and positive pressure ventilation promote 

comparable levels of ventilator-induced diaphragmatic 

dysfunction in rats. Anesthesiology 119: 652- 

62. 

117. Preuß, S., J. Scheiermann, S. Stadelmann, F.D. Omam, 

S. Winoto-Morbach, D. Lex, P. von Bismarck, S. 

Adam-Klages, F. Knerlich-Lukoschus, D. Wesch, J. 

Held-Feindt, S. Uhlig, S. Schütze, M.F. Krause. 2013. 

18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar 

epithelial apoptosis and profibrotic stimulus 

in a neonatal piglet model of acute respiratory distress 

syndrome. Pulm Pharmacol Ther. 2013 Oct 15. 

pii: S1094-5539(13)00175-2. 

118. Bel-Brunona, A., S. Kehla, C. Martin, S. Uhlig, W. 

A. Wall. Numerical identification method for the 

non-linear viscoelastic compressible behaviour of 

soft tissue using uniaxial tensile tests and image 

registration - Application to rat lung parenchyma. J. 

Mechan. Behavior Biomed. Materials¸ in press. 

Reviews & Editorials 

119. Uhlig, S., und A. Wendel. 1992. The physiological 

consequences of glutathione variations. Life Sci. 51: 

1083-1094. 

120. Uhlig, S., J. Barsig, G. Tiegs und A. Wendel. 1994. Die 

modulierende Wirkung von Kolonie-stimulierenden 

Faktoren in experimentellen Sepsis-Modellen. 

Sepsis - Klinik und Grundlagenforschung im Dialog. 

Herausgeber: Verein zur Förderung der Klinischen 

und Experimentellen Molekularen Medizin e. V., S. 

91-93. 


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121. Uhlig, S. 1995. Analysis of edema formation in isolated 

perfused rat lungs ventilated by negative pressure. 

In Ninth Freiburg Focus on Biomeasurement, 

Pharmacological evaluation of cardioprotective 

substances. Biomesstechnik Verlag GmbH, March, 

p. 152-161. 

122. Uhlig, S., A. Wendel. Lipid mediators in perfused rat 

lung. 1995. In Interdisziplinäre Aspekte der Pneumologie. 

Herausgeber: von Wichert, P. und Siegenthaler, 

Georg Thieme Verlag, Stuttgart, p. 66-74. 

123. Bohlinger, I., M. Leist, J. Barsig, S. Uhlig, G. Tiegs, A. 

Wendel. 1996. Tolerance against tumor necrosis 

factor α (TNF)-induced hepatotoxicity in mice: the 

role of nitric oxide. Toxicol. Lett. 82/83: 127-131. 

124. Bundschuh, D., S. Uhlig, A. Wendel. 1996. Isolation 

of rat primary lung cells: characterization of an improved 

method. Exp. Toxicol. Pathol. 48: 512-514. 

125. von Bethmann, A., S. Uhlig. 1997. Side effects of mechanical 

ventilation: molecular mechanisms. Proceedings 

of the 12th Postgraduate Course in Critical 

Care Medicine, A.P.I.C.E. ‘97, Trieste, Italy. Gullo, A. 

(ed.), Springer, Berlin Heidelberg New York. 147-154. 

126. Uhlig, S. 1998. The isolated perfused rat lung. In 

Methods in Pulmonary Research. Eds: S. Uhlig and 

A. E. Taylor. Birkhäuser Verlag, Basel. 29-55 

127. Uhlig, S., H. D. Held, R. Göggel. 2000. In Applications 

of isolated perfused lungs. Proceedings of a 

Workshop on Isolated Perfused Organs. Eds: W. Pittermann, 

M. Kiezmann, C. Grosse-Siestrup. Laboratory 

Animals Ltd., London, UK, 41-54. 

128. Martin C, S. Uhlig. 2000. Lung functions in precision-cut 

lung slices. In Applications of isolated perfused 

lungs. Proceedings of a Workshop on Isolated 

Perfused Organs. Eds: W. Pittermann, M. Kiezmann, 

C. Grosse-Siestrup. Laboratory Animals Ltd., London, 

UK, 55-67. 

129. Uhlig, S. 2000. Beatmungs-induzierte Lungenschäden 

– Gibt es sie? J. Anästhesie Intensivbehandlung 

1: 208-210. 

130. Martin, C., A. Wohlsen, S. Uhlig. 2000. 

Asthmaanfall unter dem Mikroskop. 

WGL Journal 1/2000: 5-7. 

131. Seydel, U., A. J. Ulmer, S. Uhlig, E. T. Rietschel. 2000. 

Lipopolysaccharide, a membrane-forming and inflammation-inducing 

bacterial macromolecule. In: 

Zimmer G, editor. Membrane Structure in Disease 

and Drug Therapy. New York: Marcel Dekker Inc. 

New York, 217-252. 

132. Uhlig, S., N. Kapp, M. Weisser, J. Hamacher, 

A. Wendel. 2000. Mechanisms of giant lamellar 

body formation in endotoxin-treated lungs. 

Appl. Cardiopulm. Pathophysiol. 9: 294-295. 

133. Uhlig, S. 2001.Der Einfluß des PEEP auf die beatmungs-induzierte 

Freisetzung pro-inflammatorischer 

Mediatoren. J. Anästhesie Intensivbehandlung 

8: 264-265. 

134. Uhlig, S., U. Uhlig. 2001. Molecular mechanisms 

of pro-inflammatory responses in overventilated 

lungs. Recent Res. Devel. Resp. Critical Care Med. 1: 

49-58. 

135. Uhlig, S, D. Burdon. 2002. Pro-and anti-inflammatory 

Cytokines and apoptosis in acute lung injury. In 

Sepsis and Organ dysfunction: from chaos to rationale. 

Eds. A. E. Baue, G. Berlot, A. Gullo, J.-L. Vincent. 

Milano: Springer Verlag, 77-93. 

136. Uhlig, S. 2002. Ventilation-induced lung injury 

and mechanotransduction: Stretching it too far? 

Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L892-L896. 

137. Uhlig, S., K. Lindner. 2002. Novel mechanisms of 

endothelial cell permeability in the lung. Lessons 

from studies with intact lungs and animals. In The 

microcirculation and vascular biology. Eds. J. Tooke, 

A. Shore, J. Whatmore. Bologna: Monduzzi Editore, 

221-234. 

138. Uhlig, S. 2003. Taking a peep at the upper airways. 


139. Uhlig, S., M. Ranieri, A. S. Slutsky. 2004. Biotrauma 

Hypothesis of Ventilator-induced Lung Injury. Am J 

Respir Crit Care Med. 169: 314-6 (Correspondence). 

140. Uhlig, S., U. Uhlig. 2004. Pharmacological interventions 

in ventilator-induced lung injury. Trends in 

Pharmacol. Sci. 25: 592-600. 

141. Uhlig, S. Who tidies up the lung? Ask Cox-2 and 

Nrf2. 2005. Am. J. Respir. Crit. Care Med., 171-1198- 

1999. 

142. Hamacher, J., S. Heyder, R. Lucas, R. Schramm, G. W. 

Sybrecht, S. Uhlig. 2005. Bronchoalveoläre Lavage 

beim Nager. Pneumologie 59: 486-90. 

143. Uhlig, S., R. Göggel, S. Engel. 2005. Mechanisms of 

PAF-mediated responses in the lung. Pharmacol. Reports 

57, suppl., 206-221. 

144. Uhlig, S., Reppien. 2006. Die Bedeutung von Sphingolipiden 

für die Pathophysiologie der Lunge. Intensivmed. 

Notfallmed. 43: 247-251. 

145. Winning, J, S. Uhlig, H. Huwer, R. Lucas, J. Hamacher. 

2007. Die „weisse“ Lunge: Störungen der Flüssigkeitsbilanz. 

In Intensivbuch Lunge. Eds. T. Bein, M. 

Pfeifer. Berlin: Med. Wissenschaftl. Verlagsgesellschaft, 

143-189. 

146. Uhlig, S., H. Held. 2007. Isolated perfused lung. In 

Lung metastases and isolated lung perfusion. Eds. P. 

van Schil. Nova Science Publishers, Inc., New York, 

127-139. 


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147. Uhlig, S. 2007. Vom Barotrauma zum Biotrauma – 

neue Ansätze zur protektiven Beatmung? Arzneim- 

Forsch/DrugRes 57: G752-G754. 

148. Uhlig, S., I. Frerichs. 2008. Lungenprotektive Beatmung 

- Pathophysiologie und Diagnostik. AINS 43: 

438-445. 

149. Roggen, E., M. Aufderheide, Y. Cetin, R. J. Dearman, 

S. Gibbs, I. Hermanns, I. Kimber, J. F. Regal, C. Rovida, 

D. B. Warheit, S. Uhlig, S. Casati. 2008. Progress in 

the development of novel approaches to the identification 

of chemical and protein respiratory allergens. 

ATLA 36: 591-598. 

150. Uhlig, S., E. Gulbins. Sphingolipids in the lungs. 

2008. Am. J. Respir. J. Crit. Care Med. 178: 1100-1114. 

151. Uhlig, S., C. Martin. 2008. Bronchial Asthma. In 

Encyclopedia of Molecular Pharmacology. 2nd Edition. 

Eds. Offermanns, S, Rosenthal, W. Springer- 

Verlag Berlin-Heidelberg-New York, p. 284-289. 

152. Uhlig, S., C. Martin. 2008. Chronic obstructive pulmonary 

disease. In Encyclopedia of Molecular Pharmacology. 

2nd Edition. Eds. Offermanns, S, Rosenthal, 

W. Springer-Verlag Berlin-Heidelberg-New 

York, p. 362-366. 

153. Floege, J, S. Uhlig. 2010. Kidney calling lung and callback: 

How organs talk to each other. Nephrol. Dial. 

Transplant. 25: 32-24. 

154. Kuebler, W.M., Y. Yang, R. Samapati, S. Uhlig. 2010. 

Vascular barrier regulation by PAF, sphingomyelinase, 

caveolae, and NO – an intricate signaling network 

with discrepant effects in the pulmonary and 

systemic vaculature. Cell. Physiol. Biochem. 26: 29- 

40. 

155. Uhlig, U., S. Uhlig. 2011. Ventilation-induced lung in 

jury. Comprehensive Physiol. 1: 635-661. 

156. Matute-Bello, G, G- Downey, B.B. Moore, S.D. Groshong, 

M.A. Matthay, A.S. Slutsky, W.M. Kuebler; on 

behalf of the Acute Lung Injury in Animals Study 

Group. 2011. An Official American Thoracic Society 

Workshop Report: Features and Measurements of 

Experimental Acute Lung Injury in Animals. Am. J. 

Respir. Cell Mol. Biol. 44: 725-738. 

157. Ludwig, A., A. Sommer, S. Uhlig. 2011. Assessment 

of endothelial permeability and leukocyte transmigration 

in human endothelial cell monolayers. 

Methods Mol. Biol. 763: 319-32. 

158. Yang, Y., S. Uhlig. 2011. The role of sphingolipids in 

respiratory disease. Ther. Adv. Respir. Dis. 5: 325-44. 

159. Reiss, K., U. Uhlig, S. Uhlig. 2012. Models and mechanisms 

of acute lung injury caused by direct insults. 

Eur. J. Cell Biol. 91: 590-601. 

160. Uhlig, S., Y. Yang. 2013. Sphingolipids in Acute Lung 

Injury. In: Sphingolipids in Disease. Eds. E. Gulbins, I. 

Petrache. Handbook of Experimental Pharmacology 

216, Springer-Verlag Wien, p. 227-246. 


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Publikationliste Stefan Uhlig

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