CURRICULUM VITAE - UT Southwestern

Shin Yamazaki, Ph. D.
CURRICULUM VITAE
(as of April 26, 2013)
EDUCATION
1986 Bachelor of Agriculture, Tamagawa University, Tokyo, Japan.
Thesis: Studies on the factors affecting the reproduction of the varroa mite, especially on the juvenile
hormone titer of host honeybees (in Japanese).
1988 Master of Agriculture (Biological Resources), Tamagawa University, Tokyo, Japan.
Thesis: Studies on brain photoreception in insects, with special emphasis on the calling clocks of
Anadevidia peponis (Lepidoptera: Noctuidae) (in Japanese).
1992 Doctor of Philosophy in Agriculture (Biological Resources), Tamagawa University, Tokyo, Japan.
Thesis: Studies on the insect circadian system (in Japanese).
POSTDOCTORAL TRAINING
1992-1993 Postdoctoral Fellow (Neuroscience): Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
(PI: Shin-Ichi T Inouye, Ph.D.)
1993-1994 Postdoctoral Fellow (Neuroscience): Tokyo Metropolitan Institute for Neuroscience, Tokyo,
Japan. (PI: Yoichiro Kuroda, Ph.D.)
1994-1996 Research Associate (Chronobiology): Department of Biology, University of Virginia,
Charlottesville, VA. (PIs: Michael Menaker, Ph.D. and Gene D Block, Ph.D.)
APPOINTMENTS
1996-2002 Research Scientist: Department of Biology, University of Virginia, Charlottesville, VA.
2000-2002 Center Investigator: NSF Center for Biological Timing
2002-2006 Research Assistant Professor, Department of Biological Sciences, Vanderbilt University,
Nashville, TN.
2006-2013 Member of the Vanderbilt Kennedy Center for Research on Human Development
2006-2013 Research Associate Professor, Department of Biological Sciences, Vanderbilt University,
Nashville, TN.
2008-2011 Scientist Member of the Institutional Animal Care and Use Committee
(Reviewed 46 new protocols and 44 protocol modifications for animal research, including
nonhuman primates, dogs, pigs, rabbits, rodents, fish and frogs and performed semi-annual
animal research facility inspections.)
2013-present Research Associate Professor, Department of Neuroscience, University of Texas Southwestern
Medical Center, Dallas, TX
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Society for Research on Biological Rhythms
The Society for Neuroscience
PROFESSIONAL AFFILIATIONS
OTHER ACTIVITIES
Editorial Board:
2008-present “PLoS ONE” Academic Editor (edited and published 89 papers)
2009-present “Frontiers in Molecular Neuroscience” Review Editor
Grant Review:
“The Netherlands Organization for Health Research and Development”, Netherlands
“Medical Research Council”, UK
“Biological Rhythms and Sleep” (Ad hoc NIH study section member)
“Challenge Grant (NIH RFA-OD-09-003)” Special Emphasis Panel/Scientific Review Group 2009/10 ZRG1
IFCN-A (58) mail reviewer.
“Human Frontier Science Program” mail reviewer
“NSF Neural Systems”
“NIH research expert review panel” participant (compensated)
Manuscript Review (total of 53) :
“Proceedings of National Academy of Sciences, U.S.A.”
“Journal of Neuroscience”
“European Journal of Neuroscience”
“Analytical Biochemistry”
“Physiology and Behavior”
“Journal of Comparative Physiology - A”
“Journal of Physiology”
“Zoological Science”
“Neuroscience”
“Neuroscience Letters”
“Biochemical Pharmacology”
“Journal of Biological Rhythms”
“Stem Cells”
“Genes to Cells”
“PLoS ONE”
“Journal of Neurophysiology”
“Journal of Applied Physiology”
“Chronobiology International”
“American Journal of Physiology - Lung Cellular and Molecular Physiology”
“American Journal of Physiology - Regulatory, Integrative and Comparative Physiology”
“Journal of Visualized Experiments (JoVE)”
“Biochemistry and Cell Biology”
“Addiction Biology”
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Consulting:
Development of the luminescence recording apparatus, LumiCycle (32-channel carousel luminescence
recording device and data analysis software). The LumiCycle was produced in collaboration with Dr. David
Ferster (Actimetrics Inc. Evanston IL). More than 50 of these instruments have been purchased by circadian
researchers in 8 countries (USA, Japan, Switzerland, Germany, France, UK, Brazil and China) and I have
personally traveled to 3 countries to perform on-site installation. I also serve as a consultant for 22 laboratories
using this equipment.
Outreach Program:
Organization and operation of the biological clocks booth at Brain Blast in Nashville, TN. Brain Blast is a free
event that promotes hands-on learning by children of all economic and racial backgrounds (2004-2013).
The Research Experience for High School Students:
Sponsored by the Vanderbilt Center for Science Outreach
June 4-July 13, 2012
Two high school students, Roya E Huang (Henry M Gunn High School, Palo Alto, CA) and William Z Yang
(Montgomery Bell Academy, Nashville, TN) performed independent research projects in my lab.
PATENT DISCLOSURES
“Transgenic mammals introduced a Period 1 promoter that confers rhythmical expression”. Patent number:
7,659,387 (granted on February 9th, 2010 by United States Patent Trademark Office)
CURRENT AND COMPLETED RESEARCH SUPPORT
Ongoing Research Support
IOS-1146908 Yamazaki (PI) 03/01/12-02/28/15
NSF
Exploring the Interaction between Light- and Food-Entrainable Oscillators in the Mammalian Circadian System
The major goals of this project are (i) to identify genes that are important for timekeeping in the circadian clock
that controls food anticipatory activity and the clock which controls methamphetamine-induced circadian
behavior; and (ii) to investigate those circadian oscillators as components of the integrated circadian circuit.
Role: PI
Completed Projects
11GHSU138 Yamazaki (PI) 07/01/11-06/30/12
MMPC/NIH
Interplay between circadian disorganization and obesity
The major goal of this project was to define the role of Per3 in regulating metabolism.
Role: PI
P30 ES000267 Guengerich (PI) 04/04/10-03/31/11
NIH/NIEHS Center in Molecular Toxicology Pilot Project
The effect of TCDD on the circadian gene expression rhythm in mammalian pacemakers.
Role: PI
R01 NS051278 Yamazaki (PI) 06/01/05-05/31/10 NIH/NINDS
Effect of Temperature on the Mammalian Circadian System.
The major goals of this project were to characterize the effect of temperature on the circadian rhythm in central
and peripheral tissues.
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Role: PI
R01 EY015815 McMahon (PI) 07/01/04-10/31/08
NIH/NEI
Circadian Organization of the Retina.
The major goals of this project were to define the circadian function in the retinal dopaminergic neuron.
Role: Collaborator
(my support was terminated on 10/31/08 by PI)
R01 MH075016 de la Iglesia (PI) 04/01/06-03/31/08
NIH/NIMH
Forced Desynchronization of the Rat Circadian System.
The goal of this project was to understand the coordination of circadian-regulated physiological outputs of the
brain pacemaker in the suprachiasmatic nucleus.
Role: Collaborator
(subcontract was terminated on 3/31/08 by PI)
Research Grant Yamazaki (PI) 12/22/06-12/21/09
Research Foundation for Opto-Science and Technology
Use of luminescence reporters for circadian characterization of lung tumors.
The major goals of this project are to define the circadian function in tumor progression.
Role: PI
4

MENTORING
Judong Lee: 2005
Degree: MS
Current Position: PhD candidate, University of Pittsburgh
Mijung Yeom, PhD: 2007-2009
Current Position: Research Professor, Acupuncture and Meridian Science Research (AMSRC)
Kyung Hee University, Seoul, Korea
Julie S. Pendergast, PhD: 2007-2012
Current Position: Instructor, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine,
Vanderbilt University
TEACHING AND UNDERGRADUATE RESEARCH MENTORSHIP
Department of Biological Sciences,
Vanderbilt University
BSCI 230 Biological Rhythms
(Guest lecture)
Fall 2005; 2006
BSCI 332 Seminar in Biological Rhythms
(Organizer)
Spring 2006-Fall 2011
BSCI 282 Independent Reading
Aaron J Shambley, Fall 2008
Harish Krishnamoorthi, Spring 2009
Joshua R Mastin, Spring 2010
BSCI 280 Research Internship
Swati Midha, Fall 2006
Alexandra Belenky, Fall 2006
Ester Lee, Spring 2007 and Spring 2008
Natalie Deanna Thoni, Fall 2009 and Spring
2010
BSCI 283 Directed Laboratory Research
Wendi Bond, Fall 2003
Jalin Liu, Summer 2004
Julie C Wang, Fall 2004
R Anjali Kumbla, Fall 2005
Rio C Friday, Fall 2007
Charles D Keil, Spring 2008
E Jean Pak, Fall 2008
Cathya Olivas, Spring 2009
Matthew L Sundermann, Spring 2010
BSCI 286 Independent Laboratory
Research
Wendi Bond, Spring 2004
Jalin Liu, Fall 2004
Julie C Wang, Spring 2005 and Spring 2006
R Anjali Kumbla, Spring 2006
Rio C Friday, Fall 2008 and Spring 2009
Charles D Keil, Fall 2008
Cathya Olivas, Fall 2009
BSCI 296 Honors Research
R Anjali Kumbla, Fall 2006 – Spring 2007
Neuroscience Program
NSC 292 Undergraduate Research
Derrick Choi, Spring 2004- Spring 2005
Bryan A Reyes, Fall 2005 – Spring 2006
Amy C-R Ly, Fall 2005 – Fall 2006
Alexandra Belenky, Spring 2007
Meredith L Barbour, Spring 2007 – Spring
2008
NSC 296 Honors Research
Bryan A Reyes, Fall 2006 – Spring 2007
Vanderbilt University Summer Research
Program
Bryan A Reyes, Summer 2006
Rio C Friday, Summer 2008
Vanderbilt Molecular and Cellular Biology
Program
Derrick Choi, Summer 2004
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INVITED SEMINARS AND SYMPOSIA
May 23 (2012) 13 th Biannual Meeting Society for Research on Biological Rhythms, Destin, FL
Workshop SCN Architecture
May 22 (2012) 13 th Biannual Meeting Society for Research on Biological Rhythms, Destin, FL
Symposium 13 Circadian Organization and Peripheral Oscillators “Beyond None-Canonical Rhythmicity:
Period Determination in the Food-Entrainable and Methamphetamine-Sensitive Circadian Oscillator(s)”
November 21 (2011) Department of Psychiatry, McGill University, Douglas Mental Health University
Institute, Montreal, Canada. “Distinct Roles of the Three Period Genes in the Mammalian Clockworks”
November 22 (2010) Department of Psychophysiology, National Institute of Mental Health, National Center
of Neurology & Psychiatry, Tokyo Japan. “Distinct functions of the Period genes in the mammalian circadian
system: Evidence from in vitro and in vivo studies”.
November 20 (2010) The 17 th Annual Meeting of the Japanese Society for Chronobiology, Tokyo Japan.
“Distinct function of Period 1, 2, 3 and in vivo factors”.
November 18 (2010) TARA Center, Tsukuba University, Tsukuba Japan. “Cell Cycle and Circadian Rhythm”.
April 16 (2010) Biology Department, University of Massachusetts Amherst, Amherst MA. “In vitro vs. in vivo
approaches: revealing the complex organization of the mammalian circadian system”.
February 11 (2010) The Department of Neuroscience, University of Texas Southwestern Medical Center,
Dallas TX. “In vitro vs. in vivo approaches: revealing the complex organization of the mammalian circadian
system”.
December 10 (2009) The 32th Annual Meeting of the Molecular Biology Society of Japan, Yokohama Japan.
“Circadian-independent cell mitosis in rat1 fibroblasts”. Symposium: Integrated Regulation of Biological
Cycles; Organizers: Hisao Masai, Steve McKnight, Hijime Tei
October 14 (2009) Physiology Seminar, University of Kentucky, Lexington KY. “Complex organization of the
mammalian circadian system: luminescence
reporter techniques now and then”.
February 23 (2007) Neuroscience Institute Seminar, Neuroscience Institute, Morehouse School of Medicine,
Atlanta, GA. “Luminescence Reporting Technique for Biological Clock Research.”
December 12 (2006) Department seminar, Dept. of Biophysics and Biochemistry, Graduate School of Science,
The University of Tokyo, Tokyo, Japan. “Hierarchical Structure of Central and Peripheral Clocks in Mammals
Revealed by Real-Time Luminescence Reporting Technology.”
December 11 (2006) Seminar, Consolidated Research Institute for Advanced Science and Medical Care,
Waseda University, Tokyo, Japan. “Mammalian Circadian System.”
December 8 (2006) The Molecular Biology Society of Japan 2006 Forum: Molecular Biology – the Next
Decade, Symposium, “Dynamic Regulation of Biological Clock : Molecular Orchestration and Systems”
(organized by Yagita and Tei). “Luminescence reporter techniques have uncovered complexity among
oscillatory structures in the mammalian circadian system.”
6

December 7 (2006) Department seminar, Graduate School of Bioagricultural Sciences and School of
Agricultural Sciences, Nagoya University, Nagoya, Japan. “Hierarchical Structure of Central and Peripheral
Clocks in Mammals Revealed by Real-Time Luminescence Reporting Technology.”
March 31 (2006) Mitsubishi Kagaku Institute for Life Sciences, Tokyo, Japan
“Luminescence reporter techniques have uncovered complexity among oscillatory
structures in the mammalian circadian system.”
March 28 (2006) The 83 rd Annual Meeting of the Physiological Society of Japan, Maebashi, Japan.
“Luminescence reporter techniques have uncovered complexity among oscillatory
structures in the mammalian circadian system.” Plenary Symposium for IUPS 2009
Temporal Organization of Physiology and Behaviors - Functions of
Multi-oscillatory Hierarchical System (Organized by Ken-ichi Honma)
May 12 (2005) Department of Biological Sciences, University of Manchester, UK
“Circadian Bioluminescence Recordings from Cultured Mammalian Cells.”
March 18 (2004) Department seminar, Vanderbilt University.
“Suprachiasmatic Nucleus: Ringmaster of the Circadian Circus or Conductor of the Circadian Orchestra?”
October 24 (2003) Waseda University, Tokyo, Japan. “Hierarchical Structure of Central and Peripheral Clocks
in Mammals Revealed by Real-Time Luminescence Reporting Technology.”
October 22 (2003) Electron Tube Division, Hamamatsu Photonics KK, Hamamatsu, Japan. “Real-Time
Luminescence Reporting Technology for Chronobiology.”
October 20 (2003) RITSU Seminar, Yamaguchi University, Yamaguchi, Japan. “Hierarchical Structure of
Central and Peripheral Clocks in Mammals Revealed by Real-Time Luminescence Reporting Technology.”
October 18 (2003) The 76 th Annual Meeting of the Japanese Biochemical Society, Yokohama, Japan.
“Ontogeny of Circadian Organization in Rat.”
October 16 (2003) Clock Cell Biology Group, National Institute of Advanced Industrial Science and
Technology Center, Tsukuba, Japan. “Hierarchical Structure of Central and Peripheral Clocks in Mammals
Revealed by Real-Time Luminescence Reporting Technology.”
September 9-12 (2003) 1st World Congress of Chronobiology. Sapporo, Japan. “Effect of Temperature on the
Mammalian Circadian System.”
June 26-30 (2002) Society for Behavioral Neuroendocrinology Annual Meeting. Amherst, MA, USA.
“Ontogeny of Circadian Organization in Rat.”
May 25 (2002) Eighth Meeting Society for Research on Biological Rhythms, Jacksonville, FL. “Luciferase
imaging of circadian function.”
August 9 (2001) Gordon Research Conference: Chronobiology. Salve Regina University, Rode Island.
“Chronoarchitecture: hierarchical structure of central and peripheral clocks in mammals.”
June 26 (2001) Department of Neurobiology and Physiology, Northwestern University, Evanston IL.
“Disruption of Circadian Organization in Jet-Lagged Transgenic Rats.”
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December 18 (2000) U.S.-Japan Symposium on Molecular Mechanism for Circadian Clocks: Functions of
Clock Genes. Kyoto Japan. “Coupling between the Right and Left SCN.”
April 14 (2000) Friday At Four!, University of Virginia, Charlottesville, VA, USA. “Disruption of Circadian
Organization in Jet-Lagged Transgenic Rats.”
June 10 (1998) Morehouse School of Medicine Neuroscience Institute, Atlanta, GA, USA. “How Does SCN
Control Nocturnal Activity in a Hamster?”
December 9 (1997) Stanford University Sleep Research Center, Stanford, CA, USA. “How Does SCN Control
Nocturnal Activity in a Hamster?”
December 4-6 (1997) Japan-US conference on molecular chronobiology, San Francisco, CA. USA. “How
Does SCN Control Nocturnal Activity in a Hamster?”
May 9 (1997) Friday At Four!, University of Virginia, Charlottesville, VA, USA. “Circadian Organization in
the Brain of Hamsters: Circadian Rhythms, Ultradian Rhythms, SCN, BNST, Hb, Retina, LSN; How Can I Put
Together the Pieces of This Puzzle?”
October 4 (1993) Yamagata University School of Medicine, Yamagata, Japan. “Mechanisms of the Circadian
Oscillation in Mammalian SCN.”
MEETING CO-ORGANIZATION
Rhythms In the South Eastern Region Site for 2011 (RISER 2011)
May 14-15, 2011, 59 attendees
Rhythms In the South Eastern Region Site for 2009 (RISER 2009)
May 16, 2009, 64 attendees
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Bibliography:
PEER-REVIEWED PRIMARY PUBLICATIONS (TOTAL OF 60):
Pendergast JS, Branecky KL, Yang W, Ellacott KL, Niswender KD, Yamazaki S (2013)
High-fat diet acutely affects circadian organisation and eating behavior. Eur J Neurosci. doi:
10.1111/ejn.12133.
Pendergast JS, Oda GA, Niswender KD, Yamazaki S (2012) Period determination in the food-entrainable and
methamphetamine-sensitive circadian oscillator(s). Proc Natl Acad Sci U S A. 109:14218-14219. PMCID:
PMC3435193[Available on 2013/2/28]
Pendergast JS, Yamazaki S (2012) The Mammalian Circadian System is Resistant to Dioxin.
J Biol Rhythms 27:156-163. PMCID: PMC3337685
Pendergast JS, Niswender KD, Yamazaki S (2012) Tissue-Specific Function of Period3 in Circadian
Rhythmicity. PLoS ONE 7(1): e30254. doi:10.1371/journal.pone.0030254. PMCID: PMC3256228
Pendergast JS, Yamazaki S (2011) Masking Responses to Light in Period Mutant Mice.
Chronobiol Int. 28:657-663.
Nakamura TJ, Nakamura W, Yamazaki S, Kudo T, Cutler T, Colwell CS, Block GD (2011) Age-related
decline in circadian output. J Neurosci. 31:10201-10205. PMCID: PMC3155746
Um JH, Pendergast JS, Springer DA, Foretz M, Viollet B, Brown A, Kim MK, Yamazaki S, Chung JH (2011)
AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner. PLoS One 6(3):e18450.
PMCID: PMC3069094
Pendergast JS, Yeom M, Reyes BA, Ohmiya Y, Yamazaki S (2010) Disconnected circadian and cell cycles in a
tumor-driven cell line. Commun Integr Biol. 3:536-539. PMCID: PMC3038057
Pendergast JS, Friday RC, Yamazaki S (2010) Photic Entrainment of Period Mutant Mice is Predicted from
Their Phase Response Curves. J Neurosci. 30:12179-84. PMCID: PMC2943870
Yeom M, Pendergast JS, Ohmiya Y, Yamazaki S (2010) Circadian-independent cell mitosis in immortalized
fibroblasts. Proc Natl Acad Sci U S A. 107:9665-9670.
PMCID: PMC2906903
Shi S, Hida A, McGuinness OP, Wasserman DH, Yamazaki S, Johnson CH (2010) Circadian Clock Gene
Bmal1 Is Not Essential; Functional Replacement with its Paralog, Bmal2.
Curr Biol. 20: 316-21. PMCID: PMC2907674
Pendergast JS, Friday RC, Yamazaki S (2010) Distinct Functions of Period2 and Period3 in the Mouse
Circadian System Revealed by In Vitro Analysis. PLoS ONE 5(1): e8552. doi:10.1371/journal.pone.0008552.
PMCID: PMC2804141
Pendergast JS, Friday RC, Yamazaki S (2009) Endogenous Rhythms in Period1 Mutant Suprachiasmatic
Nuclei In Vitro Do Not Represent Circadian Behavior. J Neurosci 29:14681-14686. PMCID: PMC2806308
9

Pendergast JS, Nakamura W, Friday RC, Hatanaka F, Takumi T, Yamazaki S (2009) Robust food anticipatory
activity in BMAL1-deficient mice. PLoS ONE 4(3):e4860. PMCID: PMC2654093
Yamazaki S, Yoshikawa T, Biscoe EW, Numano R, Gallaspy LM, Soulsby S, Papadimas E, Pezuk P, Doyle
SE, Tei H, Sakaki Y, Block GD, Menaker M (2009) Ontogeny of Circadian Organization in the Rat. J Biol
Rhythms 24:55-63. PMCID: PMC2665126
Mistlberger RE, Yamazaki S, Pendergast JS, Landry GJ, Takumi T, Nakamura W (2008) Comment on
"Differential rescue of light- and food-entrainable circadian rhythms". Science 322:675. PMCID: PMC2583785
Ruan GX, Allen GC, Yamazaki S, McMahon DG (2008) An autonomous circadian clock in the inner mouse
retina regulated by dopamine and GABA. PLoS Biol 6(10):e249. PMCID: PMC2567003
Hiler DJ, Bhattacherjee A, Yamazaki S, Tei H, Geusz ME (2008) Circadian mPer1 Gene Expression in
Mesencephalic Trigeminal Nucleus Cultures. Brain Res 1214:84-93.
Akashi M, Hayasaka N, Yamazaki S, Node K (2008) Mitogen-Activated Protein Kinase Is a Functional
Component of the Autonomous Circadian System in the Suprachiasmatic Nucleus. J Neurosci 28: 4619-4623.
PMCID: PMC2440636
Kusanagi H, Hida A, Satoh K, Echizenya M, Shimizu T, Pendergast JS, Yamazaki S, Mishima K (2008)
Expression profiles of ten circadian clock genes in human peripheral blood mononuclear cells. Neurosci Res
61: 136-142.
Nakamura W, Yamazaki S, Nakamura TJ, Shirakawa T, Block GD, Takumi T (2008) In vivo monitoring of
circadian timing in freely moving mice. Current Biol 18: 381-385.
Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD (2008) Resetting of central and peripheral
circadian oscillators in aged rats. Neurobiology of Aging 29:471-477. PMCID: PMC1635489
Reyes BA, Pendergast JS, Yamazaki S (2008) Mammalian Peripheral Circadian Oscillators are Temperature
Compensated. J Biol Rhythms 23:95-98. PMCID: PMC2365757
Um JH, Yang S, Yamazaki S, Kang H, Viollet B, Chung JH (2007) Activation of AMPK with diabetes drug
metformin induces CKIe-dependent degradation of clock protein mPer2. J Biol Chem 282:20794-20798.
Davidson AJ, Sellix MT, Daniel J, Yamazaki S, Menaker M, Block GD (2006) Chronic Jet-lag increases
mortality in aged mice. Current Biol 16:R914-916. PMCID: PMC1635966
Ruan G, Zhang D-Q, Zhou T, Yamazaki S and McMahon DG (2006) Circadian Organization of the
Mammalian Retina. Proc Natl Acad Sci USA 103:9703-9708. PMCID: PMC1480470
Numano R, Yamazaki S, Umeda N, Samura T, Sujino M, Takahashi RI, Ueda M, Mori A, Yamada K, Sakaki
Y, Inouye SIT, Menaker M, Tei H (2006) Constitutive Expression of the Period1 Gene Impairs Behavioral and
Molecular Circadian Rhythms. Proc Natl Acad Sci USA 103:3716-3721. PMCID: PMC1450145
Yoshikawa T, Yamazaki S, Menaker M (2005) Effects of preparation time on phase of cultured tissues reveal
complexity of circadian organization. J Biol Rhythms 20: 500-512. PMCID: PMC1470468
Nakamura W, Yamazaki S, Takasu NN, Mishima K, Block GD (2005) Differential response of Per1
expression within the suprachiasmatic nucleus. J Neurosci 25: 5481-5487.
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Fukuhara C, Yamazaki S, Liang, J (2005) Pineal circadian clocks gate arylalkylamine. J Neurochem 93: 156-
162.
Yoo SH, Ko C, Lowrey P, Buhr E, Song E-J, Chang S, Yoo O, Yamazaki S, Lee C, Takahashi JS (2005) A
Novel E-box Enhancer Drives Mouse Period2 Circadian Oscillations in vivo. Proc Natl Acad Sci USA 102:
2608-2613. PMCID: PMC548324
Ohta H, Yamazaki S, McMahon DG (2005) Constant light desynchronizes mammalian clock neurons. Nat
Neurosci 8: 267-269.
Aton SJ, Block GD, Tei H, Yamazaki S, Herzog ED (2004) Plasticity of circadian behavior and the
suprachiasmatic nucleus following exposure to Non-24 hour light cycles. J Biol Rhythms 19: 198-207.
Yoo S-H, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong H-K, Oh WJ, Yoo OJ,
Menaker M, Takahashi JS (2004) PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals
persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci USA 101: 5339-5346. PMCID:
PMC397382
Izumo M, Johnson CH, Yamazaki S (2003) Circadian gene expression in mammalian fibroblasts revealed by
real-time luminescence reporting: temperature compensation and damping. Proc Natl Acad Sci USA 100:
16089-16094. PMCID: PMC307697
Vansteensel MJ, Yamazaki S, Albus H, Deboer T, Block GD, Meijer JH (2003) Dissociation between circadian
Per1 and neuronal and behavioral rhythms following a shifted environmental cycle. Curr Biol 13: 1538-1542.
Davidson AJ, Poole AS, Yamazaki S, Menaker M (2003) Is the food-entrainable circadian oscillator in the
digestive system? Genes Brain Behav 2: 32-39.
Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD (2002) Effects of aging on central and
peripheral mammalian clocks. Proc Natl Acad Sci USA 99: 10801-10806. PMCID: PMC125050
Yamazaki S, Alones V, Menaker M (2002) Interaction of retina with suprachiasmatic pacemakers in the
control of circadian behavior. J Biol Rhythms 17: 315-329.
Davidson AJ, Stokkan K-A, Yamazaki S, Menaker M (2002) Food-anticipatory activity and liver Per1-
luciferase expression in diabetic transgenic rats. Physiol Behav 76: 21-26.
Abe M, Herzog ED, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD (2002) Circadian
rhythms in isolated brain regions. J Neurosci 22: 350-356.
Wilsbacher LD, Yamazaki S, Herzog ED, Song EJ, Radcliffe LA, Abe M, Block G, Spitznagel E, Menaker M,
Takahashi JS (2002) Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo.
Proc Natl Acad Sci USA 99: 489-494. PMCID: PMC117587
Stokkan K-A, Yamazaki S, Tei H, Sakaki Y and Menaker M (2001) Entrainment of the circadian clock in the
liver by feeding. Science 291: 490-493.
Yamazaki S, Numano R, Abe M, Hida A, Takahashi RI, Ueda M, Block GD, Sakaki Y, Menaker M and Tei H
(2000) Resetting central and peripheral circadian oscillators in transgenic rats. Science 288: 682-685.
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Lowrey PL, Shimomura K, Antoch MP, Yamazaki S, Zemenides PD, Ralph MR, Menaker M and Takahashi JS
(2000) Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.
Science 288: 483-491.
Miranda-Anaya M, Bartell PA, Yamazaki S and Menaker M (2000) Circadian rhythms of ERG in Iguana
iguana: role of the pineal. J Biol Rhythms 15: 163-171.
Yamazaki S, Goto M and Menaker M (1999) No evidence for extraocular photoreceptors in the circadian
system of the Syrian hamster. J Biol Rhythms 14: 197-201.
Yamazaki S, Alones V, Irelan W and Menaker M (1999) Serotonin-containing cell bodies in novel brain
locations: effects of light input. NeuroReport 10: 431-435.
Yamazaki S, Kerbeshian MC, Hocker CG, Block GD and Menaker M (1998) Rhythmic properties of the
hamster suprachiasmatic nucleus in vivo. J Neurosci 18: 10709-10723.
Shimomura K, Kornhauser JM, Wisor JP, Umezu T, Yamazaki S, Ihara NL, Takahashi JS and Menaker M
(1998) Circadian behavior and plasticity of light-induced c-fos expression in SCN of tau mutant hamsters. J
Biol Rhythms 13: 305-314.
Yamazaki S, Mizuno M and Sasaki M (1995) Relationships between bilateral circadian pacemakers in intact
and neurally separated optic-lobes of a carabid beetle. Appl Entomol Zool 30: 537-542.
Yamazaki S, Inouye SIT and Kuroda Y (1995) TTX-resistant Ca2+ oscillation in cultured hypothalamus:
similarity to the mammalian circadian pacemaker. NeuroReport 6: 1306-1308.
Yamazaki S, Ishida Y and Inouye SIT (1994) Circadian rhythms of adenosine triphosphate contents in the
suprachiasmatic nucleus, anterior hypothalamic area and caudate putamen of the rat: negative correlation with
electrical activity. Brain Res 664: 237-240.
Yamazaki S, Maruyama M, Cagampang FRA and Inouye SIT (1994) Circadian fluctuations of cAMP content
in the suprachiasmatic nucleus and anterior hypothalamus of the rat. Brain Res 651: 329-331.
Cagampang FRA, Yamazaki S, Otori Y and Inouye SIT (1993) Serotonin in the raphe nuclei: regulation by
light and an endogenous pacemaker. NeuroReport 4: 49-52.
Otori Y, Cagampang FRA, Yamazaki S, Inouye SIT, Mano T and Tano Y (1993) Circadian rhythm of
neuropeptide Y-like immunoreactivity in the iris-ciliary body of the rat. Current Eye Res 12: 803-807.
Otori Y, Tominaga K, Fukuhara C, Yang J, Yamazaki S, Cagampang FRA, Okamura H and Inouye SIT (1993)
Substance P-like immunoreactivity in the suprachiasmatic nucleus of the rat. Brain Res 619: 271-277.
Yamazaki S (1992) Entrainment of the larval locomotor activity rhythm of a carabid beetle, Carabus insulicola
insulicola (Coleoptera: Carabidae) to T21 and T24 cycles and after-effects on free-running period. Jpn J Appl
Entomol Zool 36: 169-175. in Japanese
Yamazaki S and Yamashita S (1991) Efferent control in the ocellus of a noctuid moth. J Comp Physiol A 169:
647-652.
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Sasaki M, Yamazaki S and Chiba K (1987) Brain photoreception in the calling rhythm of a noctuid moth,
Anadevidia peponis: method of making eyeless moth and micro-irradiation of brain with fiber optics. Bulletin
of the Faculty of Agriculture, Tamagawa University 27: 81-90. in Japanese
REVIEW ARTICLES AND BOOK CHAPTERS (TOTAL OF 12):
Yamazaki S (2012) Peripheral Circadian Clocks. Dojin Bioscience 02 Chronobiology (Ebihara S and
Yoshimura T ed) Kagaku Dojin Co (Kyoto, Japan) 80-90.
Yamazaki S (2011) Peripheral Clocks. Japanese Journal of Sleep Medicine 5:55-61. in Japanese
Yamazaki S, Takahashi JS (2005) Real-time luminescence reporting of circadian gene expression in mammals.
Methods Enzymol 393: 288-301.
Davidson AJ, Yamazaki S, Menaker M (2003) SCN: Ringmaster of the circadian circus or conductor of the
circadian orchestra? Novartis Found Symp 253: 89-99.
Yamazaki S (2003) Oscillation mechanisms of the circadian rhythms. Brain Medical 15: 125-132. in Japanese
Yamazaki S (2001) “Chronoarchitecture”, hierarchical structure of central and peripheral clocks in mammals.
Japanese Society for Chronobiology 7(2): 5-12. in Japanese
Yamazaki S, Tei H (2000) Clock genes in mice and humans. In: Molecular Biology in Behavior (Yamamoto
D ed) Springer (Tokyo, Japan) 111-126 in Japanese
Yamazaki S (2000) Neural activity in the SCN. Clinical Neuroscience 18: 1143-1146. in Japanese
Yamazaki S (1999) Neural activity in the hamster SCN. J Clinical and Experimental Medicine 190: 285-286.
in Japanese
Yoshida T, Sasaki M and Yamazaki S (1995) Parasitism and reproduction of Varroa mite on the Japanese
honeybee, Apis cerana japonica. In: The Asiatic Hive Bee: Apiculture, Biology, and Role in Sustainable
Development in Tropical and Subtropical Asia (Kevan PG ed) Enviroquest Ltd (Ontario, CANADA) pp171-
175.
Inouye SIT, Shinohara K, Tominaga K, Takeuchi J, Nagasaki H, Isobe Y, Fukuhara C, Otori Y, Yang J,
Cagampang FRA, Yamazaki S and Tokumasu A (1993) Circadian rhythms in peptides and their precursor
messenger RNAs in the suprachiasmatic nucleus. In: New Functional Aspects of the Suprachiasmatic Nucleus
of the Hypothalamus (Nakagawa H, Oomura Y and Nagai K eds) John Libbey & Company Ltd, pp219-233.
Yamazaki S and Inouye SIT (1993) Oscillatory mechanisms of the circadian rhythm. Brain Medical 5: 267-
273 (in Japanese).
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