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Farmacologie van de inhalatie-anesthetica

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Toxiciteit: isoflurane en <strong>de</strong>sflurane<br />

• wegens <strong>de</strong> geringe metabolisatie <strong>de</strong> veiligste producten<br />

• <strong>de</strong>sflurane: keuzeproduct voor langdurige anesthesies<br />

• No <strong>de</strong>gradation by absorbent<br />

• BUT CO production especially by Desflurane in excessively<br />

dry absorbant ( first case of day) ( less with Iso and Enfl):<br />

pulse oxym. may be fooled<br />

Chronische toxiciteit<br />

• mutageen ?: enkel <strong>anesthetica</strong> met dubbele bindingen<br />

(divinyl ether, fluroxene, trichloorethyleen)<br />

• cancerogeen: surveys: zeer twijfelachtig: iets meer kanker<br />

(1.3x) bij vrouwen met chronische expositie<br />

• teratogeen: ?

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