Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
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Toxiciteit: halothane<br />
• reductieve metabolieten: type I<br />
• meer bij leverischemie (halothane reduces liver blood<br />
flow)<br />
• immunologisch mechanisme: type II: acyl hali<strong>de</strong><br />
intermediate breakdown molecule binds to liver cells, this<br />
complex is recognized by immunocompetent cells<br />
Toxiciteit: enflurane<br />
• cytochroom P 450 mediated : difluoromethoxydifluoroacetaat,<br />
inorganic fluori<strong>de</strong><br />
• nefrotoxiciteit (tubuluscel beschadiging met polyure<br />
nierinsufficiëntie) indien F > 50 µM/L ( which is never<br />
reached ) / not to be used in renal insufficiency ?<br />
• MAC-uur: langdurige anesthesies<br />
• Resistant to <strong>de</strong>gradation by absorbent
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