Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
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Biotransformatie<br />
Mth Methoxyflurane 40 - 50 %<br />
Halothane 15 - 20 %<br />
Sevoflurane 3 %<br />
Enflurane 2 %<br />
Isoflurane 0.2 %<br />
Desflurane 0.02 %<br />
Toxiciteit: halothane<br />
• halothane hepatitis: 1/10 000 volw.; extremely rare in children: type I &<br />
type II<br />
• type I: asymptomatic transient transam. increase 2 w post anest.<br />
requires no treatment<br />
• type II: onset from 7 – 28 d post anest. mortaliteit 50%<br />
• spontaneous <strong>de</strong>composition: Thymol
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