Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica
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Mechanism of action 2:<br />
• GABA A receptor – chlori<strong>de</strong> channel : inhibitory<br />
• Voltage – sensitive calcium channels:<br />
• T – type calcium channel<br />
• L – type<br />
• N – type<br />
• Specific mechanism for Isoflurane<br />
• NMDA receptor : Ketamine is inhibitor<br />
• Nicotinic i acetylcholine li receptors<br />
• Voltage – gated sodium channels<br />
The notion MAC: <strong>de</strong>finitions:<br />
• Mac awake : allows a voluntary response to commands in 50% of patients ( ~ amnestic dose: e.g.<br />
0,7 MAC Halothane)<br />
• MAC 95 : prevents 95% of patients responding to <strong>de</strong>fined noxious stimulus ( original standard MAC<br />
stimulus = skin incision in humans) = 1,3 MAC Halothane (other stimulus = other MAC value for<br />
that particular stimulus e.g.: intubation-MAC)<br />
• MAC BAR : blocks adrenergic response in 50% of patients = 1,5 MAC Halothane<br />
• MAC BAR95 : blocks 95% of patients = 2 MAC Halothane
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