Farmacologie van de inhalatie-anesthetica
Farmacologie van de inhalatie-anesthetica Farmacologie van de inhalatie-anesthetica
PaCO2 (mmHg) 90 80 70 60 50 40 desflurane + O2 isoflurane desflurane + N2O halothane N2O 30 0 0.5 1 1.5 2 MAC Eger EI II Desflurane Compendium, 1993 100 % of awake CO2-response slope 50 enflurane halothane 0 isoflurane 0 1 2 MAC Eger EI II Anesthesiology 55:559,1981
20 V (L/min) 15 10 5 25 20 15 10 hypoxic response awake halothane 0.1 MAC awake 5 halothane 1.1 MAC 40 50 60 70 80 90 100 PO2 mmHg Knill RL, Gelb AW Anesthesiology 49:244,1979 600 desflurane+60% N2O desflurane 8 300 Vt ml 4 V L/min 40 30 20 10 awake 1 2 MAC RR (b/min) 85 75 65 55 45 awake 1 2 MAC PaCO2 mmHg awake 1 2 MAC awake 1 2 MAC male volunteers Wartlier DC, Pagel PS Anest Analg 75:517,1992
- Page 1 and 2: Volatiele anesthetica Farmacodynami
- Page 3 and 4: Mechanism of action 2: • GABA A r
- Page 5 and 6: The notion MAC Additiviteit van MAC
- Page 8 and 9: MAC N2O Halo Enfl Isofl Desfl Sevo
- Page 10 and 11: F Br F Cl F F C C H H C O C C F F C
- Page 12 and 13: Nitrous oxide • 30 maal meer oplo
- Page 14 and 15: Nitrous oxide: biotransformatie en
- Page 16 and 17: Isoflurane: hemodynamica • matige
- Page 18 and 19: Sevoflurane: hemodynamica • vermi
- Page 20 and 21: HR (bts/min) 30 20 halothane isoflu
- Page 22 and 23: Cerebrale effecten • enflurane is
- Page 26 and 27: Bronchomotor tonus • bronchodilat
- Page 28 and 29: Mucociliaire functie • andere fac
- Page 30 and 31: Maligne hyperthermie Alle volatiele
- Page 32 and 33: Toxiciteit: halothane • reductiev
- Page 34 and 35: Toxiciteit: isoflurane en desfluran
- Page 36 and 37: Xenon : Xenon :
20 V (L/min)<br />
15<br />
10<br />
5<br />
25<br />
20<br />
15<br />
10<br />
hypoxic response<br />
awake<br />
halothane 0.1 MAC<br />
awake<br />
5<br />
halothane 1.1 MAC<br />
40 50 60 70 80 90 100<br />
PO2 mmHg<br />
Knill RL, Gelb AW Anesthesiology 49:244,1979<br />
600<br />
<strong>de</strong>sflurane+60% N2O<br />
<strong>de</strong>sflurane<br />
8<br />
300<br />
Vt<br />
ml<br />
4<br />
V<br />
L/min<br />
40<br />
30<br />
20<br />
10<br />
awake 1 2 MAC<br />
RR<br />
(b/min)<br />
85<br />
75<br />
65<br />
55<br />
45<br />
awake 1 2 MAC<br />
PaCO2<br />
mmHg<br />
awake 1 2 MAC<br />
awake 1 2 MAC<br />
male volunteers<br />
Wartlier DC, Pagel PS Anest Analg 75:517,1992
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